Detailed information for compound 1502874

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 925.2 | Formula: C48H84N4O13
  • H donors: 7 H acceptors: 7 LogP: 3.68 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)CCCNC(=O)Nc1ccc(cc1)C)C)(C)O
  • InChi: 1S/C48H84N4O13/c1-15-36-48(11,59)40(54)32(7)52(22-16-21-49-45(57)50-34-19-17-27(2)18-20-34)26-28(3)24-46(9,58)42(65-44-38(53)35(51(12)13)23-29(4)61-44)30(5)39(31(6)43(56)63-36)64-37-25-47(10,60-14)41(55)33(8)62-37/h17-20,28-33,35-42,44,53-55,58-59H,15-16,21-26H2,1-14H3,(H2,49,50,57)/t28-,29-,30+,31-,32-,33+,35+,36-,37+,38-,39+,40-,41+,42-,44+,46-,47-,48-/m1/s1
  • InChiKey: WNTLTALNLSXVBG-GWRUIMLNSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0339128 0.203994 0.203994
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0339128 0.203994 0.202823
Echinococcus granulosus proteasome subunit alpha type 6 0.0339128 0.203994 0.203994
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.00262956 0.00528216 0.00528216
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Echinococcus granulosus lamin b receptor 0.0024567 0.00418414 0.00418414
Leishmania major hypothetical protein, conserved 0.0309874 0.185412 0.185412
Brugia malayi hypothetical protein 0.0064 0.0292321 0.0292321
Brugia malayi nuclear hormone receptor family member nhr-6 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) PAS-3 protein 0.0339128 0.203994 0.203994
Trypanosoma brucei proteasome beta 7 subunit 0.0339128 0.203994 0.203994
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0339128 0.203994 0.203994
Trypanosoma brucei Emopamil binding protein, putative 0.0309874 0.185412 0.185412
Echinococcus multilocularis proteasome (prosome, macropain) 0.159228 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.00571468 0.0248789 0.0248789
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.00571468 0.0248789 0.0248789
Trypanosoma cruzi solanesyl-diphosphate synthase 0.00262956 0.00528216 0.00528216
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0339128 0.203994 0.202823
Echinococcus granulosus proteasome subunit beta type 6 0.0339128 0.203994 0.203994
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0121147 0.0655319 0.0655319
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0121147 0.0655319 0.0655319
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0121147 0.0655319 0.0655319
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.00248345 0.00435408 0.00435408
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00202936 0.00146964 0.00146964
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00298369 0.00753159 0.00753159
Echinococcus granulosus phospholipase D 0.00877247 0.0443021 0.0443021
Leishmania major p-glycoprotein 0.00202936 0.00146964 0.00146964
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.00571468 0.0248789 0.12139
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00202936 0.00146964 0.00146964
Onchocerca volvulus 0.00571468 0.0248789 0.12139
Trypanosoma cruzi cardiolipin synthetase, putative 0.00335522 0.00989156 0.00989156
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0339128 0.203994 0.202823
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Echinococcus multilocularis proteasome subunit alpha type 2 0.0339128 0.203994 0.203994
Schistosoma mansoni RAR-like nuclear receptor 0.0121147 0.0655319 0.0655319
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0339128 0.203994 0.203994
Echinococcus granulosus subfamily T1A non peptidase ue 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0339128 0.203994 0.202823
Schistosoma mansoni nuclear hormone receptor 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi C-14 sterol reductase, putative 0.0024567 0.00418414 0.00418414
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0339128 0.203994 0.203994
Brugia malayi photoreceptor-specific nuclear receptor 0.0121147 0.0655319 0.0655319
Echinococcus multilocularis proteasome subunit alpha type 6 0.0339128 0.203994 0.203994
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0339128 0.203994 0.203994
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00202936 0.00146964 0.00146964
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi Emopamil binding protein, putative 0.0309874 0.185412 0.185412
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292321 0.0292321
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.00202936 0.00146964 0.00146964
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0843875 0.524611 0.524611
Brugia malayi Polyprenyl synthetase family protein 0.0104209 0.0547727 0.0547727
Loa Loa (eye worm) multidrug resistance protein 3 0.00202936 0.00146964 0.00146964
Brugia malayi Phospholipase D. Active site motif family protein 0.00181877 0.000132005 0.000132005
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0339128 0.203994 0.202823
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00202936 0.00146964 0.00146964
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0292321 0.0292321
Trypanosoma cruzi 20S proteasome subunit 0.091819 0.571816 0.571816
