Detailed information for compound 1504631

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 568.731 | Formula: C29H40N6O4S
  • H donors: 2 H acceptors: 4 LogP: 2.47 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCNC(=O)Nc1sc2c(c1C(=O)N1CCN(CC1)C1CCN(CC1)C(=O)C1CCN(CC1)C(=O)C)cccc2
  • InChi: 1S/C29H40N6O4S/c1-3-30-29(39)31-26-25(23-6-4-5-7-24(23)40-26)28(38)35-18-16-33(17-19-35)22-10-14-34(15-11-22)27(37)21-8-12-32(13-9-21)20(2)36/h4-7,21-22H,3,8-19H2,1-2H3,(H2,30,31,39)
  • InChiKey: OCMGPIXKGNDYPZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0693 0.5
Schistosoma mansoni zinc finger protein 0.0074 0.2685 0.3995
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.4251 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.2542 0.3763
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0157 0.6392 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0715 0.4328
Echinococcus multilocularis lamin dm0 0.0029 0.0669 0.1047
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.0936 0.1777
Loa Loa (eye worm) hypothetical protein 0.0039 0.1135 0.1303
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0157 0.6392 0.7317
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0157 0.6392 0.7317
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0157 0.6392 0.7317
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.4251 0.4122
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0936 0.1003
Brugia malayi Nuclear hormone receptor-like 1 0.0157 0.6392 0.7317
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.2127 0.4732
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0157 0.6392 1
Brugia malayi nuclear receptor RXR 0.0083 0.3082 0.3487
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.2127 0.3328
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0768 0.1361
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0693 0.4596
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0157 0.6392 0.7338
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0074 0.2685 0.3995
Leishmania major DNA polymerase eta, putative 0.0035 0.0936 0.1777
Echinococcus granulosus lamin 0.0029 0.0669 0.1047
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0693 0.0484
Schistosoma mansoni terminal deoxycytidyl transferase 0.0035 0.0936 0.116
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.4251 0.6651
Schistosoma mansoni intermediate filament proteins 0.0029 0.0669 0.0729
Schistosoma mansoni thyroid hormone receptor 0.0157 0.6392 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.2127 0.4732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0157 0.6392 0.7338
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0219 0.0343
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0074 0.2685 0.4201
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0715 0.0803
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.4251 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0157 0.6392 0.7317
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.4251 0.6651
Brugia malayi nuclear receptor RXR 0.0074 0.2685 0.3028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0157 0.6392 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0715 0.1118
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.125 0.2556
Loa Loa (eye worm) nuclear hormone receptor 0.0074 0.2685 0.3083
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.2542 0.5761
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.4251 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0157 0.6392 0.6133
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.4251 0.488
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0693 0.1175
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.2211 0.494
Plasmodium vivax SET domain protein, putative 0.003 0.0715 0.4125
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0219 0.0252
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0693 0.3944
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.142 0.1228
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0083 0.3082 0.4638
Onchocerca volvulus 0.003 0.0715 0.0049
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0157 0.6392 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0074 0.2685 0.3083
Brugia malayi photoreceptor-specific nuclear receptor 0.0157 0.6392 0.7317
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Schistosoma mansoni retinoic acid receptor RXR 0.0157 0.6392 1
Schistosoma mansoni nuclear receptor 0.0074 0.2685 0.3995
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.6328 0.7243
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0074 0.2685 0.3995
Brugia malayi steroid hormone receptor 0.0157 0.6392 0.7317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0157 0.6392 0.7338
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0157 0.6392 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Echinococcus multilocularis ecdysone induced protein 78C 0.0157 0.6392 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.125 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.4251 0.488
Brugia malayi nuclear hormone receptor 0.0074 0.2685 0.3028
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0693 0.0484
Loa Loa (eye worm) hypothetical protein 0.0028 0.0646 0.0741
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0157 0.6392 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0693 0.0484
Echinococcus multilocularis dna polymerase eta 0.0035 0.0936 0.1464
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0074 0.2685 0.3028
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.142 0.2222
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0157 0.6392 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.1252 0.2561
Echinococcus multilocularis musashi 0.0029 0.0669 0.1047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0157 0.6392 0.7317
Echinococcus granulosus dna polymerase kappa 0.0064 0.2211 0.3459
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.3082 0.3487
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0219 0.0174
Echinococcus granulosus ecdysone induced protein 78C 0.0157 0.6392 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.4251 0.4122
Echinococcus granulosus Nuclear hormone receptor HR96 0.0074 0.2685 0.4201
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0693 0.4153
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0035 0.0936 0.1074
Schistosoma mansoni thyroid hormone receptor 0.0157 0.6392 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0035 0.0936 0.1464
Brugia malayi nuclear hormone receptor family member odr-7 0.0074 0.2685 0.3028
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.2542 0.5761
Brugia malayi hypothetical protein 0.0083 0.3082 0.3487
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0693 0.4153
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.871 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0074 0.2685 0.4201
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1135 0.2272
Trypanosoma brucei unspecified product 0.0024 0.0451 0.0576
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0715 0.0803
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0219 0.0343
Echinococcus multilocularis FTZ F1 alpha 0.0157 0.6392 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0669 0.0768
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.125 0.9979
Brugia malayi nuclear receptor NHR-88 0.0074 0.2685 0.3028
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.4251 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.2211 0.494
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.1252 0.2561
Loa Loa (eye worm) hypothetical protein 0.003 0.0715 0.082
