TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 454.827 | Formula: C21H18ClF3N2O4
H donors: 1 H acceptors: 3 LogP: 4.14 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: O=C(OCC(=O)N(CC(=O)Nc1ccccc1Cl)C)/C=C/c1ccc(cc1)C(F)(F)F
InChi: 1S/C21H18ClF3N2O4/c1-27(12-18(28)26-17-5-3-2-4-16(17)22)19(29)13-31-20(30)11-8-14-6-9-15(10-7-14)21(23,24)25/h2-11H,12-13H2,1H3,(H,26,28)/b11-8+
InChiKey: WXNMDBSFFATVJB-DHZHZOJOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.02	0.6975	0.8915
Plasmodium falciparum	glutathione reductase	0.0088	0.2735	0.3306
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.092	0.2483
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.0321	0.1175
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0316	0.2715
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0321	0.1175
Loa Loa (eye worm)	glutathione reductase	0.0088	0.2735	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0024	0.0321	0.019
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.0321	0.1175
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.092	0.3366
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0316	0.1154
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Mycobacterium tuberculosis	Probable oxidoreductase	0.0222	0.7818	1
Leishmania major	cathepsin L-like protease	0.0024	0.0321	0.0023
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.004	0.092	0.25
Plasmodium vivax	vivapain-2	0.0024	0.0321	0.0397
Mycobacterium tuberculosis	Probable reductase	0.02	0.6975	0.8915
Loa Loa (eye worm)	hypothetical protein	0.0018	0.009	0.033
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.003	0.0571	0.5
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.003	0.0571	0.0608
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.003	0.0571	0.209
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0208	0.0208
Onchocerca volvulus		0.0024	0.0321	1
Loa Loa (eye worm)	cysteine protease	0.0024	0.0321	0.1175
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0208	0.076
Trichomonas vaginalis	mercuric reductase, putative	0.003	0.0571	0.4174
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0208	0.076
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.003	0.0571	0.0601
Leishmania major	cathepsin L-like protease	0.0024	0.0321	0.0023
Entamoeba histolytica	cysteine proteinase 2	0.0024	0.0321	0.0094
Trypanosoma brucei	trypanothione reductase	0.0088	0.2735	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.004	0.092	0.3366
Trypanosoma brucei	unspecified product	0.0027	0.0456	0.0558
Entamoeba histolytica	cysteine proteinase 1, putative	0.0024	0.0321	0.0094
Plasmodium falciparum	thioredoxin reductase	0.0088	0.2735	0.3306
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.003	0.0571	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.092	0.2483
Brugia malayi	steroid hormone receptor	0.0021	0.0208	0.076
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.003	0.0571	0.5795
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0321	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0208	0.076
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0321	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0316	0.1154
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.009	0.0112
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.0321	0.1175
Plasmodium vivax	vivapain-3	0.0024	0.0321	0.0397
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Plasmodium vivax	unspecified product	0.023	0.8089	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0316	0.2715
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0316	0.2715
Entamoeba histolytica	deoxycytidyl transferase, putative	0.004	0.092	1
Onchocerca volvulus	Cathepsin F homolog	0.0024	0.0321	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.003	0.0571	0.209
Plasmodium vivax	thioredoxin reductase, putative	0.0088	0.2735	0.3381
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0316	0.1154
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0208	0.0208
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0024	0.0321	0.1175
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0208	0.0208
Leishmania major	cathepsin L-like protease	0.0024	0.0321	0.0023
Onchocerca volvulus		0.0024	0.0321	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0088	0.2735	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.003	0.0571	0.0601
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0316	0.2715
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0208	0.076
Treponema pallidum	NADH oxidase	0.003	0.0571	0.5
Mycobacterium tuberculosis	Conserved hypothetical protein	0.004	0.092	0.1116
Trichomonas vaginalis	DNA polymerase eta, putative	0.004	0.092	1
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.0321	0.1175
Plasmodium vivax	glutathione reductase, putative	0.0088	0.2735	0.3381
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0088	0.2735	0.3453
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0571	0.209
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0456	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0018	0.009	0.033
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0024	0.0321	0.019
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0208	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0208	0.076
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0321	0.0094
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0018	0.009	0.033
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0321	0.1175
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0571	0.209
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0208	0.076
Schistosoma mansoni	hypothetical protein	0.0179	0.619	0.619
Trypanosoma cruzi	cruzipain precursor, putative	0.0024	0.0321	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0208	0.076
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.003	0.0571	0.0666
Plasmodium falciparum	cysteine proteinase falcipain 1	0.023	0.8089	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0208	0.076
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0222	0.7818	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0088	0.2754	0.4255
