Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0038 | 0.0069 | 0.0069 |
Brugia malayi | Protein kinase domain containing protein | 0.0044 | 0.0137 | 0.0586 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0186 | 0.0688 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0185 | 0.162 | 1 |
Brugia malayi | protein kinase C3,putative | 0.0032 | 0.001 | 0.0043 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0287 | 0.2702 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0256 | 0.237 | 0.237 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.2343 | 1 |
Brugia malayi | hypothetical protein | 0.0254 | 0.2343 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0254 | 0.2343 | 0.8674 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0586 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0032 | 0.001 | 0.0037 |
Onchocerca volvulus | 0.0052 | 0.0214 | 1 | |
Echinococcus multilocularis | unc 13 (munc13) | 0.0038 | 0.0069 | 0.0069 |
Onchocerca volvulus | 0.0038 | 0.0069 | 0.322 | |
Entamoeba histolytica | protein kinase, putative | 0.0044 | 0.0137 | 1 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0032 | 0.001 | 0.0043 |
Echinococcus granulosus | unc 13 munc13 | 0.0038 | 0.0069 | 0.0255 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0044 | 0.0137 | 0.0509 |
Toxoplasma gondii | AGC kinase | 0.0044 | 0.0137 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0044 | 0.0137 | 0.0586 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0137 | 0.0068 |
Brugia malayi | Protein kinase c protein 2 | 0.0244 | 0.2243 | 0.9571 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0044 | 0.0137 | 0.0586 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0044 | 0.0137 | 0.0137 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0044 | 0.0137 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.1675 | 0.7147 |
Brugia malayi | protein kinase C II. | 0.0082 | 0.0538 | 0.2296 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0137 | 0.0509 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0137 | 0.0068 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0205 | 0.1832 | 0.6781 |
Entamoeba histolytica | protein kinase, putative | 0.0044 | 0.0137 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0044 | 0.0137 | 0.0586 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0287 | 0.2702 | 1 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0044 | 0.0137 | 0.0586 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0186 | 0.0688 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0082 | 0.0538 | 0.1991 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0186 | 0.0186 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0032 | 0.001 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0137 | 0.0509 |
Brugia malayi | Cytochrome P450 family protein | 0.0057 | 0.0265 | 0.113 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0082 | 0.0538 | 0.0538 |
Brugia malayi | Protein kinase domain containing protein | 0.0032 | 0.001 | 0.0043 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0032 | 0.001 | 0.001 |
Entamoeba histolytica | protein kinase, putative | 0.0044 | 0.0137 | 1 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0032 | 0.001 | 0.0037 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0038 | 0.0069 | 0.0255 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0137 | 0.0068 |
Schistosoma mansoni | protein kinase C | 0.0038 | 0.0069 | 0.0255 |
Echinococcus granulosus | protein kinase C gamma type | 0.0256 | 0.237 | 0.8772 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0137 | 0.0068 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0044 | 0.0137 | 0.0509 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0137 | 0.0068 |
Schistosoma mansoni | protein kinase C mu | 0.0032 | 0.001 | 0.0037 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0186 | 0.0793 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0186 | 0.0688 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0044 | 0.0137 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0069 | 0.0294 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0287 | 0.2702 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0044 | 0.0137 | 0.0586 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0137 | 0.0068 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0044 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0032 | 0.001 | 0.0043 |
Entamoeba histolytica | protein kinase, putative | 0.0044 | 0.0137 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0137 | 0.0509 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0205 | 0.1832 | 0.1832 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.2164 | 0.9234 |
Schistosoma mansoni | atypical protein kinase C | 0.0076 | 0.0469 | 0.1736 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.1832 | 0.7818 |
Brugia malayi | Protein kinase domain containing protein | 0.0044 | 0.0137 | 0.0586 |
Brugia malayi | C1-like domain containing protein | 0.0032 | 0.001 | 0.0043 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0254 | 0.2343 | 0.2343 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0287 | 0.2702 | 0.2702 |
Echinococcus granulosus | protein kinase c iota type | 0.0076 | 0.0469 | 0.1736 |
Echinococcus granulosus | NDR protein kinase | 0.0044 | 0.0137 | 0.0509 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0186 | 0.0688 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0137 | 0.0068 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0032 | 0.001 | 0.0043 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0214 | 0.0792 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0137 | 0.0068 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0044 | 0.0137 | 0.0586 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0044 | 0.0137 | 0.0586 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0057 | 0.0265 | 0.113 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0044 | 0.0137 | 0.0137 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0044 | 0.0137 | 0.0509 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.019 | 0.1675 | 0.7147 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0044 | 0.0137 | 0.0137 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0186 | 0.0793 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0137 | 0.0509 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0044 | 0.0137 | 0.0137 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0137 | 0.0068 |
Schistosoma mansoni | serine/threonine kinase | 0.0044 | 0.0137 | 0.0509 |
Schistosoma mansoni | unc-13 (munc13) | 0.0038 | 0.0069 | 0.0255 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0082 | 0.0538 | 0.2296 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0137 | 0.0068 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0205 | 0.1832 | 0.1832 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0044 | 0.0137 | 0.0509 |
Echinococcus multilocularis | protein kinase c iota type | 0.0076 | 0.0469 | 0.0469 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0186 | 0.0688 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0044 | 0.0137 | 0.0137 |
Brugia malayi | Hr1 repeat family protein | 0.0044 | 0.0137 | 0.0586 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0186 | 0.0186 |
Schistosoma mansoni | unc-13 (munc13) | 0.0038 | 0.0069 | 0.0255 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0044 | 0.0137 | 0.0586 |
Schistosoma mansoni | survival motor neuron protein | 0.0052 | 0.0214 | 0.0792 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0052 | 0.0214 | 0.0913 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0213 | 0.1911 | 0.8155 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0082 | 0.0538 | 0.1991 |
Trichomonas vaginalis | AGC family protein kinase | 0.0044 | 0.0137 | 0.0068 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.