TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 418.528 | Formula: C26H30N2O3
H donors: 1 H acceptors: 3 LogP: 6.17 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCN(c1ccc(cn1)C(=O)O)c1ccc(c(c1)OCCCc1ccccc1)C(C)C
InChi: 1S/C26H30N2O3/c1-4-28(25-15-12-21(18-27-25)26(29)30)22-13-14-23(19(2)3)24(17-22)31-16-8-11-20-9-6-5-7-10-20/h5-7,9-10,12-15,17-19H,4,8,11,16H2,1-3H3,(H,29,30)
InChiKey: NSJIEKPNKVMLGM-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	retinoid X receptor, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative	Get druggable targets OG5_130073	All targets in OG5_130073
Echinococcus granulosus	retinoic acid receptor rxr beta a	Get druggable targets OG5_130073	All targets in OG5_130073
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	Get druggable targets OG5_130073	All targets in OG5_130073
Schistosoma mansoni	retinoic acid receptor RXR	Get druggable targets OG5_130073	All targets in OG5_130073

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	ecdysteroid receptor	retinoid X receptor, alpha	435 aa	352 aa	23.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0047	0.3149	0.3149
Brugia malayi	RE15519p	0.0047	0.3149	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.3149	0.3282
Brugia malayi	sulfakinin receptor protein	0.0047	0.3149	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.3149	0.3282
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0047	0.3149	0.3282
Schistosoma mansoni	amine GPCR	0.0047	0.3149	0.3149
Loa Loa (eye worm)	G-protein coupled receptor	0.0047	0.3149	1
Schistosoma mansoni	histamine h1 receptor	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus multilocularis	neuropeptide s receptor	0.0047	0.3149	0.3282
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0047	0.3149	0.3282
Brugia malayi	hypothetical protein	0.0047	0.3149	1
Onchocerca volvulus		0.0047	0.3149	1
Echinococcus granulosus	allatostatin A receptor	0.0047	0.3149	0.3149
Echinococcus granulosus	somatostatin receptor	0.0047	0.3149	0.3149
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.3149	0.3149
Echinococcus granulosus	neuropeptide receptor	0.0047	0.3149	0.3149
Onchocerca volvulus		0.0047	0.3149	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.3149	0.3149
Brugia malayi	neuropeptide F receptor	0.0047	0.3149	1
Echinococcus granulosus	g protein coupled receptor	0.0047	0.3149	0.3149
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0047	0.3149	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0047	0.3149	0.3282
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.3149	0.3149
Echinococcus multilocularis	allatostatin A receptor	0.0047	0.3149	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0047	0.3149	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0047	0.3149	0.3282
Echinococcus multilocularis	G protein coupled receptor 139	0.0047	0.3149	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Onchocerca volvulus		0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.3149	0.3282
Echinococcus granulosus	sex peptide receptor	0.0047	0.3149	0.3149
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0047	0.3149	0.3149
Brugia malayi	Serotonin receptor	0.0047	0.3149	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.3149	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0047	0.3149	0.3149
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0047	0.3149	1
Schistosoma mansoni	opsin-like receptor	0.0047	0.3149	0.3149
Brugia malayi	Dopamine receptor	0.0047	0.3149	1
Schistosoma mansoni	amine GPCR	0.0047	0.3149	0.3149
Echinococcus multilocularis	orexin receptor type 2	0.0047	0.3149	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Brugia malayi	hypothetical protein	0.0047	0.3149	1
Onchocerca volvulus		0.0047	0.3149	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.3149	0.3149
Loa Loa (eye worm)	melatonin receptor type 1A	0.0047	0.3149	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.3149	0.3282
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0047	0.3149	0.3149
Schistosoma mansoni	biogenic amine receptor	0.0047	0.3149	0.3149
Schistosoma mansoni	neuropeptide receptor	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Schistosoma mansoni	neuropeptide receptor	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus granulosus	fmrfamide receptor	0.0047	0.3149	0.3149
Echinococcus granulosus	g protein coupled receptor	0.0047	0.3149	0.3149
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.3149	0.3149
Schistosoma mansoni	hypothetical protein	0.0047	0.3149	0.3149
Echinococcus multilocularis	neuropeptides capa receptor	0.0047	0.3149	0.3282
Schistosoma mansoni	neuropeptide F-like receptor	0.0047	0.3149	0.3149
Echinococcus granulosus	biogenic amine 5HT receptor	0.0047	0.3149	0.3149
Echinococcus granulosus	hypothetical protein	0.0047	0.3149	0.3149
Brugia malayi	putative neuropeptide receptor NPR1	0.0047	0.3149	1
Echinococcus granulosus	neuropeptide receptor	0.0047	0.3149	0.3149
