Detailed information for compound 1503740

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 321.385 | Formula: C17H17F2NOS
  • H donors: 0 H acceptors: 1 LogP: 3.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)CSC(c1ccc(cc1)F)c1ccc(cc1)F)C
  • InChi: 1S/C17H17F2NOS/c1-20(2)16(21)11-22-17(12-3-7-14(18)8-4-12)13-5-9-15(19)10-6-13/h3-10,17H,11H2,1-2H3
  • InChiKey: NLRWOEZSKHEPLZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus High affinity copper uptake protein 1 homolog Dopamine transporter   619 aa 599 aa 44.2 %
Brugia malayi Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 578 aa 33.4 %
Echinococcus multilocularis sodium and chloride dependent glycine Dopamine transporter   619 aa 599 aa 41.9 %
Onchocerca volvulus Transmembrane protein 120 homolog Dopamine transporter   619 aa 578 aa 32.9 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Dopamine transporter   619 aa 551 aa 39.9 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Dopamine transporter   619 aa 557 aa 23.9 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Dopamine transporter   619 aa 522 aa 36.0 %
Neospora caninum sodium-dependent transporter, putative Dopamine transporter   619 aa 498 aa 32.3 %
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Dopamine transporter   619 aa 604 aa 37.9 %
Plasmodium vivax hypothetical protein, conserved Dopamine transporter   619 aa 657 aa 20.1 %
Schistosoma mansoni sodium/chloride dependent transporter Dopamine transporter   619 aa 558 aa 41.8 %
Onchocerca volvulus Dopamine transporter   619 aa 612 aa 23.5 %
Schistosoma mansoni sodium/chloride dependent transporter Dopamine transporter   619 aa 588 aa 40.3 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Dopamine transporter   619 aa 509 aa 40.1 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 578 aa 32.9 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 636 aa 31.8 %
Echinococcus granulosus sodium and chloride dependent glycine Dopamine transporter   619 aa 594 aa 41.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0019 0.0071 0.0073
Echinococcus multilocularis integrin alpha ps 0.0222 0.2241 0.2391
Loa Loa (eye worm) hypothetical protein 0.0028 0.0171 0.0214
Loa Loa (eye worm) hypothetical protein 0.0043 0.0332 0.0415
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0004
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0889 0.9361 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0171 0.3435
Giardia lamblia High cysteine protein 0.0025 0.0135 0.014
Toxoplasma gondii hypothetical protein 0.0019 0.0071 0.1356
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.0162
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0013 0.0007 0.0004
Schistosoma mansoni integrin alpha 0.0222 0.2241 0.2238
Loa Loa (eye worm) hypothetical protein 0.0138 0.135 0.169
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0889 0.9361 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0109 0.1042 0.1301
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0129 0.0135
Plasmodium vivax JmjC domain containing protein 0.0028 0.0171 0.463
Schistosoma mansoni hypothetical protein 0.035 0.3612 0.361
Loa Loa (eye worm) serotonin transporter b 0.0109 0.1042 0.1304
Onchocerca volvulus 0.0043 0.0332 0.2037
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.002 0.0018
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0129 0.0135
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0147 0.0153
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0071 0.0068
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.0071 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.002 0.011
Mycobacterium ulcerans beta-lactamase 0.0024 0.0129 0.2619
Schistosoma mansoni DNA helicase recq5 0.0013 0.0007 0.0004
Onchocerca volvulus 0.0024 0.0129 0.0451
Schistosoma mansoni Smad4 0.0013 0.0014 0.0011
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.002 0.0344
Loa Loa (eye worm) hypothetical protein 0.0208 0.209 0.2617
Loa Loa (eye worm) hypothetical protein 0.002 0.0086 0.0108
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0008
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0085 0.1645
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.0169
Schistosoma mansoni hypothetical protein 0.0093 0.0868 0.0865
Onchocerca volvulus 0.0042 0.0325 0.1986
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0484 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.002 0.011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0425 0.0532
Schistosoma mansoni hypothetical protein 0.0031 0.0204 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0889 0.9361 1
Mycobacterium leprae Probable lipase LipE 0.0024 0.0129 1
Echinococcus multilocularis bloom syndrome protein 0.0013 0.0007 0.0004
