Detailed information for compound 1502874

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 925.2 | Formula: C48H84N4O13
  • H donors: 7 H acceptors: 7 LogP: 3.68 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)CCCNC(=O)Nc1ccc(cc1)C)C)(C)O
  • InChi: 1S/C48H84N4O13/c1-15-36-48(11,59)40(54)32(7)52(22-16-21-49-45(57)50-34-19-17-27(2)18-20-34)26-28(3)24-46(9,58)42(65-44-38(53)35(51(12)13)23-29(4)61-44)30(5)39(31(6)43(56)63-36)64-37-25-47(10,60-14)41(55)33(8)62-37/h17-20,28-33,35-42,44,53-55,58-59H,15-16,21-26H2,1-14H3,(H2,49,50,57)/t28-,29-,30+,31-,32-,33+,35+,36-,37+,38-,39+,40-,41+,42-,44+,46-,47-,48-/m1/s1
  • InChiKey: WNTLTALNLSXVBG-GWRUIMLNSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.00262956 0.00528216 0.00528216
Schistosoma mansoni multidrug resistance protein 0.00202936 0.00146964 0.00146964
Brugia malayi proteasome subunit alpha type 3 0.0339128 0.203994 0.203994
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0339128 0.203994 0.203994
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0339128 0.203994 0.202823
Trypanosoma brucei C-8 sterol isomerase, putative 0.14701 0.922393 0.922393
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0339128 0.203994 0.203994
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0339128 0.203994 0.202823
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0104209 0.0547727 0.0533815
Schistosoma mansoni retinoic acid receptor RXR 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi Emopamil binding protein, putative 0.0309874 0.185412 0.185412
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0339128 0.203994 0.203994
Brugia malayi proteasome subunit alpha type 1 0.0339128 0.203994 0.203994
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0339128 0.203994 0.202823
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0339128 0.203994 0.203994
Leishmania major polyprenyl synthase, putative 0.00262956 0.00528216 0.00528216
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0292321 0.0292321
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.00671635 0.0312416 0.0312416
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.00262956 0.00528216 0.00528216
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0339128 0.203994 0.203994
Loa Loa (eye worm) nuclear receptor nhr-7B 0.00571468 0.0248789 0.0248789
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.00262956 0.00528216 0.00528216
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0121147 0.0655319 0.0655319
Schistosoma mansoni phospholipase D 0.00985617 0.0511858 0.0511858
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0339128 0.203994 0.203994
Brugia malayi photoreceptor-specific nuclear receptor 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) PAS-3 protein 0.0339128 0.203994 0.203994
Trypanosoma brucei proteasome beta 6 subunit 0.150499 0.944554 0.944554
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.091819 0.571816 0.571186
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0121147 0.0655319 0.0655319
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0339128 0.203994 0.202823
Leishmania major proteasome beta-1 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0339128 0.203994 0.203994
Echinococcus multilocularis phospholipase D1 0.00985617 0.0511858 0.0511858
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0339128 0.203994 0.203994
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.00202936 0.00146964 0.00146964
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121147 0.0655319 0.0655319
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121147 0.0655319 0.0655319
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.091819 0.571816 0.571816
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0104209 0.0547727 0.0547727
Schistosoma mansoni nuclear receptor 0.00571468 0.0248789 0.0248789
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0339128 0.203994 0.203994
Trypanosoma brucei proteasome beta 7 subunit 0.0339128 0.203994 0.203994
Schistosoma mansoni thyroid hormone receptor 0.0121147 0.0655319 0.0655319
Plasmodium falciparum proteasome subunit beta type-5 0.159228 1 1
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0339128 0.203994 0.202823
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0339128 0.203994 0.202823
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0121147 0.0655319 0.0655319
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.159228 1 1
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0339128 0.203994 0.203994
Brugia malayi steroid hormone receptor 0.0121147 0.0655319 0.0655319
Schistosoma mansoni nuclear hormone receptor 0.0121147 0.0655319 0.0655319
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.00262956 0.00528216 0.00528216
Brugia malayi Proteasome subunit alpha type 7-1 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0339128 0.203994 0.202823
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0339128 0.203994 0.203994
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00571468 0.0248789 0.0248789
