Detailed information for compound 1503870

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 273.37 | Formula: C17H23NO2
  • H donors: 0 H acceptors: 1 LogP: 2.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C1CCN(CC1)C(=O)[C@H]1C[C@@H]1C
  • InChi: 1S/C17H23NO2/c1-12-10-16(12)17(19)18-8-6-13(7-9-18)14-4-3-5-15(11-14)20-2/h3-5,11-13,16H,6-10H2,1-2H3/t12-,16-/m0/s1
  • InChiKey: BKBJCQGZAHTWKZ-LRDDRELGSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0258 0.1771 0.1732
Schistosoma mansoni hypothetical protein 0.0302 0.212 0.2083
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0258 0.1771 0.1732
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0258 0.1771 0.1732
Echinococcus multilocularis ecdysone induced protein 78C 0.0078 0.0369 0.0324
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.004 0.0071 0.0025
Echinococcus multilocularis FTZ F1 alpha 0.0078 0.0369 0.0324
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0258 0.1771 0.1732
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0258 0.1771 0.1771
Toxoplasma gondii aminopeptidase N, putative 0.0037 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0078 0.0369 0.0324
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0369 0.0324
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0078 0.0369 0.0324
Echinococcus multilocularis thyroid hormone receptor alpha 0.0078 0.0369 0.0324
Echinococcus multilocularis aminopeptidase N 0.0037 0.0047 0.0001
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0258 0.1771 0.1771
Echinococcus granulosus Proteasome subunit alpha type 7 0.0258 0.1771 0.1733
Trypanosoma brucei proteasome beta 6 subunit 0.1019 0.7715 0.7705
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0632 0.4689 0.4664
Loa Loa (eye worm) hypothetical protein 0.0129 0.0763 0.072
Brugia malayi nuclear receptor NHR-88 0.0078 0.0369 0.0324
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0258 0.1771 0.1771
Echinococcus granulosus tumor protein p63 0.0332 0.235 0.2315
Loa Loa (eye worm) hypothetical protein 0.0078 0.0369 0.0324
Echinococcus multilocularis proteasome subunit beta type 7 0.0258 0.1771 0.1733
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0258 0.1771 0.1732
Brugia malayi Pip kinase protein 2 0.016 0.1005 0.0963
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0258 0.1771 0.1771
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0258 0.1771 0.1732
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0258 0.1771 0.1733
Loa Loa (eye worm) proteasome subunit beta type 1 0.1019 0.7715 0.7705
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1312 1 1
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0258 0.1771 0.1732
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1312 1 1
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0258 0.1771 0.1733
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0078 0.0369 0.0324
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0258 0.1771 0.1733
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0258 0.1771 0.1771
Toxoplasma gondii proteasome subunit alpha type, putative 0.0258 0.1771 0.1771
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0078 0.0369 0.0324
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.0081 0.0035
Echinococcus granulosus dna polymerase eta 0.0044 0.0102 0.0056
Echinococcus multilocularis proteasome subunit beta type 6 0.0258 0.1771 0.1733
Brugia malayi proteasome subunit alpha type 6 0.0258 0.1771 0.1733
Toxoplasma gondii proteasome subunit beta type, putative 0.1312 1 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0258 0.1771 0.1771
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0258 0.1771 0.1733
Trypanosoma cruzi Aminopeptidase M1, putative 0.0037 0.0047 0.0047
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0078 0.0369 0.0324
Schistosoma mansoni retinoic acid receptor RXR 0.0078 0.0369 0.0324
Schistosoma mansoni thyroid hormone receptor 0.0078 0.0369 0.0324
Toxoplasma gondii aminopeptidase n, putative 0.0037 0.0047 0.0047
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0037 0.0047 0.0047
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0258 0.1771 0.1771
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0258 0.1771 0.1732
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0258 0.1771 0.1733
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0078 0.0369 0.0324
Onchocerca volvulus Notchless protein homolog 0.0258 0.1771 1
Loa Loa (eye worm) TATA binding protein associated factor 0.0037 0.0047 0.0001
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0258 0.1771 0.1733
Plasmodium vivax proteasome subunit beta type-2, putative 0.0632 0.4689 0.4664
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0258 0.1771 0.1732
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0047 0.0001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0078 0.0369 0.0324
Echinococcus granulosus proteasome subunit beta type 7 0.0258 0.1771 0.1733
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0078 0.0369 0.0324
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0258 0.1771 0.1732
Echinococcus multilocularis snurportin 1 0.0302 0.212 0.2083
Echinococcus multilocularis tumor protein p63 0.0332 0.235 0.2315
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0258 0.1771 0.1732
Brugia malayi ecdysteroid receptor 0.0078 0.0369 0.0324
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0258 0.1771 0.1733
Loa Loa (eye worm) proteasome subunit beta type 2 0.0632 0.4689 0.4664
Leishmania major proteasome alpha 7 subunit, putative 0.0258 0.1771 0.1771
