Detailed information for compound 1501804

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 589.07 | Formula: C26H32ClF3N4O4S
  • H donors: 4 H acceptors: 4 LogP: 1.9 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: N[C@H](Cc1cc(F)c(cc1F)F)CC(=O)N1CCSC1C(=O)NCc1ccc(cc1)NC(C(=O)O)C(C)C.Cl
  • InChi: 1S/C26H31F3N4O4S.ClH/c1-14(2)23(26(36)37)32-18-5-3-15(4-6-18)13-31-24(35)25-33(7-8-38-25)22(34)11-17(30)9-16-10-20(28)21(29)12-19(16)27;/h3-6,10,12,14,17,23,25,32H,7-9,11,13,30H2,1-2H3,(H,31,35)(H,36,37);1H/t17-,23?,25?;/m1./s1
  • InChiKey: WGTQOPKMWHLPHY-RPOQZWNMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0029 0.0127 0.0173
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.005 0.0068
Mycobacterium ulcerans lipase LipD 0.0035 0.0207 0.0271
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.01 0.0983 0.1339
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0426 0.0534
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0012 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0128 0.131 0.131
Onchocerca volvulus 0.0029 0.0134 0.024
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.005 0.0113
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.005 0.005
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.005 0.0113
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0134 0.0182
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.005 0.0068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0426 0.0533
Schistosoma mansoni tar DNA-binding protein 0.0128 0.131 0.131
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0035 0.0066
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0123 0.1253 0.1662
Schistosoma mansoni hypothetical protein 0.0132 0.1364 0.1364
Loa Loa (eye worm) hypothetical protein 0.0075 0.0686 0.0934
Echinococcus granulosus tar DNA binding protein 0.0128 0.131 0.131
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0127 0.0173
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0374 0.4242 0.6612
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0449 0.0611
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0048 0.0018
Echinococcus granulosus GPCR family 2 0.0098 0.096 0.096
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0043 0.03 0.0362
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0523 0.0523
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0204 0.0525
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0048 0.0048
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Leishmania major UDP-galactopyranose mutase 0.0081 0.0749 0.2217
Brugia malayi Patched related family protein 4 0.0019 0.0017 0.0023
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.004 0.0258 0.0305
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Onchocerca volvulus 0.0019 0.0017 0.0031
Loa Loa (eye worm) ICD-1 protein 0.0038 0.024 0.0327
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Loa Loa (eye worm) hypothetical protein 0.032 0.36 0.4901
Brugia malayi Latrophilin receptor protein 2 0.0098 0.096 0.1307
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.0523 0.0523
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Loa Loa (eye worm) TAR-binding protein 0.0128 0.131 0.1783
Schistosoma mansoni hypothetical protein 0.0856 1 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.0261 0.0261
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0459 0.0665
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0134 0.0134
Toxoplasma gondii hypothetical protein 0.0019 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0459 0.0624
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0523 0.0523
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0139 0.1447 0.1447
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.005 0.0047
Onchocerca volvulus 0.0022 0.0048 0.0087
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0204 0.0231
Brugia malayi nuclear hormone receptor 0.0062 0.0523 0.0712
Onchocerca volvulus 0.0022 0.005 0.009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0081 0.0749 0.102
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.03 0.0408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Schistosoma mansoni ap endonuclease 0.0021 0.0035 0.0035
Brugia malayi beta-lactamase 0.0035 0.0207 0.0282
Leishmania major hypothetical protein, conserved 0.0051 0.0395 0.1118
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0686 0.2021
Schistosoma mansoni hypothetical protein 0.0098 0.096 0.096
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0523 0.0523
Onchocerca volvulus 0.0022 0.0048 0.0087
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.005 0.0113
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0291 0.3257 0.3257
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0181 0.02
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0065
Toxoplasma gondii exonuclease III APE 0.0021 0.0035 0.0048
Brugia malayi NAD-dependent deacetylase SIRT1 0.0123 0.1253 0.1706
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.005 0.005
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0046 0.034 0.034
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0048 0.0018
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0523 0.0523
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0592 0.1728
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.005 0.0024
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0523 0.0523
Loa Loa (eye worm) jmjC domain-containing protein 0.0165 0.1754 0.2387
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0012 0.0016
Schistosoma mansoni hypothetical protein 0.0548 0.6321 0.6321
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0258 0.0351
Schistosoma mansoni coup transcription factor 0.0062 0.0523 0.0523
Onchocerca volvulus Huntingtin homolog 0.0136 0.141 0.2534
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0897 0.1221
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0523 0.0523
Echinococcus multilocularis muscleblind protein 0.0166 0.1766 0.1766
Brugia malayi hypothetical protein 0.0042 0.0283 0.0385
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0523 0.0523
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0204 0.0204
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0181 0.0247
Onchocerca volvulus Protein patched homolog 0.0019 0.0017 0.0031
Brugia malayi hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0523 0.0712
Onchocerca volvulus 0.0052 0.0403 0.0725
Brugia malayi AMP-binding enzyme family protein 0.0022 0.005 0.0068
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1671 0.1671
Entamoeba histolytica hypothetical protein 0.0038 0.024 0.028
Toxoplasma gondii isocitrate dehydrogenase 0.0068 0.0592 0.0805
Entamoeba histolytica hypothetical protein 0.0634 0.7347 0.9976
Brugia malayi Myosin head containing protein 0.0019 0.0017 0.0023
Brugia malayi N-terminal motif family protein 0.0385 0.4381 0.5964
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0134 0.0134
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0897 0.1221
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0686 0.0888
Echinococcus multilocularis Niemann Pick C1 protein 0.032 0.36 0.36
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0012 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0523 0.0712
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0749 0.5414
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0181 0.0247
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0139 0.1447 0.197
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0449 0.0611
Brugia malayi Isocitrate dehydrogenase 0.0068 0.0592 0.0805
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0137 0.1423 0.1937
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0181 0.1215
Toxoplasma gondii ABC1 family protein 0.0035 0.0207 0.0282