Onchocerca volvulus 0.0109 0.1042 0.7591
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0334 0.0353
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.002 0.0344
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0129 0.0135
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0071 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.012 0.1156 0.1153
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.002 0.0344
Schistosoma mansoni smad1 5 8 and 0.0013 0.0014 0.0011
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0889 0.9361 1
Giardia lamblia High cysteine protein 0.0025 0.0135 0.014
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.002 0.0344
Loa Loa (eye worm) hypothetical protein 0.0116 0.1106 0.1385
Brugia malayi Kelch motif family protein 0.0116 0.1106 0.1381
Echinococcus multilocularis serotonin transporter 0.0109 0.1042 0.111
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.0071 0.0068
Echinococcus granulosus integrin alpha 3 0.0106 0.1008 0.1074
Leishmania major cytochrome p450-like protein 0.0014 0.002 0.0018
Brugia malayi cytochrome P450 0.0014 0.002 0.0021
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0889 0.9361 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.0071 0.0068
Brugia malayi beta-lactamase family protein 0.0024 0.0129 0.0158
Plasmodium falciparum ataxin-2 like protein, putative 0.0039 0.0286 1
Echinococcus multilocularis musashi 0.0043 0.0332 0.0351
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0484 0.0481
Echinococcus granulosus adam 0.0025 0.0135 0.014
Toxoplasma gondii ABC1 family protein 0.0024 0.0129 0.2565
Plasmodium falciparum amino acid transporter, putative 0.0019 0.0071 0.2318
Giardia lamblia Tenascin-like 0.0025 0.0135 0.014
Echinococcus granulosus bloom syndrome protein 0.0013 0.0007 0.0004
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0017 0.0058 0.0059
Loa Loa (eye worm) norepinephrine transporter 0.0109 0.1042 0.1304
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0019 0.0071 0.5
Brugia malayi Bromodomain containing protein 0.0031 0.0204 0.0252
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0024 0.0129 0.0836
Brugia malayi Integrin alpha pat-2 precursor 0.0222 0.2241 0.2803
Brugia malayi Muscleblind-like protein 0.0182 0.1819 0.2274
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0071 0.0068
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0484 0.0481
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.002 0.0344
Echinococcus granulosus smad 0.0013 0.0014 0.0012
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0013 0.0007 0.0008
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0013 0.0007 0.0004
Echinococcus multilocularis neuropeptide receptor A26 0.0292 0.2992 0.3194
Schistosoma mansoni sodium-dependent amino acid transporter 0.0019 0.0071 0.0068
Brugia malayi EGF-like domain containing protein 0.0025 0.0135 0.0165
Echinococcus multilocularis adam 0.0025 0.0135 0.014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.012 0.1156 0.1232
Echinococcus granulosus muscleblind protein 0.0182 0.1819 0.194
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0043 0.0334 0.0353
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0171 0.0179
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0085 0.0088
Brugia malayi hypothetical protein 0.0116 0.1106 0.1381
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.0071 0.0073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0484 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0169 0.1672 0.1784
Loa Loa (eye worm) hypothetical protein 0.0028 0.0175 0.0219
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0043 0.0334 0.0414
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0204 0.0215
Toxoplasma gondii hypothetical protein 0.0025 0.0135 0.2679
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0171 0.0168
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0171 0.0214
Schistosoma mansoni hypothetical protein 0.0889 0.9361 0.9361
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.002 0.0344
Entamoeba histolytica DNA repair and recombination protein, putative 0.0889 0.9361 1
Echinococcus granulosus neuropeptide receptor A26 0.0292 0.2992 0.3194
Loa Loa (eye worm) Smad1 0.0013 0.0014 0.0018
Giardia lamblia Sgs1 DNA helicase, putative 0.0013 0.0007 0.0004
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0171 0.3435
Onchocerca volvulus 0.0024 0.0129 0.0451
Trypanosoma cruzi PAB1-binding protein , putative 0.0039 0.0286 0.0302
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0171 0.0179
Schistosoma mansoni smad1 5 8 and 0.0013 0.0014 0.0011
Loa Loa (eye worm) MH1 domain-containing protein 0.0013 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0093 0.0868 0.1087