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Onchocerca volvulus		0.0047	0.3149	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0047	0.3149	0.3282
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0123	0.9594	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0047	0.3149	0.3282
Echinococcus multilocularis	fmrfamide receptor	0.0047	0.3149	0.3282
Echinococcus granulosus	serotonin receptor	0.0047	0.3149	0.3149
Onchocerca volvulus		0.0047	0.3149	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.3149	0.3282
Brugia malayi	ORL1-like opioid receptor	0.0047	0.3149	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0047	0.3149	0.3282
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0047	0.3149	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus granulosus	neuropeptide receptor A26	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Onchocerca volvulus		0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0047	0.3149	0.3149
Schistosoma mansoni	hypothetical protein	0.0047	0.3149	0.3149
Onchocerca volvulus		0.0047	0.3149	1
Schistosoma mansoni	neuropeptide receptor	0.0047	0.3149	0.3149
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.3149	0.3149
Brugia malayi	hypothetical protein	0.0047	0.3149	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0047	0.3149	0.3282
Brugia malayi	G-protein coupled receptor	0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus granulosus	neuropeptides capa receptor	0.0047	0.3149	0.3149
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.3149	0.3149
Echinococcus multilocularis	g-protein coupled receptor	0.0047	0.3149	0.3282
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.3149	0.3149
Brugia malayi	GnHR receptor homolog	0.0047	0.3149	1
Schistosoma mansoni	myosin xvIII	0.0047	0.3149	0.3149
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.3149	0.3282
Echinococcus multilocularis	serotonin receptor	0.0047	0.3149	0.3282
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0047	0.3149	0.3149
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0047	0.3149	0.3149
Brugia malayi	Melatonin receptor type 1A	0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Loa Loa (eye worm)	TYRA-2 protein	0.0047	0.3149	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0047	0.3149	0.3282
Brugia malayi	larval opioid receptor	0.0047	0.3149	1
Echinococcus granulosus	orexin receptor type 2	0.0047	0.3149	0.3149
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.3149	0.3149
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0047	0.3149	0.3149
Schistosoma mansoni	opsin-like receptor	0.0047	0.3149	0.3149
Loa Loa (eye worm)	neuropeptide F receptor	0.0047	0.3149	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0047	0.3149	0.3149
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.3149	0.3282
Brugia malayi	hypothetical protein	0.0047	0.3149	1
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.3149	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus granulosus	g-protein coupled receptor	0.0047	0.3149	0.3149
Brugia malayi	follicle stimulating hormone receptor	0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Onchocerca volvulus		0.0047	0.3149	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0047	0.3149	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.3149	0.3149
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.3149	0.3282
Echinococcus granulosus	neuropeptide Y receptor	0.0047	0.3149	0.3149
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0047	0.3149	0.3149
Onchocerca volvulus		0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Schistosoma mansoni	hypothetical protein	0.0047	0.3149	0.3149
Echinococcus granulosus	7tm_1 domain containing protein	0.0047	0.3149	0.3149
Schistosoma mansoni	hypothetical protein	0.0047	0.3149	0.3149
Echinococcus granulosus	dro:myosuppressin receptor	0.0047	0.3149	0.3149
Brugia malayi	Serotonin receptor	0.0047	0.3149	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0047	0.3149	0.3149
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0047	0.3149	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0047	0.3149	1
Schistosoma mansoni	amine GPCR	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0047	0.3149	0.3282
Brugia malayi	G protein-coupled receptor F59B2.13	0.0047	0.3149	1
Brugia malayi	hypothetical protein	0.0047	0.3149	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0047	0.3149	0.3282
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0047	0.3149	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.3149	0.3149
Onchocerca volvulus		0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Onchocerca volvulus		0.0047	0.3149	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.3149	0.3149
Echinococcus granulosus	biogenic amine 5HT receptor	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0047	0.3149	0.3149
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0047	0.3149	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0047	0.3149	1