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0686 0.9096
Leishmania major hypothetical protein, conserved 0.0035 0.0207 0.0534
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.049 0.0667
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0897 0.0897
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Echinococcus multilocularis phd:f box containing protein 0.0043 0.03 0.03
Onchocerca volvulus 0.0022 0.005 0.009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0311 0.349 0.4751
Schistosoma mansoni hypothetical protein 0.0051 0.0395 0.0395
Echinococcus multilocularis Niemann Pick C1 protein 0.0457 0.5237 0.5237
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0033 0.0181 0.02
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.03 0.0408
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0239
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0208 0.2266 0.6926
Echinococcus multilocularis peroxidasin 0.0056 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0056 0.0452 0.0615
Leishmania major hypothetical protein, conserved 0.0043 0.03 0.0821
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.005 0.0244
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0012 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0426 0.0533
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0523 0.0712
Onchocerca volvulus 0.0035 0.0207 0.0372
Loa Loa (eye worm) hypothetical protein 0.0056 0.0459 0.0624
Echinococcus multilocularis slit 2 protein 0.0018 0.0003 0.0003
Schistosoma mansoni poly(ADP-ribose) glycohydrolase 0.0634 0.7347 0.7347
Loa Loa (eye worm) glutaminase 2 0.0554 0.6399 0.871
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Echinococcus granulosus Niemann Pick C1 protein 0.0457 0.5237 0.5237
Loa Loa (eye worm) hypothetical protein 0.0136 0.141 0.1919
Onchocerca volvulus 0.0029 0.0134 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0283 0.1967
Trypanosoma brucei glucosidase, putative 0.0035 0.0204 0.0231
Trypanosoma cruzi oligopeptidase b 0.0033 0.0181 0.02
Loa Loa (eye worm) hypothetical protein 0.0043 0.03 0.0408
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.0749 0.2254
Brugia malayi MH2 domain containing protein 0.013 0.1338 0.1822
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0207 0.0594
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.004 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Toxoplasma gondii kringle domain-containing protein 0.0051 0.0395 0.0538
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0523 0.0712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0523 0.0712
Onchocerca volvulus 0.0035 0.0207 0.0372
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0137 0.1423 0.1937
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0449 0.0611
Echinococcus granulosus JmjC domain containing protein 4 0.0043 0.03 0.03
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0523 0.0523
Mycobacterium leprae Probable lipase LipE 0.0035 0.0207 0.2246
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0449 0.0611
Onchocerca volvulus 0.0022 0.0048 0.0087
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0208 0.2266 0.3051
Schistosoma mansoni hypothetical protein 0.0132 0.1364 0.1364
Brugia malayi hypothetical protein 0.0019 0.0012 0.0016
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0123 0.1253 0.1662
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Onchocerca volvulus Peroxidase homolog 0.0056 0.0449 0.0807
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0008 0.0008
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0207 0.0207
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0635 0.7364 1
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0033 0.0181 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.024 0.028
Leishmania major hypothetical protein, conserved 0.0133 0.137 0.4143
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0048 0.0018
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.005 0.0024
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0134 0.0134
Echinococcus granulosus phd:f box containing protein 0.0043 0.03 0.03
Brugia malayi jmjC domain containing protein 0.0165 0.1754 0.2387
Loa Loa (eye worm) prolyl oligopeptidase 0.0033 0.0181 0.0247
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0033 0.0181 0.1878
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0134 0.0134
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0339 0.0415
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0207 0.0207
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0523 0.0523
Onchocerca volvulus Cathepsin F homolog 0.0022 0.0048 0.0087
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0484 0.5562 0.7571
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.024 0.028
Trypanosoma cruzi PAB1-binding protein , putative 0.0133 0.137 0.1825
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.0048 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0523 0.0523
Brugia malayi DIX domain containing protein 0.0019 0.0012 0.0016
Trypanosoma brucei prolyl endopeptidase 0.0033 0.0181 0.02
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0426 0.1307
Schistosoma mansoni cpg binding protein 0.0064 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Brugia malayi RNA binding protein 0.0128 0.131 0.1783
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Mycobacterium tuberculosis Conserved protein 0.0035 0.0207 0.0594
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0239
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Schistosoma mansoni alpha glucosidase 0.0035 0.0204 0.0204
Onchocerca volvulus Slit protein homolog 0.0018 0.0003 0.0005
Schistosoma mansoni jumonji/arid domain-containing protein 0.0165 0.1754 0.1754
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0283 0.0385
Schistosoma mansoni hypothetical protein 0.0029 0.0127 0.0127
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.004 0.0258 0.0305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0523 0.0712
Leishmania major cysteine peptidase A (CPA) 0.0022 0.0048 0.0041
Trichomonas vaginalis glutaminase, putative 0.0554 0.6399 0.8683
Chlamydia trachomatis protoporphyrinogen oxidase 0.0081 0.0749 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0204 0.0231
Schistosoma mansoni tar DNA-binding protein 0.0128 0.131 0.131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Echinococcus multilocularis acylamino acid releasing enzyme 0.0033 0.0181 0.0181
Toxoplasma gondii NAC domain-containing protein 0.0038 0.024 0.0327
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0592 0.0592
Entamoeba histolytica hypothetical protein 0.0094 0.0908 0.1192
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.1307 0.1307
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0426 0.0533
Toxoplasma gondii propionate-CoA ligase 0.0022 0.005 0.0068
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0028 0.0116 0.0355
Echinococcus multilocularis 0.0081 0.0749 0.0749
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0207 0.0282
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0181 0.02
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.028 0.3121 0.3121
Loa Loa (eye worm) fibroinase 0.0022 0.0048 0.0065
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0127 0.0127
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0098 0.096 0.1307
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.005 0.0113
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0282
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0204 0.0231
Brugia malayi protein C24B5.3 0.0019 0.0017 0.0023
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) isocitrate dehydrogenase 0.0068 0.0592 0.0805
Echinococcus granulosus Protein patched homolog 1 0.0137 0.1423 0.1423
