Detailed information for compound 1498960

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 472.514 | Formula: C22H24N4O6S
  • H donors: 2 H acceptors: 6 LogP: 1.37 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)CCc1nc(O)c2c(n1)cccc2)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C22H24N4O6S/c1-31-19-7-6-15(33(29,30)26-10-12-32-13-11-26)14-18(19)24-21(27)9-8-20-23-17-5-3-2-4-16(17)22(28)25-20/h2-7,14H,8-13H2,1H3,(H,24,27)(H,23,25,28)
  • InChiKey: VTRCSDYZQDNSKC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0129 0.0087 0.0327
Leishmania major oligopeptidase b 0.0041 0.0016 0.0016
Leishmania major cytochrome p450-like protein 0.005 0.0024 0.0024
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0041 0.0016 0.0016
Onchocerca volvulus 0.0151 0.0105 0.0396
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0087 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0087 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.041 0.0313 0.0313
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.001 0.001
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.005 0.0024 0.0024
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0087 0.0053 0.0053
Brugia malayi acetyltransferase, GNAT family protein 0.0265 0.0196 0.0196
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0035 0.0011 0.0011
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0061 0.0032 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.001 0.001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0078 0.0046 0.0173
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0026 0.0004 0.0015
Schistosoma mansoni nuclear receptor 0.0193 0.0139 0.0404
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0033 0.001 0.001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0216 0.0157 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0003 0.0003
Schistosoma mansoni inositol monophosphatase 0.0061 0.0032 0.0093
Brugia malayi nuclear receptor NHR-88 0.0193 0.0139 0.0139
Echinococcus granulosus tumor protein p63 0.0292 0.0219 0.0825
Echinococcus granulosus nuclear receptor nhr 48 0.0193 0.0139 0.0524
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0026 0.0004 0.0004
Brugia malayi MH1 domain containing protein 0.0041 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0118 0.0078 0.0227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0011 0.0032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0373 0.0284 0.0284
Mycobacterium ulcerans beta-lactamase 0.0033 0.001 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0026 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.0116 0.0077 0.0223
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1388 0.1102 0.4155
Echinococcus granulosus tissue type plasminogen activator 0.0027 0.0005 0.0019
Schistosoma mansoni glutaminase 0.0231 0.0169 0.0491
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.005 0.0024 0.1558
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.041 0.0313 0.0313
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.041 0.0313 0.0911
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.001 0.001
Entamoeba histolytica steroid 5-alpha reductase, putative 1.2431 1 1
Loa Loa (eye worm) hypothetical protein 1.2431 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.041 0.0313 0.0313
Brugia malayi hypothetical protein 0.038 0.0289 0.0289
Brugia malayi hypothetical protein 0.0193 0.0139 0.0139
Trichomonas vaginalis glutaminase, putative 0.0231 0.0169 0.0169
Trypanosoma cruzi oligopeptidase b 0.0041 0.0016 0.0016
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0506 0.0391 0.1473
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0027 0.0005 0.0019
Onchocerca volvulus 0.3311 0.2651 1
Entamoeba histolytica hypothetical protein 0.3311 0.2651 0.2648
Brugia malayi Nuclear hormone receptor family member nhr-25 0.041 0.0313 0.0313
Onchocerca volvulus 0.0027 0.0005 0.0019
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0026 0.0004 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.041 0.0313 0.0313
Schistosoma mansoni nocturnin 0.0026 0.0004 0.0012
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0026 0.0004 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.001 0.001
Mycobacterium tuberculosis Probable exported protein 0.0026 0.0004 0.0265
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0104 0.0067 0.0193
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0011 0.0011
Plasmodium falciparum histone acetyltransferase GCN5 0.0071 0.0041 0.0153
Loa Loa (eye worm) hypothetical protein 0.0087 0.0053 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0003 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0597 0.0464 0.0464
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0091 0.0091
Schistosoma mansoni thyroid hormone receptor 0.0519 0.0401 0.1166
Brugia malayi beta-lactamase 0.0033 0.001 0.001
Brugia malayi MH2 domain containing protein 0.0597 0.0464 0.0464
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0026 0.0004 0.0004
Echinococcus granulosus inositol monophosphatase 1 0.0061 0.0032 0.012
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0087 0.0053 0.0053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0488 0.0377 0.142
Leishmania major hypothetical protein, conserved 0.0033 0.001 0.001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0 0.0001
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0026 0.0004 0.0004
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0061 0.0032 0.0028
Echinococcus multilocularis beta LACTamase domain containing family member 0.0033 0.001 0.0036
Schistosoma mansoni biogenic amine (5HT) receptor 0.0229 0.0167 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0014 0.0014
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0026 0.0004 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.0093 0.0093
Mycobacterium ulcerans lipase LipD 0.0033 0.001 0.001
Echinococcus multilocularis Niemann Pick C1 protein 0.0128 0.0087 0.0326
Plasmodium falciparum cysteine repeat modular protein 1 0.0027 0.0005 0.0019
Trypanosoma cruzi cytochrome P450, putative 0.0111 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0419 0.0321 0.0321
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.0087 0.0053 0.0154
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.3311 0.2651 0.2651
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0087 0.0053 0.0053
Echinococcus multilocularis tumor protein p63 0.0292 0.0219 0.0825
Loa Loa (eye worm) runx1 0.0048 0.0021 0.0021
