Detailed information for compound 1499957

Basic information

Technical information
  • TDR Targets ID: 1499957
  • Name: 4-chloro-5-(4-methylphenyl)thieno[3,2-e]pyrim idine
  • MW: 260.742 | Formula: C13H9ClN2S
  • H donors: 0 H acceptors: 2 LogP: 4.51 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1csc2c1c(Cl)ncn2
  • InChi: 1S/C13H9ClN2S/c1-8-2-4-9(5-3-8)10-6-17-13-11(10)12(14)15-7-16-13/h2-7H,1H3
  • InChiKey: IJQIOVCRRZEROH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SBB015608
  • ZINC00097774
  • AE-848/36501036
  • 4-Chloro-5-p-tolyl-thieno[2,3-d]pyrimidine
  • MLS000587869
  • SMR000211880

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.0004 0.01 0.0192
Schistosoma mansoni Smad4 0.001 0.0319 0.1172
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0652 0.1262
Leishmania major phosphatidylinositol kinase, putative 0.0004 0.01 0.0276
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0664 0.1911
Echinococcus granulosus liprin beta 1 0.0006 0.0171 0.0171
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0664 0.0664
Schistosoma mansoni smad1 5 8 and 0.001 0.0319 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0004 0.01 0.01
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0004 0.01 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0171 0.2581
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0298 0.4489
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0319 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0009 0.0298 0.0577
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0004 0.01 0.0365
Loa Loa (eye worm) phosphatidylinositol 3 0.0004 0.01 0.0192
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0652 0.0652
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0004 0.01 0.01
Entamoeba histolytica hypothetical protein 0.0009 0.0298 0.3518
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0004 0.01 0.1499
Loa Loa (eye worm) hypothetical protein 0.0049 0.1729 0.3348
Echinococcus granulosus serine protein kinase ATM 0.0011 0.0359 0.0359
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0004 0.01 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0004 0.01 0.1499
Loa Loa (eye worm) hypothetical protein 0.0019 0.0652 0.1262
Loa Loa (eye worm) hypothetical protein 0.0004 0.0123 0.0238
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0664 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0004 0.01 0.01
Loa Loa (eye worm) MH1 domain-containing protein 0.0004 0.0123 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0664 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.5164 1
Schistosoma mansoni hypothetical protein 0.0006 0.0171 0.0629
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0664 0.1286
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0004 0.01 0.0286
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0006 0.0171 0.0171
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0664 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0004 0.01 0.1499
Schistosoma mansoni smad 0.0004 0.0123 0.0453
Brugia malayi MH1 domain containing protein 0.001 0.0319 0.0618
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0664 1
Brugia malayi hypothetical protein 0.0006 0.0171 0.0332
Entamoeba histolytica hypothetical protein 0.0009 0.0298 0.3518
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2724 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0664 0.1911
Trichomonas vaginalis 2-5A-dependent ribonuclease, putative 0.0001 0.000000022332 0.00000033625
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0298 0.4489
Trichomonas vaginalis unc-44 ankyrins, putative 0.0001 0.000000022332 0.00000033625
Loa Loa (eye worm) hypothetical protein 0.006 0.2136 0.4136
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0004 0.01 0.0365
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0664 0.0664
Echinococcus granulosus liprin alpha 2 0.0006 0.0171 0.0171
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.000000022332 0.00000033625
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.0359 0.1034
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0664 0.2438
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0004 0.01 0.0192
Trichomonas vaginalis unc-44 ankyrins, putative 0.0001 0.000000022332 0.00000033625
Echinococcus multilocularis liprin alpha 2 0.0006 0.0171 0.0171
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0319 0.1172
Loa Loa (eye worm) hypothetical protein 0.0005 0.0161 0.0311
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2724 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0652 0.1262
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0009 0.0298 0.0298
Schistosoma mansoni smad1 5 8 and 0.001 0.0319 0.1172
Brugia malayi coiled-coil like protein 1 0.0006 0.0171 0.0332
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0009 0.0298 0.3518
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0004 0.01 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0004 0.0123 0.0238
Giardia lamblia GTOR 0.0019 0.0664 1
Brugia malayi RNA binding protein 0.0076 0.2724 0.5274
Echinococcus multilocularis tankyrase 0.0065 0.2297 0.2297
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0004 0.01 0.1499
Echinococcus multilocularis liprin beta 1 0.0006 0.0171 0.0171
Brugia malayi Smad1 0.001 0.0319 0.0618
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0652 0.0652
Schistosoma mansoni Smad4 0.0004 0.0123 0.0453
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0298 0.4489
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0009 0.0298 0.3518
