TDR Targets

Basic information

Technical information

TDR Targets ID: 1500319
Name: EU-0079031
MW: 496.93 | Formula: C23H20ClF3N2O3S
H donors: 1 H acceptors: 3 LogP: 5.84 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccccc1NC(=O)CN(S(=O)(=O)c1ccccc1)c1cc(ccc1Cl)C(F)(F)F
InChi: 1S/C23H20ClF3N2O3S/c1-2-16-8-6-7-11-20(16)28-22(30)15-29(33(31,32)18-9-4-3-5-10-18)21-14-17(23(25,26)27)12-13-19(21)24/h3-14H,2,15H2,1H3,(H,28,30)
InChiKey: MVQSAJRPOYUYEK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

NCGC00099531-01
ZINC01145530

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0033	0.1051	1
Echinococcus multilocularis	cathepsin L	0.0012	0.0087	0.0087
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.1051	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0012	0.0087	0.0087
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0033	0.1051	0.3233
Schistosoma mansoni	lipoxygenase	0.0164	0.6862	0.6862
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0012	0.0087	0.0087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Plasmodium falciparum	ABC transporter G family member 2	0.001	0.0014	0.0032
Loa Loa (eye worm)	ctsf protein	0.0012	0.0087	0.0267
Onchocerca volvulus		0.0012	0.0087	0.0659
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0012	0.0087	0.0267
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Onchocerca volvulus		0.0033	0.1051	0.7993
Loa Loa (eye worm)	oxidoreductase	0.0033	0.1051	0.3233
Echinococcus granulosus	cathepsin L	0.0012	0.0087	0.0087
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.1051	0.1051
Loa Loa (eye worm)	oxidoreductase	0.0033	0.1051	0.3233
Echinococcus granulosus	ATP binding cassette sub family G	0.001	0.0014	0.0014
Echinococcus multilocularis	Polycystic kidney disease protein	0.0039	0.1315	0.1315
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.1051	0.1051
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0033	0.1051	0.3233
Schistosoma mansoni	rab6-interacting	0.0039	0.1315	0.1315
Brugia malayi	hypothetical protein	0.0039	0.1315	0.4045
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0033	0.1051	0.3233
Onchocerca volvulus		0.0033	0.1051	0.7993
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0012	0.0087	0.0191
Loa Loa (eye worm)	oxidoreductase	0.0033	0.1051	0.3233
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0012	0.0087	0.0824
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0012	0.0087	0.0824
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Onchocerca volvulus		0.0033	0.1051	0.7993
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.1051	0.1051
Onchocerca volvulus		0.0033	0.1051	0.7993
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.001	0.0014	0.0137
Schistosoma mansoni	hypothetical protein	0.0083	0.325	0.325
Echinococcus multilocularis	cysteine protease	0.0012	0.0087	0.0087
Echinococcus granulosus	aldo keto reductase	0.0033	0.1051	0.1051
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0012	0.0087	0.0191
Plasmodium vivax	vivapain-1	0.0112	0.4548	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0416	0.0416
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.0087	0.0267
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.1051	1
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0087	0.0267
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.224	0.6893
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0012	0.0087	0.0824
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Onchocerca volvulus		0.0012	0.0087	0.0659
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.1051	0.1051
Trypanosoma cruzi	cysteine peptidase, putative	0.0012	0.0087	0.0824
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1315	0.4045
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0083	0.325	0.325
Entamoeba histolytica	cysteine proteinase 1, putative	0.0012	0.0087	0.0824
Leishmania major	aldo-keto reductase-like protein	0.0033	0.1051	1
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0087	0.0267
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0235	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0087	0.0824
Schistosoma mansoni	apoptosis regulator bax	0.0083	0.325	0.325
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.1051	0.1051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	0.001	0.0014	0.0014
Mycobacterium leprae	Conserved hypothetical protein	0.0024	0.0622	0.5922
Schistosoma mansoni	hypothetical protein	0.0019	0.0416	0.0416
Leishmania major	ATP-binding cassette protein subfamily G, member 4, putative	0.001	0.0014	0.0137