Echinococcus multilocularis 0.005 0.0024 0.0089
Mycobacterium tuberculosis Conserved protein 0.0033 0.001 0.0629
Loa Loa (eye worm) hypothetical protein 0.041 0.0313 0.0313
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.041 0.0313 0.0313
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0054 0.0027 0.176
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.0091 0.5951
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Brugia malayi steroid hormone receptor 0.041 0.0313 0.0313
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0033 0.001 0.0629
Echinococcus multilocularis sentrin specific protease 1 0.003 0.0007 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0952 0.075 0.075
Trypanosoma cruzi oligopeptidase b 0.0041 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.041 0.0313 0.0313
Brugia malayi latrophilin 2 splice variant baaae 0.0255 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.005 0.0024 0.1558
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0026 0.0004 0.0004
Schistosoma mansoni protease m14 carboxypeptidase 0.0087 0.0053 0.0154
Schistosoma mansoni zinc finger protein 0.0193 0.0139 0.0404
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0118 0.0078 0.0295
Loa Loa (eye worm) hypothetical protein 0.041 0.0313 0.0313
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.005 0.0024 0.0024
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 1.2431 1 1
Loa Loa (eye worm) CYP4Cod1 0.0111 0.0073 0.0073
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0026 0.0004 0.0004
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0193 0.0139 0.0139
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0087 0.0053 0.02
Brugia malayi hypothetical protein 0.0217 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0217 0.0158 0.0158
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0061 0.0032 0.0032
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0033 0.001 0.0629
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.021 0.0152 1
Brugia malayi Zinc carboxypeptidase family protein 0.0087 0.0053 0.0053
Leishmania major hypothetical protein, conserved 0.0026 0.0004 0.0004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0129 0.0087 0.0087
Loa Loa (eye worm) zinc carboxypeptidase 0.0087 0.0053 0.0053
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0026 0.0004 0.0004
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0087 0.0053 0.0053
Brugia malayi tailless protein 0.0193 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0018
Echinococcus multilocularis L aminoadipate semialdehyde 0.0072 0.0041 0.0155
Echinococcus granulosus Smad4 0.0041 0.0016 0.006
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0118 0.0078 0.0227
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.009 0.0055 0.0051
Schistosoma mansoni hypothetical protein 0.0037 0.0013 0.0038
Mycobacterium leprae Probable lipase LipE 0.0033 0.001 0.3576
Schistosoma mansoni hypothetical protein 0.0037 0.0013 0.0038
Loa Loa (eye worm) hypoxia-induced factor 1 0.013 0.0088 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0003 0.0003
Schistosoma mansoni retinoic acid receptor RXR 0.041 0.0313 0.0911
Echinococcus granulosus ecdysone induced protein 78C 0.041 0.0313 0.1182
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.005 0.0024 0.1558
Echinococcus granulosus Desert hedgehog protein 0.0126 0.0085 0.0319
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0087 0.0053 0.0053
Echinococcus granulosus Niemann Pick C1 protein 0.0128 0.0087 0.0326
Trichomonas vaginalis ap endonuclease, putative 0.0129 0.0087 0.0087
Onchocerca volvulus 0.0031 0.0008 0.0031
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0061 0.0032 0.0032
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0093 0.0058 0.3799
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0129 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.0021
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.2431 1 1
Trichomonas vaginalis helicase, putative 0.0025 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.041 0.0313 0.0313
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.015 0.015
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.0087 0.0053 0.02
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 1.2431 1 1
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.3311 0.2651 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0035 0.0011 0.0041
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0087 0.0053 0.0053
Plasmodium vivax SET domain protein, putative 0.0021 0 0.0001
Brugia malayi nuclear hormone receptor family member odr-7 0.0193 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.003 0.0007 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.005 0.0024 0.1558
Echinococcus granulosus beta LACTamase domain containing family member 0.0033 0.001 0.0036
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3311 0.2651 1
Loa Loa (eye worm) hypothetical protein 0.041 0.0313 0.0313
Loa Loa (eye worm) DR-78 0.0193 0.0139 0.0139
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0041 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.041 0.0313 0.0313
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.0091 0.0091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0234 0.0172 0.0499
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0004 0.0015
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0506 0.0391 0.1473
Trichomonas vaginalis bromodomain-containing protein, putative 0.0078 0.0046 0.0046
Brugia malayi Zinc carboxypeptidase family protein 0.0087 0.0053 0.0053
Echinococcus multilocularis GPCR, family 2 0.0118 0.0078 0.0295
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0087 0.0053 0.02
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0016 0.0016
Loa Loa (eye worm) glutaminase 2 0.0231 0.0169 0.0169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.041 0.0313 0.1182
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0033 0.001 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0129 0.0087 0.0087
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0061 0.0032 0.0032
Brugia malayi Zinc carboxypeptidase family protein 0.0087 0.0053 0.0053
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.005 0.0024 0.0024
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.3311 0.2651 0.2651
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Brugia malayi nuclear receptor RXR 0.0217 0.0158 0.0158
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.005 0.0024 0.1558