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0127 0.0173
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0291 0.3257 0.3257
Loa Loa (eye worm) glutaminase 0.0554 0.6399 0.871
Schistosoma mansoni amine oxidase 0.0081 0.0749 0.0749
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0068 0.0592 0.0592
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.005 0.0113
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0426 0.0579
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.024 0.1652
Brugia malayi jmjC domain containing protein 0.0221 0.2417 0.329
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0181 0.0557
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0449 0.0611
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0204 0.0278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0523 0.0523
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0022 0.0048 0.023
Echinococcus granulosus lysine specific demethylase 6a 0.0043 0.03 0.03
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0118 0.1197 0.1585
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0221 0.2417 0.2417
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.0421 0.0572
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0033 0.0181 0.02
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0068 0.0592 0.4249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0043 0.03 0.03
Onchocerca volvulus 0.0056 0.0449 0.0807
Trypanosoma cruzi UDP-galactopyranose mutase 0.0081 0.0749 0.0977
Brugia malayi Patched protein homolog 1 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0239
Mycobacterium tuberculosis Possible oxidoreductase 0.0081 0.0749 0.2254
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0033 0.0181 0.0515
Onchocerca volvulus 0.0035 0.0207 0.0372
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0118 0.1197 0.1197
Brugia malayi Patched related family protein 10 0.0019 0.0017 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0207 0.1406
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0134 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.1423 0.1893
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0048 0.0018
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0283 0.0283
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0042 0.0283 0.0385
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0207 0.0235
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0207 0.0235
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0134 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0523 0.0712
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0311 0.349 0.349
Echinococcus multilocularis GPCR, family 2 0.0098 0.096 0.096
Schistosoma mansoni microtubule-associated protein tau 0.0705 0.8198 0.8198
Loa Loa (eye worm) hypothetical protein 0.0133 0.137 0.1864
Echinococcus granulosus microtubule associated protein 2 0.0705 0.8198 0.8198
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0523 0.0523
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.096 0.1307
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Leishmania major oligopeptidase b 0.0033 0.0181 0.0455
Schistosoma mansoni alpha-glucosidase 0.0136 0.1409 0.1409
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0208 0.2266 0.3051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.005 0.0024
Brugia malayi hypothetical protein 0.0086 0.0808 0.11
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0686 0.1023
Brugia malayi hypothetical protein 0.0029 0.0134 0.0182
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.028 0.3121 0.3121
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0523 0.0712
Entamoeba histolytica SWIRM domain protein 0.0024 0.0077 0.0057
Trypanosoma brucei prolyl oligopeptidase, putative 0.0033 0.0181 0.02
Onchocerca volvulus 0.0019 0.0017 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0134 0.0134
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1671 0.1671
Onchocerca volvulus Huntingtin homolog 0.0136 0.141 0.2534
Trypanosoma cruzi PAB1-binding protein , putative 0.0133 0.137 0.1825
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0043 0.03 0.0362
Onchocerca volvulus 0.0022 0.0048 0.0087
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0075 0.0686 0.1023
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Plasmodium vivax ataxin-2 like protein, putative 0.0133 0.137 1
Schistosoma mansoni phd/f-box containing protein 0.0043 0.03 0.03
Entamoeba histolytica hypothetical protein 0.0024 0.0077 0.0057
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Brugia malayi SWIRM domain containing protein 0.0335 0.3781 0.5147
Mycobacterium ulcerans hypothetical protein 0.0035 0.0207 0.0271
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0134 0.0134
Brugia malayi prolyl oligopeptidase family protein 0.0208 0.2266 0.3085
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0048 0.0048
Loa Loa (eye worm) beta-lactamase 0.0035 0.0207 0.0282
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0291 0.3257 0.4406
Echinococcus multilocularis poly(ADP ribose) glycohydrolase 0.0634 0.7347 0.7347
Loa Loa (eye worm) hypothetical protein 0.0123 0.1253 0.1706
Schistosoma mansoni hypothetical protein 0.006 0.0496 0.0496
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0282
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0395 0.0493
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0048 0.0065
Schistosoma mansoni hypothetical protein 0.0042 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0051 0.0395 0.0538
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.006 0.0496 0.0496
Schistosoma mansoni loxhd1 0.0042 0.0283 0.0283
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0139 0.1447 0.1447
Loa Loa (eye worm) patched family protein 0.0019 0.0017 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0022 0.005 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0686 0.206
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0523 0.094
Brugia malayi Niemann-Pick C1 protein precursor 0.032 0.36 0.4901
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0081 0.0749 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.006 0.0496 0.0496
Trypanosoma cruzi prolyl endopeptidase 0.0033 0.0181 0.02
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0043 0.03 0.0362
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0134 0.024
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0239
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0426 0.0426
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0403 0.0403
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2478 0.7549
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.005 0.0047
Brugia malayi hypothetical protein 0.0019 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.0248 0.2741 0.2741
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0523 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0213 0.2324 0.3163
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0118 0.1197 0.1197
Brugia malayi hypothetical protein 0.0033 0.0175 0.0239
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Onchocerca volvulus 0.0042 0.0283 0.0509
Mycobacterium tuberculosis Conserved protein 0.0035 0.0207 0.0594
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0749 0.5414
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0048 0.0048
Onchocerca volvulus Prolyl endopeptidase homolog 0.0033 0.0181 0.0326
Echinococcus multilocularis sterol regulatory element binding protein 0.0137 0.1423 0.1423
Onchocerca volvulus Chorion peroxidase homolog 0.0056 0.0449 0.0807
Schistosoma mansoni peroxidasin 0.0056 0.0449 0.0449
Brugia malayi CHE-14 protein 0.0137 0.1423 0.1937
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0523 0.0712
