Detailed information for compound 1503869

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 289.412 | Formula: C18H27NO2
  • H donors: 0 H acceptors: 1 LogP: 3.69 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(=O)N1CCC(CC1)c1cccc(c1)OC)CC
  • InChi: 1S/C18H27NO2/c1-4-14(5-2)18(20)19-11-9-15(10-12-19)16-7-6-8-17(13-16)21-3/h6-8,13-15H,4-5,9-12H2,1-3H3
  • InChiKey: FAVFOXOOLNVKQX-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Proteasome A-type and B-type family protein 0.0231 0.1059 0.1059
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0231 0.1059 0.1059
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0231 0.1059 0.1059
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0565 0.4229 0.4229
Echinococcus granulosus proteasome subunit beta t family 0.0231 0.1059 0.1059
Leishmania major proteasome beta 7 subunit, putative 0.0231 0.1059 0.1059
Brugia malayi Proteasome A-type and B-type family protein 0.0231 0.1059 0.1059
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0231 0.1059 0.1059
Brugia malayi proteasome subunit alpha type 6 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0565 0.4229 0.4229
Echinococcus multilocularis proteasome subunit alpha type 2 0.0231 0.1059 0.1059
Leishmania major proteasome alpha 7 subunit, putative 0.0231 0.1059 0.1059
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0231 0.1059 0.1059
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0231 0.1059 0.1059
Loa Loa (eye worm) PAS-3 protein 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0231 0.1059 0.1059
Brugia malayi proteasome subunit beta type 3 0.0231 0.1059 0.1059
Brugia malayi 20S proteasome alpha5 subunit 0.0231 0.1059 0.1059
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0231 0.1059 0.1059
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0565 0.4229 0.4229
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0231 0.1059 0.1059
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0231 0.1059 0.1059
Leishmania major proteasome beta 5 subunit, putative 0.1174 1 1
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1174 1 1
Mycobacterium ulcerans proteasome PrcB 0.1174 1 1
Plasmodium vivax proteasome subunit beta type-1, putative 0.0912 0.7518 0.7224
Leishmania major proteasome alpha 1 subunit, putative 0.0231 0.1059 0.1059
Giardia lamblia Proteasome subunit beta type 2 0.0565 0.4229 0.3546
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0231 0.1059 0.1059
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0231 0.1059 0.1059
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0231 0.1059 0.1059
Brugia malayi proteasome subunit alpha type 2 0.0231 0.1059 0.1059
Trypanosoma brucei proteasome alpha 7 subunit 0.0231 0.1059 0.1059
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0565 0.4229 0.4229
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1174 1 1
Brugia malayi proteasome subunit beta type 2 0.0565 0.4229 0.4229
Leishmania major proteasome alpha 2 subunit, putative 0.0231 0.1059 0.1059
Loa Loa (eye worm) proteasome subunit beta type 2 0.0565 0.4229 0.4229
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0231 0.1059 0.1059
Echinococcus granulosus proteasome subunit alpha type 2 0.0231 0.1059 0.1059
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0231 0.1059 0.1059
Plasmodium falciparum proteasome subunit beta type-5 0.1174 1 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0231 0.1059 0.1059
Echinococcus multilocularis proteasome subunit alpha type 6 0.0231 0.1059 0.1059
Leishmania major proteasome beta 3 subunit, putative 0.0231 0.1059 0.1059
Brugia malayi Proteasome subunit alpha type 1 0.0231 0.1059 0.1059
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0231 0.1059 0.1059
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0231 0.1059 0.1059
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0565 0.4229 0.3546
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0912 0.7518 0.7518
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0231 0.1059 0.1059
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0231 0.1059 0.1059
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0231 0.1059 0.1059
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0912 0.7518 0.7518
Echinococcus granulosus subfamily T1A non peptidase ue 0.0231 0.1059 0.1059
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0912 0.7518 0.7224
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0231 0.1059 0.1059
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0231 0.1059 0.1059
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0231 0.1059 0.1059
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0231 0.1059 0.1059
Plasmodium vivax proteasome subunit beta type-2, putative 0.0565 0.4229 0.3546
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0231 0.1059 0.1059
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0231 0.1059 0.1059
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0231 0.1059 0.1059
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0231 0.1059 0.1059
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1174 1 1
Echinococcus granulosus proteasome subunit beta type 6 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0231 0.1059 0.1059
Leishmania major proteasome beta 2 subunit, putative 0.0565 0.4229 0.4229
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0231 0.1059 0.1059
Onchocerca volvulus Notchless protein homolog 0.0231 0.1059 0.5
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0231 0.1059 0.1059
Echinococcus granulosus proteasome subunit alpha type 6 0.0231 0.1059 0.1059
Echinococcus granulosus proteasome prosome macropain 0.1174 1 1
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0912 0.7518 0.7518
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0912 0.7518 0.7518