Brugia malayi ecdysone receptor 0.0193 0.0139 0.0139
Mycobacterium tuberculosis Conserved protein 0.0033 0.001 0.0629
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.3311 0.2651 0.2648
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.0093 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0003 0.0003
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0026 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.041 0.0313 0.0911
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0003 0.0003
Toxoplasma gondii prolyl endopeptidase 0.0104 0.0067 0.0067
Onchocerca volvulus 0.0193 0.0139 0.0524
Loa Loa (eye worm) hypothetical protein 0.0217 0.0158 0.0158
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.003 0.0007 0.0021
Loa Loa (eye worm) hypothetical protein 0.0087 0.0053 0.0053
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0104 0.0067 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.005 0.0024 0.1558
Loa Loa (eye worm) cytochrome P450 family protein 0.0101 0.0065 0.0065
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.3311 0.2651 1
Echinococcus multilocularis synaptic glycoprotein sc2 0.3311 0.2651 1
Brugia malayi Cytochrome P450 family protein 0.005 0.0024 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.015 0.015
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0193 0.0139 0.0524
Loa Loa (eye worm) transcription factor SMAD2 0.0597 0.0464 0.0464
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0026 0.0004 0.0004
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0087 0.0053 0.0053
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0026 0.0004 0.0004
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0091 0.0057 0.0164
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0026 0.0004 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0217 0.0158 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.015 0.015
Onchocerca volvulus 0.0193 0.0139 0.0524
Brugia malayi exodeoxyribonuclease III family protein 0.0129 0.0087 0.0087
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.005 0.0024 0.0024
Onchocerca volvulus Putative neutral sphingomyelinase 0.0026 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.3311 0.2651 0.2651
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0003 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.0488 0.0377 0.142
Brugia malayi Nuclear hormone receptor-like 1 0.0217 0.0158 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.1567 0.1246 0.362
Echinococcus multilocularis microtubule associated protein 2 0.1662 0.1322 0.4987
Loa Loa (eye worm) hypothetical protein 0.041 0.0313 0.0313
Trypanosoma cruzi zinc carboxypeptidase, putative 0.0087 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.001
Brugia malayi Kringle domain containing protein 0.0027 0.0005 0.0005
Brugia malayi nuclear hormone receptor 0.041 0.0313 0.0313
Brugia malayi beta-lactamase family protein 0.0033 0.001 0.001
Brugia malayi MH1 domain containing protein 0.0022 0.0001 0.0001
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0026 0.0004 0.0015
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.0087 0.0053 0.0154
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0091 0.0091
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.005 0.0024 0.0024
Loa Loa (eye worm) nuclear receptor NHR-67 0.0193 0.0139 0.0139
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0193 0.0139 0.0524
Loa Loa (eye worm) hypothetical protein 0.3311 0.2651 0.2651
Echinococcus multilocularis hedgehog 0.0126 0.0085 0.0319
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.005 0.0024 0.1558
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.005 0.0024 0.0024
Schistosoma mansoni peptidase 0.0087 0.0053 0.0154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0193 0.0139 0.0524
Brugia malayi nuclear receptor NHR-88 0.041 0.0313 0.0313
Schistosoma mansoni carbon catabolite repressor protein 0.0026 0.0004 0.0012
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0016 0.006
Onchocerca volvulus Protein ultraspiracle homolog 0.041 0.0313 0.1182
Brugia malayi Nuclear hormone receptor E75 0.0193 0.0139 0.0139
Brugia malayi Carboxypeptidase A2 precursor 0.0087 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Mycobacterium ulcerans hypothetical protein 1.2431 1 1
Schistosoma mansoni coup transcription factor 0.041 0.0313 0.0911
Echinococcus granulosus microtubule associated protein 2 0.1662 0.1322 0.4987
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0026 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.3311 0.2651 0.2651
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0026 0.0004 0.0004
Echinococcus granulosus GPCR family 2 0.0118 0.0078 0.0295
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0087 0.0053 0.0053
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0026 0.0004 0.0004
Toxoplasma gondii flagellar/basal body protein 0.0087 0.0053 0.0053
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0133 0.009 0.009
Onchocerca volvulus 0.0033 0.001 0.0036
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0026 0.0004 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0003 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.041 0.0313 0.1182
Loa Loa (eye worm) hypothetical protein 0.0217 0.0158 0.0158
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.041 0.0313 0.0911
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.3311 0.2651 0.2651
Brugia malayi MH2 domain containing protein 0.0041 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.038 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.001
Onchocerca volvulus 0.011 0.0072 0.0271
Plasmodium vivax hypothetical protein, conserved 0.0087 0.0053 0.02
Trypanosoma brucei Carboxypeptidase-like protein 0.0087 0.0053 0.0053
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.005 0.0024 0.0024
Echinococcus multilocularis ecdysone induced protein 78C 0.041 0.0313 0.1182
Echinococcus multilocularis prolyl endopeptidase 0.0104 0.0067 0.0251
Echinococcus multilocularis traf and tnf receptor associated protein 0.0026 0.0004 0.0015
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0026 0.0004 0.0004
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.3311 0.2651 0.2651
Echinococcus multilocularis protein patched 0.0039 0.0014 0.0053
Leishmania major hypothetical protein, conserved 0.0026 0.0004 0.0004
Mycobacterium tuberculosis Conserved protein 0.0033 0.001 0.0629
Plasmodium falciparum DNase I-like protein, putative 0.0026 0.0004 0.0015
