Detailed information for compound 1498889

Basic information

Technical information
  • TDR Targets ID: 1498889
  • Name: 11-methylbenzo[a]carbazole-1,4-dione
  • MW: 261.275 | Formula: C17H11NO2
  • H donors: 0 H acceptors: 2 LogP: 2.87 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C=CC(=O)c2c1ccc1c2n(C)c2c1cccc2
  • InChi: 1S/C17H11NO2/c1-18-13-5-3-2-4-10(13)11-6-7-12-14(19)8-9-15(20)16(12)17(11)18/h2-9H,1H3
  • InChiKey: IUPDQKLAXUTBLE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 11-methylbenzo[a]carbazole-1,4-quinone
  • 68452-38-0
  • 1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl-
  • NSC92937
  • AIDS-073724
  • AIDS073724
  • NCI60_042064

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Plasmodium falciparum heat shock protein 90, putative Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2) Dengue virus type 2 NS3 protein Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens arrestin, beta 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei 2'-O-ribose RNA methyltransferase SPB1 homolog Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum ftsJ-like methyltransferase domain-containing protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans potential FtsJ-like methyltransferase similar to S. cerevisiae SPB1 (YCL054W) putative rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium falciparum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis rrna methyltransferase 3 Get druggable targets OG5_126871 All targets in OG5_126871
Treponema pallidum glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans similar to S. cerevisiae MRM2 (YGL136C) mitochondrial rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ribosomal RNA methyltransferase (FtsJ) family protein Get druggable targets OG5_126871 All targets in OG5_126871
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis 6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Treponema pallidum cell division protein (ftsJ) Get druggable targets OG5_126871 All targets in OG5_126871
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii Glucose-6-phosphate dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus granulosus beta arrestin 1 Get druggable targets OG5_131375 All targets in OG5_131375
Babesia bovis ribosomal RNA large subunit methyltransferase J family protein Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus beta arrestin 1 Get druggable targets OG5_131375 All targets in OG5_131375
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Giardia lamblia FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis beta arrestin 1 Get druggable targets OG5_131375 All targets in OG5_131375
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Theileria parva rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax ribosomal RNA large subunit methyltransferase J, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04439 arrestin, putative Get druggable targets OG5_131375 All targets in OG5_131375
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma congolense FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Probable beta-arrestin Get druggable targets OG5_131375 All targets in OG5_131375
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni cell division protein ftsj Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Theileria parva glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma congolense FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Entamoeba histolytica ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma mansoni beta-arrestin 1 Get druggable targets OG5_131375 All targets in OG5_131375
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis ribosomal RNA large subunit methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans potential FtsJ-like methyltransferase similar to S. cerevisiae SPB1 (YCL054W) putative rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis beta arrestin 1 Get druggable targets OG5_131375 All targets in OG5_131375
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum Beta-arrestin-1, putative Get druggable targets OG5_131375 All targets in OG5_131375
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis beta arrestin 1 Get druggable targets OG5_131375 All targets in OG5_131375
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax heat shock protein, putative Get druggable targets OG5_144951 All targets in OG5_144951
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis heat shock protein 90 Get druggable targets OG5_144951 All targets in OG5_144951
Plasmodium vivax FtsJ-like methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum Putative rRNA methyltransferase 3, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K00599 rRNA methyltransferase Spb1 [EC:2.1.1.-], putative Get druggable targets OG5_126871 All targets in OG5_126871
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Putative ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni beta-arrestin 1 Get druggable targets OG5_131375 All targets in OG5_131375
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii Hsp90 domain-containing protein Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus beta arrestin 1 Get druggable targets OG5_131375 All targets in OG5_131375
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_126871 All targets in OG5_126871
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania donovani FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum large subunit rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131375 All targets in OG5_131375
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium berghei large subunit rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K00036 glucose-6-phosphate 1-dehydrogenase [EC1.1.1.49], putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis FtsJ cell division protein Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei gambiense FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium knowlesi glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus granulosus putative ribosomal RNA methyltransferase/cell division FtsJ protein Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126871 All targets in OG5_126871
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii heat shock protein 83 Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Babesia bovis ribosomal RNA large subunit methyltransferase J protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium berghei ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi large subunit rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein Get druggable targets OG5_126871 All targets in OG5_126871