Brugia malayi latrophilin 2 splice variant baaae 0.0213 0.2324 0.3163
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0204 0.0204
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0024 0.0077 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0686 0.0934
Echinococcus multilocularis lysine specific demethylase 5A 0.0162 0.1713 0.1713
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0523 0.094
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0686 0.0934
Onchocerca volvulus 0.0042 0.0283 0.0509
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0068 0.0592 0.0592
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0207 0.0207
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0426 0.0426
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0523 0.094
Loa Loa (eye worm) hypothetical protein 0.0075 0.0686 0.0934
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0426 0.1212
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0068 0.0592 0.1771
Entamoeba histolytica hypothetical protein 0.0282 0.3154 0.4255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Plasmodium falciparum ataxin-2 like protein, putative 0.0133 0.137 1
Schistosoma mansoni phosphatidylserine receptor 0.0043 0.03 0.03
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.005 0.0068
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0523 0.0523
Schistosoma mansoni alpha-glucosidase 0.0136 0.1409 0.1409
Schistosoma mansoni lipoxygenase 0.0174 0.1866 0.1866
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0081 0.0749 0.0749
Echinococcus granulosus acylamino acid releasing enzyme 0.0033 0.0181 0.0181
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0523 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0291 0.3257 0.4396
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0249 0.2761 0.2761
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Trypanosoma brucei RNA helicase, putative 0.0248 0.2741 0.3701
Onchocerca volvulus 0.0022 0.0048 0.0087
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0043 0.03 0.0408
Mycobacterium ulcerans beta-lactamase 0.0035 0.0207 0.0271
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0503 0.0685
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0084 0.0793 0.1079
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0181 0.02
Echinococcus granulosus muscleblind protein 0.0166 0.1766 0.1766
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0422 0.1251
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Brugia malayi tailless protein 0.0029 0.0134 0.0182
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.032 0.36 0.4865
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0523 0.0523
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0311 0.3499 0.4762
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Loa Loa (eye worm) hypothetical protein 0.0067 0.0583 0.0793
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0207 0.0594
Plasmodium falciparum protoporphyrinogen oxidase 0.0081 0.0749 0.5414
Schistosoma mansoni amine oxidase 0.0081 0.0749 0.0749
Brugia malayi MAP kinase sur-1 0.0054 0.0426 0.0579
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0204 0.0231
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.07 0.07
Onchocerca volvulus 0.0022 0.005 0.009
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0204 0.0231
Trypanosoma cruzi oligopeptidase b 0.0033 0.0181 0.02
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0043 0.03 0.0408
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0012 0.0012
Loa Loa (eye worm) cysteine protease 0.0022 0.0048 0.0065
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0065
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.03 0.0408
Onchocerca volvulus 0.0051 0.0395 0.071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Echinococcus granulosus RUN 0.0042 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0118 0.1197 0.1585
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.005 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0048 0.0018
Echinococcus multilocularis geminin 0.0548 0.6321 0.6321
Brugia malayi SWIRM domain containing protein 0.0024 0.0077 0.0104
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.005 0.0244
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0686 0.1023
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0897 0.1179
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1671 0.2275
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0081 0.0749 0.1123
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0207 0.0235
Brugia malayi Protein kinase domain containing protein 0.0053 0.0421 0.0572
Toxoplasma gondii SWIRM domain-containing protein 0.0024 0.0077 0.0104
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0523 0.0523
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0035 0.5
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0635 0.7364 1
Schistosoma mansoni hypothetical protein 0.0098 0.096 0.096
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.005 0.0113
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0036 0.0216 0.0247
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0374 0.4242 0.6612
Brugia malayi beta-NAC-like protein 0.0038 0.024 0.0327
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0123 0.1253 0.1662
Toxoplasma gondii LsmAD domain-containing protein 0.0133 0.137 0.1864
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0033 0.0181 0.02
Onchocerca volvulus 0.0022 0.0048 0.0087
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.096 0.096
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0012 0.0012
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0094 0.0908 0.1192
Mycobacterium ulcerans glutaminase 0.0554 0.6399 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.005 0.0021
Toxoplasma gondii patched family protein 0.0019 0.0017 0.0023
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0048 0.0018
Brugia malayi steroid hormone receptor 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0282
Brugia malayi protein C24B5.3 0.0019 0.0017 0.0023
Onchocerca volvulus 0.0062 0.0523 0.094
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0523 0.0712
Onchocerca volvulus 0.0019 0.0017 0.0031
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0048 0.0087
Loa Loa (eye worm) phosphatidylinositol 3 0.0094 0.0908 0.1237
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0012 0.0012
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0449 0.0611
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0012 0.0012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0139 0.1447 0.197
Schistosoma mansoni rab6-interacting 0.0042 0.0283 0.0283
Onchocerca volvulus 0.0075 0.0686 0.1234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Brugia malayi jmjC domain containing protein 0.0043 0.03 0.0408
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0221 0.2417 0.2417
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0523 0.0523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0686 0.0888
Schistosoma mansoni nuclear receptor 0.0029 0.0134 0.0134
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0207 0.0594
Schistosoma mansoni jumonji domain containing protein 0.0201 0.2188 0.2188
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0127 0.0173
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0035 0.0048
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0523 0.0523
Echinococcus multilocularis protein patched 0.0137 0.1423 0.1423
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0123 0.1253 0.1253
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0207 0.0235
Loa Loa (eye worm) hypothetical protein 0.0166 0.1766 0.2403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.005 0.0068