Schistosoma mansoni hypothetical protein 0.0092 0.0057 0.0166
Loa Loa (eye worm) hypothetical protein 0.0087 0.0053 0.0053
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.005 0.0024 0.1558
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.001
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.005 0.0024 0.1558
Leishmania major endonuclease/exonuclease protein-like protein 0.0026 0.0004 0.0004
Giardia lamblia Synaptic glycoprotein SC2 0.3311 0.2651 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0067 0.0067
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.005 0.0024 0.0024
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0026 0.0004 0.0004
Loa Loa (eye worm) cytochrome P450 family protein 0.0111 0.0073 0.0073
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0033 0.001 0.0629
Echinococcus granulosus Nuclear hormone receptor HR96 0.0193 0.0139 0.0524
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0011 0.0032
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0033 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0035 0.0011 0.0041
Brugia malayi ecdysteroid receptor 0.041 0.0313 0.0313
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0016 0.006
Brugia malayi cytochrome P450 0.005 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0014
Loa Loa (eye worm) CXXC zinc finger family protein 0.011 0.0072 0.0072
Onchocerca volvulus 0.038 0.0289 0.109
Loa Loa (eye worm) hypothetical protein 0.0952 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Brugia malayi Cytochrome P450 family protein 0.0111 0.0073 0.0073
Onchocerca volvulus 0.0033 0.001 0.0036
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0265 0.0196 0.0571
Schistosoma mansoni hypothetical protein 0.129 0.1022 0.2971
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0217 0.0158 0.0594
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0193 0.0139 0.0139
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0026 0.0004 0.0004
Schistosoma mansoni synaptojanin 0.0026 0.0004 0.0012
Loa Loa (eye worm) inositol-1 0.0061 0.0032 0.0032
Echinococcus granulosus cpg binding protein 0.0116 0.0077 0.029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0091 0.0091
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.005 0.0024 0.1558
Echinococcus multilocularis survival motor neuron protein 1 0.0327 0.0247 0.0931
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0054 0.0027 1
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3311 0.2651 0.2651
Schistosoma mansoni smad1 5 8 and 0.0041 0.0016 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0003 0.0003
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0026 0.0004 0.0004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0118 0.0078 0.0295
Schistosoma mansoni synaptic glycoprotein sc2 related 0.3311 0.2651 0.7705
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0026 0.0004 0.0004
Echinococcus multilocularis 0.0087 0.0053 0.02
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0217 0.0158 0.0458
Brugia malayi Zinc carboxypeptidase family protein 0.0087 0.0053 0.0053
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.005 0.0024 0.0024
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0041 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0026 0.0004 0.0004
Leishmania major RNA-editing complex protein MP100, putative 0.0026 0.0004 0.0004
Brugia malayi hypothetical protein 0.0193 0.0139 0.0139
Mycobacterium ulcerans hypothetical protein 0.0033 0.001 0.001
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.4291 0.3441 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Brugia malayi Zinc carboxypeptidase family protein 0.0087 0.0053 0.0053
Echinococcus granulosus sterol regulatory element binding protein 0.0039 0.0014 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.041 0.0313 0.0313
Mycobacterium leprae conserved hypothetical protein 0.0033 0.001 0.3576
Brugia malayi hypothetical protein 0.0327 0.0247 0.0247
Onchocerca volvulus 0.0043 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.001
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.0087 0.0053 0.02
Loa Loa (eye worm) Smad1 0.0041 0.0016 0.0016
Giardia lamblia hypothetical protein 0.0026 0.0004 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.041 0.0313 0.1182
Schistosoma mansoni hypothetical protein 0.0027 0.0005 0.0015
Schistosoma mansoni hypothetical protein 0.0087 0.0053 0.0154
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.005 0.0024 0.1558
Loa Loa (eye worm) latrophilin receptor protein 2 0.0118 0.0078 0.0078
Leishmania major hypothetical protein, conserved 0.0026 0.0004 0.0004
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.0087 0.0053 0.02
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.005 0.0024 0.0024
Brugia malayi Latrophilin receptor protein 2 0.0118 0.0078 0.0078
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.005 0.0024 0.1558
Trichomonas vaginalis glucosylceramidase, putative 0.0144 0.0099 0.0099
Brugia malayi nuclear hormone receptor 0.0193 0.0139 0.0139
Echinococcus multilocularis inositol monophosphatase 1 0.0061 0.0032 0.012
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0026 0.0004 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0033 0.001 0.0036
Echinococcus multilocularis Niemann Pick C1 protein 0.009 0.0055 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.3311 0.2651 0.2651
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.001 0.001
Brugia malayi Zinc carboxypeptidase family protein 0.0087 0.0053 0.0053
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.2431 1 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Toxoplasma gondii ABC1 family protein 0.0033 0.001 0.001
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.0087 0.0053 0.02
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0078 0.0046 0.0046
Onchocerca volvulus 0.0026 0.0004 0.0015
Echinococcus multilocularis Protein lozenge 0.0048 0.0021 0.0081
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.078 0.0612 0.1778
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.0093 0.0093
Brugia malayi nuclear receptor NHR-67 0.0193 0.0139 0.0139
Onchocerca volvulus 0.0087 0.0053 0.02
Brugia malayi Cytochrome P450 family protein 0.0111 0.0073 0.0073
Echinococcus granulosus L aminoadipate semialdehyde 0.0072 0.0041 0.0155
Schistosoma mansoni ap endonuclease 0.0129 0.0087 0.0252
Echinococcus multilocularis synaptojanin 1 0.0026 0.0004 0.0015