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0004 0.01 0.1499
Loa Loa (eye worm) hypothetical protein 0.0012 0.0404 0.0782
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0004 0.01 0.0365
Toxoplasma gondii FATC domain-containing protein 0.0011 0.0359 0.4601
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0319 0.0319
Echinococcus multilocularis mothers against decapentaplegic 6 0.0004 0.0123 0.0123
Leishmania major phosphatidylinositol 3-kinase, putative 0.0004 0.01 0.0276
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0278 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0359 0.541
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0171 0.2581
Loa Loa (eye worm) phosphatidylinositol 3 0.0004 0.01 0.0192
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0004 0.01 0.1499
Loa Loa (eye worm) nuclear factor I 0.0005 0.0161 0.0311
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2724 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0004 0.0123 0.0122
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0004 0.01 0.1499
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0404 0.6088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0359 0.0695
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0359 0.1319
Schistosoma mansoni hypothetical protein 0.0041 0.1449 0.532
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0004 0.01 0.0276
Echinococcus granulosus tankyrase 0.0065 0.2297 0.2297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0225 0.3385
Schistosoma mansoni hypothetical protein 0.0006 0.0171 0.0629
Brugia malayi MH1 domain containing protein 0.0005 0.0161 0.0312
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.000000022332 0.00000033625
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0004 0.01 0.01
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0404 0.5399
Loa Loa (eye worm) hypothetical protein 0.0004 0.01 0.0192
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0004 0.01 0.0286
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0009 0.0298 0.0858
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Leishmania major hypothetical protein, unknown function 0.0004 0.01 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0004 0.01 0.0286
Mycobacterium leprae conserved hypothetical protein 0.0004 0.01 0.5
Echinococcus granulosus SAM domain containing protein 0.0006 0.0171 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0298 0.4489
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2136 0.4136
Echinococcus multilocularis Zinc finger, PHD finger 0.0004 0.01 0.01
Entamoeba histolytica hypothetical protein 0.0009 0.0298 0.3518
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0359 0.4601
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0298 0.4489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0008 0.027 0.027
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0009 0.0298 0.0298
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0004 0.01 0.0365
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0009 0.0298 0.1095
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0298 0.4489
Echinococcus multilocularis GPCR, family 2 0.0019 0.0652 0.0652
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0577
Trypanosoma brucei poly(adp-ribose) polymerase 0.0009 0.0298 0.4489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.5164 1
Entamoeba histolytica zinc finger protein, putative 0.0009 0.0298 0.3518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0359 0.541
Echinococcus granulosus mothers against decapentaplegic 6 0.0004 0.0123 0.0123
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0011 0.0359 0.1319
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1449 0.2806
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0664 0.1286
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0006 0.0171 0.0331
Echinococcus granulosus stromal interaction molecule 1 0.0006 0.0171 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0404 0.6088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Giardia lamblia Hypothetical protein 0.0004 0.01 0.1499
Trichomonas vaginalis ankyrin, putative 0.0001 0.000000022332 0.00000033625
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0004 0.01 0.0193
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0004 0.01 0.0193
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0011 0.0359 0.541
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0664 1
Echinococcus granulosus GPCR family 2 0.0019 0.0652 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0004 0.0123 0.0123
Onchocerca volvulus Tankyrase homolog 0.0058 0.2059 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0004 0.01 0.0276
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0001 0.000000022332 0.00000033625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0359 0.541
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0359 0.0696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0359 0.4601
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0664 0.1911
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0004 0.01 0.1499
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0004 0.01 0.01
Echinococcus multilocularis 0.0004 0.01 0.01
Echinococcus granulosus poly adp ribose polymerase 2 0.0009 0.0298 0.0298
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0319 0.0618
Brugia malayi Tnks protein 0.0064 0.2287 0.4429
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0298 0.4489
Schistosoma mansoni sarm1 0.0006 0.0171 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0225 0.3385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0009 0.0298 0.0858
