Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0039 | 0.125 | 0.125 |
Plasmodium vivax | oxidoreductase NAD-binding domain containing protein | 0.0023 | 0.0343 | 0.0343 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0097 | 0.438 | 0.438 |
Echinococcus multilocularis | serotonin transporter | 0.0097 | 0.438 | 0.438 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0123 | 0.5832 | 0.5832 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0199 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.01 | 0.4594 | 0.4594 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0097 | 0.438 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0177 | 0.8761 | 0.8761 |
Brugia malayi | FAD binding domain containing protein | 0.0123 | 0.5832 | 0.5832 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0076 | 0.3272 | 0.2433 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0199 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0099 | 0.4511 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0076 | 0.3272 | 0.2433 |
Onchocerca volvulus | 0.0023 | 0.0343 | 0.0784 | |
Entamoeba histolytica | type A flavoprotein, putative | 0.0076 | 0.3272 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0097 | 0.438 | 0.438 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.1448 | 0.1448 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0177 | 0.8761 | 0.8607 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0076 | 0.3272 | 0.2433 |
Plasmodium falciparum | NADH-cytochrome b5 reductase, putative | 0.0023 | 0.0343 | 0.0343 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0023 | 0.0343 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0199 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0076 | 0.3272 | 0.3272 |
Brugia malayi | diaphorase | 0.0023 | 0.0343 | 0.0343 |
Treponema pallidum | flavodoxin | 0.0076 | 0.3272 | 0.7257 |
Giardia lamblia | Hypothetical protein | 0.0177 | 0.8761 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0097 | 0.438 | 0.438 |
Leishmania major | hypothetical protein, conserved | 0.0076 | 0.3272 | 0.3033 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0023 | 0.0343 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0199 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0039 | 0.125 | 0.125 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0199 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0177 | 0.8761 | 0.8717 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0199 | 1 | 1 |
Chlamydia trachomatis | Na(+)-translocating NADH-quinone reductase subunit F | 0.0023 | 0.0343 | 0.0588 |
Chlamydia trachomatis | sulfite reductase | 0.0123 | 0.5832 | 1 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0023 | 0.0343 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0023 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | serotonin transporter b | 0.0097 | 0.438 | 0.438 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0097 | 0.438 | 0.438 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0076 | 0.3272 | 0.3272 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0123 | 0.5832 | 0.5832 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | diaphorase | 0.0023 | 0.0343 | 0.0343 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0076 | 0.3272 | 0.3033 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0076 | 0.3272 | 0.5 |
Onchocerca volvulus | 0.0097 | 0.438 | 1 | |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0097 | 0.438 | 0.438 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0076 | 0.3272 | 0.3033 |
Leishmania major | p450 reductase, putative | 0.0199 | 1 | 1 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0023 | 0.0343 | 0.0343 |
Plasmodium vivax | hypothetical protein, conserved | 0.0076 | 0.3272 | 0.3272 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0076 | 0.3272 | 0.3272 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.438 | 0.438 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0076 | 0.3272 | 0.2433 |
Echinococcus multilocularis | methionine synthase reductase | 0.0123 | 0.5832 | 0.5832 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0177 | 0.8761 | 1 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0023 | 0.0343 | 0.0343 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0023 | 0.0343 | 0.0343 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0023 | 0.0343 | 0.0343 |
Plasmodium vivax | ferredoxin--NADP reductase, putative | 0.0023 | 0.0343 | 0.0343 |
Schistosoma mansoni | cytochrome B5 | 0.0023 | 0.0343 | 0.0343 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0076 | 0.3272 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0199 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0199 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0076 | 0.3272 | 0.3033 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0199 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0076 | 0.3272 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0039 | 0.125 | 0.125 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0023 | 0.0343 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.438 | 0.438 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0097 | 0.438 | 0.438 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0099 | 0.4511 | 0.4511 |
Toxoplasma gondii | NADH-cytochrome b5 reductase 1, putative | 0.0023 | 0.0343 | 0.0761 |
Toxoplasma gondii | ferredoxin NADP+ oxidoreductase FNR | 0.0023 | 0.0343 | 0.0761 |
Echinococcus granulosus | methionine synthase reductase | 0.0123 | 0.5832 | 0.5832 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0023 | 0.0343 | 0.0343 |
Plasmodium falciparum | ferredoxin--NADP reductase | 0.0023 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0967 | 0.0967 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.1448 | 0.1448 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0023 | 0.0343 | 0.5 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0023 | 0.0343 | 0.0343 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.438 | 0.438 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0076 | 0.3272 | 0.5 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0076 | 0.3272 | 0.3272 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0023 | 0.0343 | 0.0343 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0039 | 0.125 | 0.125 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0199 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0099 | 0.4511 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0199 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0199 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0199 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0199 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0199 | 1 | 1 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0076 | 0.3272 | 0.3033 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 14 mg kg-1 | Antagonism of pentylenetetrazole-induced convulsion in mice by oral administration. | ChEMBL. | 6110780 |
ED50 (functional) | = 14 mg kg-1 | Antagonism of pentylenetetrazole-induced convulsion in mice by oral administration. | ChEMBL. | 6110780 |
ED50 (functional) | > 100 mg kg-1 | Muscle relaxation activity using the rotarod performance test in mice by oral administration. | ChEMBL. | 6110780 |
ED50 (functional) | > 100 mg kg-1 | Muscle relaxation activity using the rotarod performance test in mice by oral administration. | ChEMBL. | 6110780 |
LD50 (ADMET) | > 1000 mg kg-1 | Acute toxicity expressed as LD50 in mice after oral administration. | ChEMBL. | 6110780 |
LD50 (ADMET) | > 1000 mg kg-1 | Acute toxicity expressed as LD50 in mice after oral administration. | ChEMBL. | 6110780 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.