TDR Targets

Basic information

Technical information

TDR Targets ID: 1501097
Name: 1-(1-methyl-3,4-dihydro-2H-isoquinolin-1-yl)c yclohexan-1-ol
MW: 245.36 | Formula: C16H23NO
H donors: 2 H acceptors: 1 LogP: 2.49 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: OC1(CCCCC1)C1(C)NCCc2c1cccc2
InChi: 1S/C16H23NO/c1-15(16(18)10-5-2-6-11-16)14-8-4-3-7-13(14)9-12-17-15/h3-4,7-8,17-18H,2,5-6,9-12H2,1H3
InChiKey: VMXYNNOLPQQSFF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(1-methyl-3,4-dihydro-2H-isoquinolin-1-yl)-1-cyclohexanol
ChemDiv2_002180
EU-0019691
A2759/0117096
Oprea1_354121

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	peregrin	0.0035	0.1113	0.1022
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0471	0.0798
Loa Loa (eye worm)	hypothetical protein	0.002	0.0321	0.0544
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0321	0.0544
Schistosoma mansoni	hypothetical protein	0.0205	1	1
Brugia malayi	hypothetical protein	0.0035	0.1094	0.1854
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.3079	0.522
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.5899	0.5857
Brugia malayi	PHD-finger family protein	0.0035	0.1113	0.1887
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0471	0.5
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0636	0.1078
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0321	0.0544
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.5315	0.5267
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0471	0.5
Echinococcus granulosus	tar DNA binding protein	0.0126	0.5899	0.5857
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.0321	0.0544
Entamoeba histolytica	hypothetical protein	0.0035	0.1094	1
Echinococcus multilocularis	lamin	0.0026	0.0636	0.054
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0321	0.0544
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.0321	0.0222
Echinococcus multilocularis	thyroid hormone receptor alpha	0.002	0.0321	0.0222
Entamoeba histolytica	hypothetical protein	0.0035	0.1094	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0321	0.0544
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.1113	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.1907	0.3233
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.1907	0.3233
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.0321	0.0222
Onchocerca volvulus		0.0026	0.0636	0.3979
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.5899	0.5857
Schistosoma mansoni	hypothetical protein	0.0035	0.1094	0.1002
Schistosoma mansoni	hypothetical protein	0.0034	0.1071	0.098
Echinococcus granulosus	lamin	0.0026	0.0636	0.054
Brugia malayi	RNA recognition motif domain containing protein	0.0126	0.5899	1
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0321	0.0544
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0321	0.0544
Loa Loa (eye worm)	hypothetical protein	0.006	0.2432	0.4123
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0471	0.0798
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.0321	0.0222
Loa Loa (eye worm)	hypothetical protein	0.002	0.0321	0.0544
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0126	0.5899	1
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.5899	0.5857
Entamoeba histolytica	hypothetical protein	0.0035	0.1094	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0471	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0471	1
Schistosoma mansoni	hypothetical protein	0.0035	0.1113	0.1022
Echinococcus multilocularis	musashi	0.0026	0.0636	0.054
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0471	0.5
Schistosoma mansoni	lamin	0.0026	0.0636	0.054
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0471	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0636	0.1078
Entamoeba histolytica	hypothetical protein	0.0035	0.1094	1
Schistosoma mansoni	coup transcription factor	0.002	0.0321	0.0222
Giardia lamblia	PHD finger protein 15	0.0035	0.1113	0.5
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0471	0.5
Brugia malayi	RNA binding protein	0.0126	0.5899	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0321	0.0222
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0321	0.0544
Loa Loa (eye worm)	hypothetical protein	0.002	0.0321	0.0544
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.1501	0.1414
Echinococcus multilocularis	lamin dm0	0.0026	0.0636	0.054
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0471	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0166	0.0282
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0321	0.0222
Brugia malayi	nuclear receptor NHR-88	0.002	0.0321	0.0544
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0321	0.0544
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.0321	0.0222
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0636	0.1078
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0471	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0166	0.0282
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0321	0.0544
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0321	0.0544
Brugia malayi	Bromodomain containing protein	0.0035	0.1113	0.1887
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.1113	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0166	0.0282
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0321	0.0544
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0321	0.0222
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0471	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0471	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.1094	0.1002
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0321	0.0222
Echinococcus multilocularis	peregrin	0.0035	0.1113	0.1022
Brugia malayi	steroid hormone receptor	0.002	0.0321	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0611	0.1036
Schistosoma mansoni	lamin	0.0026	0.0636	0.054
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.5899	0.5857
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0471	0.0798
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0321	0.0222
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.1113	0.1022
