Detailed information for compound 1501101

Basic information

Technical information
  • TDR Targets ID: 1501101
  • Name: (2R,3S)-1-methyl-5-oxo-2-pyridin-3-ylpyrrolid ine-3-carboxylic acid
  • MW: 220.225 | Formula: C11H12N2O3
  • H donors: 1 H acceptors: 4 LogP: -0.58 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@H]1CC(=O)N([C@H]1c1cccnc1)C
  • InChi: 1S/C11H12N2O3/c1-13-9(14)5-8(11(15)16)10(13)7-3-2-4-12-6-7/h2-4,6,8,10H,5H2,1H3,(H,15,16)/t8-,10-/m0/s1
  • InChiKey: DEYLVDCFTICBTB-WPRPVWTQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3S)-1-methyl-5-oxo-2-(3-pyridyl)pyrrolidine-3-carboxylic acid
  • (2R,3S)-1-methyl-5-oxo-2-(3-pyridyl)-3-pyrrolidinecarboxylic acid
  • (2R,3S)-5-keto-1-methyl-2-(3-pyridyl)pyrrolidine-3-carboxylic acid
  • (2R,3S)-1-methyl-5-oxo-2-pyridin-3-yl-pyrrolidine-3-carboxylic acid
  • NCGC00163530-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.1559 0.1582
Echinococcus multilocularis GPCR, family 2 0.001 0.0003 0.0003
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0037 0.1647 0.1671
Trypanosoma brucei metacaspase MCA3 0.003 0.1246 0.4227
Loa Loa (eye worm) hypothetical protein 0.0016 0.0408 0.0414
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0037 0.1647 0.3576
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0011 0.0113 0.0383
Brugia malayi hypoxia-induced factor 1 0.0091 0.4877 0.4948
Schistosoma mansoni lamin 0.0016 0.0408 0.0414
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0037 0.1647 0.1722
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0006 0.0019
Schistosoma mansoni hypothetical protein 0.001 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0059 0.2947 0.2991
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.001 0.0003 0.0003
Schistosoma mansoni caspase-3 (C14 family) 0.0114 0.6213 0.6305
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0036 0.1559 0.1582
Trypanosoma cruzi metacaspase, putative 0.003 0.1246 0.4227
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0028 0.1087 0.1103
Schistosoma mansoni intermediate filament proteins 0.0016 0.0408 0.0414
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0059 0.2947 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0028 0.1087 0.1103
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0011 0.0113 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0028 0.1087 0.1136
Echinococcus granulosus caspase 2 0.003 0.1246 0.1303
Loa Loa (eye worm) hypothetical protein 0.0099 0.5334 0.5412
Entamoeba histolytica hypothetical protein, conserved 0.0059 0.2947 0.2867
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0006 0.0006
Trypanosoma cruzi metacaspase, putative 0.003 0.1246 0.4227
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Echinococcus granulosus caspase 0.0114 0.6213 0.6497
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.1559 0.1582
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0059 0.2947 0.3082
Onchocerca volvulus Cell death protein 3 homolog 0.003 0.1246 1
Echinococcus granulosus lamin dm0 0.0016 0.0408 0.0427
Trypanosoma brucei metacaspase MCA2 0.003 0.1246 0.4227
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0011 0.0113 0.0118
Brugia malayi Calcitonin receptor-like protein seb-1 0.003 0.1235 0.1254
Treponema pallidum fructose-bisphosphate aldolase 0.0177 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0028 0.1087 0.1103
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0037 0.1647 0.1671
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.9855 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0016 0.0408 0.0414
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0177 1 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.1246 0.1146
Schistosoma mansoni hypothetical protein 0.001 0.0003 0.0003
Onchocerca volvulus 0.0022 0.0735 0.3899
Schistosoma mansoni hypothetical protein 0.0031 0.1303 0.1322
Leishmania major metacaspase, putative 0.003 0.1246 0.4227
Brugia malayi Cytochrome P450 family protein 0.001 0.0006 0.0006
Loa Loa (eye worm) acetyltransferase 0.0175 0.9855 1
Trypanosoma cruzi metacaspase 5, putative 0.003 0.1246 0.4227
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.1246 0.1146
Loa Loa (eye worm) latrophilin receptor protein 2 0.001 0.0003 0.0003
Mycobacterium ulcerans putative regulatory protein 0.0022 0.0735 0.1589
Brugia malayi exodeoxyribonuclease III family protein 0.0011 0.0113 0.0115
Brugia malayi Intermediate filament tail domain containing protein 0.0016 0.0408 0.0414
Loa Loa (eye worm) hypothetical protein 0.0016 0.039 0.0396
Plasmodium vivax hypothetical protein, conserved 0.003 0.1246 0.4988