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0309874 0.185412 0.185412
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0064 0.0292321 0.0292321
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0339128 0.203994 0.203994
Schistosoma mansoni zinc finger protein 0.00571468 0.0248789 0.0248789
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121147 0.0655319 0.0655319
Onchocerca volvulus 0.0309874 0.185412 0.908851
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.00262956 0.00528216 0.00528216
Brugia malayi nuclear receptor NHR-88 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0339128 0.203994 0.203994
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.091819 0.571816 0.571186
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.00671635 0.0312416 0.0312416
Brugia malayi proteasome subunit beta type 3 0.0339128 0.203994 0.203994
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0121147 0.0655319 0.0655319
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0339128 0.203994 0.202823
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0104209 0.0547727 0.0547727
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.00262956 0.00528216 0.00381814
Brugia malayi Proteasome A-type and B-type family protein 0.159228 1 1
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0339128 0.203994 0.203994
Schistosoma mansoni multidrug resistance protein 0.00202936 0.00146964 0.00146964
Leishmania major polyprenyl synthase, putative 0.00262956 0.00528216 0.00528216
Loa Loa (eye worm) hypothetical protein 0.00202351 0.0014325 0.0014325
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.00262956 0.00528216 0.00528216
Brugia malayi Nuclear hormone receptor E75 0.00571468 0.0248789 0.0248789
Echinococcus granulosus proteasome prosome macropain 0.159228 1 1
Loa Loa (eye worm) hypothetical protein 0.00181877 0.000132005 0.000132005
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0339128 0.203994 0.203994
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0339128 0.203994 0.203994
Leishmania major cytochrome p450-like protein 0.00248345 0.00435408 0.00435408
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0339128 0.203994 0.203994
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.00262956 0.00528216 1
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0339128 0.203994 0.203994
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0104209 0.0547727 0.0533815
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0339128 0.203994 0.203994
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0339128 0.203994 0.202823
Trypanosoma brucei C-8 sterol isomerase, putative 0.14701 0.922393 0.922393
Schistosoma mansoni Lamin B receptor (ERG24) 0.0024567 0.00418414 0.00418414
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit beta type 1, putative 0.150499 0.944554 0.944472
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0104209 0.0547727 0.0533815
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.091819 0.571816 0.571816
Trypanosoma cruzi polyprenyl synthase, putative 0.00262956 0.00528216 0.00528216
Schistosoma mansoni smdr2 0.00202936 0.00146964 0.00146964
Leishmania major proteasome alpha 1 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus granulosus multidrug resistance protein 1 0.00202936 0.00146964 0.00146964
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.150499 0.944554 0.944554
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0339128 0.203994 0.203994
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0196794 0.113583 0.113583
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0339128 0.203994 0.202823
Leishmania major phosphatidylglycerophosphate synthase, putative 0.00181877 0.000132005 0.000132005
Plasmodium falciparum proteasome subunit beta type-4 0.0339128 0.203994 0.202823
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0121147 0.0655319 0.0655319
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0339128 0.203994 0.203994
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00202936 0.00146964 0.00146964
Echinococcus granulosus phospholipase D1 0.00985617 0.0511858 0.0511858
Schistosoma mansoni retinoic acid receptor RXR 0.0121147 0.0655319 0.0655319
Brugia malayi 20S proteasome alpha5 subunit 0.0339128 0.203994 0.203994
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00273707 0.00596507 0.00450204
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) proteasome subunit beta type 3 0.0339128 0.203994 0.203994
Brugia malayi proteasome subunit beta type 2 0.091819 0.571816 0.571816
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121147 0.0655319 0.0655319
Trypanosoma brucei cytochrome P450, putative 0.00248345 0.00435408 0.00435408
Leishmania major proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.159228 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) hypothetical protein 0.00256075 0.00484507 0.00484507
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0339128 0.203994 0.202823
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Plasmodium falciparum proteasome subunit beta type-2, putative 0.091819 0.571816 0.571186