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0078 0.0046 0.0046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.001 0.0028
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0072 0.0041 0.0119
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.041 0.0313 0.0911
Trichomonas vaginalis set domain proteins, putative 0.0151 0.0105 0.0105
Schistosoma mansoni Smad4 0.0041 0.0016 0.0046
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0016 0.006
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0129 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Plasmodium vivax polyprenol reductase, putative 0.3311 0.2651 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.0078 0.0078
Brugia malayi CHE-14 protein 0.0039 0.0014 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0003 0.0003
Echinococcus granulosus smad 0.0041 0.0016 0.006
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.005 0.0024 0.1558
Chlamydia trachomatis pyruvate kinase 0.0021 0 0.5
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.005 0.0024 0.1558
Loa Loa (eye worm) glutaminase 0.0231 0.0169 0.0169
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.015 0.015
Echinococcus multilocularis Smad4 0.0041 0.0016 0.006
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.041 0.0313 0.0313
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0118 0.0078 0.0078
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0087 0.0053 0.0053
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.005 0.0024 0.1558
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0129 0.0087 0.5699
Brugia malayi Zinc carboxypeptidase family protein 0.0087 0.0053 0.0053
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0129 0.0087 0.0327
Onchocerca volvulus 0.0087 0.0053 0.02
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0087 0.0053 0.0053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0026 0.0004 0.0004
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0193 0.0139 0.0524
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Brugia malayi MH1 domain containing protein 0.0022 0.0001 0.0001
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0193 0.0139 0.0524
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.003 0.0007 0.0003
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0129 0.0087 1
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0087 0.0053 0.0053
Schistosoma mansoni cellular tumor antigen P53 0.0043 0.0018 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.041 0.0313 0.0313
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.001 0.001
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0087 0.0053 0.0053
Toxoplasma gondii cytochrome p450 superfamily protein 0.005 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.005 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.005 0.0024 0.0024
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0087 0.0053 0.0053
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.005 0.0024 0.1558
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0217 0.0158 0.0158
Schistosoma mansoni survival motor neuron protein 0.0067 0.0037 0.0107
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.041 0.0313 0.1182
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.001 0.0028
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0061 0.0032 0.0032
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.0091 0.0341
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0006 0.0017
Echinococcus granulosus geminin 0.129 0.1022 0.3856
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0005 0.0005
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0026 0.0004 0.0004
Echinococcus multilocularis tissue type plasminogen activator 0.0027 0.0005 0.0019
Loa Loa (eye worm) hypothetical protein 0.041 0.0313 0.0313
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.041 0.0313 0.0313
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0265 0.0196 0.0741
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.009 0.0055 0.0055
Echinococcus multilocularis thyroid hormone receptor alpha 0.0519 0.0401 0.1513
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.005 0.0024 0.0024
Echinococcus granulosus thyroid hormone receptor alpha 0.0193 0.0139 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-49 0.041 0.0313 0.0313
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0078 0.0046 0.0046
Mycobacterium tuberculosis Probable lipase LipE 0.0033 0.001 0.0629
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0109 0.0071 0.0267
Brugia malayi Protein kinase domain containing protein 0.0027 0.0005 0.0005
Mycobacterium ulcerans esterase/lipase LipP 0.0033 0.001 0.001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.041 0.0313 0.0911
Loa Loa (eye worm) cytochrome P450 family protein 0.0111 0.0073 0.0073
Brugia malayi hypoxia-induced factor 1 0.013 0.0088 0.0088
Brugia malayi orphan nuclear receptor NR2E1 0.0193 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0061 0.0032 0.0032
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0026 0.0004 0.0004
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0208 0.015 0.015
Echinococcus granulosus FTZ F1 alpha 0.041 0.0313 0.1182
Brugia malayi Smad1 0.0041 0.0016 0.0016
Schistosoma mansoni cript-related 0.0026 0.0004 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.0111 0.0073 0.0073
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0193 0.0139 0.0524
Leishmania major cytochrome p450-like protein 0.0111 0.0073 0.0073
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.005 0.0024 0.0024
Giardia lamblia Histone acetyltransferase GCN5 0.0071 0.0041 0.0153
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.041 0.0313 0.0313
Schistosoma mansoni nuclear hormone receptor 0.0193 0.0139 0.0404
Trichomonas vaginalis inositol monophosphatase, putative 0.0061 0.0032 0.0032
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0129 0.0087 0.0327
Brugia malayi beta-lactamase family protein 0.0033 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0003 0.0003
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0016 0.0046
Echinococcus granulosus mixed lineage leukemia protein mll 0.0028 0.0006 0.0021
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0217 0.0158 0.0594
Loa Loa (eye worm) hypothetical protein 0.0087 0.0053 0.0053
Trypanosoma brucei RNA editing exonuclease 2 0.0026 0.0004 0.0004
Echinococcus granulosus biogenic amine 5HT receptor 0.0229 0.0167 0.0631
Plasmodium falciparum sentrin-specific protease 1 0.003 0.0007 0.0027