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum ribosomal RNA large subunit methyltransferase J, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum Arrestin red cell isoform 2, putative Get druggable targets OG5_131375 All targets in OG5_131375
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum Spb1p-like, FtsJ methylase Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus granulosus rrna methyltransferase 3 Get druggable targets OG5_126871 All targets in OG5_126871
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K02427 cell division protein methyltransferase FtsJ, putative Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii FtsJ cell division protein Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium falciparum ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Babesia bovis glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0123 0.3393 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0457 0.1196
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0457 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.0738
Trypanosoma brucei heat shock protein 84, putative 0.0037 0.0659 0.2111
Loa Loa (eye worm) glutaminase 2 0.033 1 1
Echinococcus multilocularis heat shock protein 90 0.0055 0.125 0.1954
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.1142 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.023 0.1286
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Trichomonas vaginalis endoplasmin, putative 0.004 0.0767 0.0549
Schistosoma mansoni DNA polymerase eta 0.0054 0.121 0.1125
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0457 0.0596
Schistosoma mansoni heat shock protein 0.0037 0.0659 0.0568
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0742 0.2138
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0123 0.3393 0.3238
Trypanosoma brucei Heat shock protein 83, putative 0.0055 0.125 0.4006
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Echinococcus granulosus dna polymerase eta 0.0054 0.121 0.1886
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.3121 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.2167 0.3506
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1286 0.1081
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.121 0.1125
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0845 0.1268
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.023 0.0738
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3121 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0845 0.1268
Plasmodium falciparum heat shock protein 90 0.0055 0.125 0.1902
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0773 0.0555
Trypanosoma brucei unspecified product 0.0023 0.023 0.0738
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3121 0.2958
Plasmodium falciparum endoplasmin, putative 0.004 0.0767 0.1106
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0609 0.0846
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.023 0.0136
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0074 0.183 0.1638
Schistosoma mansoni beta-arrestin 1 0.0042 0.0814 0.0725
Echinococcus multilocularis beta arrestin 1 0.0044 0.0875 0.1319
Schistosoma mansoni glutaminase 0.033 1 1
Brugia malayi jmjC domain containing protein 0.0043 0.0845 0.0757
Echinococcus multilocularis dna polymerase eta 0.0054 0.121 0.1886
Schistosoma mansoni endoplasmin 0.0055 0.125 0.1166
Loa Loa (eye worm) hypothetical protein 0.0044 0.0875 0.0787
Echinococcus multilocularis beta arrestin 1 0.0042 0.0814 0.1216
Echinococcus granulosus beta arrestin 1 0.0042 0.0814 0.1216
Echinococcus granulosus expressed protein 0.004 0.0773 0.1146
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.3121 0.3054
Leishmania major DNA polymerase eta, putative 0.0054 0.121 0.3683
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.023 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.0738
Schistosoma mansoni heat shock protein 0.0055 0.125 0.1166
Schistosoma mansoni chromobox protein 0.0084 0.2167 0.2092
Trypanosoma brucei heat shock protein, putative 0.0055 0.125 0.4006
Echinococcus granulosus heat shock protein 0.0055 0.125 0.1954
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.023 0.0445
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3121 0.2958
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.3121 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0609 0.0846
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0457 0.1466
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0996 0.2975
Echinococcus granulosus jumonji domain containing protein 0.0049 0.1048 0.1612
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.023 0.0445
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.125 0.3817
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Toxoplasma gondii heat shock protein 90, putative 0.0055 0.125 0.1902
Toxoplasma gondii Hsp90 domain-containing protein 0.021 0.6166 1
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1286 0.1081
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0609 0.0869
Echinococcus granulosus endoplasmin 0.0052 0.1142 0.1771
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0742 0.2138
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0113 0.3074 0.9851
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0037 0.0659 0.0106
Onchocerca volvulus 0.0182 0.5299 1
Schistosoma mansoni rotamase 0.004 0.0773 0.0683
Echinococcus granulosus heat shock protein 90 0.0047 0.0996 0.1523
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0742 0.1065
Plasmodium vivax heat shock protein 86, putative 0.0055 0.125 0.1902
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3121 0.2958
Echinococcus multilocularis geminin 0.0205 0.6004 1
Brugia malayi jmjC domain containing protein 0.0115 0.316 0.3094
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0996 0.2975
Brugia malayi Bromodomain containing protein 0.0035 0.0609 0.0519
Leishmania major DNA polymerase eta, putative 0.0038 0.0698 0.1991
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.023 0.0738
Echinococcus multilocularis heat shock protein 90 0.0047 0.0996 0.1523
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Trypanosoma brucei heat shock protein, putative 0.0055 0.125 0.4006
Plasmodium vivax endoplasmin, putative 0.0055 0.125 0.1902
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3121 0.2958
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0609 0.0846