Leishmania major cytochrome p450-like protein 0.0014 0.002 0.0018
Schistosoma mansoni integrin beta subunit 0.0448 0.4651 0.4649
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.002 0.011
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.0071 0.0089
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.0071 0.0068
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0012 0.0003 0.0004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0153 0.1509 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0136 0.1329 0.1663
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0019 0.0071 0.0085
Giardia lamblia Neurogenic locus notch-like protein 0.0025 0.0135 0.014
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0106 0.1008 0.1259
Echinococcus granulosus neuropeptide s receptor 0.0292 0.2992 0.3194
Brugia malayi jmjC domain containing protein 0.0028 0.0171 0.021
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0204 0.0256
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0109 0.1042 0.1039
Brugia malayi beta-lactamase 0.0024 0.0129 0.0158
Loa Loa (eye worm) intermediate filament protein 0.0043 0.0332 0.0415
Brugia malayi Integrin beta pat-3 precursor 0.076 0.7987 1
Schistosoma mansoni smad1 5 8 and 0.0013 0.0014 0.0011
Brugia malayi hypothetical protein 0.0138 0.135 0.1686
Brugia malayi hypothetical protein 0.0019 0.0071 0.0085
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.0162
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0171 0.0168
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0889 0.9361 1
Brugia malayi Cytochrome P450 family protein 0.0026 0.0147 0.018
Loa Loa (eye worm) hypothetical protein 0.0116 0.1106 0.1385
Echinococcus multilocularis lamin dm0 0.0043 0.0332 0.0351
Loa Loa (eye worm) solute carrier family 6 member 4 0.0109 0.1042 0.1304
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.0162
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0889 0.9361 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.002 0.011
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.002 0.011
Loa Loa (eye worm) transcription factor SMAD2 0.0194 0.1945 0.2435
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.012 0.1156 0.1153
Echinococcus multilocularis geminin 0.035 0.3612 0.3857
Echinococcus granulosus fibrillin 2 0.0025 0.0135 0.014
Trypanosoma brucei PAB1-binding protein , putative 0.0039 0.0286 0.0302
Loa Loa (eye worm) apoptosis regulator protein 0.0052 0.0425 0.0532
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0019 0.0071 0.0073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0484 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0052 0.0425 0.0451
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0089
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0147 0.0184
Trichomonas vaginalis esterase, putative 0.0024 0.0129 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.002 0.011
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0071 0.0068
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0171 0.0168
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0171 0.0179
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0024 0.0129 0.0158
Echinococcus granulosus geminin 0.035 0.3612 0.3857
Echinococcus granulosus serotonin transporter 0.0109 0.1042 0.111
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0007 0.0004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0071 0.0068
Echinococcus multilocularis dna polymerase eta 0.0028 0.0175 0.0184
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0405
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0171 0.0168
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0071 0.0068
Plasmodium vivax ataxin-2 like protein, putative 0.0039 0.0286 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.012 0.1156 0.1444
Brugia malayi jmjC domain containing protein 0.0028 0.0171 0.021
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.0071 0.0073
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0129 0.0126
Loa Loa (eye worm) hypothetical protein 0.002 0.0086 0.0108
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0171 0.0179
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0013 0.0007 0.0004
Echinococcus granulosus survival motor neuron protein 1 0.0208 0.209 0.223
Brugia malayi Cytochrome P450 family protein 0.0038 0.0277 0.0343
Loa Loa (eye worm) hypothetical protein 0.0136 0.1329 0.1663
Brugia malayi PHD-finger family protein 0.0031 0.0204 0.0252
Echinococcus multilocularis GPCR, family 2 0.0043 0.0334 0.0353
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0731 0.7669 0.8192
Echinococcus granulosus phd:f box containing protein 0.0028 0.0171 0.0179
