Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1765 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0484 | 0.1258 | 0.1258 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0484 | 0.1258 | 0.1258 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0484 | 0.1258 | 0.1258 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.1765 | 1 | 1 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.1765 | 1 | 0.5 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0561 | 0.1785 | 0.1785 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0484 | 0.1258 | 0.1258 |
Trypanosoma brucei | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.0824 | 0.358 | 0.2656 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Leishmania major | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.1765 | 1 | 1 |
Mycobacterium ulcerans | polyprenyl diphosphate synthetase, GrcC1 | 0.0824 | 0.358 | 0.2185 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0824 | 0.358 | 1 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 0.5 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0824 | 0.358 | 0.358 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0824 | 0.358 | 0.358 |
Schistosoma mansoni | glutathione synthetase | 0.0561 | 0.1785 | 0.1785 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 0.5 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0561 | 0.1785 | 0.1785 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0484 | 0.1258 | 0.1258 |
Plasmodium falciparum | octaprenyl pyrophosphate synthase | 0.0824 | 0.358 | 0.358 |
Brugia malayi | hypothetical protein | 0.0565 | 0.1815 | 0.1815 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0824 | 0.358 | 0.5 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.064 | 0.2324 | 0.2324 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0824 | 0.358 | 0.358 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.064 | 0.2324 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0824 | 0.358 | 1 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0824 | 0.358 | 0.358 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0824 | 0.358 | 1 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0824 | 0.358 | 0.358 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0484 | 0.1258 | 0.1258 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0484 | 0.1258 | 0.1258 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.1765 | 1 | 0.5 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0879 | 0.3955 | 0.3955 |
Echinococcus granulosus | carbonic anhydrase II | 0.0484 | 0.1258 | 0.1258 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.064 | 0.2324 | 0.2324 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0561 | 0.1785 | 0.5 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Schistosoma mansoni | trans-prenyltransferase | 0.0824 | 0.358 | 0.358 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.1765 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.