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0258 0.1771 0.1733
Toxoplasma gondii proteasome subunit alpha1, putative 0.0258 0.1771 0.1771
Loa Loa (eye worm) steroid hormone receptor 0.0078 0.0369 0.0324
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0078 0.0369 0.0324
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1312 1 1
Mycobacterium ulcerans proteasome PrcA 0.0258 0.1771 0.1732
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.0369 0.0324
Echinococcus granulosus FTZ F1 alpha 0.0078 0.0369 0.0324
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0078 0.0369 0.0324
Trypanosoma cruzi 20S proteasome subunit 0.0632 0.4689 0.4689
Schistosoma mansoni DNA polymerase eta 0.0044 0.0102 0.0056
Schistosoma mansoni RAR-like nuclear receptor 0.0078 0.0369 0.0324
Plasmodium vivax proteasome subunit beta type-5, putative 0.1312 1 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0047 0.0047
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0258 0.1771 0.1733
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1312 1 1
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0258 0.1771 0.1771
Echinococcus multilocularis proteasome subunit alpha type 2 0.0258 0.1771 0.1733
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0037 0.0047 0.0047
Toxoplasma gondii proteasome subunit 0.0258 0.1771 0.1771
Echinococcus multilocularis serotonin receptor 0.0129 0.0763 0.072
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0696 0.5187 0.5165
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0037 0.0047 0.0001
Echinococcus granulosus Proteasome subunit alpha beta 0.0258 0.1771 0.1733
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0258 0.1771 0.1732
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0369 0.0324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0078 0.0369 0.0324
Schistosoma mansoni aminopeptidase A (M01 family) 0.0037 0.0047 0.0001
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0047 0.0047
Toxoplasma gondii peptidase, T1 family protein 0.0258 0.1771 0.1771
Onchocerca volvulus 0.0049 0.0138 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.0369 0.0324
Echinococcus granulosus leukotriene A 4 hydrolase 0.0696 0.5187 0.5165
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0258 0.1771 0.1733
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.1019 0.7715 0.7715
Loa Loa (eye worm) hypothetical protein 0.0078 0.0369 0.0324
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0632 0.4689 0.4664
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0078 0.0369 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0078 0.0369 0.0324
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0258 0.1771 0.1771
Brugia malayi hypothetical protein 0.0037 0.0047 0.0001
Plasmodium vivax proteasome subunit beta type-3, putative 0.0258 0.1771 0.1732
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0047 0.0001
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0258 0.1771 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.0369 0.0324
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0258 0.1771 0.1733
Onchocerca volvulus 0.0037 0.0047 0.0004
Schistosoma mansoni steroid hormone receptor ad4bp 0.0078 0.0369 0.0324
Brugia malayi proteasome subunit alpha type 4 0.0258 0.1771 0.1733
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0258 0.1771 0.1771
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.0081 0.0035
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0258 0.1771 0.1732
Brugia malayi Nuclear hormone receptor-like 1 0.0078 0.0369 0.0324
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0632 0.4689 0.4664
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0258 0.1771 0.1771
Brugia malayi hypothetical protein 0.0041 0.0081 0.0035
Echinococcus multilocularis proteasome subunit alpha type 6 0.0258 0.1771 0.1733
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0258 0.1771 0.1732
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0696 0.5187 0.5165
Leishmania major proteasome beta-1 subunit, putative 0.0258 0.1771 0.1771
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0258 0.1771 0.1733
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0258 0.1771 0.1732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0078 0.0369 0.0324
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0258 0.1771 0.1732
Leishmania major proteasome alpha 7 subunit, putative 0.0258 0.1771 0.1771
Leishmania major proteasome beta 2 subunit, putative 0.0258 0.1771 0.1771
Trypanosoma brucei proteasome alpha 7 subunit 0.0258 0.1771 0.1732
Leishmania major DNA polymerase eta, putative 0.0044 0.0102 0.0102
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0047 0.0001
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0258 0.1771 0.1732
Giardia lamblia Proteasome subunit beta type 1 0.1019 0.7715 0.7224
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0369 0.0324
Leishmania major proteasome alpha 1 subunit, putative 0.0258 0.1771 0.1771
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0258 0.1771 0.1733
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1312 1 1
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0258 0.1771 0.1771
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.016 0.1005 0.0963
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0258 0.1771 0.1733
Echinococcus multilocularis serotonin receptor 0.0129 0.0763 0.072
Leishmania major proteasome alpha 3 subunit, putative 0.0258 0.1771 0.1771
Schistosoma mansoni thyroid hormone receptor 0.0078 0.0369 0.0324
Loa Loa (eye worm) hypothetical protein 0.0078 0.0369 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.0369 0.0324
