Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | PHD-finger family protein | 0.003 | 0.1008 | 0.1008 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4192 | 0.4541 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3411 | 0.3411 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9232 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.2184 | 0.4775 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.4573 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7253 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.4573 | 0.5792 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2986 | 0.4117 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.4573 | 0.4954 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.024 | 0.026 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.2184 | 0.4775 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0583 | 0.0803 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.005 | 0.0069 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.4573 | 0.6305 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.005 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3424 | 0.3709 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2986 | 0.4117 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0583 | 0.0738 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0583 | 0.0803 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.4573 | 0.4573 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.2184 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.024 | 0.0303 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.4573 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.005 | 0.0069 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7896 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3849 | 0.4169 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7253 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.4573 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.4573 | 0.6305 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.