Echinococcus multilocularis tar DNA binding protein 0.0076 0.2724 0.2724
Loa Loa (eye worm) tnks protein 0.0059 0.2094 0.4054
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2724 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0004 0.01 0.1499
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0004 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0008 0.027 0.0991
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0008 0.027 0.0522
Trypanosoma cruzi hypothetical protein, conserved 0.0097 0.3475 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0664 0.184
Echinococcus multilocularis stromal interaction molecule 1 0.0006 0.0171 0.0171
Plasmodium falciparum protein kinase, putative 0.0006 0.0171 1
Schistosoma mansoni hypothetical protein 0.0019 0.0652 0.2394
Echinococcus multilocularis serine protein kinase ATM 0.0011 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0004 0.01 0.0365
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0652 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0298 0.4489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0359 0.541
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0664 0.1911
Schistosoma mansoni hypothetical protein 0.0006 0.0171 0.0629
Schistosoma mansoni smad1 5 8 and 0.001 0.0319 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0006 0.0171 0.0629
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0004 0.01 0.1499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0359 0.541
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0004 0.01 0.01
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0004 0.01 0.0193
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.000000022332 0.00000033625
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0664 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.000000022332 0.00000033625
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.2724 0.5274
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0664 0.1285
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0004 0.01 0.01
Echinococcus multilocularis smad 0.001 0.0319 0.0319
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0319 0.0618
Loa Loa (eye worm) hypothetical protein 0.0006 0.0171 0.0331
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0004 0.01 0.1499
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0004 0.01 0.0286
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0009 0.0298 0.0298
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0004 0.01 0.0193
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0008 0.027 0.027
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0004 0.01 0.0365
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0319 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Schistosoma mansoni hypothetical protein 0.0019 0.0652 0.2394
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0664 0.184
Loa Loa (eye worm) hypothetical protein 0.0006 0.0171 0.0331
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0004 0.01 0.01
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0006 0.0171 0.1273
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0004 0.01 0.1499
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0004 0.01 0.0286
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0664 0.2438
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.2724 0.5274
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0359 0.0359
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0004 0.01 0.0193
Schistosoma mansoni tankyrase 0.0065 0.2301 0.8446
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0404 0.6088
Echinococcus granulosus Smad4 0.001 0.0319 0.0319
Loa Loa (eye worm) RNA binding protein 0.0076 0.2724 0.5274
Plasmodium falciparum tyrosine kinase-like protein 0.0006 0.0171 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0004 0.01 0.0286
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0664 0.184
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0004 0.01 0.1499
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0004 0.01 0.1499
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0002 0.0019 0.0288
Loa Loa (eye worm) hypothetical protein 0.0006 0.0171 0.0331
Trichomonas vaginalis multiple ankyrin repeats single kh domain protein, putative 0.0001 0.000000022332 0.00000033625
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2136 0.4136
Plasmodium vivax tyrosine kinase-like protein, putative 0.0006 0.0171 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0004 0.01 0.1499
Brugia malayi MH2 domain containing protein 0.001 0.0319 0.0618
Schistosoma mansoni hypothetical protein 0.0004 0.01 0.0365
Echinococcus multilocularis mothers against decapentaplegic 2 0.0004 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0006 0.0171 0.0331
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0004 0.01 0.0286
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0664 0.184
Schistosoma mansoni hypothetical protein 0.0019 0.0652 0.2394
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0171 0.2581
Echinococcus multilocularis Smad4 0.001 0.0319 0.0319
Echinococcus granulosus poly ADP ribose polymerase 1 0.0009 0.0298 0.0298
Brugia malayi hypothetical protein 0.0006 0.0171 0.0332
Loa Loa (eye worm) TAR-binding protein 0.0076 0.2724 0.5274
Brugia malayi MH2 domain containing protein 0.0004 0.0123 0.0239
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0664 1
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0001 0.000000022332 0.00000033625