Brugia malayi Nuclear hormone receptor E75 0.0193 0.0139 0.0139
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.041 0.0313 0.1182
Schistosoma mansoni smad 0.0041 0.0016 0.0046
Loa Loa (eye worm) hypothetical protein 0.0217 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Loa Loa (eye worm) acetyltransferase 0.0265 0.0196 0.0196
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0091 0.0263
Plasmodium falciparum polyprenol reductase, putative 0.3311 0.2651 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.2431 1 1
Echinococcus multilocularis dnaJ subfamily B 0.1567 0.1246 0.4698
Loa Loa (eye worm) hypothetical protein 0.0141 0.0097 0.0097
Onchocerca volvulus Bile acid receptor homolog 0.041 0.0313 0.1182
Brugia malayi Pre-SET motif family protein 0.0133 0.009 0.009
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.003 0.0007 0.0021
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0072 0.0041 0.0041
Onchocerca volvulus 0.0021 0 0.0001
Loa Loa (eye worm) cytochrome P450 0.005 0.0024 0.0024
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0026 0.0004 0.0015
Schistosoma mansoni nuclear receptor 0.0193 0.0139 0.0404
Onchocerca volvulus 0.0067 0.0037 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-14 0.041 0.0313 0.0313
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0129 0.0087 0.0327
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0087 0.0053 0.0053
Schistosoma mansoni nuclear receptor nhr-48 0.0193 0.0139 0.0404
Treponema pallidum exodeoxyribonuclease (exoA) 0.0129 0.0087 1
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0087 0.0053 0.0053
Brugia malayi Hint module family protein 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0193 0.0139 0.0404
Schistosoma mansoni hypothetical protein 0.0067 0.0037 0.0107
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.041 0.0313 0.1182
Onchocerca volvulus 0.0072 0.0041 0.0155
Brugia malayi Niemann-Pick C1 protein precursor 0.009 0.0055 0.0055
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.3311 0.2651 0.2651
Onchocerca volvulus Carboxypeptidase D homolog 0.0087 0.0053 0.02
Brugia malayi nuclear receptor RXR 0.0193 0.0139 0.0139
Echinococcus multilocularis deoxyribonuclease 1 2 0.0026 0.0004 0.0015
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0067 0.0037 0.0037
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0026 0.0004 0.0015
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0061 0.0032 0.0032
Brugia malayi photoreceptor-specific nuclear receptor 0.041 0.0313 0.0313
Schistosoma mansoni synaptic glycoprotein sc2 related 0.3311 0.2651 0.7705
Echinococcus granulosus single minded 2 0.0031 0.0008 0.0031
Brugia malayi Inositol-1 0.0061 0.0032 0.0032
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.041 0.0313 0.1182
Loa Loa (eye worm) nuclear factor I 0.0022 0.0001 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.0093 0.0093
Trichomonas vaginalis Phospholipase C precursor, putative 0.0026 0.0004 0.0004
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.2431 1 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0042 0.0017 0.0049
Schistosoma mansoni nuclear hormone receptor 0.0193 0.0139 0.0404
Onchocerca volvulus 0.0026 0.0004 0.0015
Trypanosoma cruzi Carboxypeptidase-like protein 0.0087 0.0053 0.0053
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.005 0.0024 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0035 0.0011 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.015 0.015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.041 0.0313 0.0313
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0129 0.0087 0.0087
Schistosoma mansoni neutral sphingomyelinase 0.0026 0.0004 0.0012
Loa Loa (eye worm) steroid hormone receptor 0.041 0.0313 0.0313
Brugia malayi Nuclear hormone receptor family member nhr-31 0.041 0.0313 0.0313
Toxoplasma gondii kringle domain-containing protein 0.0027 0.0005 0.0005
Brugia malayi CCR4 0.0026 0.0004 0.0004
Brugia malayi conserved hypotetical protein 0.0193 0.0139 0.0139
Echinococcus granulosus Nuclear hormone receptor HR96 0.0193 0.0139 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0003 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0035 0.0011 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.041 0.0313 0.0313
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 1.2431 1 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.005 0.0024 0.0024
Onchocerca volvulus 0.0506 0.0391 0.1473
Echinococcus granulosus cytosolic carboxypeptidase 1 0.0087 0.0053 0.02
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.005 0.0024 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0519 0.0401 0.1166
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0021 0 0.0001
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0087 0.0053 0.0053
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.041 0.0313 0.1182
Echinococcus multilocularis protein dispatched 1 0.0044 0.0019 0.007
Onchocerca volvulus Glucosylceramidase homolog 0.0136 0.0093 0.035
Schistosoma mansoni hypothetical protein 0.0037 0.0013 0.0038
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0003 0.0003
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0193 0.0139 0.0404
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0035 0.0011 0.0011
Echinococcus multilocularis geminin 0.129 0.1022 0.3856
Echinococcus granulosus cytochrome P450 2K1 0.005 0.0024 0.0089
Loa Loa (eye worm) hypothetical protein 0.0255 0.0189 0.0189
Mycobacterium leprae putative cytochrome p450 0.005 0.0024 0.8852
Brugia malayi prolyl oligopeptidase family protein 0.0104 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0087 0.0053 0.0053
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0229 0.0167 0.0631
Onchocerca volvulus 0.0506 0.0391 0.1473
Brugia malayi nuclear hormone receptor family member nhr-6 0.0193 0.0139 0.0139
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.005 0.0024 0.1558
Schistosoma mansoni inositol monophosphatase 0.0061 0.0032 0.0093
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.038 0.0289 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.041 0.0313 0.0313
Echinococcus granulosus dnaJ subfamily B 0.1567 0.1246 0.4698
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0011 0.0032
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.041 0.0313 0.1182
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0026 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0217 0.0158 0.0158
Loa Loa (eye worm) zinc carboxypeptidase 0.0087 0.0053 0.0053