Leishmania major sterol C-24 reductase, putative 0.0024567 0.00418414 0.00418414
Onchocerca volvulus 0.0121147 0.0655319 0.320805
Brugia malayi nuclear receptor NHR-88 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0309874 0.185412 0.185412
Schistosoma mansoni nuclear hormone receptor 0.00571468 0.0248789 0.0248789
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0339128 0.203994 0.203994
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0104209 0.0547727 0.0547727
Brugia malayi Cytochrome P450 family protein 0.00481839 0.0191857 0.0191857
Echinococcus multilocularis multidrug resistance protein 1 0.00202936 0.00146964 0.00146964
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0339128 0.203994 0.203994
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.00262956 0.00528216 0.00528216
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0064 0.0292321 0.0292321
Echinococcus granulosus Nuclear hormone receptor HR96 0.00571468 0.0248789 0.0248789
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.00671635 0.0312416 0.0312416
Schistosoma mansoni glutathione synthetase 0.00262956 0.00528216 0.00528216
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.00262956 0.00528216 0.00528216
Loa Loa (eye worm) steroid hormone receptor 0.0121147 0.0655319 0.0655319
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0121147 0.0655319 0.0655319
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00202936 0.00146964 0.00146964
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.00262956 0.00528216 0.00528216
Leishmania major proteasome beta 7 subunit, putative 0.0339128 0.203994 0.203994
Toxoplasma gondii proteasome subunit 0.0339128 0.203994 0.203994
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0064 0.0292321 0.0292321
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0339128 0.203994 0.202823
Trypanosoma cruzi C-14 sterol reductase, putative 0.0024567 0.00418414 0.00418414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) phospholipase D 0.00181877 0.000132005 0.000132005
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0339128 0.203994 0.203994
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0339128 0.203994 0.202823
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) hypothetical protein 0.00202936 0.00146964 0.00146964
Brugia malayi ecdysone receptor 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.00202936 0.00146964 0.00146964
Schistosoma mansoni nuclear receptor 0.00571468 0.0248789 0.0248789
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.00671635 0.0312416 0.0298158
Echinococcus multilocularis ATP binding cassette sub family B 0.00202351 0.0014325 0.0014325
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.00202351 0.0014325 0.0014325
Trypanosoma brucei proteasome subunit beta type-2, putative 0.091819 0.571816 0.571816
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121147 0.0655319 0.0655319
Schistosoma mansoni nuclear hormone receptor 0.00571468 0.0248789 0.0248789
Leishmania major farnesyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Loa Loa (eye worm) hypothetical protein 0.00650095 0.0298733 0.0298733
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.00262956 0.00528216 0.00528216
Loa Loa (eye worm) polyprenyl synthetase 0.0104209 0.0547727 0.0547727
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0339128 0.203994 0.202823
Brugia malayi Phospholipase d protein 1 0.00985617 0.0511858 0.0511858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00273707 0.00596507 0.00450204
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.00262956 0.00528216 0.00528216
Echinococcus multilocularis Nuclear hormone receptor HR96 0.00571468 0.0248789 0.0248789
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0339128 0.203994 0.203994
Loa Loa (eye worm) cytochrome P450 family protein 0.00481839 0.0191857 0.0191857
Brugia malayi proteasome subunit alpha type 6 0.0339128 0.203994 0.203994
Brugia malayi proteasome subunit alpha type 2 0.0339128 0.203994 0.203994
Echinococcus multilocularis FTZ F1 alpha 0.0121147 0.0655319 0.0655319
Brugia malayi Nuclear hormone receptor E75 0.00571468 0.0248789 0.0248789
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Brugia malayi nuclear receptor RXR 0.0064 0.0292321 0.0292321
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0339128 0.203994 0.203994
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.091819 0.571816 0.571816
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.00262956 0.00528216 0.00381814
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0339128 0.203994 0.203994
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0339128 0.203994 0.202823
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121147 0.0655319 0.0655319
Plasmodium vivax proteasome subunit beta type-3, putative 0.0339128 0.203994 0.202823
Brugia malayi ecdysteroid receptor 0.0121147 0.0655319 0.0655319
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.00262956 0.00528216 0.00381814
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.00671635 0.0312416 0.0312416