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Trypanosoma cruzi	cysteine proteinase, putative	0.0012	0.0087	0.0824
Plasmodium vivax	ABC transporter G family member 2, putative	0.001	0.0014	0.0032
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0033	0.1051	0.3233
Onchocerca volvulus		0.0033	0.1051	0.7993
Schistosoma mansoni	aldo-keto reductase	0.0033	0.1051	0.1051
Echinococcus granulosus	lipoxygenase domain containing protein	0.0039	0.1315	0.1315
Leishmania major	ATP-binding cassette protein subfamily G, member 6, putative	0.001	0.0014	0.0137
Trypanosoma cruzi	cysteine peptidase, putative	0.0012	0.0087	0.0824
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.224	0.6893
Echinococcus granulosus	aldehyde reductase	0.0024	0.0622	0.0622
Entamoeba histolytica	ABC transporter, putative	0.001	0.0014	0.0137
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.1051	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.1051	0.1051
Trypanosoma brucei	prostaglandin f synthase	0.0033	0.1051	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Echinococcus multilocularis	cathepsin L cysteine protease	0.0012	0.0087	0.0087
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0033	0.1051	1
Brugia malayi	hypothetical protein	0.0039	0.1315	0.4045
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0012	0.0087	0.0087
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0012	0.0087	0.0191
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0087	0.0824
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1315	0.4045
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.1051	1
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.0087	0.0267
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Loa Loa (eye worm)	oxidoreductase	0.0033	0.1051	0.3233
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0083	0.325	1
Entamoeba histolytica	aldose reductase, putative	0.0033	0.1051	1
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0012	0.0087	0.0824
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Giardia lamblia	Aldose reductase	0.0033	0.1051	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.1051	0.1051
Onchocerca volvulus		0.0039	0.1315	1
Toxoplasma gondii	cathepsin CPL	0.0012	0.0087	0.0824
Onchocerca volvulus	Cathepsin L homolog	0.0012	0.0087	0.0659
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.1396	0.4295
Echinococcus granulosus	cysteine protease	0.0012	0.0087	0.0087
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.0087	0.0267
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.1051	0.1051
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0087	0.0087
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0416	0.0416
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0083	0.325	0.325
Echinococcus multilocularis	aldo keto reductase	0.0033	0.1051	0.1051
Schistosoma mansoni	hypothetical protein	0.0019	0.0416	0.0416
Plasmodium vivax	vivapain-2	0.0012	0.0087	0.0191
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0039	0.1315	0.1315
Echinococcus granulosus	GPCR family 2	0.0019	0.0416	0.0416
Onchocerca volvulus	Cathepsin L homolog	0.0012	0.0087	0.0659
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.001	0.0014	0.0137
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0087	0.0087
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.1051	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.224	0.6893
Plasmodium vivax	unspecified product	0.0105	0.4217	0.9273
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.1051	0.1051
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0033	0.1051	1
Trypanosoma cruzi	cysteine protease, putative	0.0012	0.0087	0.0824
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0012	0.0087	0.0824
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0416	0.0416
Schistosoma mansoni	rab6-interacting	0.0039	0.1315	0.1315
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0087	0.0824
Trypanosoma brucei	ATP-binding cassette protein, putative	0.001	0.0014	0.0137
Trypanosoma cruzi	aldo-keto reductase	0.0033	0.1051	1
Echinococcus granulosus	Polycystic kidney disease protein	0.0039	0.1315	0.1315
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Entamoeba histolytica	cysteine proteinase 2	0.0012	0.0087	0.0824
Onchocerca volvulus		0.0012	0.0087	0.0659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0033	0.1051	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0012	0.0087	0.0267
Trypanosoma cruzi	cysteine proteinase, putative	0.0012	0.0087	0.0824
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0416	0.128