Echinococcus granulosus lamin b receptor 0.0024567 0.00418414 0.00418414
Plasmodium vivax proteasome subunit beta type-5, putative 0.159228 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0121147 0.0655319 0.0655319
Onchocerca volvulus 0.0309874 0.185412 0.908851
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.00671635 0.0312416 0.0298158
Loa Loa (eye worm) hypothetical protein 0.00202936 0.00146964 0.00146964
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.00202936 0.00146964 0.00146964
Schistosoma mansoni nuclear receptor nhr-48 0.00571468 0.0248789 0.0248789
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0339128 0.203994 0.203994
Toxoplasma gondii proteasome subunit 0.0339128 0.203994 0.203994
Brugia malayi Polyprenyl synthetase family protein 0.00262956 0.00528216 0.00528216
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0339128 0.203994 0.203994
Toxoplasma gondii proteasome subunit beta type 1, putative 0.150499 0.944554 0.944554
Loa Loa (eye worm) hypothetical protein 0.00256075 0.00484507 0.00484507
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.0358007 0.215986 0.215986
Leishmania major proteasome beta 7 subunit, putative 0.0339128 0.203994 0.203994
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0104209 0.0547727 0.0533815
Echinococcus multilocularis FTZ F1 alpha 0.0121147 0.0655319 0.0655319
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121147 0.0655319 0.0655319
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0339128 0.203994 0.202823
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0339128 0.203994 0.202823
Onchocerca volvulus Notchless protein homolog 0.0339128 0.203994 1
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0339128 0.203994 0.157868
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0339128 0.203994 0.203994
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) nuclear receptor NHR-67 0.00571468 0.0248789 0.0248789
Brugia malayi Nuclear hormone receptor E75 0.00571468 0.0248789 0.0248789
Schistosoma mansoni trans-prenyltransferase 0.00262956 0.00528216 0.00528216
Brugia malayi nuclear hormone receptor 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) hypothetical protein 0.00202351 0.0014325 0.0014325
Leishmania major proteasome beta 5 subunit, putative 0.159228 1 1
Schistosoma mansoni nuclear hormone receptor 0.00571468 0.0248789 0.0248789
Trypanosoma cruzi Emopamil binding protein, putative 0.0309874 0.185412 0.185412
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00273707 0.00596507 0.00450204
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00202936 0.00146964 0.00146964
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.159228 1 1
Schistosoma mansoni zinc finger protein 0.00571468 0.0248789 0.0248789
Toxoplasma gondii proteasome subunit alpha1, putative 0.0339128 0.203994 0.203994
Entamoeba histolytica phospholipase D, putative 0.00985617 0.0511858 0.0497893
Echinococcus granulosus proteasome subunit beta type 7 0.0339128 0.203994 0.203994
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0309874 0.185412 0.185412
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Brugia malayi 20S proteasome alpha5 subunit 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0339128 0.203994 0.202823
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0339128 0.203994 0.203994
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0064 0.0292321 0.0292321
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Plasmodium vivax proteasome subunit beta type-2, putative 0.091819 0.571816 0.571186
Brugia malayi Cytochrome P450 family protein 0.00481839 0.0191857 0.0191857
Loa Loa (eye worm) steroid hormone receptor 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) hypothetical protein 0.0754882 0.468082 0.468082
Leishmania major proteasome alpha 1 subunit, putative 0.0339128 0.203994 0.203994
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0121147 0.0655319 0.0655319
Schistosoma mansoni nuclear receptor 0.00571468 0.0248789 0.0248789
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0339128 0.203994 0.203994
Trypanosoma brucei proteasome subunit beta type-2, putative 0.091819 0.571816 0.571816
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0339128 0.203994 0.203994
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Plasmodium vivax proteasome subunit beta type-4, putative 0.0339128 0.203994 0.202823
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0339128 0.203994 0.203994
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.150499 0.944554 0.944554
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.00262956 0.00528216 0.00381814
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Brugia malayi Proteasome A-type and B-type family protein 0.0339128 0.203994 0.203994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0121147 0.0655319 0.0655319
Giardia lamblia 20S proteasome alpha subunit 3 0.0339128 0.203994 0.157868
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Leishmania major proteasome beta 3 subunit, putative 0.0339128 0.203994 0.203994