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0171 0.5875
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.002 0.0344
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0024 0.0129 0.0162
Brugia malayi Smad1 0.0013 0.0014 0.0014
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0007 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0557 0.0697
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.002 0.011
Echinococcus granulosus integrin alpha ps 0.0106 0.1008 0.1074
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0116 0.1106 0.1385
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.002 0.0018
Schistosoma mansoni hypothetical protein 0.035 0.3612 0.361
Echinococcus multilocularis fibrillin 1 0.0025 0.0135 0.014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0118
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0129 0.0135
Echinococcus granulosus integrin alpha ps 0.0222 0.2241 0.2391
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0043 0.0334 0.0353
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0129 0.0126
Echinococcus granulosus integrin beta 2 0.0563 0.5884 0.6284
Giardia lamblia Tenascin precursor 0.0025 0.0135 0.014
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0021 0.0094 0.0097
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0171 0.0179
Echinococcus granulosus lamin dm0 0.0043 0.0332 0.0351
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0147 0.2983
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.002 0.0344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.012 0.1156 0.1153
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.0071 0.1356
Brugia malayi Cytochrome P450 family protein 0.0014 0.002 0.0021
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0171 0.0179
Echinococcus granulosus mothers against decapentaplegic 5 0.0013 0.0014 0.0012
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0019 0.0071 0.0073
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.002 0.0344
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0057 0.0484 0.0514
Leishmania major DNA polymerase eta, putative 0.0028 0.0175 0.0184
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0013 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0106 0.1008 0.1262
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0129 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0171 0.0214
Onchocerca volvulus Alhambra homolog 0.0031 0.0204 0.1038
Mycobacterium tuberculosis Probable lipase LipD 0.0024 0.0129 0.0836
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.002 0.0344
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0071 0.0085
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0023 0.0119 0.0149
Brugia malayi hypothetical protein 0.0039 0.0286 0.0354
Toxoplasma gondii hypothetical protein 0.0019 0.0071 0.1356
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0171 0.0179
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0204 0.6187
Schistosoma mansoni hypothetical protein 0.0017 0.0058 0.0055
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0057 0.0484 0.3193
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.002 0.0018
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0889 0.9361 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0171 0.0214
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0052 0.0425 0.0528
Schistosoma mansoni hypothetical protein 0.0106 0.1008 0.1005
Mycobacterium tuberculosis Probable lipase LipE 0.0024 0.0129 0.0836
Loa Loa (eye worm) hypothetical protein 0.0071 0.0631 0.079
Brugia malayi MH2 domain containing protein 0.0013 0.0014 0.0014
Toxoplasma gondii aldehyde dehydrogenase 0.0057 0.0484 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.002 0.011
Schistosoma mansoni intermediate filament proteins 0.0043 0.0332 0.0329
Loa Loa (eye worm) MH2 domain-containing protein 0.0013 0.0014 0.0018
Schistosoma mansoni lamin 0.0043 0.0332 0.0329
Trypanosoma cruzi PAB1-binding protein , putative 0.0039 0.0286 0.0302
Mycobacterium ulcerans hypothetical protein 0.0024 0.0129 0.2619
Brugia malayi MH2 domain containing protein 0.0013 0.0014 0.0014
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0024 0.0129 0.0836
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0171 0.0214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0089
Echinococcus multilocularis smad 0.0013 0.0014 0.0012
Trichomonas vaginalis DNA helicase recq1, putative 0.0013 0.0007 0.0004
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0171 0.0179
Toxoplasma gondii LsmAD domain-containing protein 0.0039 0.0286 0.5847
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0019 0.0071 0.0073
Echinococcus multilocularis 0.0014 0.002 0.0018
Schistosoma mansoni survival motor neuron protein 0.0042 0.0325 0.0322