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0035 0.0011 0.0042
Schistosoma mansoni nuclear hormone receptor 0.041 0.0313 0.0911
Schistosoma mansoni hypothetical protein 0.129 0.1022 0.2971
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0506 0.0391 0.1135
Echinococcus multilocularis transfer RNA-Lys 0.0031 0.0008 0.0031
Echinococcus granulosus prolyl endopeptidase 0.0104 0.0067 0.0251
Brugia malayi hypothetical protein 0.0141 0.0097 0.0097
Trichomonas vaginalis ap endonuclease, putative 0.0129 0.0087 0.0087
Brugia malayi Synaptic glycoprotein SC2 0.3311 0.2651 0.2651
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.005 0.0024 0.0024
Brugia malayi MH2 domain containing protein 0.0041 0.0016 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0003 0.0003
Onchocerca volvulus 0.0033 0.001 0.0036
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0026 0.0004 0.0004
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0506 0.0391 0.1473
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0217 0.0158 0.0458
Trypanosoma brucei prolyl oligopeptidase, putative 0.0041 0.0016 0.0016
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0041 0.0016 0.1071
Echinococcus multilocularis cpg binding protein 0.0116 0.0077 0.029
Plasmodium vivax exodeoxyribonuclease III, putative 0.0026 0.0004 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.0093 0.0093
Trypanosoma brucei oligopeptidase b 0.0041 0.0016 0.0016
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0028 0.0006 0.0021
Mycobacterium leprae Conserved hypothetical protein 0.005 0.0024 0.8852
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0026 0.0004 0.0004
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0087 0.0053 0.0053
Echinococcus granulosus Protein patched homolog 1 0.0039 0.0014 0.0053
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0193 0.0139 0.0524
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.005 0.0024 0.1558
Brugia malayi hypothetical protein 0.0217 0.0158 0.0158
Toxoplasma gondii exonuclease III APE 0.0129 0.0087 0.0087
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0087 0.0053 0.0053
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0026 0.0004 0.0004
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3311 0.2651 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0016 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0003 0.0003
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0193 0.0139 0.0524
Onchocerca volvulus 0.0506 0.0391 0.1473
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0026 0.0004 0.0004
Schistosoma mansoni patched 1 0.0039 0.0014 0.0041
Echinococcus granulosus Zinc carboxypeptidase family protein 0.0087 0.0053 0.02
Schistosoma mansoni smad1 5 8 and 0.0041 0.0016 0.0046
Trypanosoma brucei cytochrome P450, putative 0.0111 0.0073 0.0073
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.0091 0.0091
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.005 0.0024 0.0024
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0016 0.0016
Mycobacterium tuberculosis Probable lipase LipD 0.0033 0.001 0.0629
Echinococcus granulosus histone acetyltransferase KAT2B 0.0257 0.019 0.0718
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3311 0.2651 0.2651
Onchocerca volvulus Prolyl endopeptidase homolog 0.0104 0.0067 0.0251
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0006 0.0021
Giardia lamblia Inositol 5-phosphatase 4 0.0026 0.0004 0.0015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.041 0.0313 0.0911
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.005 0.0024 0.0024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.041 0.0313 0.1182
Brugia malayi glutaminase DH11.1 0.0231 0.0169 0.0169
Schistosoma mansoni cytochrome P450 0.005 0.0024 0.0069
Schistosoma mansoni hypothetical protein 0.0255 0.0189 0.0548
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.001 0.001
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0109 0.0071 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-40 0.041 0.0313 0.0313
Schistosoma mansoni hypothetical protein 0.0026 0.0004 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0003 0.0003
Loa Loa (eye worm) beta-lactamase 0.0033 0.001 0.001
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.005 0.0024 0.0024
Loa Loa (eye worm) TK/ROR protein kinase 0.0027 0.0005 0.0005
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0026 0.0004 0.0015
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.005 0.0024 0.0024
Mycobacterium ulcerans glutaminase 0.0231 0.0169 0.0169
Trypanosoma cruzi mitochondrial protein 99, putative 0.0026 0.0004 0.0004
Toxoplasma gondii zinc carboxypeptidase, putative 0.0087 0.0053 0.0053
Mycobacterium tuberculosis Probable hydrolase 0.0033 0.001 0.0629
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.001
Mycobacterium ulcerans putative regulatory protein 0.0031 0.0008 0.0008
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.003 0.0007 0.0007
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0026 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0109 0.0071 0.0206
Leishmania major lanosterol 14-alpha-demethylase, putative 0.005 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0087 0.0053 0.0053
Brugia malayi Hint module family protein 0.0034 0.0011 0.0011
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0041 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0072 0.0041 0.0041
Echinococcus multilocularis expressed conserved protein 0.0084 0.0051 0.0193
Schistosoma mansoni cpg binding protein 0.0116 0.0077 0.0223
Brugia malayi CXXC zinc finger family protein 0.011 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0087 0.0053 0.0053
Loa Loa (eye worm) histone methyltransferase 0.0035 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor 0.0193 0.0139 0.0139
Schistosoma mansoni carboxypeptidase N (M14 family) 0.0087 0.0053 0.0154
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0208 0.015 0.015
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.0091 0.0341
Schistosoma mansoni lozenge 0.0048 0.0021 0.0062
Schistosoma mansoni hypothetical protein 0.005 0.0024 0.0069
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0697 0.0545 0.2054
Brugia malayi PAS domain containing protein 0.0042 0.0017 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.041 0.0313 0.0313
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.005 0.0024 0.1558
Echinococcus granulosus retinoic acid receptor rxr beta a 0.041 0.0313 0.1182
