TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 364.441 | Formula: C21H24N4O2
H donors: 3 H acceptors: 2 LogP: 3.86 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccc2c1cn[nH]2)N[C@@H]1CCOc2c1cccc2C(C)(C)C
InChi: 1S/C21H24N4O2/c1-21(2,3)15-7-4-6-13-17(10-11-27-19(13)15)24-20(26)23-16-8-5-9-18-14(16)12-22-25-18/h4-9,12,17H,10-11H2,1-3H3,(H,22,25)(H2,23,24,26)/t17-/m1/s1
InChiKey: FGVFFUSBPJFGCF-QGZVFWFLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	transient receptor potential cation channel, subfamily V, member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0051	0.077
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.005	0.0231
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.0083	0.0132
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0083	0.0385
Echinococcus granulosus	geminin	0.0165	0.1463	0.233
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0136	0.1937
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0051	0.0238
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0119	0.1021	0.0919
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0242	0.0131
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0242	0.6561
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0238	0.332
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0051	0.1393
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0083	0.0385
Schistosoma mansoni	hypothetical protein	0.0165	0.1463	0.233
Schistosoma mansoni	hypothetical protein	0.0011	0.0004	0.0006
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0051	0.0425
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0083	0.0385
Onchocerca volvulus		0.0036	0.0242	0.3625
Entamoeba histolytica	hypothetical protein	0.0023	0.0113	0.0935
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.1064	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.0083	0.0132
Brugia malayi	hypothetical protein	0.0016	0.0051	0.0236
Onchocerca volvulus	Protein ultraspiracle homolog	0.002	0.0083	0.1242
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0242	0.038
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0242	0.1123
Onchocerca volvulus		0.0016	0.0051	0.077
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0238	0.6439
Echinococcus granulosus	lamin	0.0027	0.0153	0.0243
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0119	0.1021	0.1622
Echinococcus granulosus	intermediate filament protein	0.0027	0.0153	0.0243
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0242	0.0131
Brugia malayi	steroid hormone receptor	0.002	0.0083	0.0385
Schistosoma mansoni	lamin	0.0027	0.0153	0.0243
Entamoeba histolytica	fatty acid elongase, putative	0.0138	0.1208	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0153	0.0709
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.0083	0.0132
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0083	0.0132
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.0369	0.5
Brugia malayi	Smad1	0.0016	0.005	0.0231
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0369	0.0582
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.002	0.0026
Brugia malayi	beta-lactamase family protein	0.0036	0.0242	0.1123
Echinococcus multilocularis	lamin dm0	0.0027	0.0153	0.0238
Onchocerca volvulus		0.0016	0.0051	0.077
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.0083	0.0132
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0238	0.1966
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0242	0.0131
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0242	0.6561
Schistosoma mansoni	smad1 5 8 and	0.0016	0.005	0.0079
Echinococcus multilocularis	smad	0.0016	0.005	0.0074
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0119	0.1021	0.1627
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0369	0.0582
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0437	0.8824
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0083	0.0385
Brugia malayi	MAP kinase sur-1	0.005	0.0369	0.1712
Onchocerca volvulus		0.0036	0.0242	0.3625
Brugia malayi	MH2 domain containing protein	0.0016	0.005	0.0231
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0083	0.0126
Loa Loa (eye worm)	fibroinase	0.0016	0.0051	0.0238
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0369	0.3275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0083	0.0385
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0238	0.0378
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.0083	0.0132
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0119	0.1021	0.0919
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0119	0.1021	0.0919
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0242	0.6561
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.005	0.0079
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.1064	1	1
Echinococcus multilocularis	lamin	0.0027	0.0153	0.0238
Mycobacterium ulcerans	lipase LipD	0.0036	0.0242	0.0131
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0369	0.0588
Schistosoma mansoni	lamin	0.0027	0.0153	0.0243
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0202	0.6876
Loa Loa (eye worm)	hypothetical protein	0.0013	0.002	0.0092
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0238	0.4263
Onchocerca volvulus		0.0027	0.0153	0.2288
Onchocerca volvulus		0.0027	0.0153	0.2288
Onchocerca volvulus		0.0016	0.0051	0.077
Entamoeba histolytica	hypothetical protein	0.0035	0.0229	0.1893
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0136	0.0631
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0488	1
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0113	0.0636
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0369	1
Plasmodium vivax	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	0.1064	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0385
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0136	0.0085
Brugia malayi	beta-lactamase	0.0036	0.0242	0.1123
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0136	0.0085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0051	0.1393
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Echinococcus granulosus	neuropeptide receptor A26	0.0464	0.4299	0.6848
Schistosoma mansoni	aldehyde dehydrogenase	0.0119	0.1021	0.1627
Echinococcus multilocularis	neuropeptide receptor A26	0.0464	0.4299	0.6846
Entamoeba histolytica	hypothetical protein	0.0035	0.0229	0.1893
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0136	0.1937
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0369	0.7271
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0385
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0242	0.4366
Entamoeba histolytica	fatty acid elongase, putative	0.0138	0.1208	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0238	0.4263
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0229	0.0364
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0083	0.0132
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0051	0.077
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0242	0.1123
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0336	0.0535
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0242	0.0131
Echinococcus granulosus	lamin dm0	0.0027	0.0153	0.0243
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0051	0.0082
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0369	0.0588
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0083	0.0132
Schistosoma mansoni	hypothetical protein	0.0035	0.0229	0.0364
Onchocerca volvulus		0.0016	0.0051	0.077
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0369	0.7271
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0242	0.344
Echinococcus multilocularis	musashi	0.0027	0.0153	0.0238
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0113	0.0636