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0004
Echinococcus multilocularis survival motor neuron protein 1 0.0208 0.209 0.223
Brugia malayi EGF-like domain containing protein 0.0025 0.0135 0.0165
Giardia lamblia Tenascin-37 0.0025 0.0135 0.014
Loa Loa (eye worm) jmjC domain-containing protein 0.0105 0.0989 0.1238
Echinococcus multilocularis muscleblind protein 0.0182 0.1819 0.194
Brugia malayi EGF-like domain containing protein 0.0025 0.0135 0.0165
Trypanosoma cruzi DNA polymerase eta, putative 0.0028 0.0175 0.0184
Schistosoma mansoni DNA helicase recq1 0.0013 0.0007 0.0004
Brugia malayi Intermediate filament tail domain containing protein 0.0043 0.0332 0.0412
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.012 0.1156 0.1232
Brugia malayi MH1 domain containing protein 0.0013 0.0014 0.0014
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.002 0.0344
Schistosoma mansoni DNA polymerase eta 0.0028 0.0175 0.0172
Schistosoma mansoni jumonji domain containing protein 0.0148 0.145 0.1447
Brugia malayi latrophilin 2 splice variant baaae 0.0093 0.0868 0.1083
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0889 0.9361 1
Plasmodium falciparum transporter, putative 0.0019 0.0071 0.2318
Schistosoma mansoni hypothetical protein 0.0042 0.0325 0.0322
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0071 0.0085
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0889 0.9361 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.0071 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0089
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0013 0.0007 0.0004
Giardia lamblia Tenascin-X 0.0025 0.0135 0.014
Echinococcus granulosus peregrin 0.0031 0.0204 0.0215
Schistosoma mansoni hypothetical protein 0.0043 0.0334 0.033
Loa Loa (eye worm) hypothetical protein 0.0182 0.1819 0.2278
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.002 0.0018
Brugia malayi hypothetical protein 0.0208 0.209 0.2614
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.002 0.011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.012 0.1156 0.1232
Leishmania major hypothetical protein, conserved 0.0028 0.0171 0.0179
Schistosoma mansoni jumonji/arid domain-containing protein 0.0105 0.0989 0.0986
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0277 0.0347
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0089
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.0071 0.0089
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.002 0.011
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0204 0.4134
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.0325 0.0403
Mycobacterium ulcerans lipase LipD 0.0024 0.0129 0.2619
Loa Loa (eye worm) hypothetical protein 0.0043 0.0334 0.0418
Loa Loa (eye worm) RecQ helicase 0.0013 0.0007 0.0008
Schistosoma mansoni cytochrome P450 0.0014 0.002 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.002 0.011
Schistosoma mansoni sodium/chloride dependent transporter 0.0109 0.1042 0.1039
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0013 0.0007 0.0000000012754
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.002 0.011
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0024 0.0129 0.2619
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.0169
Schistosoma mansoni smad 0.0013 0.0014 0.0011
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0007 0.0004
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0204 0.0256
Mycobacterium tuberculosis Probable hydrolase 0.0024 0.0129 0.0836
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0013 0.0014 0.0011
Giardia lamblia hypothetical protein 0.0025 0.0135 0.014
Loa Loa (eye worm) integrin alpha pat-2 0.0222 0.2241 0.2806
Entamoeba histolytica hypothetical protein, conserved 0.0889 0.9361 1
Onchocerca volvulus 0.0024 0.0129 0.0451
Schistosoma mansoni integrin alpha-ps 0.0116 0.1106 0.1103
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.002 0.0344
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0013 0.0014 0.0012
Echinococcus multilocularis protein jagged 2 0.0025 0.0135 0.014
Loa Loa (eye worm) hypothetical protein 0.0109 0.1042 0.1304
Schistosoma mansoni hypothetical protein 0.0043 0.0334 0.033
Echinococcus granulosus lysine specific demethylase 5A 0.0105 0.0989 0.1054
Leishmania major DNA polymerase eta, putative 0.002 0.0085 0.0088
Leishmania major cytochrome p450-like protein 0.0026 0.0147 0.0153
Loa Loa (eye worm) hypothetical protein 0.0182 0.1819 0.2278
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0171 0.0179
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.002 0.011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.0162
Echinococcus granulosus Smad4 0.0013 0.0014 0.0012
