Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0843 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0045 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1197 | 0.1197 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0465 | 0.3882 |
Schistosoma mansoni | gliotactin | 0.0142 | 0.1197 | 0.0768 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0142 | 0.1197 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0142 | 0.1197 | 0.0768 |
Echinococcus multilocularis | acetylcholinesterase | 0.0843 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0843 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0843 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0142 | 0.1197 | 0.0768 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.0465 | 0.0465 |
Schistosoma mansoni | acetylcholinesterase | 0.0142 | 0.1197 | 0.0768 |
Echinococcus multilocularis | neuroligin | 0.0142 | 0.1197 | 0.0768 |
Onchocerca volvulus | 0.0142 | 0.1197 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0843 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0142 | 0.1197 | 0.0768 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0142 | 0.1197 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0142 | 0.1197 | 0.0768 |
Brugia malayi | Carboxylesterase family protein | 0.0843 | 1 | 1 |
Onchocerca volvulus | 0.0142 | 0.1197 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1197 | 0.1197 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1197 | 0.1197 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1197 | 0.1197 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0843 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0142 | 0.1197 | 0.0768 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0142 | 0.1197 | 0.0768 |
Loa Loa (eye worm) | carboxylesterase | 0.0142 | 0.1197 | 0.1197 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0142 | 0.1197 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.0045 | 0.0376 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0142 | 0.1197 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0142 | 0.1197 | 0.0768 |
Brugia malayi | Carboxylesterase family protein | 0.0142 | 0.1197 | 0.1197 |
Loa Loa (eye worm) | carboxylesterase | 0.0142 | 0.1197 | 0.1197 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0142 | 0.1197 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0142 | 0.1197 | 0.0768 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0843 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0142 | 0.1197 | 0.0768 |
Onchocerca volvulus | 0.0142 | 0.1197 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0843 | 1 | 1 |
Onchocerca volvulus | 0.0142 | 0.1197 | 1 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0142 | 0.1197 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0142 | 0.1197 | 0.0768 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.0465 | 0.0465 |
Echinococcus granulosus | acetylcholinesterase | 0.0843 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0142 | 0.1197 | 0.1197 |
Loa Loa (eye worm) | carboxylesterase | 0.0843 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0843 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0142 | 0.1197 | 0.1197 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0045 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1197 | 0.1197 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0465 | 0.3882 |
Brugia malayi | Carboxylesterase family protein | 0.0142 | 0.1197 | 0.1197 |
Onchocerca volvulus | 0.0142 | 0.1197 | 1 | |
Echinococcus granulosus | neuroligin | 0.0142 | 0.1197 | 0.0768 |
Brugia malayi | Carboxylesterase family protein | 0.0142 | 0.1197 | 0.1197 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1197 | 0.1197 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0142 | 0.1197 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1197 | 0.1197 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.