Schistosoma mansoni	coup transcription factor	0.002	0.0083	0.0132
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.005	0.0079
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0336	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0242	0.1123
Onchocerca volvulus		0.0036	0.0242	0.3625
Schistosoma mansoni	aldehyde dehydrogenase	0.0119	0.1021	0.1627
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0083	0.0385
Trichomonas vaginalis	esterase, putative	0.0036	0.0242	0.6561
Echinococcus multilocularis	cysteine protease	0.0016	0.0051	0.0076
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0004	0.0006
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0081	0.0668	0.1058
Brugia malayi	Inositol-1	0.0036	0.0238	0.1102
Onchocerca volvulus		0.002	0.0083	0.1242
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0385
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0336	0.1558
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.005	0.0079
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0385
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.1064	1	1
Echinococcus granulosus	L aminoadipate semialdehyde	0.0081	0.0668	0.1064
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0369	1
Loa Loa (eye worm)	inositol-1	0.0036	0.0238	0.1102
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.0083	0.0385
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0083	0.0132
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0361	0.7098
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.002	0.0083	0.1242
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0051	0.1393
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0488	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0051	0.0076
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0238	0.6439
Toxoplasma gondii	aldehyde dehydrogenase	0.0119	0.1021	1
Echinococcus granulosus	smad	0.0016	0.005	0.0079
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0034	0.0156
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0083	0.0385
Schistosoma mansoni	Smad4	0.0016	0.005	0.0079
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0083	0.0132
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0488	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0242	0.4366
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0051	0.1393
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0385
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0488	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0083	0.0385
Entamoeba histolytica	fatty acid elongase, putative	0.0138	0.1208	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0051	0.0238
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0229	0.0364
Loa Loa (eye worm)	cysteine protease	0.0016	0.0051	0.0238
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0369	0.3275
Echinococcus multilocularis	microtubule associated protein 2	0.0672	0.6278	1
Brugia malayi	intermediate filament protein	0.0027	0.0153	0.0709
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0083	0.0385
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0488	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0242	0.1123
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0051	0.1393
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0083	0.0132
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0369	0.6823
Brugia malayi	hypothetical protein	0.0035	0.0229	0.1061
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0051	0.0076
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0488	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0242	0.0386
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0083	0.0126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Schistosoma mansoni	hypothetical protein	0.0165	0.1463	0.233
Plasmodium falciparum	beta-ketoacyl-ACP synthase III	0.1064	1	1
Leishmania major	cathepsin L-like protease	0.0062	0.0488	0.4504
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.0083	0.0126
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0336	0.0529
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0083	0.0132
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.0083	0.0132
Entamoeba histolytica	hypothetical protein	0.0035	0.0229	0.1893
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0242	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0148	0.0687
Loa Loa (eye worm)	MH2 domain-containing protein	0.0238	0.2155	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0242	0.1123
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0083	0.0126
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0242	0.0131
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.0083	0.0132
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0242	0.1123
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0153	0.0709
Onchocerca volvulus		0.0081	0.0668	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0083	0.0385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0119	0.1021	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.0083	0.0385
Schistosoma mansoni	smad1 5 8 and	0.0016	0.005	0.0079
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0051	0.0238
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0051	0.0082
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0238	0.192
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0242	0.0131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Leishmania major	hypothetical protein, conserved	0.0036	0.0242	0.1966
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0488	1
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.0083	0.0385
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0051	0.1393
Schistosoma mansoni	smad	0.0016	0.005	0.0079
Onchocerca volvulus		0.0016	0.0051	0.077
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.005	0.0074
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0238	0.0378
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0083	0.0385
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0369	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0336	0.1558
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0051	0.0082
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0488	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.0083	0.0132
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0242	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0242	0.0131
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0083	0.0126
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0242	0.0131
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0242	0.0131
Brugia malayi	hypothetical protein	0.0025	0.0136	0.0631
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.005	0.0231
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.0083	0.0126
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0051	0.1393
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0242	0.0131
Brugia malayi	beta-lactamase family protein	0.0036	0.0242	0.1123
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.0083	0.0132
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0488	1
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0083	0.0385
Onchocerca volvulus		0.0016	0.0051	0.077
Loa Loa (eye worm)	ctsf protein	0.0016	0.0051	0.0238
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0083	0.0132
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)	0.1064	1	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0233	0.2107	0.2017
Entamoeba histolytica	hypothetical protein	0.0035	0.0229	0.1893
Echinococcus multilocularis	neuropeptide s receptor	0.0464	0.4299	0.6846
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0668	0.3099
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0113	0.0062
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0369	0.3275
