Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0048 | 0.0055 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0283 | 0.0802 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0107 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0033 | 0.0123 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0379 | 0.1107 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0048 | 0.0178 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0169 | 0.2211 | 0.6783 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0107 | 0.04 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0048 | 0.0055 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0169 | 0.2211 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0048 | 0.0178 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 0.099 | 0.2987 |
Mycobacterium ulcerans | thymidylate synthase | 0.0169 | 0.2211 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0169 | 0.2211 | 0.6783 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0379 | 0.1307 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0016 | 0.0107 | 0.0187 |
Leishmania major | cysteine peptidase A (CPA) | 0.0016 | 0.0107 | 0.0187 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0379 | 0.1038 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0379 | 0.1079 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0142 | 0.0529 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0379 | 0.1107 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0107 | 0.0187 |
Echinococcus granulosus | thymidine kinase | 0.0238 | 0.3156 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0269 | 0.0755 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0016 | 0.0107 | 0.0238 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0283 | 0.0802 |
Trypanosoma brucei | thymidine kinase | 0.0244 | 0.3237 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0244 | 0.3237 | 1 |
Giardia lamblia | Thymidine kinase | 0.0244 | 0.3237 | 0.314 |
Entamoeba histolytica | thymidine kinase, putative | 0.0244 | 0.3237 | 1 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0061 | 0.0043 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0379 | 0.1079 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0142 | 0.0348 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0061 | 0.0043 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Onchocerca volvulus | Cathepsin F homolog | 0.0016 | 0.0107 | 0.0245 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.2679 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0142 | 0.0295 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.074 | 0.217 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Onchocerca volvulus | Cathepsin L homolog | 0.0016 | 0.0107 | 0.0245 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.074 | 0.217 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0107 | 0.0281 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0142 | 0.0339 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0379 | 0.1413 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0142 | 0.0348 |
Echinococcus multilocularis | thymidine kinase | 0.0238 | 0.3156 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0016 | 0.0107 | 0.0238 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0016 | 0.0107 | 0.0238 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0061 | 0.0043 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0379 | 0.1038 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0107 | 0.0187 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.074 | 0.217 |
Loa Loa (eye worm) | thymidylate synthase | 0.0169 | 0.2211 | 0.825 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0142 | 0.0295 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.2679 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0327 | 0.0894 |
Entamoeba histolytica | cysteine protease, putative | 0.0016 | 0.0107 | 0.0232 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.074 | 0.217 |
Brugia malayi | thymidylate synthase | 0.0169 | 0.2211 | 0.8229 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0283 | 0.0802 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0379 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0379 | 0.1531 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.074 | 0.217 |
Onchocerca volvulus | 0.0016 | 0.0107 | 0.0245 | |
Trypanosoma cruzi | thymidine kinase, putative | 0.0244 | 0.3237 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0169 | 0.2211 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0283 | 0.0802 |
Echinococcus multilocularis | thymidine kinase | 0.0238 | 0.3156 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0169 | 0.2211 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0049 | 0.0556 | 0.1595 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0283 | 0.0578 |
Echinococcus granulosus | thymidine kinase | 0.0238 | 0.3156 | 1 |
Onchocerca volvulus | 0.0016 | 0.0107 | 0.0245 | |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0142 | 0.0295 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0379 | 0.1079 |
Schistosoma mansoni | thymidine kinase | 0.0238 | 0.3156 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0238 | 0.3156 | 1 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.074 | 0.217 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0081 | 0.099 | 0.2955 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.074 | 0.217 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0107 | 0.0281 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0244 | 0.3237 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.074 | 0.217 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.074 | 0.217 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0142 | 0.0529 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0142 | 0.0435 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0142 | 0.0113 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0283 | 0.0947 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0142 | 0.0435 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0142 | 0.0295 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0107 | 0.0187 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0142 | 0.0295 |
Loa Loa (eye worm) | ctsf protein | 0.0016 | 0.0107 | 0.04 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0244 | 0.3237 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0283 | 0.1058 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0379 | 0.1038 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0142 | 0.0295 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0081 | 0.099 | 0.41 |
Onchocerca volvulus | Cathepsin L homolog | 0.0016 | 0.0107 | 0.0245 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0142 | 0.0348 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.074 | 0.217 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 0.3066 | 0.9467 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0379 | 0.129 |
Onchocerca volvulus | 0.0232 | 0.3066 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0379 | 0.089 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0142 | 0.0113 |
Onchocerca volvulus | 0.0029 | 0.0283 | 0.0826 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0061 | 0.0043 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.074 | 0.217 |
Loa Loa (eye worm) | fibroinase | 0.0016 | 0.0107 | 0.04 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.074 | 0.217 |
Echinococcus multilocularis | thymidylate synthase | 0.0169 | 0.2211 | 0.69 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0142 | 0.0411 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0016 | 0.0107 | 0.04 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0283 | 0.0838 |
Loa Loa (eye worm) | cysteine protease | 0.0016 | 0.0107 | 0.04 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0016 | 0.0107 | 0.0238 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0142 | 0.0348 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0142 | 0.0411 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Leishmania major | thymidine kinase, putative | 0.0244 | 0.3237 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.074 | 0.217 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0107 | 0.0281 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Onchocerca volvulus | 0.0016 | 0.0107 | 0.0245 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0016 | 0.0107 | 0.0238 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0107 | 0.0281 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.0048 | 0.0178 |
Brugia malayi | hypothetical protein | 0.0081 | 0.099 | 0.3616 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0016 | 0.0107 | 0.0281 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0142 | 0.0348 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0169 | 0.2211 | 0.6974 |
Onchocerca volvulus | 0.0016 | 0.0107 | 0.0245 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.074 | 0.217 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0169 | 0.2211 | 0.6783 |
Onchocerca volvulus | 0.0016 | 0.0107 | 0.0245 | |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0107 | 0.0187 |
Onchocerca volvulus | 0.0169 | 0.2211 | 0.718 | |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0033 | 0.0123 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0238 | 0.3156 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0577 | 0.1744 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0016 | 0.0107 | 0.04 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0142 | 0.0295 |
Onchocerca volvulus | 0.0016 | 0.0107 | 0.0245 | |
Onchocerca volvulus | 0.0016 | 0.0107 | 0.0245 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0107 | 0.0281 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0283 | 0.0838 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.074 | 0.217 |
Echinococcus granulosus | thymidylate synthase | 0.0169 | 0.2211 | 0.6974 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0057 | 0.0665 | 0.1937 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0061 | 0.0043 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0169 | 0.2211 | 1 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0142 | 0.0295 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0142 | 0.0113 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.074 | 0.217 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0062 | 0.074 | 0.217 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0283 | 0.0802 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0016 | 0.0107 | 0.0232 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0169 | 0.2211 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0379 | 0.1038 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0107 | 0.0281 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0016 | 0.0107 | 0.0232 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0379 | 0.1079 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.074 | 0.217 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0142 | 0.0339 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0142 | 0.0348 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0142 | 0.0339 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0244 | 0.3237 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0283 | 0.0578 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0379 | 0.1107 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0107 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0033 | 0.0123 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0142 | 0.0295 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | = 48 mg kg-1 | Acute toxicity determined after intravenal administration in mice | ChEMBL. | 3806567 |
LD50 (ADMET) | = 48 mg kg-1 | Acute toxicity determined after intravenal administration in mice | ChEMBL. | 3806567 |
No. of positive cases (functional) | = 4 | Incidence of arrhythmias in rats after a intravenal administration at 4mg/kg, expressed as no. of positive cases out of no. of tested cases (10) | ChEMBL. | 3806567 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.