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.1142 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.023 0.1286
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3121 0.2958
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.2167 0.2092
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0845 0.0757
Echinococcus multilocularis beta arrestin 1 0.0044 0.0875 0.1319
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.0738
Trichomonas vaginalis heat shock protein, putative 0.0052 0.1142 0.0933
Trypanosoma brucei heat shock protein, putative 0.0055 0.125 0.4006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0845 0.0757
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.023 0.0738
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.3074 0.9846
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.3121 0.3054
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0037 0.0659 0.0953
Loa Loa (eye worm) glutaminase 0.033 1 1
Plasmodium falciparum heat shock protein 90, putative 0.0032 0.0512 0.0686
Trypanosoma brucei heat shock protein, putative 0.0055 0.125 0.4006
Trichomonas vaginalis heat shock protein, putative 0.0055 0.125 0.1044
Echinococcus granulosus dna polymerase kappa 0.0023 0.023 0.0228
Trypanosoma brucei polo-like protein kinase 0.0114 0.3121 1
Echinococcus granulosus chromobox protein 1 0.0084 0.2167 0.3506
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.0738
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.125 0.3224
Trichomonas vaginalis rotamase, putative 0.004 0.0773 0.0555
Trypanosoma brucei heat shock protein, putative 0.0055 0.125 0.4006
Schistosoma mansoni hypothetical protein 0.0205 0.6004 0.5966
Echinococcus granulosus chromobox protein 1 0.0084 0.2167 0.3506
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0037 0.0659 0.0953
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.0996 0.242
Toxoplasma gondii heat shock protein HSP90 0.0055 0.125 0.1902
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.0738
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.023 0.0228
Brugia malayi heat shock protein 90 0.0055 0.125 0.1166
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0113 0.3074 0.3007
Loa Loa (eye worm) heat shock protein 75 0.0037 0.0659 0.0568
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0113 0.3074 1
Echinococcus multilocularis peregrin 0.0035 0.0609 0.0869
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.3121 0.3054
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.0738
Echinococcus granulosus beta arrestin 1 0.0044 0.0875 0.1319
Schistosoma mansoni endoplasmin 0.0055 0.125 0.1166
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.023 0.0445
Schistosoma mansoni beta-arrestin 1 0.0044 0.0875 0.0787
Onchocerca volvulus 0.0037 0.0666 0.012
Brugia malayi hypothetical protein 0.0182 0.5299 0.5253
Trypanosoma cruzi Heat shock protein 83, putative 0.0055 0.125 0.3817
Trichomonas vaginalis heat shock protein, putative 0.004 0.0767 0.0549
Echinococcus multilocularis endoplasmin 0.0052 0.1142 0.1771
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.1104 0.1055
Loa Loa (eye worm) hypothetical protein 0.003 0.0457 0.0365
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0113 0.3074 0.3007
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1104 0.0894
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0047 0.0996 0.1523
Plasmodium vivax heat shock protein 90, putative 0.0037 0.0659 0.0928
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.3393 0.3238
Plasmodium vivax heat shock protein, putative 0.021 0.6166 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.023 0.0228
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0113 0.3074 0.5041
Schistosoma mansoni hypothetical protein 0.0035 0.0609 0.0519
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3121 1
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.125 0.3817
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.3074 0.9846
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0609 0.0519
Brugia malayi Endoplasmin precursor 0.0055 0.125 0.1166
Echinococcus multilocularis dna polymerase kappa 0.0023 0.023 0.0228
Giardia lamblia PHD finger protein 15 0.0035 0.0609 0.1198
Loa Loa (eye worm) hypothetical protein 0.0047 0.099 0.0903
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0773 0.0683
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3121 0.2958
Toxoplasma gondii heat shock protein 75, putative 0.0037 0.0659 0.0928
Brugia malayi Heterochromatin protein 1 0.0084 0.2167 0.2092
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.1142 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0457 0.0596
Loa Loa (eye worm) hypothetical protein 0.0054 0.121 0.1125
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0742 0.2138
Echinococcus multilocularis heat shock protein 0.0055 0.125 0.1954
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1104 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0552 0.0329
Loa Loa (eye worm) endoplasmin 0.0055 0.125 0.1166
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0512 0.0289
Schistosoma mansoni kinase 0.0058 0.1334 0.125
Echinococcus granulosus heat shock protein 90 0.0055 0.125 0.1954
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0996 0.0783
Leishmania major hypothetical protein, conserved 0.003 0.0457 0.1196
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1803 0.1724
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Schistosoma mansoni jumonji domain containing protein 0.0092 0.2405 0.2332
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0096 0.0307
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0123 0.3393 0.5432
Brugia malayi hypothetical protein 0.002 0.0114 0.0018
Echinococcus granulosus beta arrestin 1 0.0044 0.0875 0.1319
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.3121 0.5119
Giardia lamblia Grp94/Hsp90 0.0052 0.1142 0.2882
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.121 0.3877
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2167 0.1983
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.023 0.0136
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0609 0.0519
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0123 0.3393 0.5432
Mycobacterium ulcerans glutaminase 0.033 1 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.3121 0.5355
Echinococcus granulosus geminin 0.0205 0.6004 1
Brugia malayi chromobox protein homolog 3 0.0047 0.099 0.0903
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0698 0.1991
