Detailed information for compound 150385

Basic information

Technical information
  • TDR Targets ID: 150385
  • Name: 2-(3,4-dimethoxyphenyl)-5,7-dimethoxychromen- 4-one
  • MW: 342.343 | Formula: C19H18O6
  • H donors: 0 H acceptors: 1 LogP: 3.07 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c2c(c1)oc(cc2=O)c1ccc(c(c1)OC)OC
  • InChi: 1S/C19H18O6/c1-21-12-8-17(24-4)19-13(20)10-15(25-18(19)9-12)11-5-6-14(22-2)16(7-11)23-3/h5-10H,1-4H3
  • InChiKey: CLXVBVLQKLQNRQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-chromen-4-one
  • 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-1-benzopyran-4-one
  • 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-chromone
  • 5,7,3',4'-tetramethylluteolin
  • 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4-chromenone
  • 855-97-0
  • Luteolin tetramethylether
  • 2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-4H-1-benzopyran-4-one
  • 3',4',5,7-Tetramethoxyflavone
  • 3',4',5,7-Tetramethyl-luteolin
  • 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-
  • Tetramethoxyluteolin
  • ZINC01081533
  • ST5309218

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Plasmodium falciparum thioredoxin reductase 0.0044 0.028 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0046 0.002
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0211 0.0211
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0285 0.0285
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.02 0.4393
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0143 0.6743
Loa Loa (eye worm) hypothetical protein 0.0035 0.0211 0.108
Schistosoma mansoni dep domain containing protein 0.001 0.0006 0.0006
Brugia malayi Pre-SET motif family protein 0.0035 0.0211 0.108
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0105 0.0105
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0105 0.0059
Giardia lamblia DINP protein human, muc B family 0.0022 0.0105 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Entamoeba histolytica DNA repair and recombination protein, putative 0.1232 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.02 0.0174
Brugia malayi Pre-SET motif family protein 0.0242 0.1898 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0096 0.0709 0.0709
Plasmodium falciparum glutathione reductase 0.0044 0.028 1
Mycobacterium ulcerans hypothetical protein 0.0184 0.1428 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.01
Echinococcus granulosus dna polymerase kappa 0.0022 0.0105 0.0105
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0105 0.0561
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.2781 0.2748
Echinococcus granulosus cpg binding protein 0.0035 0.0209 0.0209
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.01 0.0739 0.5084
Schistosoma mansoni ap endonuclease 0.0022 0.01 0.01
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0025 0.0025
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.2781 0.2748
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0194 0.0992
Entamoeba histolytica hypothetical protein 0.0027 0.0143 0.0118
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0046 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0285 0.0285
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.1898 1
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0006 0.0006
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.01 0.0074
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0046 0.0787
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0046 0.002
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0046 0.002
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0951 0.0927
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0046 0.0906
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0105 0.0561
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0111 0.083 0.5735
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.01 0.0054
Toxoplasma gondii exonuclease III APE 0.0022 0.01 0.2128
Trypanosoma brucei unspecified product 0.0022 0.0105 0.0059
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.01 0.0739 0.7373
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0046 0.0046
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0105 0.0059
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0046 0.0787
Trypanosoma brucei unspecified product 0.0015 0.0048 0.0002
Giardia lamblia Rrm3p helicase 0.1232 1 1
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0033 0.019 0.0969
Toxoplasma gondii thioredoxin reductase 0.0044 0.028 0.6208
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0509 0.0509
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.0951 0.0951
Echinococcus granulosus microtubule associated protein 2 0.0799 0.6455 0.6455
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.01 0.01
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.1232 1 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0013 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.02 0.0174
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.02 0.0174
Loa Loa (eye worm) phosphofructokinase 0.0126 0.0951 0.4994
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.01 0.0739 0.5084
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.02 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0017 0.0017
Trichomonas vaginalis set domain proteins, putative 0.0275 0.2171 0.215
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0211 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.01 0.0496
Trypanosoma brucei mitochondrial DNA polymerase beta 0.035 0.2781 0.2748
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0046 0.0046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.1428 1
Trichomonas vaginalis conserved hypothetical protein 0.1232 1 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0209 0.1631 0.7508
Echinococcus multilocularis cpg binding protein 0.0035 0.0209 0.0209
Brugia malayi multidrug resistance protein 3 0.0013 0.0026 0.0106
Echinococcus multilocularis dna polymerase eta 0.0022 0.0105 0.0105
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0006 0.0006
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0046 0.0787
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0324 0.0279
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0111 0.083 0.5735
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0951 0.0927
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.02 0.0174
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0026 0.0106
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0209 0.1631 0.8588
Leishmania major trypanothione reductase 0.0044 0.028 0.0255