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0258 0.1771 0.1771
Echinococcus multilocularis dna polymerase eta 0.0044 0.0102 0.0056
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.0092
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.1019 0.7715 0.7705
Brugia malayi proteasome subunit beta type 1 0.1019 0.7715 0.7705
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0258 0.1771 0.1771
Brugia malayi photoreceptor-specific nuclear receptor 0.0078 0.0369 0.0324
Loa Loa (eye worm) hypothetical protein 0.0078 0.0369 0.0324
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0369 0.0324
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0047 0.0001
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0258 0.1771 0.1733
Echinococcus granulosus proteasome subunit beta type 6 0.0258 0.1771 0.1733
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0258 0.1771 0.1732
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0102 0.0056
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0078 0.0369 0.0324
Echinococcus granulosus proteasome subunit alpha type 2 0.0258 0.1771 0.1733
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.016 0.1005 0.0963
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0047 0.0001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0078 0.0369 0.0324
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0632 0.4689 0.4664
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0258 0.1771 0.1732
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0041 0.0081 0.0035
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0258 0.1771 0.1732
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0047 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0078 0.0369 0.0324
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0632 0.4689 0.4689
Loa Loa (eye worm) hypothetical protein 0.0041 0.0081 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0078 0.0369 0.0324
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0258 0.1771 0.1771
Onchocerca volvulus Bile acid receptor homolog 0.0078 0.0369 0.1868
Loa Loa (eye worm) hypothetical protein 0.016 0.1005 0.0963
Brugia malayi proteasome subunit alpha type 2 0.0258 0.1771 0.1733
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0047 0.0001
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0258 0.1771 0.1732
Entamoeba histolytica proteasome subunit beta type 1, putative 0.1019 0.7715 0.7705
Loa Loa (eye worm) peptidase family M1 containing protein 0.0037 0.0047 0.0001
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0258 0.1771 0.1733
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0258 0.1771 0.1732
Trypanosoma cruzi aminopeptidase, putative 0.0037 0.0047 0.0047
Brugia malayi Steroid receptor seven-up type 2 0.0078 0.0369 0.0324
Brugia malayi proteasome subunit alpha type 1 0.0258 0.1771 0.1733
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0047 0.0047
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0258 0.1771 0.1732
Loa Loa (eye worm) hypothetical protein 0.0078 0.0369 0.0324
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0258 0.1771 0.1732
Brugia malayi proteasome subunit beta type 2 0.0632 0.4689 0.4664
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0258 0.1771 0.1733
Brugia malayi hypothetical protein 0.0041 0.0081 0.0035
Leishmania major proteasome alpha 2 subunit, putative 0.0258 0.1771 0.1771
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0258 0.1771 0.1732
Plasmodium vivax proteasome subunit beta type-7, putative 0.0258 0.1771 0.1732
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0047 0.0001
Toxoplasma gondii proteasome subunit beta type 1, putative 0.1019 0.7715 0.7715
Echinococcus granulosus snurportin 1 0.0302 0.212 0.2083
Brugia malayi hypothetical protein 0.0037 0.0047 0.0001
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0258 0.1771 0.1732
Brugia malayi proteasome subunit beta type 3 0.0258 0.1771 0.1733
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.1019 0.7715 0.7715
Schistosoma mansoni biogenic amine (5HT) receptor 0.0129 0.0763 0.072
Plasmodium vivax proteasome subunit beta type-4, putative 0.0258 0.1771 0.1732
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0258 0.1771 0.1732
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0047 0.0001
Onchocerca volvulus 0.016 0.1005 0.556
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0258 0.1771 0.1732
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0047 0.0047
Brugia malayi nuclear hormone receptor 0.0078 0.0369 0.0324
Plasmodium falciparum proteasome subunit beta type-5 0.1312 1 1
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0258 0.1771 0.1733
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0258 0.1771 0.1771
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0258 0.1771 0.1771
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0081 0.0035
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0258 0.1771 0.1732
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0047 0.0001
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0632 0.4689 0.4664
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0102 0.0055
Brugia malayi Proteasome subunit alpha type 1 0.0258 0.1771 0.1733
Toxoplasma gondii proteasome beta subunit 0.0258 0.1771 0.1771
Mycobacterium ulcerans proteasome PrcB 0.1312 1 1
Leishmania major proteasome beta 5 subunit, putative 0.1312 1 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0369 0.0324
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0258 0.1771 0.1733