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0231 0.1059 0.1059
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1174 1 1
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0231 0.1059 0.1059
Leishmania major proteasome alpha 1 subunit, putative 0.0231 0.1059 0.1059
Echinococcus granulosus Proteasome subunit alpha type 7 0.0231 0.1059 0.1059
Plasmodium vivax proteasome subunit beta type-5, putative 0.1174 1 1
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1174 1 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1174 1 1
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0231 0.1059 0.1059
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0231 0.1059 0.1059
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0231 0.1059 0.1059
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0565 0.4229 0.3546
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0231 0.1059 0.1059
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0565 0.4229 0.3546
Trypanosoma brucei proteasome beta 7 subunit 0.0231 0.1059 0.1059
Echinococcus multilocularis proteasome subunit beta type 7 0.0231 0.1059 0.1059
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0231 0.1059 0.1059
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0231 0.1059 0.1059
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0231 0.1059 0.1059
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0231 0.1059 0.1059
Loa Loa (eye worm) proteasome subunit beta type 1 0.0912 0.7518 0.7518
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1174 1 1
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0231 0.1059 0.1059
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0231 0.1059 0.1059
Trypanosoma brucei proteasome beta 6 subunit 0.0912 0.7518 0.7518
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0912 0.7518 0.7224
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0912 0.7518 0.7224
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0231 0.1059 0.1059
Leishmania major proteasome beta-1 subunit, putative 0.0231 0.1059 0.1059
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0231 0.1059 0.1059
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0231 0.1059 0.1059
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0912 0.7518 0.7224
Brugia malayi Proteasome A-type and B-type family protein 0.0231 0.1059 0.1059
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0231 0.1059 0.1059
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1174 1 1
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0565 0.4229 0.3546
Toxoplasma gondii proteasome subunit beta type, putative 0.1174 1 1
Leishmania major proteasome beta 2 subunit, putative 0.0231 0.1059 0.1059
Leishmania major proteasome alpha 3 subunit, putative 0.0231 0.1059 0.1059
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0231 0.1059 0.1059
Brugia malayi proteasome subunit alpha type 3 0.0231 0.1059 0.1059
Trypanosoma cruzi 20S proteasome subunit 0.0565 0.4229 0.4229
Brugia malayi Proteasome subunit alpha type 7-1 0.0231 0.1059 0.1059
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0231 0.1059 0.1059
Echinococcus multilocularis proteasome subunit beta type 6 0.0231 0.1059 0.1059
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0565 0.4229 0.4229
Brugia malayi proteasome subunit alpha type 4 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0231 0.1059 0.1059
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0231 0.1059 0.1059
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0231 0.1059 0.1059
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0231 0.1059 0.5
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0912 0.7518 0.7518
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0231 0.1059 0.1059
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0231 0.1059 0.1059
Loa Loa (eye worm) proteasome subunit beta type 3 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0912 0.7518 0.7518
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0231 0.1059 0.1059
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1174 1 1
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0231 0.1059 0.1059
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0565 0.4229 0.4229
Echinococcus granulosus Proteasome subunit alpha beta 0.0231 0.1059 0.1059
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0231 0.1059 0.1059
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0231 0.1059 0.1059
Echinococcus granulosus proteasome subunit beta type 7 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0231 0.1059 0.1059
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1174 1 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0231 0.1059 0.1059
Brugia malayi proteasome subunit beta type 1 0.0912 0.7518 0.7518
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0565 0.4229 0.3546
Giardia lamblia Proteasome subunit beta type 1 0.0912 0.7518 0.7224
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0231 0.1059 0.1059
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0231 0.1059 0.1059
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0231 0.1059 0.1059
Echinococcus multilocularis proteasome (prosome, macropain) 0.1174 1 1
Leishmania major proteasome alpha 7 subunit, putative 0.0231 0.1059 0.1059
Brugia malayi proteasome subunit alpha type 1 0.0231 0.1059 0.1059
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0231 0.1059 0.1059
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0231 0.1059 0.1059
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0231 0.1059 0.1059
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0231 0.1059 0.1059

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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