Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.3277 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.3277 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3277 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.3277 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3277 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3277 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.3277 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3277 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3277 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3277 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3277 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3277 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 8 mm | Antimicrobial activity against Saccharomyces cerevisiae MTCC 171 at 100 ug/ml after 24 to 96 hrs by agar cup method | ChEMBL. | 21211971 |
IZ (functional) | = 12 mm | Antimicrobial activity against Candida albicans MTCC 227 at 100 ug/ml after 24 to 96 hrs by agar cup method | ChEMBL. | 21211971 |
MIC (functional) | = 12.5 ug ml-1 | Antimicrobial activity against Escherichia coli MTCC 443 after 24 hrs by broth dilution method | ChEMBL. | 21211971 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.