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.1051	0.1051
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0012	0.0087	0.0824
Toxoplasma gondii	aldose reductase, putative	0.0033	0.1051	1
Echinococcus granulosus	RUN	0.0039	0.1315	0.1315
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.001	0.0014	0.0137
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.1051	1
Leishmania major	cathepsin L-like protease	0.0012	0.0087	0.0824
Plasmodium vivax	unspecified product	0.0112	0.4548	1
Leishmania major	cathepsin L-like protease	0.0012	0.0087	0.0824
Echinococcus granulosus	hypothetical protein	0.0033	0.1051	0.1051
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0012	0.0087	0.0824
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.1051	1
Echinococcus multilocularis	aldo keto reductase	0.0033	0.1051	0.1051
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0087	0.0824
Loa Loa (eye worm)	doublecortin family protein	0.0039	0.1315	0.4045
Trichomonas vaginalis	aldo/keto reductase, putative	0.0033	0.1051	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.1051	0.1051
Trichomonas vaginalis	aldo/keto reductase, putative	0.0033	0.1051	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0012	0.0087	0.0824
Echinococcus multilocularis	ATP binding cassette sub family G	0.001	0.0014	0.0014
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.1051	1
Schistosoma mansoni	loxhd1	0.0039	0.1315	0.1315
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Loa Loa (eye worm)	apoptosis regulator protein	0.0083	0.325	1
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0087	0.0824
Onchocerca volvulus		0.0012	0.0087	0.0659
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.1051	0.1051
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0416	0.0416
Mycobacterium ulcerans	oxidoreductase	0.0033	0.1051	1
Schistosoma mansoni	hypothetical protein	0.0083	0.325	0.325
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0112	0.4548	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0039	0.1315	0.1315
Trypanosoma cruzi	cysteine peptidase, putative	0.0012	0.0087	0.0824
Onchocerca volvulus	Cathepsin F homolog	0.0012	0.0087	0.0659
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0083	0.325	0.325
Plasmodium vivax	vivapain-2	0.0012	0.0087	0.0191
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0087	0.0267
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0012	0.0087	0.0087
Brugia malayi	Doublecortin family protein	0.0039	0.1315	0.4045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Onchocerca volvulus		0.0012	0.0087	0.0659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0012	0.0087	0.0087
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0012	0.0087	0.0824
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.1051	1
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Entamoeba histolytica	aldose reductase, putative	0.0033	0.1051	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1396	0.4295
Trypanosoma cruzi	cysteine peptidase, putative	0.0012	0.0087	0.0824
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.1051	0.1051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Echinococcus multilocularis	aldo keto reductase	0.0033	0.1051	0.1051
Leishmania major	cathepsin L-like protease	0.0012	0.0087	0.0824
Schistosoma mansoni	polycystin 1-related	0.0039	0.1315	0.1315
Echinococcus granulosus	lipoxygenase domain containing protein	0.0039	0.1315	0.1315
Leishmania major	cathepsin L-like protease	0.0012	0.0087	0.0824
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.1051	0.1051
Mycobacterium tuberculosis	Probable oxidoreductase	0.0033	0.1051	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0012	0.0087	0.0087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Plasmodium vivax	multidomain scavenger receptor, putative	0.0039	0.1315	0.2891
Loa Loa (eye worm)	cysteine protease	0.0012	0.0087	0.0267
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0416	0.0416
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0087	0.0824
Echinococcus multilocularis	aldehyde reductase	0.0024	0.0622	0.0622
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0087	0.0267
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0033	0.1051	1
Leishmania major	cathepsin L-like protease	0.0012	0.0087	0.0824
Trypanosoma cruzi	cruzipain precursor, putative	0.0012	0.0087	0.0824
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.1051	0.1051
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0416	0.128
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG84	0.001	0.0014	0.0137