Loa Loa (eye worm) hypothetical protein 0.0107 0.106 0.1443
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0024 0.0077 0.0077
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.005 0.0021
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0686 0.2021
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0175 0.0239
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0033 0.0181 0.0247
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.096 0.096
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0385 0.4381 0.7877
Echinococcus multilocularis prolyl endopeptidase 0.0033 0.0181 0.0181
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0052 0.0411 0.0514
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0181 0.02
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0422 0.1251
Brugia malayi ecdysteroid receptor 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0181 0.02
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Brugia malayi Patched related family protein 12 0.0019 0.0017 0.0023
Echinococcus multilocularis lysine specific demethylase 6a 0.0043 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0077 0.07 0.0952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0208 0.2266 0.3051
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.005 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0207 0.0235
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0204 0.0231
Plasmodium falciparum phd finger protein, putative 0.0029 0.0127 0.0813
Toxoplasma gondii hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.0523 0.0712
Mycobacterium tuberculosis Conserved protein 0.0035 0.0207 0.0594
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0291 0.3257 0.4406
Echinococcus multilocularis JmjC domain containing protein 4 0.0043 0.03 0.03
Onchocerca volvulus 0.006 0.0503 0.0904
Plasmodium falciparum ataxin-2 like protein, putative 0.0133 0.137 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0592 0.0592
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Brugia malayi Doublecortin family protein 0.0042 0.0283 0.0385
Echinococcus multilocularis protoporphyrinogen oxidase 0.0081 0.0749 0.0749
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0449 0.0611
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Schistosoma mansoni zinc finger protein 0.0029 0.0134 0.0134
Toxoplasma gondii histone lysine-specific demethylase 0.0081 0.0749 0.102
Brugia malayi CXXC zinc finger family protein 0.006 0.0503 0.0685
Echinococcus multilocularis jumonji domain containing 1A 0.0043 0.03 0.03
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0181 0.02
Onchocerca volvulus 0.0026 0.0098 0.0177
Loa Loa (eye worm) patched family protein 0.0019 0.0017 0.0023
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0081 0.0749 0.5414
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0008 0.0008
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0012 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0043 0.03 0.0408
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0207 0.0282
Echinococcus granulosus tissue type plasminogen activator 0.0051 0.0395 0.0395
Toxoplasma gondii patched family protein 0.0019 0.0017 0.0023
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0686 0.1023
Brugia malayi hypothetical protein 0.0019 0.0017 0.0023
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0033 0.0181 0.0247
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.004 0.0258 0.0304
Loa Loa (eye worm) hypothetical protein 0.0166 0.1766 0.2403
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0216 0.0294
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0181 0.0181
Loa Loa (eye worm) ctsf protein 0.0022 0.0048 0.0065
Plasmodium falciparum cysteine proteinase falcipain 3 0.0022 0.0048 0.023
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.004 0.0258 0.0304
Brugia malayi hypothetical protein 0.0019 0.0012 0.0016
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0426 0.0579
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0128 0.131 0.131
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0897 0.1176
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0123 0.1253 0.3848
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0283 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0077 0.0057
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0204 0.0231
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0048 0.0048
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0207 0.0594
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.096 0.1307
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.024 0.028
Loa Loa (eye worm) RNA binding protein 0.0128 0.131 0.1783
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0523 0.0523
Brugia malayi hypothetical protein 0.0136 0.141 0.1919
Giardia lamblia PHD finger protein 15 0.0029 0.0127 0.039
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0181 0.02
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0141 0.1464 0.1993
Leishmania major basic transcription factor 3a, putative 0.0038 0.024 0.0638
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0022 0.0048 0.023
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0008 0.001
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0134 0.0182
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.07 0.07
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0204 0.0231
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0311 0.349 0.4751
Brugia malayi hypothetical protein 0.0108 0.1069 0.1454
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0523 0.0712
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0134 0.0182
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0012 0.0012
Brugia malayi TAR-binding protein 0.0128 0.131 0.1783
Brugia malayi hypothetical protein 0.0033 0.0175 0.0239
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0686 0.1023
Brugia malayi hypothetical protein 0.0133 0.137 0.1864
Giardia lamblia hypothetical protein 0.0024 0.0077 0.0236
Brugia malayi hypothetical protein 0.0029 0.0134 0.0182
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0068 0.0592 0.4249
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0181 0.02
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0897 0.1613
Loa Loa (eye worm) hypothetical protein 0.0335 0.3781 0.5147
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0282 0.3154 0.4293
Echinococcus granulosus lysine specific histone demethylase 1A 0.0311 0.349 0.349
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0339 0.0415
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0052 0.0403 0.0549
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0204 0.0231
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Schistosoma mansoni peroxidasin 0.0056 0.0452 0.0452
Brugia malayi EGF-like domain containing protein 0.0018 0.0003 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0207 0.0235
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0897 0.2676
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.028 0.3121 0.3121
Trypanosoma brucei PAB1-binding protein , putative 0.0133 0.137 0.1825
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0012 0.0012
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0033 0.0181 0.0181
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0316 0.3555 0.4839
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0065
Loa Loa (eye worm) hypothetical protein 0.0056 0.0459 0.0624
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0118 0.1197 0.1629
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0123 0.1253 0.1662
Echinococcus granulosus tumor protein p63 0.0354 0.4005 0.4005
Brugia malayi conserved hypotetical protein 0.0029 0.0134 0.0182
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0592 0.0592
