Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA repair and recombination protein rad54-related | 0.0007 | 0.0273 | 0.0273 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0048 | 0.2862 | 1 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0035 | 0.202 | 0.1796 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0035 | 0.202 | 0.1796 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0048 | 0.2862 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0048 | 0.2862 | 0.2662 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0035 | 0.202 | 0.6748 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0273 | 0.0002 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0035 | 0.202 | 0.6748 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0048 | 0.2862 | 0.2662 |
Trypanosoma brucei | protein kinase, putative | 0.0048 | 0.2862 | 1 |
Schistosoma mansoni | DNA repair and recombination protein rad54-related | 0.0007 | 0.0273 | 0.0273 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0048 | 0.2862 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0048 | 0.2862 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0048 | 0.2862 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0048 | 0.2862 | 0.2662 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0048 | 0.2862 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0035 | 0.202 | 0.1796 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0048 | 0.2862 | 1 |
Echinococcus multilocularis | geminin | 0.0158 | 1 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0035 | 0.202 | 0.6748 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0035 | 0.202 | 0.1796 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 1 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0035 | 0.202 | 0.202 |
Plasmodium falciparum | DNA repair and recombination protein RAD54, putative | 0.0007 | 0.0273 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0048 | 0.2862 | 0.2862 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0035 | 0.202 | 0.6748 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0048 | 0.2862 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0048 | 0.2862 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0035 | 0.202 | 0.1796 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0048 | 0.2862 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0035 | 0.202 | 0.6748 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0048 | 0.2862 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0273 | 0.0002 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0048 | 0.2862 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0035 | 0.202 | 0.1796 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0048 | 0.2862 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0048 | 0.2862 | 1 |
Plasmodium vivax | DNA repair protein RAD54, putative | 0.0007 | 0.0273 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0048 | 0.2862 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.202 | 0.6748 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0035 | 0.202 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0035 | 0.202 | 0.202 |
Loa Loa (eye worm) | type III restriction enzyme | 0.0007 | 0.0273 | 0.0002 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0048 | 0.2862 | 0.2662 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 30 % | Percent inhibition of [3H]-flunitrazepam binding to GABA-A Benzodiazepine receptor of bovine brain membranes at 34 uM | ChEMBL. | 2167984 |
Inhibition (binding) | = 30 % | Percent inhibition of [3H]-flunitrazepam binding to GABA-A Benzodiazepine receptor of bovine brain membranes at 34 uM | ChEMBL. | 2167984 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.