Brugia malayi hypothetical protein 0.0064 0.0292321 0.0292321
Leishmania major C-14 sterol reductase, putative 0.0024567 0.00418414 0.00418414
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0339128 0.203994 0.203994
Brugia malayi hypothetical protein 0.00571468 0.0248789 0.0248789
Plasmodium vivax proteasome subunit beta type-7, putative 0.0339128 0.203994 0.202823
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0121147 0.0655319 0.0655319
Schistosoma mansoni steroid hormone receptor ad4bp 0.0121147 0.0655319 0.0655319
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0339128 0.203994 0.202823
Giardia lamblia Proteasome subunit beta type 2 0.091819 0.571816 0.547005
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.00671635 0.0312416 0.0312416
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0339128 0.203994 0.202823
Schistosoma mansoni thyroid hormone receptor 0.0121147 0.0655319 0.0655319
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0196794 0.113583 0.113583
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0339128 0.203994 0.203994
Brugia malayi proteasome subunit alpha type 4 0.0339128 0.203994 0.203994
Trypanosoma cruzi cytochrome P450, putative 0.00248345 0.00435408 0.00435408
Leishmania major proteasome alpha 2 subunit, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) CYP4Cod1 0.00248345 0.00435408 0.00435408
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.00571468 0.0248789 0.0248789
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0339128 0.203994 0.202823
Giardia lamblia 20S proteasome alpha subunit 4 0.0339128 0.203994 0.157868
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0121147 0.0655319 0.0655319
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0339128 0.203994 0.203994
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) polyprenyl synthetase 0.00262956 0.00528216 0.00528216
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.0754882 0.468082 0.468082
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.150499 0.944554 0.944472
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0339128 0.203994 0.203994
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292321 0.0292321
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.00262956 0.00528216 0.00381814
Entamoeba histolytica phospholipase D, putative 0.00985617 0.0511858 0.0497893
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0339128 0.203994 1
Leishmania major proteasome beta 5 subunit, putative 0.159228 1 1
Toxoplasma gondii proteasome subunit beta type, putative 0.159228 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0121147 0.0655319 0.0655319
Leishmania major proteasome beta 2 subunit, putative 0.0339128 0.203994 0.203994
Onchocerca volvulus 0.00571468 0.0248789 0.12139
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0339128 0.203994 0.203994
Plasmodium vivax proteasome subunit beta type-6, putative 0.0339128 0.203994 0.202823
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0104209 0.0547727 0.0533815
Plasmodium vivax proteasome subunit beta type-4, putative 0.0339128 0.203994 0.202823
Trypanosoma brucei C-14 sterol reductase, putative 0.0024567 0.00418414 0.00418414
Loa Loa (eye worm) nuclear receptor NHR-67 0.00571468 0.0248789 0.0248789
Entamoeba histolytica phospholipase D, putative 0.00985617 0.0511858 0.0497893
Echinococcus granulosus Proteasome subunit alpha type 7 0.0339128 0.203994 0.203994
Leishmania major proteasome beta-1 subunit, putative 0.0339128 0.203994 0.203994
Leishmania major proteasome alpha 1 subunit, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.00298369 0.00753159 0.00753159
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Brugia malayi proteasome subunit beta type 1 0.150499 0.944554 0.944554
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0339128 0.203994 0.202823
Brugia malayi ABC transporter family protein 0.00202936 0.00146964 0.00146964
Plasmodium vivax proteasome subunit beta type-5, putative 0.159228 1 1
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0339128 0.203994 0.202823
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292321 0.0292321
Echinococcus multilocularis Nuclear hormone receptor HR96 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) cytochrome P450 family protein 0.00248345 0.00435408 0.00435408
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0339128 0.203994 0.202823
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0339128 0.203994 0.203994
Brugia malayi multidrug resistance protein 3 0.00202936 0.00146964 0.00146964
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.159228 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0843875 0.524611 0.524611
Loa Loa (eye worm) hypothetical protein 0.14701 0.922393 0.922393
Echinococcus granulosus multidrug resistance protein 1 0.00202936 0.00146964 0.00146964
Echinococcus granulosus proteasome subunit beta t family 0.0339128 0.203994 0.203994
Echinococcus granulosus proteasome prosome macropain subunit beta 0.150499 0.944554 0.944554
Toxoplasma gondii heat shock protein hslv, putative 0.0339128 0.203994 0.203994