Echinococcus granulosus neutral sphingomyelinase 0.0026 0.0004 0.0015
Echinococcus multilocularis neutral sphingomyelinase 0.0026 0.0004 0.0015
Echinococcus granulosus Niemann Pick C1 protein 0.009 0.0055 0.0209
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0026 0.0004 0.0015
Schistosoma mansoni steroid hormone receptor ad4bp 0.041 0.0313 0.0911
Loa Loa (eye worm) hypothetical protein 0.041 0.0313 0.0313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.041 0.0313 0.0313
Schistosoma mansoni hypothetical protein 0.0037 0.0013 0.0038
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0 0.0001
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0041 0.0016 0.6088
Echinococcus granulosus traf and tnf receptor associated protein 0.0026 0.0004 0.0015
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0026 0.0004 0.0004
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0129 0.0087 0.0087
Leishmania major cytochrome p450-like protein 0.005 0.0024 0.0024
Schistosoma mansoni single-minded 0.0042 0.0017 0.0049
Trypanosoma brucei prolyl endopeptidase 0.0104 0.0067 0.0067
Schistosoma mansoni microtubule-associated protein tau 0.1662 0.1322 0.3842
Schistosoma mansoni synaptojanin 0.0026 0.0004 0.0012
Schistosoma mansoni peptidase 0.0087 0.0053 0.0154
Echinococcus granulosus expressed conserved protein 0.0084 0.0051 0.0193
Trypanosoma cruzi cytochrome p450-like protein, putative 0.005 0.0024 0.0024
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.2431 1 1
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0087 0.0053 0.02
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0078 0.0046 0.0173
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0026 0.0004 0.0004
Echinococcus granulosus synaptic glycoprotein sc2 0.3311 0.2651 1
Plasmodium vivax sentrin-specific protease 1, putative 0.003 0.0007 0.0027
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.0087 0.0053 0.0053
Schistosoma mansoni smad1 5 8 and 0.0041 0.0016 0.0046
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0697 0.0545 0.2054
Trichomonas vaginalis glucosylceramidase, putative 0.0144 0.0099 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.011 0.0072 0.0209
Loa Loa (eye worm) hypothetical protein 0.0327 0.0247 0.0247
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.041 0.0313 0.1182
Leishmania major pantothenate kinase subunit, putative 0.0026 0.0004 0.0004
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0026 0.0004 0.0004
Trypanosoma cruzi prolyl endopeptidase 0.0104 0.0067 0.0067
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0091 0.0263
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0373 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.001
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0026 0.0004 0.0004
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0026 0.0004 0.0015
Schistosoma mansoni hypothetical protein 0.0118 0.0078 0.0227
Schistosoma mansoni RAR-like nuclear receptor 0.041 0.0313 0.0911
Brugia malayi bHLH-PAS transcription factor 0.0031 0.0008 0.0008
Mycobacterium tuberculosis Probable peptidase 0.0041 0.0016 0.1071
Onchocerca volvulus 0.0506 0.0391 0.1473
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.041 0.0313 0.1182
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.005 0.0024 0.1558
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0193 0.0139 0.0524
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0026 0.0004 0.0015
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3311 0.2651 0.2651
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Brugia malayi Cytochrome P450 family protein 0.0101 0.0065 0.0065
Echinococcus granulosus synaptojanin 1 0.0026 0.0004 0.0015
Echinococcus granulosus survival motor neuron protein 1 0.0327 0.0247 0.0931
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0129 0.0087 0.0083
Loa Loa (eye worm) zinc carboxypeptidase 0.0087 0.0053 0.0053
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0111 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0087 0.0053 0.0053
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.005 0.0024 0.0024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.041 0.0313 0.1182
Entamoeba histolytica acetyltransferase, GNAT family 0.0071 0.0041 0.0037
Trypanosoma cruzi mitochondrial protein 99, putative 0.0026 0.0004 0.0004
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0026 0.0004 0.0015
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0039 0.0014 0.0014
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0026 0.0004 0.0004
Brugia malayi Zinc carboxypeptidase family protein 0.0087 0.0053 0.0053
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0104 0.0067 0.0193
Onchocerca volvulus 0.041 0.0313 0.1182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.041 0.0313 0.0313
Mycobacterium tuberculosis Probable esterase LipL 0.0033 0.001 0.0629
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0035 0.0011 0.0041
Leishmania major hypothetical protein, conserved 0.0027 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0118 0.0078 0.0227
Trichomonas vaginalis esterase, putative 0.0033 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0129 0.0087 0.0327
Schistosoma mansoni ap endonuclease 0.0129 0.0087 0.0252
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.3311 0.2651 0.2648
Echinococcus multilocularis sterol regulatory element binding protein 0.0039 0.0014 0.0053
Brugia malayi MH1 domain containing protein 0.0041 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0193 0.0139 0.0139
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.003 0.0007 0.0007
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0026 0.0004 0.0015
Echinococcus multilocularis smad 0.0041 0.0016 0.006
Loa Loa (eye worm) zinc carboxypeptidase 0.0087 0.0053 0.0053
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0087 0.0053 0.0053
Echinococcus multilocularis nuclear receptor nhr 48 0.0193 0.0139 0.0524
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0061 0.0032 0.0032
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0041 0.0016 0.0016
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0061 0.0032 0.0032
Echinococcus granulosus sentrin specific protease 1 0.003 0.0007 0.0027
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0087 0.0053 0.0053
Schistosoma mansoni peptidase 0.0087 0.0053 0.0154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.041 0.0313 0.1182

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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