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0175 0.0239
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0051 0.0395 0.2795
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0065
Toxoplasma gondii isocitrate dehydrogenase 0.0068 0.0592 0.0805
Plasmodium vivax vivapain-2 0.0022 0.0048 0.023
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0283 0.0283
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.028 0.3121 0.5612
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0134 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0523 0.0712
Echinococcus granulosus cathepsin l1 0.0022 0.0048 0.0048
Echinococcus multilocularis microtubule associated protein 2 0.0705 0.8198 0.8198
Onchocerca volvulus 0.0056 0.0449 0.0807
Mycobacterium ulcerans dehydrogenase 0.0081 0.0749 0.1123
Loa Loa (eye worm) patched family protein 0.0019 0.0017 0.0023
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0075 0.0686 0.1023
Trypanosoma brucei oligopeptidase b 0.0033 0.0181 0.02
Loa Loa (eye worm) hypothetical protein 0.0042 0.0283 0.0385
Schistosoma mansoni kinase 0.0048 0.0353 0.0353
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.004 0.0258 0.0304
Entamoeba histolytica DNA repair and recombination protein, putative 0.0291 0.3257 0.4396
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0523 0.0712
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0065
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0068 0.0592 0.0761
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Brugia malayi jmjC domain containing protein 0.0043 0.03 0.0408
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0175 0.0175
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0033 0.0181 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Onchocerca volvulus 0.0056 0.0449 0.0807
Trypanosoma brucei poly(ADP-ribose) glycohydrolase, putative 0.0634 0.7347 1
Entamoeba histolytica SWIRM domain protein 0.0024 0.0077 0.0057
Loa Loa (eye worm) hypothetical protein 0.0083 0.0775 0.1054
Brugia malayi ecdysone receptor 0.0029 0.0134 0.0182
Echinococcus granulosus polyADP ribose glycohydrolase 0.0634 0.7347 0.7347
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.0523 0.0523
Echinococcus multilocularis protein dispatched 1 0.0157 0.1654 0.1654
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.024 0.1652
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0118 0.1197 0.1589
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Brugia malayi hypothetical protein 0.0081 0.0749 0.102
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0118 0.1197 0.1585
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.004 0.0258 0.0304
Echinococcus granulosus peroxidasin 0.0056 0.0452 0.0452
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.0048 0.0048
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0118 0.1197 0.1197
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0118 0.1197 0.1589
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Echinococcus multilocularis cpg binding protein 0.0064 0.0544 0.0544
Onchocerca volvulus Peroxidasin homolog 0.0056 0.0452 0.0812
Toxoplasma gondii hypothetical protein 0.0033 0.0181 0.0247
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0426 0.0426
Schistosoma mansoni lipoxygenase 0.0249 0.2761 0.2761
Echinococcus granulosus Niemann Pick C1 protein 0.032 0.36 0.36
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0422 0.1251
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0181 0.0247
Echinococcus granulosus prolyl endopeptidase 0.0033 0.0181 0.0181
Echinococcus granulosus lysine specific histone demethylase 1A 0.0081 0.0749 0.0749
Schistosoma mansoni hypothetical protein 0.0548 0.6321 0.6321
Brugia malayi prolyl oligopeptidase family protein 0.028 0.3121 0.4248
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0204 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0523 0.0712
Echinococcus granulosus peregrin 0.0029 0.0127 0.0127
Brugia malayi Calcitonin receptor-like protein seb-1 0.0311 0.3499 0.4762
Echinococcus granulosus expressed conserved protein 0.03 0.3369 0.3369
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0033 0.0181 0.0455
Onchocerca volvulus Protein patched homolog 0.0019 0.0017 0.0031
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0426 0.0534
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0208 0.2266 0.2266
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0012 0.0016
Schistosoma mansoni glutaminase 0.0554 0.6399 0.6399
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0261 0.0261
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.024 0.0281
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0046 0.034 0.034
Loa Loa (eye worm) DR-78 0.0029 0.0134 0.0182
Echinococcus multilocularis RUN 0.0042 0.0283 0.0283
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0634 0.7347 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0426 0.0534
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Schistosoma mansoni dishevelled 0.0019 0.0012 0.0012
Brugia malayi hypothetical protein 0.0042 0.0283 0.0385
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0204 0.0231
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0175 0.0175
Echinococcus multilocularis cysteine protease 0.0022 0.0048 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0204 0.0231
Echinococcus granulosus transcription factor btf3 0.0038 0.024 0.024
Echinococcus multilocularis tumor protein p63 0.0354 0.4005 0.4005
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0291 0.3257 1
Brugia malayi beta-lactamase family protein 0.0035 0.0207 0.0282
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0207 0.0594
Giardia lamblia Rrm3p helicase 0.0291 0.3257 1
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0634 0.7347 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0311 0.3499 0.4762
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0033 0.0181 0.02
Onchocerca volvulus Dual oxidase homolog 0.0056 0.0449 0.0807
Onchocerca volvulus 0.0019 0.0017 0.0031
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0311 0.349 0.349
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0207 0.0594
Echinococcus multilocularis cysteine protease 0.0022 0.0048 0.0048
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0592 0.0761
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0048 0.0087
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0282
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0426 0.0534
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0118 0.1197 0.1585
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0523 0.0523
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0897 0.0897
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0592 0.0761
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0291 0.3257 0.4406
Loa Loa (eye worm) hypothetical protein 0.0108 0.1069 0.1454
Trypanosoma brucei protein kinase, putative 0.0054 0.0426 0.0534
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0081 0.0749 0.5414
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.005 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0207 0.0235
Schistosoma mansoni nuclear receptor 0.0029 0.0134 0.0134
Giardia lamblia Kinase, PLK 0.0093 0.0897 0.2755
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0282
Brugia malayi hypothetical protein 0.0484 0.5562 0.7571
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.1144 0.1558
Loa Loa (eye worm) Poly(ADP-ribose) glycohydrolase 0.0634 0.7347 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0207 0.0207
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0181 0.02
Echinococcus multilocularis peregrin 0.0029 0.0127 0.0127
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0115 0.116 0.116