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0339128 0.203994 0.202823
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.00262956 0.00528216 0.00528216
Echinococcus granulosus tm gpcr rhodopsin 0.0843875 0.524611 0.524611
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00202936 0.00146964 0.00146964
Brugia malayi tailless protein 0.00571468 0.0248789 0.0248789
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0339128 0.203994 0.203994
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121147 0.0655319 0.0655319
Trypanosoma brucei Emopamil binding protein, putative 0.0309874 0.185412 0.185412
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0339128 0.203994 0.203994
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0104209 0.0547727 0.0547727
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121147 0.0655319 0.0655319
Leishmania major farnesyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Mycobacterium ulcerans proteasome PrcA 0.0339128 0.203994 0.203994
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.00202936 0.00146964 0.00146964
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Treponema pallidum octaprenyl-diphosphate synthase 0.00262956 0.00528216 0.5
Brugia malayi Proteasome A-type and B-type family protein 0.0339128 0.203994 0.203994
Brugia malayi proteasome subunit alpha type 2 0.0339128 0.203994 0.203994
Leishmania major proteasome alpha 3 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.00262956 0.00528216 1
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.00262956 0.00528216 0.00528216
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0339128 0.203994 0.202823
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0309874 0.185412 0.185412
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.00262956 0.00528216 0.00528216
Echinococcus granulosus Nuclear hormone receptor HR96 0.00571468 0.0248789 0.0248789
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.159228 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0064 0.0292321 0.0292321
Giardia lamblia 20S proteasome alpha subunit 1 0.0339128 0.203994 0.157868
Echinococcus granulosus phospholipase d3 0.00181877 0.000132005 0.000132005
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0339128 0.203994 0.203994
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0339128 0.203994 0.203994
Brugia malayi Nuclear hormone receptor E75 0.00571468 0.0248789 0.0248789
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0121147 0.0655319 0.0655319
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0104209 0.0547727 0.0533815
Trypanosoma brucei proteasome subunit beta type-5, putative 0.159228 1 1
Loa Loa (eye worm) hypothetical protein 0.00650095 0.0298733 0.0298733
Schistosoma mansoni multidrug resistance protein 0.00202936 0.00146964 0.00146964
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0339128 0.203994 0.203994
Leishmania major proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.00262956 0.00528216 0.00528216
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.091819 0.571816 0.571186
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.00202936 0.00146964 0.00146964
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0339128 0.203994 0.202823
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.00262956 0.00528216 0.00528216
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Brugia malayi Cytochrome P450 family protein 0.00248345 0.00435408 0.00435408
Brugia malayi Proteasome A-type and B-type family protein 0.0339128 0.203994 0.203994
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0339128 0.203994 0.203994
Echinococcus multilocularis multidrug resistance protein 1 0.00202936 0.00146964 0.00146964
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0339128 0.203994 0.203994
Leishmania major hypothetical protein, conserved 0.0309874 0.185412 0.185412
Trypanosoma cruzi polyprenyl synthase, putative 0.00262956 0.00528216 0.00528216
Loa Loa (eye worm) polyprenyl synthetase 0.00262956 0.00528216 0.00528216
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0339128 0.203994 0.203994
Leishmania major sterol C-24 reductase, putative 0.0024567 0.00418414 0.00418414
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0121147 0.0655319 0.0655319
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0339128 0.203994 0.203994
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0309874 0.185412 0.185412
Echinococcus granulosus thyroid hormone receptor alpha 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) proteasome subunit beta type 3 0.0339128 0.203994 0.203994
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121147 0.0655319 0.0655319
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.00262956 0.00528216 0.00528216
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0121147 0.0655319 0.0655319
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.159228 1 1
Brugia malayi hypothetical protein 0.00571468 0.0248789 0.0248789