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0081 0.0035
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0258 0.1771 0.1732
Brugia malayi RNA, U transporter 1 0.0081 0.0388 0.0343
Loa Loa (eye worm) hypothetical protein 0.0041 0.0081 0.0035
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0258 0.1771 0.1733
Echinococcus granulosus proteasome subunit beta t family 0.0258 0.1771 0.1733
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.0369 0.0324
Schistosoma mansoni nuclear hormone receptor 0.0078 0.0369 0.0324
Loa Loa (eye worm) aminopeptidase N 0.0037 0.0047 0.0001
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0037 0.0047 0.0001
Plasmodium falciparum proteasome subunit beta type-4 0.0258 0.1771 0.1732
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0258 0.1771 0.1732
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0258 0.1771 0.1733
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0258 0.1771 0.1732
Onchocerca volvulus Protein ultraspiracle homolog 0.0078 0.0369 0.1868
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0258 0.1771 0.1771
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0078 0.0369 0.0324
Loa Loa (eye worm) hypothetical protein 0.0044 0.0102 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0078 0.0369 0.0324
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0258 0.1771 0.1732
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0258 0.1771 0.1732
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0258 0.1771 0.1733
Schistosoma mansoni coup transcription factor 0.0078 0.0369 0.0324
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0258 0.1771 0.1732
Brugia malayi Proteasome A-type and B-type family protein 0.0258 0.1771 0.1733
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0102 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.0369 0.0324
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0258 0.1771 0.1771
Loa Loa (eye worm) hypothetical protein 0.0041 0.0081 0.0035
Giardia lamblia Proteasome subunit beta type 2 0.0632 0.4689 0.3546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0078 0.0369 0.0324
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0258 0.1771 0.1732
Brugia malayi TATA binding protein associated factor 0.0037 0.0047 0.0001
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.0081 0.0035
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0258 0.1771 0.1733
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0258 0.1771 0.1733
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0258 0.1771 0.1732
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0258 0.1771 0.1732
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0047 0.0001
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0258 0.1771 0.1732
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0078 0.0369 0.0324
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0047 0.0001
Leishmania major proteasome beta 3 subunit, putative 0.0258 0.1771 0.1771
Echinococcus granulosus proteasome prosome macropain subunit beta 0.1019 0.7715 0.7705
Onchocerca volvulus 0.0037 0.0047 0.0004
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0258 0.1771 0.1733
Echinococcus multilocularis proteasome (prosome, macropain) 0.1312 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0001
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1312 1 1
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0258 0.1771 0.1732
Toxoplasma gondii aminopeptidase N protein 0.0037 0.0047 0.0047
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0258 0.1771 0.1771
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0258 0.1771 0.1771
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0632 0.4689 0.4664
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.016 0.1005 0.0963
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0078 0.0369 0.0324
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0258 0.1771 0.1733
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0258 0.1771 0.1732
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0078 0.0369 0.0324
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0258 0.1771 0.1732
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0258 0.1771 0.1732
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0696 0.5187 0.5165
Brugia malayi Proteasome A-type and B-type family protein 0.0258 0.1771 0.1733
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0078 0.0369 0.0324
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0258 0.1771 0.1771
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0258 0.1771 0.1733
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0047 0.0047
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0258 0.1771 0.1732
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0258 0.1771 0.1732
Trypanosoma brucei proteasome beta 7 subunit 0.0258 0.1771 0.1732
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0258 0.1771 0.1733
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0081 0.0035
Brugia malayi steroid hormone receptor 0.0078 0.0369 0.0324
Echinococcus granulosus subfamily T1A non peptidase ue 0.0258 0.1771 0.1733
Onchocerca volvulus 0.0037 0.0047 0.0004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0078 0.0369 0.1868
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0258 0.1771 0.1733
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0258 0.1771 0.1771
Plasmodium vivax proteasome subunit beta type-1, putative 0.1019 0.7715 0.7705
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1312 1 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0258 0.1771 0.1771