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0459 0.3264
Schistosoma mansoni slit 0.0018 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0181 0.0557
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0426 0.1212
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0175 0.0239
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0075 0.0686 0.206
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0048 0.0018
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0105 0.104 0.1416
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0134 0.0134
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0634 0.7347 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0283 0.0283
Mycobacterium ulcerans hypothetical protein 0.0075 0.0686 0.1023
Schistosoma mansoni dep domain containing protein 0.0019 0.0012 0.0012
Schistosoma mansoni transcription factor btf3 0.0038 0.024 0.024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0523 0.0712
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0459 0.1363
Brugia malayi Muscleblind-like protein 0.0166 0.1766 0.2403
Schistosoma mansoni ap endonuclease 0.0021 0.0035 0.0035
Onchocerca volvulus Peroxidasin homolog 0.0056 0.0449 0.0807
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0016
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0035 0.5
Loa Loa (eye worm) patched family protein 0.0019 0.0017 0.0023
Trypanosoma cruzi UDP-galactopyranose mutase 0.0081 0.0749 0.0977
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0035 0.0035
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0208 0.2266 0.3051
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0325 0.3659 0.3659
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Schistosoma mansoni rab6-interacting 0.0042 0.0283 0.0283
Brugia malayi AMP-binding enzyme family protein 0.0022 0.005 0.0068
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0449 0.0611
Schistosoma mansoni hypothetical protein 0.0132 0.1364 0.1364
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0426 0.0533
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0116 0.0158
Onchocerca volvulus 0.0019 0.0017 0.0031
Brugia malayi nuclear receptor NHR-88 0.0029 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1338 0.1822
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0075 0.0686 0.1023
Brugia malayi nuclear receptor NHR-67 0.0029 0.0134 0.0182
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.005 0.0024
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.005 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0523 0.0712
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0136 0.141 0.1919
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0139 0.1447 0.1447
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0422 0.1251
Onchocerca volvulus 0.0335 0.3781 0.6798
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.005 0.0021
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.024 0.028
Schistosoma mansoni polycystin 1-related 0.0042 0.0283 0.0283
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0291 0.3257 0.4406
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0065
Echinococcus granulosus Dipeptidyl peptidase 9 0.0208 0.2266 0.2266
Onchocerca volvulus Alhambra homolog 0.0029 0.0127 0.0228
Loa Loa (eye worm) hypothetical protein 0.0024 0.0077 0.0104
Mycobacterium tuberculosis Probable peptidase 0.0033 0.0181 0.0515
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0175 0.0175
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Schistosoma mansoni SWI/SNF complex-related 0.0024 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Brugia malayi nuclear receptor RXR 0.0033 0.0175 0.0239
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0686 0.2021
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0207 0.0271
Loa Loa (eye worm) hypothetical protein 0.0385 0.4381 0.5964
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0204 0.0231
Schistosoma mansoni hypothetical protein 0.0291 0.3257 0.3257
Toxoplasma gondii patched family protein 0.0019 0.0017 0.0023
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0075 0.0686 0.0934
Schistosoma mansoni jumonji domain containing protein 0.0043 0.03 0.03
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Loa Loa (eye worm) blistered cuticle protein 3 0.0056 0.0449 0.0611
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0282 0.3154 0.4255
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0048 0.0065
Schistosoma mansoni protein phosphatase 2C 0.0043 0.03 0.03
Echinococcus granulosus lysine specific demethylase 5A 0.0165 0.1754 0.1754
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0012 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Brugia malayi Poly 0.0634 0.7347 1
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0081 0.0749 0.102
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0012 0.0012
Schistosoma mansoni chromatin regulatory protein sir2 0.0123 0.1253 0.1253
Brugia malayi nuclear hormone receptor 0.0029 0.0134 0.0182
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0057 0.0467 0.1433
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0426 0.0534
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0755 0.0982
Brugia malayi hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0134 0.1382 0.1881
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.005 0.0113
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.005 0.0113
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0081 0.0749 0.5414
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.0068
Plasmodium vivax vivapain-2 0.0022 0.0048 0.023
Loa Loa (eye worm) oxidoreductase 0.0022 0.005 0.0068
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0207 0.0271
Entamoeba histolytica cysteine protease, putative 0.0022 0.0048 0.0018
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0134 0.024
Loa Loa (eye worm) hypothetical protein 0.0056 0.0459 0.0624
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0127 0.0813
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0204 0.0278
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0139 0.1447 0.1447
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0081 0.0755 0.0982
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0081 0.0749 0.5414
Schistosoma mansoni dishevelled 0.0019 0.0012 0.0012
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0181 0.0181
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0239
Schistosoma mansoni hypothetical protein 0.0098 0.096 0.096
Echinococcus multilocularis expressed conserved protein 0.03 0.3369 0.3369
Schistosoma mansoni cpg binding protein 0.006 0.0503 0.0503
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0207 0.0235
Onchocerca volvulus 0.0019 0.0012 0.0021
Brugia malayi jmjC domain containing protein 0.0043 0.03 0.0408
Plasmodium falciparum cysteine repeat modular protein 1 0.0051 0.0395 0.2795
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0523 0.0523
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0012 0.0021
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.0048 0.0018
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.005 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.096 0.096
Brugia malayi isocitrate dehydrogenase 0.0068 0.0592 0.0805
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.004 0.0258 0.0304
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0065
Mycobacterium ulcerans monoamine oxidase 0.0081 0.0749 0.1123
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.005 0.0021
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1671 0.1671
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0134 0.0182
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.131 0.1783
Loa Loa (eye worm) prolyl oligopeptidase 0.028 0.3121 0.4248