Mycobacterium tuberculosis Conserved protein 0.0024 0.0129 0.0836
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0147 0.0153
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0171 0.0179
Loa Loa (eye worm) latrophilin receptor protein 2 0.0043 0.0334 0.0418
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.002 0.0344
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.002 0.011
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0147 0.0153
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0129 0.0135
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0057 0.0484 0.0514
Giardia lamblia Rrm3p helicase 0.0889 0.9361 1
Brugia malayi beta-lactamase family protein 0.0024 0.0129 0.0158
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.0162
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0204 0.0201
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0043 0.0334 0.0353
Schistosoma mansoni hypothetical protein 0.0052 0.0425 0.0422
Echinococcus multilocularis lamin 0.0043 0.0332 0.0351
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0043 0.0332 0.0415
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.0071 0.0073
Schistosoma mansoni hypothetical protein 0.0052 0.0425 0.0422
Leishmania major hypothetical protein, conserved 0.0024 0.0129 0.0135
Schistosoma mansoni lamin 0.0043 0.0332 0.0329
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0017 0.0058 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0129 0.0135
Schistosoma mansoni hypothetical protein 0.0043 0.0334 0.033
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0025 0.0135 0.014
Giardia lamblia Neurogenic locus Notch protein precursor 0.0025 0.0135 0.014
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0204 0.0215
Echinococcus multilocularis lysine specific demethylase 5A 0.0105 0.0989 0.1054
Brugia malayi ImpB/MucB/SamB family protein 0.0028 0.0175 0.0215
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0013 0.0007 0.0004
Plasmodium falciparum phd finger protein, putative 0.0031 0.0204 0.7071
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.0071 0.1356
Loa Loa (eye worm) hypothetical protein 0.0116 0.1106 0.1385
Brugia malayi Bloom's syndrome protein homolog 0.0013 0.0007 0.0004
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0147 0.0184
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.0169
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0204 0.4134
Brugia malayi MH2 domain containing protein 0.0194 0.1945 0.2432
Echinococcus granulosus TGF beta signal transducer SmadC 0.0013 0.0014 0.0012
Echinococcus granulosus fibrillin 1 0.0025 0.0135 0.014
Leishmania major hypothetical protein, conserved 0.0039 0.0286 0.0302
Onchocerca volvulus 0.0043 0.0332 0.2037
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.002 0.011
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0019 0.0071 0.0073
Echinococcus granulosus intermediate filament protein 0.0043 0.0332 0.0351
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.002 0.011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0024 0.0129 0.0135
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.002 0.0273
Plasmodium falciparum ataxin-2 like protein, putative 0.0039 0.0286 1
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0129 0.2692
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0052 0.0425 0.0451
Echinococcus multilocularis muscleblind protein 1 0.0182 0.1819 0.194
Brugia malayi Latrophilin receptor protein 2 0.0043 0.0334 0.0414
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0089
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.002 0.0344
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0089
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0171 0.0179
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.012 0.1156 0.1448
Trypanosoma brucei DNA polymerase eta, putative 0.0028 0.0175 0.0184
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.002 0.0344
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.0071 0.0073
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0043 0.0334 0.0353
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.002 0.011
Brugia malayi EGF-like domain containing protein 0.0025 0.0135 0.0165
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0057 0.0484 0.0514
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.0071 0.1356
Brugia malayi Calcitonin receptor-like protein seb-1 0.0136 0.1329 0.166
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0089
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0052 0.0425 0.0451
Schistosoma mansoni hypothetical protein 0.0052 0.0425 0.0422
Echinococcus multilocularis integrin beta 2 0.0563 0.5884 0.6284
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.012 0.1156 0.1232