Brugia malayi proteasome subunit alpha type 1 0.0339128 0.203994 0.203994
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0339128 0.203994 0.203994
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0339128 0.203994 0.157868
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0339128 0.203994 0.203994
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.091819 0.571816 0.571816
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0339128 0.203994 0.203994
Schistosoma mansoni multidrug resistance protein 0.00202936 0.00146964 0.00146964
Loa Loa (eye worm) hypothetical protein 0.00831972 0.0414262 0.0414262
Echinococcus granulosus phospholipase d3 0.00181877 0.000132005 0.000132005
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0339128 0.203994 0.203994
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.091819 0.571816 0.571186
Leishmania major proteasome beta 2 subunit, putative 0.091819 0.571816 0.571816
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0339128 0.203994 0.203994
Mycobacterium ulcerans proteasome PrcA 0.0339128 0.203994 0.203994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292321 0.0292321
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.00571468 0.0248789 0.0248789
Plasmodium falciparum proteasome subunit beta type-5 0.159228 1 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.159228 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0339128 0.203994 0.203994
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00202936 0.00146964 0.00146964
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.00202936 0.00146964 0.00146964
Toxoplasma gondii proteasome beta subunit 0.0339128 0.203994 0.203994
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0196794 0.113583 0.113583
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Brugia malayi Proteasome subunit alpha type 7-1 0.0339128 0.203994 0.203994
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0104209 0.0547727 0.0533815
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0339128 0.203994 0.203994
Giardia lamblia 20S proteasome alpha subunit 6 0.0339128 0.203994 0.157868
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0339128 0.203994 0.203994
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00298369 0.00753159 0.00753159
Loa Loa (eye worm) nuclear receptor nhr-7B 0.00571468 0.0248789 0.0248789
Echinococcus granulosus proteasome subunit alpha type 2 0.0339128 0.203994 0.203994
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.00262956 0.00528216 0.00528216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0121147 0.0655319 0.0655319
Onchocerca volvulus Bile acid receptor homolog 0.0121147 0.0655319 0.320805
Schistosoma mansoni nuclear receptor 0.00571468 0.0248789 0.0248789
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.159228 1 1
Giardia lamblia Proteasome subunit beta type 1 0.150499 0.944554 0.941341
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.150499 0.944554 0.944554
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0339128 0.203994 0.202823
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi C-8 sterol isomerase, putative 0.14701 0.922393 0.922393
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.00262956 0.00528216 0.00528216
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.00298369 0.00753159 0.00753159
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.00262956 0.00528216 0.00528216
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0339128 0.203994 0.203994
Echinococcus multilocularis lamin b receptor 0.0024567 0.00418414 0.00418414
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0339128 0.203994 0.203994
Schistosoma mansoni trans-prenyltransferase 0.00262956 0.00528216 0.00528216
Brugia malayi nuclear hormone receptor 0.00571468 0.0248789 0.0248789
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.00671635 0.0312416 0.0312416
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0339128 0.203994 0.203994
Giardia lamblia 20S proteasome alpha subunit 7 0.0339128 0.203994 0.157868
Toxoplasma gondii proteasome subunit alpha type, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Brugia malayi proteasome subunit alpha type 3 0.0339128 0.203994 0.203994
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0339128 0.203994 0.202823
Trypanosoma cruzi cytochrome P450, putative 0.00248345 0.00435408 0.00435408
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0339128 0.203994 0.203994
Leishmania major proteasome beta 3 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus granulosus thyroid hormone receptor alpha 0.00571468 0.0248789 0.0248789
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.150499 0.944554 0.944554
Brugia malayi conserved hypotetical protein 0.00571468 0.0248789 0.0248789
Brugia malayi Cytochrome P450 family protein 0.00248345 0.00435408 0.00435408
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0339128 0.203994 0.202823
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0339128 0.203994 0.202823
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00202936 0.00146964 0.00146964
