Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginine vasopressin receptor 1B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0497 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0497 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 5 subunit, putative | 0.1032 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.1032 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.1032 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0802 | 0.7224 | 0.7224 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0497 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0802 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0802 | 0.7224 | 0.7224 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0203 | 0 | 0.5 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.1032 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0802 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.1032 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0497 | 0.3546 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.1032 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0802 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.1032 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.1032 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0497 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0802 | 0.7224 | 0.7224 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0497 | 0.3546 | 0.3546 |
Brugia malayi | proteasome subunit beta type 2 | 0.0497 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0497 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0497 | 0.3546 | 0.3546 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0802 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0802 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.1032 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0497 | 0.3546 | 0.3546 |
Onchocerca volvulus | Notchless protein homolog | 0.0203 | 0 | 0.5 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0497 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0497 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0497 | 0.3546 | 0.3546 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.1032 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0497 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1032 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0497 | 0.3546 | 0.3546 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0497 | 0.3546 | 0.3546 |
Echinococcus granulosus | proteasome prosome macropain | 0.1032 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0802 | 0.7224 | 0.7224 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.1032 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1032 | 1 | 1 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0497 | 0.3546 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0802 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.1032 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0802 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0802 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.1032 | 1 | 1 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0802 | 0.7224 | 0.7224 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0802 | 0.7224 | 0.7224 |
Brugia malayi | proteasome subunit beta type 1 | 0.0802 | 0.7224 | 0.7224 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.1032 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 72 nM | Displacement of [3H]AVP from human V1b receptor expressed in CHO cells co-expressing VIP-luciferase by whole cell binding assay | ChEMBL. | 21353540 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.