Echinococcus multilocularis peregrin 0.0031 0.0204 0.0215
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.0071 0.0073
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.002 0.0344
Mycobacterium tuberculosis Conserved protein 0.0024 0.0129 0.0836
Echinococcus multilocularis neuropeptide s receptor 0.0292 0.2992 0.3194
Echinococcus granulosus dna polymerase eta 0.0028 0.0175 0.0184
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0358
Mycobacterium tuberculosis Conserved protein 0.0024 0.0129 0.0836
Loa Loa (eye worm) hypothetical protein 0.0109 0.1042 0.1304
Echinococcus multilocularis integrin alpha 3 0.0106 0.1008 0.1074
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.002 0.0344
Echinococcus granulosus beta LACTamase domain containing family member 0.0024 0.0129 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.002 0.011
Echinococcus multilocularis integrin alpha ps 0.0106 0.1008 0.1074
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0052 0.0425 0.0422
Echinococcus granulosus GPCR family 2 0.0043 0.0334 0.0353
Brugia malayi jmjC domain containing protein 0.0105 0.0989 0.1235
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0129 0.0135
Onchocerca volvulus 0.0138 0.135 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.002 0.011
Brugia malayi jmjC domain containing protein 0.0169 0.1672 0.2091
Loa Loa (eye worm) beta-lactamase 0.0024 0.0129 0.0162
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0071 0.0068
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.0169
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.0162
Schistosoma mansoni apoptosis regulator bax 0.0052 0.0425 0.0422
Echinococcus multilocularis mothers against decapentaplegic 5 0.0013 0.0014 0.0012
Brugia malayi cytoplasmic intermediate filament protein 0.0023 0.0119 0.0145
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0129 0.0135
Loa Loa (eye worm) integrin beta-2 0.076 0.7987 1
Schistosoma mansoni integrin alpha-ps 0.0222 0.2241 0.2238
Echinococcus multilocularis fibrillin 2 0.0025 0.0135 0.014
Brugia malayi hypothetical protein 0.0025 0.014 0.0171
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.002 0.0344
Treponema pallidum sodium- and chloride- dependent transporter 0.0109 0.1042 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0194 0.1945 0.2435
Brugia malayi jmjC domain containing protein 0.0028 0.0171 0.021
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0171 0.0168
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0052 0.0425 0.0451
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.002 0.011
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0169 0.1672 0.1784
Brugia malayi MH1 domain containing protein 0.0013 0.0014 0.0014
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0171 0.0179
Brugia malayi intermediate filament protein 0.0043 0.0332 0.0412
Giardia lamblia PHD finger protein 15 0.0031 0.0204 0.0215
Schistosoma mansoni jumonji/arid domain-containing protein 0.0105 0.0989 0.0986
Mycobacterium tuberculosis Probable esterase LipL 0.0024 0.0129 0.0836
Brugia malayi jmjC domain containing protein 0.0028 0.0171 0.021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0136 0.1329 0.166
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0021 0.0094 0.0097
Echinococcus granulosus lamin 0.0043 0.0332 0.0351
Loa Loa (eye worm) hypothetical protein 0.0109 0.1042 0.1304
Echinococcus multilocularis integrin alpha ps 0.0222 0.2241 0.2391
Echinococcus multilocularis Smad4 0.0013 0.0014 0.0012
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0334 0.0353
Loa Loa (eye worm) cytochrome P450 0.0014 0.002 0.0025
Schistosoma mansoni hypothetical protein 0.0043 0.0334 0.033
Schistosoma mansoni hypothetical protein 0.0014 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0106 0.1008 0.1262
Mycobacterium ulcerans esterase/lipase LipP 0.0024 0.0129 0.2619
Brugia malayi Cytochrome P450 family protein 0.0026 0.0147 0.018
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0147 0.0184
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.002 0.0344
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0024 0.0129 0.0836
Onchocerca volvulus 0.0025 0.0135 0.0494
Trichomonas vaginalis hypothetical protein 0.0025 0.0135 0.014
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.002 0.0344

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat brain membranes at 10 uM ChEMBL. 21344069
Ki (binding) = 9510 nM Displacement of [3H]WIN35428 from DAT in Sprague-Dawley rat brain membranes ChEMBL. 21344069
Ki (binding) = 25900 nM Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brain membranes ChEMBL. 21344069

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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