Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E receptor 4 (subtype EP4) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.3187 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3187 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3187 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.3187 | 1 | 0.5 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.1292 | 0.2617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3187 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3187 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3187 | 1 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3187 | 1 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.3187 | 1 | 0.5 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.1292 | 0.2617 | 0.2965 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.2887 | 0.8828 | 1 |
Trypanosoma brucei | beta lactamase | 0.062 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.3187 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.062 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3187 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3187 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 nM | Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting | ChEMBL. | 21215624 |
IC50 (binding) | = 3 nM | Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay | ChEMBL. | 26764191 |
IC50 (binding) | = 14 nM | Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum | ChEMBL. | 21215624 |
IC50 (functional) | = 78 nM | Antagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 release | ChEMBL. | 21215624 |
IC50 (binding) | = 78 nM | Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay | ChEMBL. | 26764191 |
Ki (functional) | = 0.3 nM | Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay | ChEMBL. | 21215624 |
Ki (functional) | = 3.1 nM | Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay in presence of 10% human serum | ChEMBL. | 21215624 |
Stability (ADMET) | = 96 % | Metabolic stability in human hepatocytes | ChEMBL. | 21215624 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.