Trypanosoma cruzi metacaspase 5, putative 0.003 0.1246 0.4227
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.1246 0.1146
Schistosoma mansoni single-minded 0.003 0.1192 0.1209
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0006 0.0019
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.003 0.1246 0.1264
Echinococcus multilocularis transfer RNA-Lys 0.0022 0.0735 0.0746
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.001 0.0003 0.0003
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.2498 1
Plasmodium falciparum metacaspase-like protein 0.003 0.1246 0.5556
Plasmodium vivax metacaspase 1, putative 0.003 0.1246 0.4988
Giardia lamblia Rrm3p helicase 0.0059 0.2947 0.2867
Echinococcus multilocularis lamin dm0 0.0016 0.0408 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.003 0.1246 0.1146
Brugia malayi Cytochrome P450 family protein 0.001 0.0006 0.0006
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0037 0.1647 0.3422
Loa Loa (eye worm) hypothetical protein 0.003 0.1235 0.1254
Brugia malayi bHLH-PAS transcription factor 0.0022 0.0735 0.0746
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0028 0.1087 0.1136
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0114 0.6213 0.6305
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.2498 0.2612
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.1087 0.1103
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.2242 0.2154
Loa Loa (eye worm) pigment dispersing factor receptor c 0.003 0.1235 0.1254
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0059 0.2947 0.2991
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0059 0.2947 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.9562 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0036 0.1559 0.1631
Brugia malayi Cell death protein 3 precursor 0.003 0.1246 0.1264
Loa Loa (eye worm) hypothetical protein 0.003 0.1246 0.1264
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0011 0.0113 0.0383
Schistosoma mansoni caspase-7 (C14 family) 0.0114 0.6213 0.6305
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0087 0.4595 1
Schistosoma mansoni aryl hydrocarbon receptor 0.003 0.1192 0.1209
Schistosoma mansoni hypothetical protein 0.0021 0.0665 0.0675
Plasmodium falciparum metacaspase 1 0.003 0.1246 0.5556
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.1246 0.1146
Brugia malayi hypothetical protein 0.0099 0.5334 0.5412
Brugia malayi jmjC domain containing protein 0.0036 0.1559 0.1582
Loa Loa (eye worm) hypothetical protein 0.003 0.1246 0.1264
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.1246 0.1146
Brugia malayi jmjC domain containing protein 0.0036 0.1559 0.1582
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0177 1 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.1246 0.1146
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.1246 0.1146
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0032 0.1367 0.1388
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0059 0.2947 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0059 0.2947 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.1087 0.1103
Echinococcus multilocularis caspase 2 0.003 0.1246 0.1264
Schistosoma mansoni hypothetical protein 0.001 0.0003 0.0003
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0011 0.0113 0.0452
Schistosoma mansoni lamin 0.0016 0.0408 0.0414
Leishmania major cytochrome p450-like protein 0.001 0.0006 0.0019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.001 0.0003 0.0003
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.003 0.1246 0.4988
Brugia malayi intermediate filament protein 0.0016 0.0408 0.0414
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.003 0.1246 0.4988
Toxoplasma gondii exonuclease III APE 0.0011 0.0113 0.0452
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.1246 0.1146
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.1559 0.1582
Loa Loa (eye worm) intermediate filament protein 0.0016 0.0408 0.0414
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0028 0.1087 0.1103
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.9855 1
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0006 0.0006
Trypanosoma cruzi metacaspase, putative 0.003 0.1246 0.4227
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0011 0.0113 0.0383
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.1246 0.1264
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0177 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0177 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.1559 0.1582