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0001
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0258 0.1771 0.1732
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0258 0.1771 0.1771
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0258 0.1771 0.1771
Brugia malayi Proteasome subunit alpha type 7-1 0.0258 0.1771 0.1733
Brugia malayi nuclear receptor RXR 0.0041 0.0081 0.0035
Echinococcus granulosus proteasome subunit alpha type 6 0.0258 0.1771 0.1733
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0258 0.1771 0.1771
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0258 0.1771 0.1733
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1312 1 1
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0258 0.1771 0.1771
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0258 0.1771 0.1732
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.1019 0.7715 0.7705
Brugia malayi proteasome subunit alpha type 3 0.0258 0.1771 0.1733
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0258 0.1771 0.1732
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1019 0.7715 0.7705
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0258 0.1771 0.1771
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0632 0.4689 0.4689
Echinococcus granulosus biogenic amine 5HT receptor 0.0129 0.0763 0.072
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0258 0.1771 0.1733
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.0081 0.0035
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0258 0.1771 0.1732
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1312 1 1
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0258 0.1771 0.1732
Loa Loa (eye worm) proteasome subunit beta type 3 0.0258 0.1771 0.1733
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0258 0.1771 0.1733
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0258 0.1771 0.1732
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0078 0.0369 0.0324
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.212 0.2083
Loa Loa (eye worm) hypothetical protein 0.0129 0.0763 0.072
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.0369 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0078 0.0369 0.0324
Brugia malayi Proteasome A-type and B-type family protein 0.0258 0.1771 0.1733
Leishmania major proteasome beta 7 subunit, putative 0.0258 0.1771 0.1771
Echinococcus granulosus ecdysone induced protein 78C 0.0078 0.0369 0.0324
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0258 0.1771 0.1733
Leishmania major proteasome alpha 1 subunit, putative 0.0258 0.1771 0.1771
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0258 0.1771 0.1771
Brugia malayi hypothetical protein 0.032 0.2254 0.2218
Loa Loa (eye worm) pip kinase 2 0.016 0.1005 0.0963
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0258 0.1771 0.1732
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0258 0.1771 0.1733
Leishmania major proteasome beta 2 subunit, putative 0.0632 0.4689 0.4689
Plasmodium vivax proteasome subunit beta type-6, putative 0.0258 0.1771 0.1732
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0037 0.0047 0.0047
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0632 0.4689 0.4664
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0258 0.1771 0.1771
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0138 0.0092
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0632 0.4689 0.4664
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0258 0.1771 0.1733
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0258 0.1771 0.1771
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0258 0.1771 0.1733
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0037 0.0047 0.0001
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0258 0.1771 0.1732
Plasmodium falciparum proteasome subunit beta type-1, putative 0.1019 0.7715 0.7705
Brugia malayi 20S proteasome alpha5 subunit 0.0258 0.1771 0.1733
Trypanosoma cruzi aminopeptidase, putative 0.0037 0.0047 0.0047
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0078 0.0369 0.0324
Loa Loa (eye worm) hypothetical protein 0.0078 0.0369 0.0324
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0258 0.1771 0.1771
Loa Loa (eye worm) hypothetical protein 0.0041 0.0081 0.0035
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1312 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0078 0.0369 0.0324
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0047 0.0001
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0632 0.4689 0.4664
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0258 0.1771 0.1732
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.016 0.1005 0.0963
Echinococcus granulosus aminopeptidase N 0.0037 0.0047 0.0001
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0047 0.0001
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0258 0.1771 0.1771
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.1019 0.7715 0.7715
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0258 0.1771 0.1732
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0001
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0258 0.1771 0.1732
Onchocerca volvulus 0.0078 0.0369 0.1868
Echinococcus granulosus proteasome prosome macropain 0.1312 1 1
Loa Loa (eye worm) PAS-3 protein 0.0258 0.1771 0.1733
Toxoplasma gondii heat shock protein hslv, putative 0.0258 0.1771 0.1771
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0258 0.1771 0.1732

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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