Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1721 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1721 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1721 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1721 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0708 | 0.4053 | 0.4053 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1721 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.0708 | 0.4053 | 0.4053 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.0292 | 0.0292 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.0292 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 0.0292 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0292 | 0.0292 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0807 | 0.4634 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0708 | 0.4053 | 0.4053 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1721 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.0292 | 0.0292 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0708 | 0.4053 | 0.4053 |
Brugia malayi | CHE-14 protein | 0.0708 | 0.4053 | 0.4053 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.0292 | 0.0292 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0807 | 0.4634 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1093 | 0.1093 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1721 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0708 | 0.4053 | 0.4053 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0292 | 0.0292 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0708 | 0.4053 | 0.4053 |
Echinococcus granulosus | geminin | 0.0205 | 0.1093 | 0.1093 |
Echinococcus multilocularis | protein dispatched 1 | 0.0708 | 0.4053 | 0.4053 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0708 | 0.4053 | 0.4053 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0807 | 0.4634 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0807 | 0.4634 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0292 | 0.0292 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0708 | 0.4053 | 0.4053 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0292 | 0.0292 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1721 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1721 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1093 | 0.1093 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1093 | 0.1093 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0708 | 0.4053 | 0.8747 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0292 | 0.0292 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0708 | 0.4053 | 0.4053 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0708 | 0.4053 | 0.4053 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.9349 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.