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0026 0.0026
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.0951 0.4994
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1275 0.1235
Schistosoma mansoni regulator of G protein signaling 0.001 0.0006 0.0006
Leishmania major DNA polymerase kappa, putative 0.0022 0.0105 0.0079
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0105 0.0079
Plasmodium falciparum thioredoxin reductase 0.0015 0.0046 0.0787
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0026 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Brugia malayi CXXC zinc finger family protein 0.0033 0.0194 0.0992
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.1232 1 1
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0105 0.0105
Brugia malayi 6-phosphofructokinase 0.0126 0.0952 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.01 0.0527
Mycobacterium tuberculosis Probable reductase 0.01 0.0739 0.5084
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0105 0.0521
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.0951 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.02 0.6846
Onchocerca volvulus 0.0096 0.0709 0.3248
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0143 0.0098
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.1232 1 1
Schistosoma mansoni multidrug resistance protein 0.0013 0.0026 0.0026
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.01 0.0739 0.5084
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0105 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0211 0.0211
Schistosoma mansoni smdr2 0.0013 0.0026 0.0026
Trypanosoma brucei trypanothione reductase 0.0044 0.028 0.0235
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.02 0.4393
Echinococcus multilocularis microtubule associated protein 2 0.0799 0.6455 0.6455
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0211 0.0211
Onchocerca volvulus 0.0035 0.0211 0.0945
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0143 0.0704
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0105 0.0521
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0106
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0096 0.0709 0.0709
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0448 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.1232 1 1
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.028 0.1448
Plasmodium vivax glutathione reductase, putative 0.0044 0.028 1
Onchocerca volvulus 0.0275 0.2171 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0046 0.0787
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.0951 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0324 0.0279
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.1275 0.1235
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.1232 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0105 0.0424
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.028 1
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.1232 1 1
Echinococcus granulosus dna polymerase eta 0.0022 0.0105 0.0105
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0143 0.4617
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1275 0.1252
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0006 0.0006
Onchocerca volvulus 0.0013 0.0026 0.0092
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0105 0.0059
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0951 0.0927
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0006 0.0006
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0046 0.0906
Mycobacterium tuberculosis Probable oxidoreductase 0.0111 0.083 0.5735
Plasmodium falciparum glutathione reductase 0.0015 0.0046 0.0787
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0006 0.0006
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.0951 0.0951
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0105 0.0079
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.028 0.1812
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.02 0.6846
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0211 0.0211
Onchocerca volvulus 0.0033 0.0194 0.0868
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.01 0.0074
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.0951 0.0951
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0026 0.0026
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0026 0.0106
Loa Loa (eye worm) DEAH box polypeptide 35 0.0033 0.019 0.0969
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0143 0.311
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0048 0.0002
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0026 0.0026
Brugia malayi Thioredoxin reductase 0.0044 0.028 0.1448
Brugia malayi glutathione reductase 0.0044 0.028 0.1448
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0211 0.4632
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0143 1
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.02 0.4393
Loa Loa (eye worm) glutathione reductase 0.0044 0.028 0.1448
Loa Loa (eye worm) hypothetical protein 0.0022 0.0105 0.0521
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0105 0.0521
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.028 0.0235
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0025 0.0025
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0026 0.0026
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0951 0.0927
Schistosoma mansoni microtubule-associated protein tau 0.0799 0.6455 0.6455
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0048 0.0002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0046 0.0211
Toxoplasma gondii hypothetical protein 0.0056 0.0383 0.8542
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.0951 0.0909
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0951 0.0927
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.0951 0.6598
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0016 0.0049
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.02 0.0174
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0106
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.01 0.0054
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0006 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.02 0.0174
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.0951 0.4994
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.01 0.01
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.02 0.1701
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.01 0.039
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.01 0.5546