Giardia lamblia 20S proteasome alpha subunit 5 0.0339128 0.203994 0.157868
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0339128 0.203994 0.202823
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0339128 0.203994 0.203994
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0339128 0.203994 0.202823
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0339128 0.203994 0.203994
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0339128 0.203994 0.157868
Toxoplasma gondii phospholipase D active site domain-containing protein 0.00335522 0.00989156 0.00989156
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.00671635 0.0312416 0.0312416
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0339128 0.203994 0.157868
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.00262956 0.00528216 0.00528216
Brugia malayi Proteasome A-type and B-type family protein 0.0339128 0.203994 0.203994
Loa Loa (eye worm) proteasome subunit beta type 1 0.150499 0.944554 0.944554
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0339128 0.203994 0.202823
Plasmodium vivax proteasome subunit beta type-1, putative 0.150499 0.944554 0.944472
Giardia lamblia Proteasome subunit beta type 5 precursor 0.159228 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.00571468 0.0248789 0.12139
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0339128 0.203994 0.203994
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0339128 0.203994 0.203994
Leishmania major solanesyl-diphosphate synthase, putative 0.00262956 0.00528216 0.00528216
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0121147 0.0655319 0.0655319
Echinococcus multilocularis nuclear receptor nhr 48 0.00571468 0.0248789 0.0248789
Echinococcus multilocularis thyroid hormone receptor alpha 0.0121147 0.0655319 0.0655319
Trypanosoma brucei proteasome beta 6 subunit 0.150499 0.944554 0.944554
Echinococcus granulosus proteasome subunit beta type 7 0.0339128 0.203994 0.203994
Trypanosoma cruzi sterol C-24 reductase, putative 0.0024567 0.00418414 0.00418414
Trypanosoma cruzi cardiolipin synthetase, putative 0.00335522 0.00989156 0.00989156
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0339128 0.203994 0.203994
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Trypanosoma brucei proteasome subunit beta type-5, putative 0.159228 1 1
Toxoplasma gondii proteasome subunit beta type 2, putative 0.091819 0.571816 0.571816
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.00262956 0.00528216 0.00381814
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0339128 0.203994 0.203994
Echinococcus multilocularis proteasome subunit beta type 7 0.0339128 0.203994 0.203994
Giardia lamblia Proteasome subunit beta type 3 0.0339128 0.203994 0.157868
Trypanosoma cruzi polyprenyl synthase, putative 0.00262956 0.00528216 0.00528216
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Brugia malayi nuclear hormone receptor family member odr-7 0.00571468 0.0248789 0.0248789
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0339128 0.203994 0.202823
Echinococcus granulosus proteasome prosome macropain subunit beta 0.091819 0.571816 0.571816
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292321 0.0292321
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0339128 0.203994 0.203994
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0339128 0.203994 0.202823
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Schistosoma mansoni coup transcription factor 0.0121147 0.0655319 0.0655319
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.00262956 0.00528216 0.00528216
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.00202936 0.00146964 0.00146964
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0339128 0.203994 0.203994
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0104209 0.0547727 0.0547727
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.00671635 0.0312416 0.0312416
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0339128 0.203994 0.203994
Toxoplasma gondii peptidase, T1 family protein 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Brugia malayi Proteasome A-type and B-type family protein 0.0339128 0.203994 0.203994
Toxoplasma gondii proteasome subunit beta type 1, putative 0.150499 0.944554 0.944554
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0339128 0.203994 0.203994
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.00262956 0.00528216 0.00528216
Echinococcus multilocularis proteasome subunit beta type 6 0.0339128 0.203994 0.203994
Echinococcus granulosus ecdysone induced protein 78C 0.0121147 0.0655319 0.0655319
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.091819 0.571816 0.571186
Giardia lamblia 20S proteasome alpha subunit 1 0.0339128 0.203994 0.157868
Brugia malayi Proteasome A-type and B-type family protein 0.0339128 0.203994 0.203994
Trypanosoma brucei proteasome alpha 7 subunit 0.0339128 0.203994 0.203994
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0339128 0.203994 0.203994
Plasmodium falciparum proteasome subunit beta type-1, putative 0.150499 0.944554 0.944472
