Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 7 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 9 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | dipeptidyl-peptidase 7 | 492 aa | 471 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0432 | 0.9309 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0432 | 0.9309 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0208 | 0.2877 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0208 | 0.2877 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0432 | 0.9309 | 0.9029 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.028 | 0.4931 | 0.2884 |
Echinococcus multilocularis | acetylcholinesterase | 0.0432 | 0.9309 | 0.9029 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0208 | 0.2877 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.9309 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0141 | 0.0951 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0432 | 0.9309 | 0.9029 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.028 | 0.4931 | 0.2884 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0208 | 0.2877 | 0.3091 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.028 | 0.4931 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.9309 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0208 | 0.2877 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.028 | 0.4931 | 0.5298 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.028 | 0.4931 | 0.2884 |
Brugia malayi | prolyl oligopeptidase family protein | 0.028 | 0.4931 | 0.5298 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0456 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0208 | 0.2877 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0432 | 0.9309 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0432 | 0.9309 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0432 | 0.9309 | 0.9029 |
Echinococcus granulosus | acetylcholinesterase | 0.0432 | 0.9309 | 0.9029 |
Echinococcus granulosus | carboxylesterase 5A | 0.0432 | 0.9309 | 0.9029 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0456 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0432 | 0.9309 | 0.9029 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 uM | Inhibition of DPP4 | ChEMBL. | 21320777 |
IC50 (binding) | = 8.1 uM | Inhibition of DPP9 | ChEMBL. | 21320777 |
IC50 (binding) | = 16 uM | Inhibition of QPP | ChEMBL. | 21320777 |
IC50 (binding) | = 22 uM | Inhibition of DPP8 | ChEMBL. | 21320777 |
IC50 (binding) | > 35 uM | Inhibition of FAP | ChEMBL. | 21320777 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.