Mycobacterium tuberculosis Probable dehydrogenase 0.01 0.0739 0.5084
Leishmania major mitochondrial DNA polymerase beta 0.035 0.2781 0.2762
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.02 0.6846
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.02 0.6846
Brugia malayi N-terminal motif family protein 0.0209 0.1631 0.8588
Schistosoma mansoni dishevelled 0.001 0.0006 0.0006
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0026 0.0026
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0143 0.0118
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0046 0.002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.01 0.0739 0.5084
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0111 0.083 0.8502
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.02 0.0174
Plasmodium vivax SET domain protein, putative 0.0035 0.0211 0.7261
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.01 0.2911
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0105 0.0105
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0143 0.4617
Schistosoma mansoni multidrug resistance protein 0.0013 0.0026 0.0026
Brugia malayi ABC transporter family protein 0.0013 0.0026 0.0106
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0194 0.0194
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0017 0.0055
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0105 0.0105
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0105 0.0105
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0412 0.0368
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.0951 0.0951
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.01 0.0496
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0048 0.0002
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.0026 0.0453
Trypanosoma brucei unspecified product 0.0015 0.0048 0.0002
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0026 0.0026
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0006 0.0006
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0046 0.1149
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.01 0.0054
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0143 0.311
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.02 1
Schistosoma mansoni cpg binding protein 0.0033 0.0194 0.0194
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.02 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.01 0.0596
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0017 0.0017
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0013 0.0037
Schistosoma mansoni hypothetical protein 0.1232 1 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.02 0.0155
Schistosoma mansoni DNA polymerase eta 0.0022 0.0105 0.0105
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.0026 0.0453
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0324 0.0279
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0026 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0211 0.0211
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0105 0.0059
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0951 0.0927
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.0951 0.6548
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0026 0.0026
Schistosoma mansoni dishevelled 0.001 0.0006 0.0006
Schistosoma mansoni ap endonuclease 0.0022 0.01 0.01
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0324 0.0279
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0026 0.0026
Echinococcus multilocularis L aminoadipate semialdehyde 0.0096 0.0709 0.0709
Entamoeba histolytica hypothetical protein, conserved 0.1232 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0105 0.0424
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.1232 1 1
Schistosoma mansoni cpg binding protein 0.0035 0.0209 0.0209
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0046 0.0046
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.0951 0.0909
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0026 0.0026
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.1232 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0046 0.002
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0096 0.0709 0.3715
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0143 0.0704
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0105 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0211 0.0211
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0143 0.1075
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0105 0.0079
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.01 0.0054
Brugia malayi phosphofructokinase 0.0126 0.0951 0.4994
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0951 0.0927
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.01 0.2911
Brugia malayi Probable ATP-dependent helicase DHX35 0.0033 0.019 0.0969
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0046 0.0143
Loa Loa (eye worm) hypothetical protein 0.0096 0.0709 0.3715
Leishmania major DNA polymerase eta, putative 0.0022 0.0105 0.0079
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.01 0.0074
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0105 0.0059
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.01 0.0074
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0143 0.0836
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0006 0.0006
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0026 0.0026
Schistosoma mansoni multidrug resistance protein 0.0013 0.0026 0.0026
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.0951 0.0927
Brugia malayi 6-phosphofructokinase 0.0126 0.0951 0.4994
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0026 0.0026
Schistosoma mansoni cpg binding protein 0.0035 0.0209 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0105 0.0059

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = -15.3 % Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 30 uM on day 8 relative to control ChEMBL. 21493073
Activity (functional) = 2.6 % Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 1 uM on day 8 relative to control ChEMBL. 21493073
Activity (functional) = 3.1 % Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 3 uM on day 8 relative to control ChEMBL. 21493073
Activity (functional) = 7.4 % Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 10 uM on day 8 relative to control ChEMBL. 21493073
IA (functional) 0 Minimum inhibitory concentration, that inhibits growth of S. aureus in the presence of subinhibitory (30 ug/mL) Berberine; Inactive ChEMBL. 11170636

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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