Brugia malayi	G-protein coupled receptor	0.0047	0.3149	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0047	0.3149	0.3282
Brugia malayi	Dopamine receptor protein 2	0.0047	0.3149	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.3149	0.3282
Schistosoma mansoni	biogenic amine receptor	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Brugia malayi	hypothetical protein	0.0047	0.3149	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0047	0.3149	0.3282
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0047	0.3149	0.3149
Echinococcus granulosus	G protein coupled receptor 139	0.0047	0.3149	0.3149
Echinococcus granulosus	7TM GPCR rhodopsin	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Brugia malayi	putative neuropeptide receptor	0.0047	0.3149	1
Echinococcus multilocularis	neuropeptide receptor	0.0047	0.3149	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Brugia malayi	neuropeptide F receptor	0.0047	0.3149	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0047	0.3149	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0047	0.3149	0.3149
Echinococcus multilocularis	fmrfamide receptor	0.0047	0.3149	0.3282
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0047	0.3149	0.3149
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0047	0.3149	0.3149
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0047	0.3149	1
Echinococcus granulosus	neuropeptides capa receptor	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0047	0.3149	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0047	0.3149	0.3149
Brugia malayi	hypothetical protein	0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus multilocularis	somatostatin receptor	0.0047	0.3149	0.3282
Onchocerca volvulus		0.0047	0.3149	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.3149	0.3149
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Schistosoma mansoni	amine GPCR	0.0047	0.3149	0.3149
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.3149	0.3149
Schistosoma mansoni	retinoic acid receptor RXR	0.0128	1	1
Schistosoma mansoni	neuropeptide receptor	0.0047	0.3149	0.3149
Schistosoma mansoni	amine GPCR	0.0047	0.3149	0.3149
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.3149	0.3282
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0047	0.3149	1
Echinococcus granulosus	g protein coupled receptor	0.0047	0.3149	0.3149
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.3149	0.3282
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0047	0.3149	0.3149
Schistosoma mansoni	adenoreceptor	0.0047	0.3149	0.3149
Brugia malayi	hypothetical protein	0.0047	0.3149	1
Echinococcus granulosus	neuropeptide s receptor	0.0047	0.3149	0.3149
Brugia malayi	hypothetical protein	0.0047	0.3149	1
Onchocerca volvulus		0.0047	0.3149	1
Brugia malayi	AKH receptor	0.0047	0.3149	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0047	0.3149	1
Echinococcus multilocularis	serotonin receptor	0.0047	0.3149	0.3282
Echinococcus granulosus	neuropeptide Y receptor	0.0047	0.3149	0.3149
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0047	0.3149	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0047	0.3149	0.3149
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.3149	0.3149
Schistosoma mansoni	biogenic amine receptor	0.0047	0.3149	0.3149
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.3149	0.3149
Brugia malayi	G protein-coupled receptor	0.0047	0.3149	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.3149	0.3282
Brugia malayi	hypothetical protein	0.0047	0.3149	1
Schistosoma mansoni	opsin-like receptor	0.0047	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.3149	1
Onchocerca volvulus		0.0047	0.3149	1
Echinococcus multilocularis	sex peptide receptor	0.0047	0.3149	0.3282
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.3149	0.3149
Schistosoma mansoni	growth hormone secretagogue receptor	0.0047	0.3149	0.3149
Loa Loa (eye worm)	neuropeptide F receptor	0.0047	0.3149	1
Brugia malayi	Dopamine receptor protein 1	0.0047	0.3149	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0047	0.3149	0.3282
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.3149	0.3149
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.3149	0.3149
Onchocerca volvulus		0.0047	0.3149	1
Echinococcus multilocularis	neuropeptide receptor	0.0047	0.3149	0.3282
Onchocerca volvulus		0.0047	0.3149	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0047	0.3149	1

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 820 nM	Agonist activity at RXRalpha transfected in human COS1 cells after 18 hrs by luciferase reporter gene transactivation assay	ChEMBL.	24900241
Emax (functional)	= 78 %	Agonist activity at RXRalpha transfected in human COS1 cells at 1 uM after 18 hrs by luciferase reporter gene transactivation assay relative to LGD1069	ChEMBL.	24900241

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1688394

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1499629