Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxycarboxylic acid receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | G-protein coupled receptor, putative | hydroxycarboxylic acid receptor 2 | 363 aa | 294 aa | 20.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | hypothetical protein | 0.482 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.1194 | 0.1885 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0646 | 0.0657 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0646 | 0.0657 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.482 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0646 | 0.0657 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0646 | 0.0657 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0646 | 0.0657 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0646 | 0.0657 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.482 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.098 | 0.1405 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.482 | 1 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.482 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0646 | 0.0657 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.482 | 1 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0646 | 0.0657 | 0.3485 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0646 | 0.0657 | 0.4677 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0646 | 0.0657 | 0.3485 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.482 | 1 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0646 | 0.0657 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.0344 | 0.2446 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.482 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0646 | 0.0657 | 0.4677 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1402 nM | Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation | ChEMBL. | 24900295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.