Echinococcus granulosus	aldo keto reductase	0.0033	0.1051	0.1051
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.1051	0.1051
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.1051	0.1051
Leishmania major	cathepsin L-like protease	0.0012	0.0087	0.0824
Echinococcus granulosus	ATP binding cassette sub family G	0.001	0.0014	0.0014
Schistosoma mansoni	hypothetical protein	0.0039	0.1315	0.1315
Trichomonas vaginalis	aldo/keto reductase, putative	0.0033	0.1051	1
Echinococcus granulosus	ATP binding cassette sub family G	0.001	0.0014	0.0014
Trypanosoma brucei	ABC transporter, putative	0.001	0.0014	0.0137
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.224	0.6893
Echinococcus multilocularis	ATP binding cassette sub family G	0.001	0.0014	0.0014
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.1051	0.1051
Leishmania major	prostaglandin f synthase, putative	0.0033	0.1051	1
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0083	0.325	0.325
Trypanosoma cruzi	cysteine peptidase, putative	0.0012	0.0087	0.0824
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0416	0.128
Loa Loa (eye worm)	fibroinase	0.0012	0.0087	0.0267
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0012	0.0087	0.0824
Echinococcus granulosus	cathepsin l1	0.0012	0.0087	0.0087
Leishmania major	cathepsin L-like protease	0.0012	0.0087	0.0824
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0087	0.0267
Leishmania major	cysteine peptidase A (CPA)	0.0012	0.0087	0.0824
Schistosoma mansoni	hypothetical protein	0.0041	0.1396	0.1396
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0012	0.0087	0.0824
Schistosoma mansoni	hypothetical protein	0.0083	0.325	0.325
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.1051	0.1051
Echinococcus multilocularis	RUN	0.0039	0.1315	0.1315
Loa Loa (eye worm)	oxidoreductase	0.0033	0.1051	0.3233
Echinococcus multilocularis	cysteine protease	0.0012	0.0087	0.0087
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0012	0.0087	0.0087
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0416	0.128
Schistosoma mansoni	lipoxygenase	0.0235	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.1051	1
Plasmodium vivax	vivapain-3	0.0012	0.0087	0.0191
Entamoeba histolytica	aldose reductase, putative	0.0033	0.1051	1
Giardia lamblia	Aldose reductase	0.0033	0.1051	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.1051	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0087	0.0267
Schistosoma mansoni	pol-related	0.0033	0.1051	0.1051
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.1051	0.1051
Echinococcus multilocularis	ATP binding cassette sub family G	0.001	0.0014	0.0014
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.1051	1
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1051	0.3233
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0033	0.1051	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0012	0.0087	0.0824
Trypanosoma brucei	aldo-keto reductase, putative	0.0033	0.1051	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0416	0.0416
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Echinococcus multilocularis	aldo keto reductase	0.0033	0.1051	0.1051
Onchocerca volvulus		0.0012	0.0087	0.0659
Trypanosoma cruzi	ATP-binding cassette protein, putative	0.001	0.0014	0.0137
Schistosoma mansoni	hypothetical protein	0.0019	0.0416	0.0416
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Trypanosoma cruzi	ABC transporter, putative	0.001	0.0014	0.0137
Onchocerca volvulus		0.0033	0.1051	0.7993
Loa Loa (eye worm)	hypothetical protein	0.0083	0.325	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0087	0.0824
Onchocerca volvulus		0.0012	0.0087	0.0659
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0087	0.0267
Echinococcus granulosus	cathepsin L cysteine protease	0.0012	0.0087	0.0087
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0012	0.0087	0.0087
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0083	0.325	0.325
Plasmodium falciparum	LCCL domain-containing protein	0.0039	0.1315	0.2891
Trypanosoma cruzi	aldo/keto reductase, putative	0.0033	0.1051	1
Echinococcus granulosus	aldo keto reductase	0.0033	0.1051	0.1051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0012	0.0087	0.0824
Onchocerca volvulus		0.0039	0.1315	1
Schistosoma mansoni	aldo-keto reductase	0.0033	0.1051	0.1051
Entamoeba histolytica	cysteine protease, putative	0.0012	0.0087	0.0824
Leishmania major	cathepsin L-like protease	0.0012	0.0087	0.0824

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1716093

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1500319