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.092	0.2483
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0208	0.076
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.009	0.0047
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0024	0.0321	0.1175
Echinococcus multilocularis	cathepsin L cysteine protease	0.0024	0.0321	0.019
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.092	0.3366
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0024	0.0321	0.0289
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.003	0.0571	0.1036
Trypanosoma cruzi	cysteine proteinase, putative	0.0024	0.0321	0.1175
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.02	0.6975	0.8915
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0208	0.076
Echinococcus multilocularis	cysteine protease	0.0024	0.0321	0.019
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0208	0.076
Plasmodium falciparum	glutathione reductase	0.003	0.0571	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0316	0.1154
Echinococcus granulosus	cathepsin l1	0.0024	0.0321	0.019
Brugia malayi	Thioredoxin reductase	0.0088	0.2735	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0208	0.076
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0316	0.1154
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0024	0.0321	0.0289
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.003	0.0571	0.5
Echinococcus multilocularis	dna polymerase eta	0.004	0.092	0.1191
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0208	0.0208
Schistosoma mansoni	cathepsin F (C01 family)	0.0024	0.0321	0.0321
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.092	1
Onchocerca volvulus		0.0024	0.0321	1
Schistosoma mansoni	coup transcription factor	0.0021	0.0208	0.0208
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.003	0.0571	0.0571
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.02	0.6975	0.8915
Leishmania major	DNA polymerase eta, putative	0.004	0.092	0.25
Leishmania major	cathepsin L-like protease	0.0024	0.0321	0.0023
Echinococcus granulosus	cathepsin L	0.0024	0.0321	0.019
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.092	0.2483
Schistosoma mansoni	DNA polymerase eta	0.004	0.092	0.092
Echinococcus multilocularis	dna polymerase kappa	0.004	0.092	0.1191
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0208	0.0208
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.003	0.0571	0.1057
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.003	0.0571	0.1036
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0208	0.0208
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.003	0.0571	0.0706
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0208	0.076
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0222	0.7818	1
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Echinococcus granulosus	dna polymerase eta	0.004	0.092	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0018	0.009	0.033
Brugia malayi	glutathione reductase	0.0088	0.2735	1
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0208	0.0208
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.092	0.2483
Echinococcus multilocularis	cysteine protease	0.0024	0.0321	0.019
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0316	0.2715
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0316	0.2715
Schistosoma mansoni	terminal deoxycytidyl transferase	0.004	0.092	0.092
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0208	0.076
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0208	0.076
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0321	0.1175
Leishmania major	cathepsin L-like protease	0.0024	0.0321	0.0023
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.092	0.3366
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0571	0.209
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0208	0.0208
Loa Loa (eye worm)	hypothetical protein	0.004	0.092	0.3366
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0208	0.076
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.0321	0.1175
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.003	0.0571	0.5795
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.003	0.0571	0.1057
Onchocerca volvulus		0.0024	0.0321	1
Brugia malayi	nuclear hormone receptor	0.0021	0.0208	0.076
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.003	0.0571	0.1036
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0321	0.1175
Echinococcus granulosus	thioredoxin glutathione reductase	0.0088	0.2754	0.4255
Trypanosoma brucei	unspecified product	0.004	0.092	0.2483
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0208	0.076
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.003	0.0571	0.209
Onchocerca volvulus		0.0024	0.0321	1
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0208	0.0208
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0208	0.076
Loa Loa (eye worm)	fibroinase	0.0024	0.0321	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0208	0.076
Loa Loa (eye worm)	thioredoxin reductase	0.0088	0.2735	1
Trypanosoma cruzi	cysteine protease, putative	0.0024	0.0321	0.1175
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.0321	0.1175
Leishmania major	cathepsin L-like protease	0.0024	0.0321	0.0023
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0321	0.0094
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0321	0.1175
Mycobacterium tuberculosis	Probable dehydrogenase	0.02	0.6975	0.8915
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0316	0.2715
Brugia malayi	ImpB/MucB/SamB family protein	0.004	0.092	0.3366
Echinococcus granulosus	geminin	0.0179	0.619	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0222	0.7818	1
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0321	0.0094
Echinococcus multilocularis	cathepsin L	0.0024	0.0321	0.019
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.092	0.2483
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0208	0.0208
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0208	0.076
Loa Loa (eye worm)	ctsf protein	0.0024	0.0321	0.1175
Schistosoma mansoni	hypothetical protein	0.0179	0.619	0.619
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0208	0.076
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.004	0.092	0.1191