Onchocerca volvulus	Alhambra homolog	0.0035	0.1113	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.0321	0.0544
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.5899	0.5857
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0321	0.0544
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.0321	0.0222
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0636	0.054
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.1836	0.1752
Loa Loa (eye worm)	RNA binding protein	0.0126	0.5899	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.1907	0.3233
Brugia malayi	nuclear hormone receptor	0.002	0.0321	0.0544
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.1907	0.3233
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.1501	0.1414
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.0321	0.0222
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0321	0.0544
Loa Loa (eye worm)	hypothetical protein	0.002	0.0321	0.0544
Onchocerca volvulus		0.0023	0.0471	0.1887
Brugia malayi	ecdysteroid receptor	0.002	0.0321	0.0544
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0471	0.0798
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.1501	0.1414
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0321	0.0544
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0321	0.0544
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0321	0.0544
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0321	0.0222
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.1113	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0321	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1071	0.1816
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0471	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0471	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0471	0.0798
Loa Loa (eye worm)	TAR-binding protein	0.0126	0.5899	1
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.1094	0.1002
Brugia malayi	jmjC domain containing protein	0.0115	0.5315	0.901
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0321	0.0222
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.1113	0.1887
Brugia malayi	jmjC domain containing protein	0.0043	0.1501	0.2545
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0321	0.0544
Echinococcus multilocularis	tar DNA binding protein	0.0126	0.5899	0.5857
Loa Loa (eye worm)	hypothetical protein	0.002	0.0321	0.0544
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0102	0.0172
Brugia malayi	intermediate filament protein	0.0026	0.0636	0.1078
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.0321	0.0222
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0166	0.139
Echinococcus granulosus	intermediate filament protein	0.0026	0.0636	0.054
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0166	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0321	0.0222
Echinococcus multilocularis	geminin	0.0205	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0321	0.0544
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0471	1
Plasmodium falciparum	phd finger protein, putative	0.0035	0.1113	1
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0102	0.0172
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.0321	0.0222
Brugia malayi	TAR-binding protein	0.0126	0.5899	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0102	0.0172
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.0321	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1113	0.1887
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.1501	0.2545
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0166	0.0282
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0321	0.0222
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0471	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0102	0.0172
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.1836	0.1752
Echinococcus granulosus	lamin dm0	0.0026	0.0636	0.054
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0471	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0636	0.1078
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.1071	0.1816
Onchocerca volvulus		0.0026	0.0636	0.3979
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.0321	0.0222
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.0321	0.0544
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.0321	0.0222
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0321	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0166	0.0282
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0321	0.0222
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0321	0.0222
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.4071	0.4011
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0321	0.0544
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0321	0.0544
Loa Loa (eye worm)	hypothetical protein	0.002	0.0321	0.0544
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0321	0.0222
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.1501	0.1414
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.1094	0.1002
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.5315	0.5267
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.1113	0.1022
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.0321	0.0222
Schistosoma mansoni	hypothetical protein	0.0205	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0321	0.0544
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0321	0.0544
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0321	0.0222
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.0321	0.0222
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.1113	0.1022
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0321	0.0222
Loa Loa (eye worm)	hypothetical protein	0.002	0.0321	0.0544

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.8913 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	6.5131 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	32.6427 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1715847

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1501097