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0238	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0051	0.0238
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0083	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0242	0.1123
Leishmania major	cathepsin L-like protease	0.0062	0.0488	0.4504
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Loa Loa (eye worm)	transcription factor SMAD2	0.0238	0.2155	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0202	0.009
Onchocerca volvulus		0.0016	0.0051	0.077
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0051	0.077
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0081	0.0668	0.1064
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0385
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0488	1
Brugia malayi	ecdysteroid receptor	0.002	0.0083	0.0385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0336	0.0535
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0051	0.0076
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0242	0.0192
Brugia malayi	MH2 domain containing protein	0.0016	0.005	0.0231
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0242	0.0131
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0083	0.0385
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0051	0.0425
Entamoeba histolytica	fatty acid elongase, putative	0.0138	0.1208	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0136	0.0612
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0119	0.1021	0.0919
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0136	0.0872
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0051	0.1393
Leishmania major	hypothetical protein, conserved	0.0025	0.0136	0.0872
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0083	0.0385
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0083	0.0385
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0229	0.0359
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.0083	0.0132
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0051	0.0238
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0336	0.0529
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0051	0.0082
Echinococcus multilocularis	Smad4	0.0016	0.005	0.0074
Onchocerca volvulus	Bile acid receptor homolog	0.002	0.0083	0.1242
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0242	0.0131
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0051	0.1393
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0242	0.1123
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0083	0.0385
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0242	0.0131
Brugia malayi	nuclear receptor NHR-88	0.002	0.0083	0.0385
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0242	0.0386
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0238	0.6439
Leishmania major	cathepsin L-like protease	0.0062	0.0488	0.4504
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0153	0.0709
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0488	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0369	0.7271
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0051	0.0238
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0242	0.0386
Schistosoma mansoni	microtubule-associated protein tau	0.0672	0.6278	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0488	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.002	0.0083	0.0126
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0083	0.0126
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0385
Brugia malayi	nuclear hormone receptor	0.002	0.0083	0.0385
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0369	0.1712
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0083	0.0385
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0488	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0051	0.1393
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0034	0.0156
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0238	0.0378
Trypanosoma brucei	protein kinase, putative	0.005	0.0369	0.6823
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0238	0.0126
Echinococcus multilocularis	cysteine protease	0.0016	0.0051	0.0076
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0136	0.0085
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0051	0.0076
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0051	0.1393
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0153	0.0243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0051	0.1393
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0.0113	0.5
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0238	0.192
Toxoplasma gondii	ABC1 family protein	0.0036	0.0242	0.1966
Echinococcus granulosus	Smad4	0.0016	0.005	0.0079
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0336	0.0535
Schistosoma mansoni	smad1 5 8 and	0.0016	0.005	0.0079
Echinococcus granulosus	microtubule associated protein 2	0.0672	0.6278	1
Brugia malayi	MH1 domain containing protein	0.0016	0.005	0.0231
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0083	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0242	0.1123
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0083	0.0132
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0083	0.0385
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0083	0.0385
Echinococcus granulosus	cathepsin l1	0.0016	0.0051	0.0082
Entamoeba histolytica	fatty acid elongase, putative	0.0138	0.1208	1
Loa Loa (eye worm)	Smad1	0.0016	0.005	0.0231
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0083	0.0385
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0051	0.0238
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.005	0.0074
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0051	0.0238
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0369	1
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0051	0.0425
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0081	0.0668	0.3099
Echinococcus granulosus	neuropeptide s receptor	0.0464	0.4299	0.6848
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0113	0.0636
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0242	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0242	0.6561
Echinococcus multilocularis	geminin	0.0165	0.1463	0.2326
Brugia malayi	MH1 domain containing protein	0.0016	0.005	0.0231
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0242	0.6561
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.0083	0.0132
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0336	0.0535
Mycobacterium ulcerans	beta-ketoacyl synthase-like protein	0.1064	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0488	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0015	0.007
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.002	0.0032
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0051	0.0238
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0369	0.7271
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0051	0.0238
Brugia malayi	MH2 domain containing protein	0.0238	0.2155	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0015	0.007
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0083	0.0126
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0153	0.0709
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0113	0.0062
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0238	0.0373
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0488	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0369	0.0588

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 3 nM	Antagonist activity at human TRPV1 assessed as inhibition of calcium influx	ChEMBL.	21315587

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1684275

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1502660