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0011 0.0113 0.0234
Giardia lamblia Fructose-bisphosphate aldolase 0.0177 1 1
Trypanosoma brucei Metacaspase-4 0.003 0.1246 0.4227
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.2242 0.2154
Loa Loa (eye worm) hypothetical protein 0.0021 0.0665 0.0675
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0011 0.0113 0.0504
Entamoeba histolytica DNA repair and recombination protein, putative 0.0059 0.2947 0.2867
Trypanosoma brucei metacaspase 5, putative 0.003 0.1246 0.4227
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0059 0.2947 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0059 0.2947 1
Schistosoma mansoni ap endonuclease 0.0011 0.0113 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0177 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0021 0.0665 0.0675
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0379 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.2947 0.2867
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0011 0.0113 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.003 0.1246 0.1146
Schistosoma mansoni ap endonuclease 0.0011 0.0113 0.0115
Echinococcus multilocularis caspase 0.0114 0.6213 0.6305
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.001 0.0003 0.0003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0037 0.1647 0.3576
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.1246 0.1146
Echinococcus granulosus caspase 3 0.0083 0.44 0.4602
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.9855 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0037 0.1647 0.1671
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.2242 1
Loa Loa (eye worm) CYP4Cod1 0.001 0.0006 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0177 1 1
Brugia malayi PAS domain containing protein 0.003 0.1192 0.1209
Echinococcus multilocularis musashi 0.0016 0.0408 0.0414
Trypanosoma brucei metacaspase 0.003 0.1246 0.4227
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.1246 0.1146
Echinococcus multilocularis lamin 0.0016 0.0408 0.0414
Schistosoma mansoni hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypoxia-induced factor 1 0.0091 0.4877 0.4948
Trichomonas vaginalis conserved hypothetical protein 0.003 0.1246 0.1146
Echinococcus granulosus lamin 0.0016 0.0408 0.0427
Trypanosoma cruzi metacaspase, putative 0.003 0.1246 0.4227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.1087 0.1103
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0011 0.0113 0.0383
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0177 1 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0087 0.4595 0.5
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0114 0.6213 0.6497
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.003 0.1246 0.4988
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0011 0.0113 0.0115
Echinococcus multilocularis caspase 8 0.003 0.1246 0.1264
Brugia malayi Latrophilin receptor protein 2 0.001 0.0003 0.0003
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.003 0.1246 0.1264
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.2498 0.2412
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.1559 0.1631
Schistosoma mansoni jumonji domain containing protein 0.0036 0.1559 0.1582
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0177 1 1
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0059 0.2947 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.2498 0.2412
Brugia malayi Cytochrome P450 family protein 0.0016 0.0379 0.0384
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0037 0.1647 0.5587
Echinococcus granulosus GPCR family 2 0.001 0.0003 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0177 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.2498 1
Trypanosoma brucei cytochrome P450, putative 0.001 0.0006 0.0019
Echinococcus granulosus intermediate filament protein 0.0016 0.0408 0.0427
Echinococcus granulosus single minded 2 0.0022 0.0735 0.0768
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.1246 0.1146
Echinococcus multilocularis caspase 3 0.0083 0.44 0.4465
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.2498 1
Echinococcus granulosus caspase 8 0.003 0.1246 0.1303
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.001 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.003 0.1246 0.1146
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0087 0.4595 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.003 0.1235 0.1254

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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