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0104209 0.0547727 0.0533815
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.091819 0.571816 0.571186
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292321 0.0292321
Brugia malayi proteasome subunit beta type 1 0.150499 0.944554 0.944554
Brugia malayi hypothetical protein 0.0064 0.0292321 0.0292321
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.150499 0.944554 0.944554
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0843875 0.524611 0.524611
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.00262956 0.00528216 0.00528216
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0339128 0.203994 0.202823
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292321 0.0292321
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0339128 0.203994 0.202823
Brugia malayi proteasome subunit alpha type 6 0.0339128 0.203994 0.203994
Entamoeba histolytica phospholipase D, putative 0.00985617 0.0511858 0.0497893
Giardia lamblia Proteasome subunit beta type 1 0.150499 0.944554 0.941341
Brugia malayi Proteasome A-type and B-type family protein 0.159228 1 1
Brugia malayi hypothetical protein 0.0064 0.0292321 0.0292321
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.00262956 0.00528216 0.00528216
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292321 0.0292321
Echinococcus multilocularis proteasome subunit beta type 6 0.0339128 0.203994 0.203994
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.00571468 0.0248789 0.0248789
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0339128 0.203994 0.202823
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0339128 0.203994 0.203994
Echinococcus multilocularis phospholipase d3 0.00181877 0.000132005 0.000132005
Onchocerca volvulus 0.00571468 0.0248789 0.12139
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.091819 0.571816 0.571816
Echinococcus multilocularis ATP binding cassette sub family B 0.00202351 0.0014325 0.0014325
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0339128 0.203994 0.202823
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.00571468 0.0248789 0.12139
Loa Loa (eye worm) CYP4Cod1 0.00248345 0.00435408 0.00435408
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0196794 0.113583 0.113583
Brugia malayi multidrug resistance protein 3 0.00202936 0.00146964 0.00146964
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00202936 0.00146964 0.00146964
Echinococcus granulosus proteasome subunit alpha type 6 0.0339128 0.203994 0.203994
Trypanosoma cruzi polyprenyl synthase, putative 0.00262956 0.00528216 0.00528216
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.00671635 0.0312416 0.0312416
Leishmania major p-glycoprotein 0.00202936 0.00146964 0.00146964
Echinococcus granulosus Proteasome subunit alpha beta 0.0339128 0.203994 0.203994
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0339128 0.203994 0.202823
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0196794 0.113583 0.113583
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus granulosus proteasome prosome macropain subunit beta 0.091819 0.571816 0.571816
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.00262956 0.00528216 0.00528216
Brugia malayi nuclear receptor NHR-67 0.00571468 0.0248789 0.0248789
Brugia malayi Polyprenyl synthetase family protein 0.0104209 0.0547727 0.0547727
Leishmania major proteasome alpha 1 subunit, putative 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0339128 0.203994 0.202823
Trypanosoma cruzi solanesyl-diphosphate synthase 0.00262956 0.00528216 0.00528216
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00202936 0.00146964 0.00146964
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0339128 0.203994 0.203994
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.091819 0.571816 0.571816
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0121147 0.0655319 0.0655319
Brugia malayi Phospholipase D. Active site motif family protein 0.00181877 0.000132005 0.000132005
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Brugia malayi Phospholipase D. Active site motif family protein 0.00335522 0.00989156 0.00989156
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.00671635 0.0312416 0.0312416
Brugia malayi ecdysone receptor 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) hypothetical protein 0.00181877 0.000132005 0.000132005
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0339128 0.203994 1
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0339128 0.203994 0.203994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0121147 0.0655319 0.0655319
Echinococcus multilocularis proteasome subunit alpha type 2 0.0339128 0.203994 0.203994
Onchocerca volvulus 0.0121147 0.0655319 0.320805
Trypanosoma cruzi C-8 sterol isomerase, putative 0.14701 0.922393 0.922393
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) hypothetical protein 0.00831972 0.0414262 0.0414262
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.00262956 0.00528216 0.00528216
