Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | proteasome beta 5 subunit, putative | 0.1167 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0562 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0562 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.1167 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.1167 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0907 | 0.7224 | 0.7224 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0562 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0907 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0907 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0562 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.1167 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0229 | 0 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.1167 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0907 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0907 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.1167 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.1167 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0907 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0562 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.1167 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0562 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0562 | 0.3546 | 0.3546 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0907 | 0.7224 | 0.7224 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0562 | 0.3546 | 0.3546 |
Brugia malayi | proteasome subunit beta type 2 | 0.0562 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0562 | 0.3546 | 0.3546 |
Onchocerca volvulus | Notchless protein homolog | 0.0229 | 0 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0907 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.1167 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0562 | 0.3546 | 0.3546 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.1167 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0562 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0562 | 0.3546 | 0.3546 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0562 | 0.3546 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0562 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1167 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0562 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1167 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.1167 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0907 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain | 0.1167 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0907 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.1167 | 1 | 1 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0562 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0907 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.1167 | 1 | 1 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0907 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0907 | 0.7224 | 0.7224 |
Brugia malayi | proteasome subunit beta type 1 | 0.0907 | 0.7224 | 0.7224 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.1167 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0907 | 0.7224 | 0.7224 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 40 uM | Antiproliferative activity against human A549 cells after 3 days by SRB assay | ChEMBL. | 25241925 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.