Brugia malayi nuclear receptor NHR-67 0.00571468 0.0248789 0.0248789
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0339128 0.203994 0.202823
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0196794 0.113583 0.113583
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.00262956 0.00528216 0.00528216
Trypanosoma cruzi Emopamil binding protein, putative 0.0309874 0.185412 0.185412
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121147 0.0655319 0.0655319
Trypanosoma brucei cardiolipin synthetase, putative 0.00335522 0.00989156 0.00989156
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0121147 0.0655319 0.320805
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0339128 0.203994 0.203994
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0339128 0.203994 0.203994
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.00262956 0.00528216 0.00528216
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0339128 0.203994 0.202823
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0121147 0.0655319 0.0655319
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0121147 0.0655319 0.0655319
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.091819 0.571816 0.571816
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Brugia malayi Cytochrome P450 family protein 0.00248345 0.00435408 0.00435408
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Leishmania major C-8 sterol isomerase-like protein 0.14701 0.922393 0.922393
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0339128 0.203994 0.202823
Giardia lamblia 20S proteasome alpha subunit 3 0.0339128 0.203994 0.157868
Schistosoma mansoni voltage-gated potassium channel 0.00328957 0.00947456 0.00947456
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0339128 0.203994 0.202823
Loa Loa (eye worm) DR-78 0.00571468 0.0248789 0.0248789
Echinococcus granulosus FTZ F1 alpha 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi sterol C-24 reductase, putative 0.0024567 0.00418414 0.00418414
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.00650095 0.0298733 0.0298733
Schistosoma mansoni thyroid hormone receptor 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.150499 0.944554 0.944554
Echinococcus multilocularis phospholipase D 0.00877247 0.0443021 0.0443021
Echinococcus multilocularis phospholipase D1 0.00985617 0.0511858 0.0511858
Brugia malayi steroid hormone receptor 0.0121147 0.0655319 0.0655319
Mycobacterium ulcerans proteasome PrcB 0.159228 1 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Onchocerca volvulus Protein ultraspiracle homolog 0.0121147 0.0655319 0.320805
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Schistosoma mansoni phospholipase D 0.00985617 0.0511858 0.0511858
Loa Loa (eye worm) cytochrome P450 family protein 0.00248345 0.00435408 0.00435408
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.159228 1 1
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0339128 0.203994 0.202823
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121147 0.0655319 0.0655319
Echinococcus granulosus Proteasome subunit alpha beta 0.0339128 0.203994 0.203994
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) hypothetical protein 0.0358007 0.215986 0.215986
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0339128 0.203994 0.202823
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0339128 0.203994 0.203994
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0121147 0.0655319 0.0655319
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.00262956 0.00528216 0.00528216
Plasmodium vivax proteasome subunit beta type-2, putative 0.091819 0.571816 0.571186
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0339128 0.203994 0.203994
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0121147 0.0655319 0.0655319
Trypanosoma brucei cardiolipin synthetase 0.00335522 0.00989156 0.00989156
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.0292321 0.0292321
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0104209 0.0547727 0.0533815
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0339128 0.203994 0.202823
Giardia lamblia 20S proteasome alpha subunit 2 0.0339128 0.203994 0.157868
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.150499 0.944554 0.944554
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0339128 0.203994 0.202823
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0339128 0.203994 0.203994
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.00262956 0.00528216 0.00528216
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0339128 0.203994 0.202823
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) hypothetical protein 0.00831972 0.0414262 0.0414262
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0339128 0.203994 0.202823
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0339128 0.203994 0.203994
Brugia malayi nuclear receptor RXR 0.00571468 0.0248789 0.0248789
Echinococcus multilocularis ecdysone induced protein 78C 0.0121147 0.0655319 0.0655319
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.00202936 0.00146964 0.00146964