Leishmania major heat shock protein, putative 0.0037 0.0659 0.1861
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3121 0.2958
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0742 0.2379
Trichomonas vaginalis rotamase, putative 0.0039 0.0742 0.0524
Brugia malayi Probable beta-arrestin 0.0044 0.0875 0.0787
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0226 0.043
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.023 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.0738
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.0738
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.125 0.4006
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0036 0.0642 0.1806
Brugia malayi glucose-6-phosphate dehydrogenase 0.0113 0.3074 0.3007
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.1048 0.1612
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0457 0.1196
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.316 0.5186
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0039 0.0732 0.6082
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0113 0.3074 0.5041
Schistosoma mansoni chromobox protein 0.0084 0.2167 0.2092
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0845 0.0757
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Trypanosoma brucei heat shock protein, putative 0.0055 0.125 0.4006
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0096 0.0307
Trypanosoma brucei heat shock protein, putative 0.0055 0.125 0.4006
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.125 0.3817
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.0738
Trichomonas vaginalis heat shock protein, putative 0.0052 0.1142 0.0933
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.125 0.3817
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0609 0.0869
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0037 0.0659 0.1482
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.1142 0.3459
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0742 0.1772
Echinococcus multilocularis expressed protein 0.004 0.0773 0.1146
Brugia malayi Hsp90 protein 0.0037 0.0659 0.0568
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.125 0.3529
Plasmodium falciparum heat shock protein 90, putative 0.021 0.6166 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.099 0.0812
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.099 0.0778
Schistosoma mansoni hypothetical protein 0.0205 0.6004 0.5966
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0113 0.3074 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.023 0.0445
Leishmania major DNA polymerase kappa, putative 0.0023 0.023 0.0445
Brugia malayi hypothetical protein 0.003 0.0457 0.0365
Echinococcus granulosus peregrin 0.0035 0.0609 0.0869
Loa Loa (eye worm) heat shock protein 90 0.0055 0.125 0.1166
Schistosoma mansoni heat shock protein 0.0055 0.125 0.1166
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0074 0.183 0.2857
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.3121 0.5119
Brugia malayi PHD-finger family protein 0.0035 0.0609 0.0519
Giardia lamblia Kinase, PLK 0.0114 0.3121 0.9138
Loa Loa (eye worm) hypothetical protein 0.006 0.141 0.1327
Loa Loa (eye worm) hypothetical protein 0.0182 0.5299 0.5253
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0698 0.0992
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.121 0.3683
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0123 0.3393 0.5432
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.125 0.4006
Leishmania major heat shock protein 83-1 0.0055 0.125 0.3817
Loa Loa (eye worm) hypothetical protein 0.0037 0.0666 0.0575
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.0738
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.023 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.099 0.0778
Loa Loa (eye worm) hypothetical protein 0.0035 0.0609 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0552 0.0329
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.316 0.5186
Trypanosoma brucei heat shock protein, putative 0.0055 0.125 0.4006
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0457 0.0596
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.3393 0.3238
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0113 0.3074 0.2911
Echinococcus multilocularis chromobox protein 1 0.0084 0.2167 0.3506
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0773 0.0683
Mycobacterium ulcerans heat shock protein 90 0.0052 0.1142 0.0933
Trypanosoma cruzi heat shock protein, putative 0.0037 0.0659 0.1861
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0037 0.0676 0.192
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.125 0.3529
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2167 0.1983
Plasmodium falciparum phd finger protein, putative 0.0035 0.0609 0.0846
Trichomonas vaginalis glutaminase, putative 0.033 1 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 8.017 uM PUBCHEM_BIOASSAY: Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (functional) = 8.992 uM PUBCHEM_BIOASSAY: HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
GI50 (functional) -6.132 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.598 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.47 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.454 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.166 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.159 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.003 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.939 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.895 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.797 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 1.8 uM PUBCHEM_BIOASSAY: Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) 4.59 uM PUBCHEM_BIOASSAY: Dose Response Assay for Inhibitors of the beta-Arrestin-Adaptor Protein 2 Interaction for Cherry Pick 1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504490, AID504493, AID504541] ChEMBL. No reference
IC50 (functional) 15.78 uM PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Cherrypicks in WT IDH1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.9728 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Confirmation of Cherrypicks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9173 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.4591 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.2809 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.