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0064 0.0292321 0.0292321
Trypanosoma brucei C-14 sterol reductase, putative 0.0024567 0.00418414 0.00418414
Trypanosoma brucei cytochrome P450, putative 0.00248345 0.00435408 0.00435408
Echinococcus granulosus ecdysone induced protein 78C 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) nuclear hormone receptor 0.00571468 0.0248789 0.0248789
Onchocerca volvulus 0.00571468 0.0248789 0.12139
Schistosoma mansoni Lamin B receptor (ERG24) 0.0024567 0.00418414 0.00418414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0121147 0.0655319 0.0655319
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0339128 0.203994 0.203994
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi C-14 sterol reductase, putative 0.0024567 0.00418414 0.00418414
Giardia lamblia Proteasome subunit beta type 2 0.091819 0.571816 0.547005
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) phospholipase D 0.00181877 0.000132005 0.000132005
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0339128 0.203994 0.202823
Onchocerca volvulus 0.00202936 0.00146964 0.00656147
Loa Loa (eye worm) multidrug resistance protein 3 0.00202936 0.00146964 0.00146964
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.00298369 0.00753159 0.00753159
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00298369 0.00753159 0.00753159
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0339128 0.203994 0.202823
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0104209 0.0547727 0.0533815
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0292321 0.0292321
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.00298369 0.00753159 0.00753159
Echinococcus granulosus phospholipase D 0.00877247 0.0443021 0.0443021
Schistosoma mansoni multidrug resistance protein 0.00202936 0.00146964 0.00146964
Schistosoma mansoni voltage-gated potassium channel 0.00328957 0.00947456 0.00947456
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0339128 0.203994 0.202823
Echinococcus multilocularis nuclear receptor nhr 48 0.00571468 0.0248789 0.0248789
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0121147 0.0655319 0.320805
Toxoplasma gondii peptidase, T1 family protein 0.0339128 0.203994 0.203994
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0339128 0.203994 0.203994
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0339128 0.203994 0.203994
Brugia malayi Steroid receptor seven-up type 2 0.0121147 0.0655319 0.0655319
Brugia malayi nuclear receptor NHR-88 0.00571468 0.0248789 0.0248789
Entamoeba histolytica phospholipase D active site domain-containing protein 0.00831972 0.0414262 0.0400154
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) DR-78 0.00571468 0.0248789 0.0248789
Giardia lamblia 20S proteasome alpha subunit 2 0.0339128 0.203994 0.157868
Toxoplasma gondii phospholipase D active site domain-containing protein 0.00335522 0.00989156 0.00989156
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00202936 0.00146964 0.00146964
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.150499 0.944554 0.944554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0121147 0.0655319 0.0655319
Echinococcus multilocularis thyroid hormone receptor alpha 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) proteasome subunit beta type 1 0.150499 0.944554 0.944554
Echinococcus granulosus subfamily T1A non peptidase ue 0.0339128 0.203994 0.203994
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0121147 0.0655319 0.0655319
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00202936 0.00146964 0.00146964
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0339128 0.203994 0.202823
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.150499 0.944554 0.944554
Toxoplasma gondii proteasome subunit alpha type, putative 0.0339128 0.203994 0.203994
Mycobacterium leprae proteasome (beta subunit) PrcB 0.159228 1 1
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.00262956 0.00528216 0.00381814
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.00262956 0.00528216 0.00381814
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0121147 0.0655319 0.0655319
Echinococcus granulosus Proteasome subunit alpha type 7 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0339128 0.203994 0.202823
Plasmodium falciparum proteasome subunit beta type-4 0.0339128 0.203994 0.202823
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0104209 0.0547727 0.0547727
Echinococcus multilocularis proteasome (prosome, macropain) 0.159228 1 1
Echinococcus granulosus proteasome subunit beta type 6 0.0339128 0.203994 0.203994
Echinococcus granulosus Nuclear hormone receptor HR96 0.00571468 0.0248789 0.0248789
Giardia lamblia 20S proteasome alpha subunit 5 0.0339128 0.203994 0.157868
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Onchocerca volvulus Bile acid receptor homolog 0.0121147 0.0655319 0.320805
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0196794 0.113583 0.113583
Echinococcus granulosus phospholipase D1 0.00985617 0.0511858 0.0511858
