Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | proteasome PrcB | 0.0333 | 0.1682 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.1186 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0258 | 0.0959 | 0.2554 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0333 | 0.1682 | 0.1682 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 0.2516 | 0.2516 |
Brugia malayi | hypothetical protein | 0.0545 | 0.3754 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0161 | 0.0007 | 0.0019 |
Echinococcus multilocularis | serotonin transporter | 0.0161 | 0.0007 | 0.0007 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0258 | 0.0959 | 0.0959 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0333 | 0.1682 | 0.1682 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0258 | 0.0959 | 0.5699 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0007 | 0.0007 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0258 | 0.0959 | 0.5699 |
Echinococcus granulosus | proteasome prosome macropain | 0.0333 | 0.1682 | 0.1682 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0333 | 0.1682 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0333 | 0.1682 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0333 | 0.1682 | 0.5 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0258 | 0.0959 | 0.5699 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0258 | 0.0959 | 0.5699 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0161 | 0.0007 | 0.0007 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0333 | 0.1682 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0161 | 0.0007 | 0.0007 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0333 | 0.1682 | 0.4482 |
Onchocerca volvulus | 0.0161 | 0.0007 | 0.5 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0161 | 0.0007 | 0.0007 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0258 | 0.0959 | 0.5699 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0258 | 0.0959 | 0.5699 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0258 | 0.0959 | 0.0959 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0333 | 0.1682 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 0.2516 | 0.2516 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0258 | 0.0959 | 0.5699 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0333 | 0.1682 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0258 | 0.0959 | 0.5699 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0161 | 0.0007 | 0.5 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0333 | 0.1682 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0333 | 0.1682 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0258 | 0.0959 | 0.0959 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0258 | 0.0959 | 0.5699 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.1186 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0258 | 0.0959 | 0.0959 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0333 | 0.1682 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.1186 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0333 | 0.1682 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0161 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0161 | 0.0007 | 0.0007 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0333 | 0.1682 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0161 | 0.0007 | 0.0007 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0258 | 0.0959 | 0.5699 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0333 | 0.1682 | 0.5 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0333 | 0.1682 | 0.1682 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.565 ug ml-1 | Cytotoxicity against human SGC7901 cells assessed as cell mortality after 20 hrs by MTT assay | ChEMBL. | 21296573 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21296573 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.