Brugia malayi MH2 domain containing protein 0.0144 0.5164 1
Schistosoma mansoni hypothetical protein 0.0006 0.0171 0.0629
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0664 0.0664
Onchocerca volvulus 0.0006 0.0171 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Brugia malayi Liprin-alpha 2 0.0006 0.0171 0.0332
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0652 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0359 0.541
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0004 0.01 0.1499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0359 0.541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0359 0.541
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0004 0.01 0.0286
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0001 0.000000022332 0.00000033625
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0171 0.2581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0004 0.01 0.1499
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0006 0.0171 0.0171
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0009 0.0298 0.1095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0298 0.4489
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0004 0.01 0.1499
Mycobacterium tuberculosis Conserved hypothetical protein 0.0004 0.01 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0004 0.01 0.1499
Schistosoma mansoni lip-related protein (liprin) alpha 0.0006 0.0171 0.0629
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.000000022332 0.00000033625
Loa Loa (eye worm) hypothetical protein 0.0007 0.0225 0.0435
Brugia malayi MH1 domain containing protein 0.001 0.0319 0.0618
Entamoeba histolytica hypothetical protein 0.0011 0.0359 0.4601
Brugia malayi MH1 domain containing protein 0.0005 0.0161 0.0312
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0011 0.0359 0.1034
Echinococcus granulosus smad 0.001 0.0319 0.0319
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0006 0.0171 0.2581
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0664 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0004 0.01 0.1499
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0664 0.1911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0004 0.01 0.0286
Brugia malayi Neurabin protein 1 0.0006 0.0171 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Schistosoma mansoni Smad4 0.0004 0.0123 0.0453
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0004 0.01 0.1499
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0 0.0005
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0004 0.01 0.1499
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0652 0.1262
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0004 0.01 0.0365
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0004 0.01 0.0193
Brugia malayi WGR domain containing protein 0.0009 0.0298 0.0577
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2724 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0664 0.0664
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0004 0.01 0.01
Leishmania major phosphatidylinositol 4-kinase, putative 0.0004 0.01 0.0276
Schistosoma mansoni smad 0.001 0.0319 0.1172
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0664 0.184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0171 0.0331
Brugia malayi TAR-binding protein 0.0076 0.2724 0.5274
Entamoeba histolytica hypothetical protein 0.0009 0.0298 0.3518
Echinococcus granulosus tar DNA binding protein 0.0076 0.2724 0.2724
Leishmania major hypothetical protein, conserved 0.0101 0.3609 1
Onchocerca volvulus 0.0006 0.0171 0.0367
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0001 0.000000022332 0.00000033625
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0004 0.01 0.0286
Echinococcus granulosus Sterile alpha motif SAM 0.0006 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0004 0.01 0.0192
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0664 0.1285
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0359 0.0696
Loa Loa (eye worm) Smad1 0.001 0.0319 0.0618
Trichomonas vaginalis ankyrin, putative 0.0001 0 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0004 0.01 0.1499
Brugia malayi WGR domain containing protein 0.0009 0.0298 0.0577
Loa Loa (eye worm) phosphatidylinositol kinase 0.0004 0.01 0.0192
Loa Loa (eye worm) phosphatidylinositol 3 0.0004 0.01 0.0192
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.0016 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.027 0.4063
Brugia malayi FAT domain containing protein 0.0008 0.027 0.0523
Loa Loa (eye worm) hypothetical protein 0.0041 0.1449 0.2806
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0007 0.0225 0.0647
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2136 0.4136
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0004 0.01 0.1499
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0006 0.0171 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0.000000022332 0.00000033625
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0001 0.0016 0.0234
Brugia malayi MH2 domain containing protein 0.001 0.0319 0.0618
Brugia malayi mothers against decapentaplegic homolog 3 0.0004 0.0123 0.0239
Echinococcus granulosus Ankyrin 0.0001 0.000000022332 0.000000022332
Loa Loa (eye worm) phosphatidylinositol 3 0.0004 0.01 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0664 1
Schistosoma mansoni hypothetical protein 0.0019 0.0652 0.2394
Echinococcus multilocularis SAM domain containing protein 0.0006 0.0171 0.0171

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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