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0339128 0.203994 0.202823
Echinococcus granulosus nuclear receptor nhr 48 0.00571468 0.0248789 0.0248789
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00273707 0.00596507 0.00450204
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0339128 0.203994 0.203994
Trypanosoma cruzi cytochrome P450, putative 0.00248345 0.00435408 0.00435408
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.091819 0.571816 0.571816
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0339128 0.203994 0.202823
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0339128 0.203994 0.202823
Leishmania major proteasome beta 2 subunit, putative 0.091819 0.571816 0.571816
Leishmania major solanesyl-diphosphate synthase, putative 0.00262956 0.00528216 0.00528216
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0339128 0.203994 0.203994
Echinococcus multilocularis Nuclear hormone receptor HR96 0.00571468 0.0248789 0.0248789
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.00262956 0.00528216 0.00528216
Echinococcus granulosus proteasome prosome macropain 0.159228 1 1
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Trypanosoma brucei cardiolipin synthetase 0.00335522 0.00989156 0.00989156
Loa Loa (eye worm) cytochrome P450 family protein 0.00248345 0.00435408 0.00435408
Leishmania major C-14 sterol reductase, putative 0.0024567 0.00418414 0.00418414
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0339128 0.203994 0.202823
Brugia malayi ERG2 and Sigma1 receptor like protein 0.14701 0.922393 0.922393
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0121147 0.0655319 0.0655319
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) cytochrome P450 family protein 0.00481839 0.0191857 0.0191857
Loa Loa (eye worm) PDE1B protein 0.0196794 0.113583 0.113583
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0339128 0.203994 0.202823
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0121147 0.0655319 0.0655319
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.00571468 0.0248789 0.12139
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292321 0.0292321
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Plasmodium vivax proteasome subunit beta type-1, putative 0.150499 0.944554 0.944472
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0339128 0.203994 0.202823
Echinococcus granulosus multidrug resistance protein 1 0.00202936 0.00146964 0.00146964
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00298369 0.00753159 0.00753159
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0196794 0.113583 0.113583
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi cardiolipin synthetase, putative 0.00335522 0.00989156 0.00989156
Trypanosoma cruzi 20S proteasome subunit 0.091819 0.571816 0.571816
Toxoplasma gondii proteasome beta subunit 0.0339128 0.203994 0.203994
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.00262956 0.00528216 0.00528216
Brugia malayi conserved hypotetical protein 0.00571468 0.0248789 0.0248789
Echinococcus multilocularis phospholipase D 0.00877247 0.0443021 0.0443021
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0339128 0.203994 0.157868
Schistosoma mansoni nuclear hormone receptor 0.00571468 0.0248789 0.0248789
Brugia malayi ecdysteroid receptor 0.0121147 0.0655319 0.0655319
Echinococcus multilocularis lamin b receptor 0.0024567 0.00418414 0.00418414
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0339128 0.203994 0.202823
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0339128 0.203994 0.203994
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0339128 0.203994 0.203994
Plasmodium falciparum proteasome subunit beta type-2, putative 0.091819 0.571816 0.571186
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0339128 0.203994 0.202823
Trypanosoma cruzi sterol C-24 reductase, putative 0.0024567 0.00418414 0.00418414
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0339128 0.203994 0.203994
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.159228 1 1
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.00262956 0.00528216 0.00528216
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.00262956 0.00528216 0.00528216
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.150499 0.944554 0.944554
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.00571468 0.0248789 0.0248789
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0339128 0.203994 0.202823
Trypanosoma brucei proteasome alpha 7 subunit 0.0339128 0.203994 0.203994
Giardia lamblia 20S proteasome alpha subunit 7 0.0339128 0.203994 0.157868
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.159228 1 1
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0339128 0.203994 0.203994
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Brugia malayi Proteasome subunit alpha type 1 0.0339128 0.203994 0.203994
Trypanosoma cruzi C-14 sterol reductase, putative 0.0024567 0.00418414 0.00418414
Echinococcus multilocularis multidrug resistance protein 1 0.00202936 0.00146964 0.00146964
