Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0046 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0034 | 0.139 | 0.139 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0046 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0046 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0034 | 0.139 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0046 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0034 | 0.139 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.8069 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0046 | 1 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0046 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0046 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.8069 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.8069 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0034 | 0.139 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 1 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 1 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 1 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0046 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.8069 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0046 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.1735 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.