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0339128 0.203994 0.203994
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0339128 0.203994 0.202823
Brugia malayi nuclear hormone receptor 0.0121147 0.0655319 0.0655319
Onchocerca volvulus Notchless protein homolog 0.0339128 0.203994 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0121147 0.0655319 0.0655319
Brugia malayi Phospholipase D. Active site motif family protein 0.00335522 0.00989156 0.00989156
Brugia malayi ERG2 and Sigma1 receptor like protein 0.14701 0.922393 0.922393
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121147 0.0655319 0.0655319
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00571468 0.0248789 0.0248789
Schistosoma mansoni multidrug resistance protein 0.00202936 0.00146964 0.00146964
Treponema pallidum octaprenyl-diphosphate synthase 0.00262956 0.00528216 0.5
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.159228 1 1
Brugia malayi Proteasome subunit alpha type 1 0.0339128 0.203994 0.203994
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0339128 0.203994 0.203994
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0339128 0.203994 0.203994
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0339128 0.203994 0.203994
Loa Loa (eye worm) nuclear hormone receptor 0.00571468 0.0248789 0.0248789
Brugia malayi Steroid receptor seven-up type 2 0.0121147 0.0655319 0.0655319
Echinococcus granulosus multidrug resistance protein 1 0.00202936 0.00146964 0.00146964
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.00571468 0.0248789 0.0248789
Loa Loa (eye worm) proteasome subunit beta type 2 0.091819 0.571816 0.571816
Schistosoma mansoni voltage-gated potassium channel 0.00328957 0.00947456 0.00947456
Entamoeba histolytica phospholipase D active site domain-containing protein 0.00831972 0.0414262 0.0400154
Brugia malayi orphan nuclear receptor NR2E1 0.00571468 0.0248789 0.0248789
Mycobacterium leprae proteasome (beta subunit) PrcB 0.159228 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.00571468 0.0248789 0.0248789
Echinococcus multilocularis phospholipase d3 0.00181877 0.000132005 0.000132005
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0064 0.0292321 0.0292321
Toxoplasma gondii proteasome subunit alpha1, putative 0.0339128 0.203994 0.203994
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0339128 0.203994 0.203994
Onchocerca volvulus 0.00202936 0.00146964 0.00656147
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0121147 0.0655319 0.0655319
Brugia malayi hypothetical protein 0.00571468 0.0248789 0.0248789
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0309874 0.185412 0.185412
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.159228 1 1
Loa Loa (eye worm) hypothetical protein 0.00202936 0.00146964 0.00146964
Echinococcus multilocularis multidrug resistance protein 1 0.00202936 0.00146964 0.00146964
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00202936 0.00146964 0.00146964
Brugia malayi tailless protein 0.00571468 0.0248789 0.0248789
Leishmania major proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Loa Loa (eye worm) PDE1B protein 0.0196794 0.113583 0.113583
Loa Loa (eye worm) hypothetical protein 0.00571468 0.0248789 0.0248789
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0104209 0.0547727 0.0547727
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0121147 0.0655319 0.0655319
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0339128 0.203994 0.203994
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.00671635 0.0312416 0.0312416
Schistosoma mansoni nuclear receptor nhr-48 0.00571468 0.0248789 0.0248789
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0339128 0.203994 0.202823
Loa Loa (eye worm) hypothetical protein 0.0121147 0.0655319 0.0655319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0121147 0.0655319 0.0655319
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.00262956 0.00528216 0.00528216
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0292321 0.0292321
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00571468 0.0248789 0.0248789
Leishmania major proteasome alpha 3 subunit, putative 0.0339128 0.203994 0.203994
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0339128 0.203994 0.203994
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0339128 0.203994 0.203994
Brugia malayi Polyprenyl synthetase family protein 0.00262956 0.00528216 0.00528216
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0339128 0.203994 0.203994

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 88.7 nM Antimalarial activity against chloroquine-,pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting ChEMBL. 21316974
IC50 (functional) = 138.8 nM Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting ChEMBL. 21316974
IC50 (functional) = 330.1 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting ChEMBL. 21316974

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 21316974

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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