Brugia malayi nuclear receptor RXR 0.00571468 0.0248789 0.0248789
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0339128 0.203994 0.203994
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0339128 0.203994 0.203994
Schistosoma mansoni smdr2 0.00202936 0.00146964 0.00146964
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0339128 0.203994 0.202823
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00202936 0.00146964 0.00146964
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit beta type 1, putative 0.150499 0.944554 0.944472
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.00262956 0.00528216 0.00528216
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.00202351 0.0014325 0.0014325
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.00671635 0.0312416 0.0312416
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.00671635 0.0312416 0.0312416
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.150499 0.944554 0.944472
Schistosoma mansoni glutathione synthetase 0.00262956 0.00528216 0.00528216
Toxoplasma gondii proteasome subunit beta type 2, putative 0.091819 0.571816 0.571816
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0121147 0.0655319 0.0655319
Giardia lamblia Proteasome subunit beta type 5 precursor 0.159228 1 1
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0339128 0.203994 0.202823
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0339128 0.203994 0.157868
Brugia malayi nuclear hormone receptor family member nhr-6 0.00571468 0.0248789 0.0248789
Brugia malayi nuclear receptor RXR 0.0064 0.0292321 0.0292321
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.00248345 0.00435408 0.00435408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0121147 0.0655319 0.0655319
Giardia lamblia 20S proteasome alpha subunit 4 0.0339128 0.203994 0.157868
Echinococcus multilocularis proteasome subunit alpha type 6 0.0339128 0.203994 0.203994
Brugia malayi proteasome subunit beta type 2 0.091819 0.571816 0.571816
Loa Loa (eye worm) hypothetical protein 0.14701 0.922393 0.922393
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00202936 0.00146964 0.00146964
Brugia malayi proteasome subunit alpha type 4 0.0339128 0.203994 0.203994
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0064 0.0292321 0.0292321
Brugia malayi nuclear hormone receptor 0.0121147 0.0655319 0.0655319
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0121147 0.0655319 0.0655319
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0339128 0.203994 0.203994
Trypanosoma cruzi cardiolipin synthetase, putative 0.00335522 0.00989156 0.00989156
Echinococcus multilocularis Nuclear hormone receptor HR96 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292321 0.0292321
Plasmodium falciparum proteasome subunit beta type-1, putative 0.150499 0.944554 0.944472
Giardia lamblia 20S proteasome alpha subunit 6 0.0339128 0.203994 0.157868
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.00262956 0.00528216 0.00381814
Plasmodium vivax proteasome subunit beta type-6, putative 0.0339128 0.203994 0.202823
Brugia malayi nuclear hormone receptor family member odr-7 0.00571468 0.0248789 0.0248789
Mycobacterium ulcerans proteasome PrcB 0.159228 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.00571468 0.0248789 0.0248789
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0339128 0.203994 0.202823
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.00671635 0.0312416 0.0312416
Loa Loa (eye worm) proteasome subunit beta type 2 0.091819 0.571816 0.571816
Brugia malayi hypothetical protein 0.00571468 0.0248789 0.0248789
Echinococcus granulosus proteasome prosome macropain subunit beta 0.150499 0.944554 0.944554
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0339128 0.203994 0.203994
Echinococcus granulosus multidrug resistance protein 1 0.00202936 0.00146964 0.00146964
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0339128 0.203994 0.203994
Brugia malayi Phospholipase d protein 1 0.00985617 0.0511858 0.0511858
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Echinococcus granulosus proteasome subunit alpha type 2 0.0339128 0.203994 0.203994
Brugia malayi orphan nuclear receptor NR2E1 0.00571468 0.0248789 0.0248789
Plasmodium vivax proteasome subunit beta type-7, putative 0.0339128 0.203994 0.202823
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Leishmania major proteasome alpha 2 subunit, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.159228 1 1
Brugia malayi proteasome subunit beta type 3 0.0339128 0.203994 0.203994
Brugia malayi ABC transporter family protein 0.00202936 0.00146964 0.00146964
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0339128 0.203994 0.202823
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Schistosoma mansoni coup transcription factor 0.0121147 0.0655319 0.0655319
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0121147 0.0655319 0.0655319
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0339128 0.203994 0.203994