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.092	0.2483
Brugia malayi	ecdysteroid receptor	0.0021	0.0208	0.076
Onchocerca volvulus	Cathepsin L homolog	0.0024	0.0321	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.092	0.2483
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.003	0.0571	0.1036
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0208	0.076
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0571	0.209
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.003	0.0571	0.0706
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.004	0.092	0.1191
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0024	0.0321	0.019
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0571	0.209
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0321	0.1175
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0208	0.076
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.092	0.2483
Echinococcus granulosus	cysteine protease	0.0024	0.0321	0.019
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0208	0.076
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0321	0.0094
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.004	0.092	0.3366
Trypanosoma cruzi	cysteine proteinase, putative	0.0024	0.0321	0.1175
Onchocerca volvulus		0.0024	0.0321	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0316	0.0337
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0208	0.076
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.003	0.0571	0.5795
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0456	0.0558
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0024	0.0321	0.0321
Giardia lamblia	DINP protein human, muc B family	0.004	0.092	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.092	0.3366
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0022	0.0267	0.0976
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Plasmodium falciparum	thioredoxin reductase	0.003	0.0571	0.0601
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0024	0.0321	0.0321
Leishmania major	cysteine peptidase A (CPA)	0.0024	0.0321	0.0023
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.092	0.2483
Plasmodium vivax	vivapain-1	0.023	0.8089	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0024	0.0321	0.1175
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0024	0.0321	0.0321
Plasmodium vivax	vivapain-2	0.0024	0.0321	0.0397
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.004	0.092	0.1116
Echinococcus granulosus	dna polymerase kappa	0.004	0.092	0.1191
Trichomonas vaginalis	glutathione reductase, putative	0.003	0.0571	0.4174
Echinococcus multilocularis	geminin	0.0179	0.619	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0208	0.076
Toxoplasma gondii	thioredoxin reductase	0.0088	0.2735	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0022	0.0267	0.0976
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0024	0.0321	0.019
Leishmania major	cathepsin L-like protease	0.0024	0.0321	0.0023
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0208	0.076
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0208	0.0208
Onchocerca volvulus		0.0024	0.0316	0.9502
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0321	0.0094
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.0321	0.1175
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.02	0.6975	0.8877
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.003	0.0571	0.1036
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0456	0.0558
Leishmania major	trypanothione reductase	0.0088	0.2735	1
Trypanosoma brucei	DNA polymerase eta, putative	0.004	0.092	0.2483
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.092	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0024	0.0321	0.0321
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0208	0.076
Brugia malayi	ImpB/MucB/SamB family protein	0.004	0.092	0.3366
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.004	0.092	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0316	0.0337
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.092	0.2483
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0571	0.209
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.004	0.092	0.092
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.02	0.6975	0.8915
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0208	0.076
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0208	0.076
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.0321	0.1175
Onchocerca volvulus		0.0024	0.0321	1
Onchocerca volvulus	Cathepsin L homolog	0.0024	0.0321	1
Plasmodium vivax	unspecified product	0.0214	0.7513	0.9288
Trypanosoma cruzi	trypanothione reductase, putative	0.003	0.0571	0.209
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0316	0.1154
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0208	0.076
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0024	0.0321	0.019
Leishmania major	cathepsin L-like protease	0.0024	0.0321	0.0023
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0024	0.0321	0.0289
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.003	0.0571	0.1057
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.003	0.0571	0.1057
Echinococcus granulosus	cathepsin L cysteine protease	0.0024	0.0321	0.019
Trypanosoma brucei	unspecified product	0.0027	0.0456	0.0558
Toxoplasma gondii	NADPH-glutathione reductase	0.003	0.0571	0.1036
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0208	0.076
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0208	0.076
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.003	0.0571	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0018	0.009	0.033
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.092	0.2483
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0321	0.0094
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0316	0.2715
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.092	0.2483
Leishmania major	DNA polymerase kappa, putative	0.004	0.092	0.25

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.6964 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1703479

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1499968