Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, beta | References | |
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0271962 | 1 | 1 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0175756 | 0.490264 | 0.413741 |
Loa Loa (eye worm) | carboxylesterase | 0.0271962 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0271962 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0271962 | 1 | 1 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.0107861 | 0.130528 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0271962 | 1 | 1 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0175756 | 0.490264 | 0.413741 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0175756 | 0.490264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271962 | 1 | 1 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.0107861 | 0.130528 | 0.26624 |
Brugia malayi | Carboxylesterase family protein | 0.0271962 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0271962 | 1 | 1 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0175756 | 0.490264 | 1 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0175756 | 0.490264 | 0.413741 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0175756 | 0.490264 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0271962 | 1 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0142857 | 0.315952 | 0.515443 |
Echinococcus multilocularis | acetylcholinesterase | 0.0271962 | 1 | 1 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0175756 | 0.490264 | 0.413741 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0271962 | 1 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0175756 | 0.490264 | 1 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0107861 | 0.130528 | 0.5 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0175756 | 0.490264 | 0.413741 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0107861 | 0.130528 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0271962 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0142857 | 0.315952 | 1 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0175756 | 0.490264 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0271962 | 1 | 1 |
Leishmania major | farnesyltransferase beta subunit | 0.0107861 | 0.130528 | 0.5 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0175756 | 0.490264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0175756 | 0.490264 | 0.413741 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0175756 | 0.490264 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.057 uM | Inhibition of human FTase after 15 mins by fluorimetric analysis | ChEMBL. | 21256013 |
IC50 (functional) | = 7.4 uM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs | ChEMBL. | 21256013 |
IC50 (binding) | = 23.9 uM | Inhibition of bee venom phospholipase A2 after 5 mins by spectrophotometric analysis | ChEMBL. | 21256013 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 21256013 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.