Trypanosoma cruzi cytochrome P450, putative 0.00248345 0.00435408 0.00435408
Echinococcus multilocularis ecdysone induced protein 78C 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0339128 0.203994 0.203994
Toxoplasma gondii heat shock protein hslv, putative 0.0339128 0.203994 0.203994
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0339128 0.203994 0.203994
Leishmania major proteasome beta 2 subunit, putative 0.0339128 0.203994 0.203994
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0339128 0.203994 0.203994
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0339128 0.203994 0.203994
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.00671635 0.0312416 0.0312416
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.00202936 0.00146964 0.00146964
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00202936 0.00146964 0.00146964
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.00571468 0.0248789 0.0248789
Schistosoma mansoni voltage-gated potassium channel 0.00328957 0.00947456 0.00947456
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0339128 0.203994 0.203994
Toxoplasma gondii proteasome subunit beta type, putative 0.159228 1 1
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.00262956 0.00528216 0.00381814
Leishmania major proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus granulosus multidrug resistance protein 1 0.00202936 0.00146964 0.00146964
Trypanosoma cruzi sterol C-24 reductase, putative 0.0024567 0.00418414 0.00418414
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0339128 0.203994 0.203994
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121147 0.0655319 0.0655319
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.00671635 0.0312416 0.0312416
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0339128 0.203994 0.203994
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.00831972 0.0414262 0.0414262
Leishmania major C-8 sterol isomerase-like protein 0.14701 0.922393 0.922393
Echinococcus multilocularis proteasome subunit beta type 7 0.0339128 0.203994 0.203994
Brugia malayi Nuclear hormone receptor-like 1 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0339128 0.203994 0.203994
Leishmania major phosphatidylglycerophosphate synthase, putative 0.00181877 0.000132005 0.000132005
Loa Loa (eye worm) hypothetical protein 0.00202936 0.00146964 0.00146964
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0339128 0.203994 0.203994
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0339128 0.203994 0.202823
Echinococcus granulosus FTZ F1 alpha 0.0121147 0.0655319 0.0655319
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0339128 0.203994 0.203994
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0121147 0.0655319 0.0655319
Echinococcus granulosus proteasome subunit beta t family 0.0339128 0.203994 0.203994
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0339128 0.203994 0.203994
Leishmania major cytochrome p450-like protein 0.00248345 0.00435408 0.00435408
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0339128 0.203994 0.202823
Schistosoma mansoni thyroid hormone receptor 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.00650095 0.0298733 0.0298733
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.0292321 0.0292321
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.00571468 0.0248789 0.0248789
Trypanosoma brucei cardiolipin synthetase, putative 0.00335522 0.00989156 0.00989156
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Brugia malayi Cytochrome P450 family protein 0.00248345 0.00435408 0.00435408
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0339128 0.203994 0.203994
Schistosoma mansoni RAR-like nuclear receptor 0.0121147 0.0655319 0.0655319
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0339128 0.203994 0.203994
Schistosoma mansoni steroid hormone receptor ad4bp 0.0121147 0.0655319 0.0655319
Giardia lamblia Proteasome subunit beta type 3 0.0339128 0.203994 0.157868
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0339128 0.203994 0.203994
Onchocerca volvulus Protein ultraspiracle homolog 0.0121147 0.0655319 0.320805
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) cytochrome P450 family protein 0.00248345 0.00435408 0.00435408
Brugia malayi nuclear receptor NHR-88 0.0121147 0.0655319 0.0655319
Plasmodium vivax proteasome subunit beta type-3, putative 0.0339128 0.203994 0.202823
Loa Loa (eye worm) polyprenyl synthetase 0.0104209 0.0547727 0.0547727

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 88.7 nM Antimalarial activity against chloroquine-,pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting ChEMBL. 21316974
IC50 (functional) = 138.8 nM Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting ChEMBL. 21316974
IC50 (functional) = 330.1 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting ChEMBL. 21316974

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 21316974

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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