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0686 0.0934
Brugia malayi nuclear receptor RXR 0.0029 0.0134 0.0182
Echinococcus multilocularis tissue type plasminogen activator 0.0051 0.0395 0.0395
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Trichomonas vaginalis esterase, putative 0.0035 0.0207 0.0235
Brugia malayi PHD-finger family protein 0.0029 0.0127 0.0173
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.005 0.0113
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Entamoeba histolytica acyl-coA synthetase, putative 0.0075 0.0686 0.0888
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0181 0.0247
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0068 0.0592 0.0592
Echinococcus multilocularis transcription factor btf3 0.0038 0.024 0.024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0035 0.0133
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0012 0.0012
Echinococcus granulosus sterol regulatory element binding protein 0.0137 0.1423 0.1423
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Brugia malayi nuclear receptor NHR-88 0.0062 0.0523 0.0712
Brugia malayi jmjC domain containing protein 0.0043 0.03 0.0408
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.005 0.005
Onchocerca volvulus 0.0484 0.5562 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0311 0.3499 0.4762
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0897 0.1179
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0459 0.3264
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0115 0.1155 0.1528
Schistosoma mansoni hypothetical protein 0.0098 0.096 0.096
Onchocerca volvulus 0.0091 0.0876 0.1575
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0035 0.0048
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.024 0.0281
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Echinococcus multilocularis dnaJ subfamily B 0.0856 1 1
Brugia malayi Blistered cuticle protein 3 0.0056 0.0449 0.0611
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0291 0.3257 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0283 0.1967
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0068 0.0592 0.0761
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0249 0.2761 0.2761
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0139 0.1447 0.1447
Trypanosoma brucei polo-like protein kinase 0.0093 0.0897 0.1179
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Onchocerca volvulus 0.0022 0.0048 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0048 0.0018
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0293 0.3279 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0127 0.0127
Echinococcus multilocularis isocitrate dehydrogenase 0.0068 0.0592 0.0592
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0035 0.0107
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0012 0.0012
Entamoeba histolytica hypothetical protein, conserved 0.0291 0.3257 0.4396
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0127 0.0127
Echinococcus multilocularis muscleblind protein 1 0.0166 0.1766 0.1766
Brugia malayi hypothetical protein 0.0056 0.0449 0.0611
Onchocerca volvulus Peroxidase homolog 0.0056 0.0449 0.0807
Echinococcus granulosus geminin 0.0548 0.6321 0.6321
Plasmodium falciparum peptidase, putative 0.0033 0.0181 0.1215
Plasmodium falciparum JmjC domain-containing protein, putative 0.0043 0.03 0.2089
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0123 0.1253 0.1253
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0213 0.2324 0.2324
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.096 0.096
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.131 0.1783
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.07 0.0952
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.005 0.0113
Loa Loa (eye worm) hypothetical protein 0.0056 0.0459 0.0624
Toxoplasma gondii prolyl endopeptidase 0.0033 0.0181 0.0247
Brugia malayi Bromodomain containing protein 0.0029 0.0127 0.0173
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Onchocerca volvulus 0.0019 0.0017 0.0031
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0134 0.0134
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0033 0.0181 0.0455
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0449 0.0611
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.0068
Echinococcus granulosus cpg binding protein 0.0064 0.0544 0.0544
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0134 0.0182
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1671 0.2275
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0523 0.0712
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0134 0.0134
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0897 0.0897
Loa Loa (eye worm) hypothetical protein 0.0042 0.0283 0.0385
Loa Loa (eye worm) hypothetical protein 0.0249 0.2756 0.3751
Schistosoma mansoni patched 1 0.0137 0.1423 0.1423
Echinococcus granulosus jumonji domain containing 1A 0.0043 0.03 0.03
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0634 0.7347 0.9976
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0426 0.0426
Mycobacterium ulcerans oxidoreductase 0.0081 0.0749 0.1123
Toxoplasma gondii cathepsin CPL 0.0022 0.0048 0.0065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.0132 0.1364 0.1364
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0035 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0523 0.0712
Schistosoma mansoni tar DNA-binding protein 0.0128 0.131 0.131
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0291 0.3257 0.4406
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0523 0.0712
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0181 0.0181
Plasmodium vivax JmjC domain containing protein 0.0043 0.03 0.2089
Onchocerca volvulus 0.0019 0.0017 0.0031
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0033 0.0181 0.02
Brugia malayi Peroxidasin 0.0056 0.0452 0.0615
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0523 0.0523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Brugia malayi beta-lactamase family protein 0.0035 0.0207 0.0282
Schistosoma mansoni cpg binding protein 0.0064 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) patched family protein 0.0019 0.0017 0.0023
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.005 0.0068
Brugia malayi glutaminase DH11.1 0.0554 0.6399 0.871
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0207 0.2246
Brugia malayi amine oxidase, flavin-containing family protein 0.0105 0.104 0.1416
Brugia malayi AMP-binding enzyme family protein 0.0022 0.005 0.0068
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0686 0.9096
Schistosoma mansoni jumonji/arid domain-containing protein 0.0165 0.1754 0.1754
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0208 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Loa Loa (eye worm) hypothetical protein 0.0168 0.1791 0.2438
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1338 0.1822
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0207 0.0594
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0523 0.0712
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0077 0.0057
Brugia malayi Kringle domain containing protein 0.0051 0.0395 0.0538
Toxoplasma gondii patched family protein 0.0019 0.0017 0.0023
Echinococcus multilocularis tar DNA binding protein 0.0128 0.131 0.131
Echinococcus granulosus slit 2 protein 0.0018 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.024 0.0281
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0204 0.0278
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.005 0.0113

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3 nM Inhibition of human recombinant DPP4 after 60 mins by fluorescence plate reader ChEMBL. 21306895

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.