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0693 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0157 0.6392 0.7338
Schistosoma mansoni steroid hormone receptor ad4bp 0.0157 0.6392 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0936 0.1777
Echinococcus granulosus thyroid hormone receptor alpha 0.0074 0.2685 0.4201
Schistosoma mansoni lamin 0.0029 0.0669 0.0729
Echinococcus multilocularis dna polymerase kappa 0.0064 0.2211 0.3459
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0074 0.2685 0.2161
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1135 0.2272
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0693 0.4596
Schistosoma mansoni DNA polymerase eta 0.0035 0.0936 0.116
Schistosoma mansoni lamin 0.0029 0.0669 0.0729
Leishmania major DNA polymerase kappa, putative 0.0042 0.1252 0.2561
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0074 0.2685 0.4201
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0083 0.3082 0.4822
Brugia malayi nuclear hormone receptor 0.0157 0.6392 0.7317
Echinococcus multilocularis thyroid hormone receptor alpha 0.0157 0.6392 1
Brugia malayi intermediate filament protein 0.0029 0.0669 0.0695
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Onchocerca volvulus Bile acid receptor homolog 0.0157 0.6392 0.6133
Onchocerca volvulus 0.0074 0.2685 0.2161
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.6133 0.9595
Schistosoma mansoni nuclear hormone receptor 0.0074 0.2685 0.3995
Loa Loa (eye worm) hypothetical protein 0.0029 0.0669 0.0768
Brugia malayi polk-prov protein 0.0039 0.1135 0.1234
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.2542 0.5761
Echinococcus granulosus lamin dm0 0.0029 0.0669 0.1047
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0669 0.0695
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.2211 0.494
Loa Loa (eye worm) acetyltransferase 0.0156 0.6328 0.7264
Schistosoma mansoni RAR-like nuclear receptor 0.0157 0.6392 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.2542 0.3977
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.4251 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0693 0.0484
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.6328 0.9896
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0157 0.6392 0.6133
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0157 0.6392 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0157 0.6392 0.7338
Brugia malayi 6-phosphofructokinase 0.0109 0.4251 0.484
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0157 0.6392 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0665 0.1041
Brugia malayi Pre-SET motif family protein 0.003 0.0715 0.0748
Echinococcus granulosus dna polymerase eta 0.0035 0.0936 0.1464
Loa Loa (eye worm) nuclear receptor NHR-67 0.0074 0.2685 0.3083
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.4251 0.6532
Loa Loa (eye worm) phosphofructokinase 0.0109 0.4251 0.488
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0157 0.6392 0.7317
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.3082 0.3487
Brugia malayi nuclear hormone receptor family member nhr-6 0.0074 0.2685 0.3028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0715 0.0803
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.2211 0.494
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0157 0.6392 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0157 0.6392 0.7317
Echinococcus granulosus Nuclear hormone receptor HR96 0.0074 0.2685 0.4201
Echinococcus multilocularis nuclear receptor nhr 48 0.0074 0.2685 0.4201
Onchocerca volvulus 0.0157 0.6392 0.6133
Brugia malayi tailless protein 0.0074 0.2685 0.3028
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0157 0.6392 0.7317
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0035 0.0936 0.116
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0768 0.1361
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.142 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.142 1
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.4251 0.4122
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0074 0.2685 0.4201
Brugia malayi hypothetical protein 0.0083 0.3082 0.3487
Loa Loa (eye worm) hypothetical protein 0.0083 0.3082 0.3539
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.4251 1
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.1895 0.4155
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.142 0.1228
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.2542 0.5761
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0936 0.1003
Brugia malayi orphan nuclear receptor NR2E1 0.0074 0.2685 0.3028
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0157 0.6392 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0074 0.2685 0.4201
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0083 0.3082 0.4638
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0157 0.6392 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0074 0.2685 0.4201
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0157 0.6392 1
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.4251 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0157 0.6392 1
Loa Loa (eye worm) steroid hormone receptor 0.0157 0.6392 0.7338
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0715 0.1118
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.2211 0.494
Echinococcus multilocularis lamin 0.0029 0.0669 0.1047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0936 0.1777
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0693 0.0484
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0693 0.1175
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.2542 0.5761
Giardia lamblia DINP protein human, muc B family 0.0042 0.1252 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0064 0.2211 0.2036
Brugia malayi ecdysone receptor 0.0074 0.2685 0.3028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0157 0.6392 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.6328 0.99
Brugia malayi hypothetical protein 0.0074 0.2685 0.3028
Echinococcus granulosus intermediate filament protein 0.0029 0.0669 0.1047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0074 0.2685 0.4201
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0219 0.5
Schistosoma mansoni nuclear hormone receptor 0.0157 0.6392 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Loa Loa (eye worm) DR-78 0.0074 0.2685 0.3083
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0157 0.6392 0.7317
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.2211 0.494
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0693 0.0484
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0157 0.6392 1
Schistosoma mansoni nuclear receptor 0.0074 0.2685 0.3995
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0157 0.6392 0.7317
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.2127 0.2382
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.1942 0.223
Trichomonas vaginalis DNA polymerase eta, putative 0.0064 0.2211 0.2036
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Brugia malayi nuclear receptor NHR-88 0.0157 0.6392 0.7317
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Brugia malayi Steroid receptor seven-up type 2 0.0157 0.6392 0.7317
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0693 0.3944
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.2542 0.2918
Brugia malayi Pre-SET motif family protein 0.0209 0.871 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.4251 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0083 0.3082 0.4822
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.4251 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.2127 0.4732
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.1252 0.2561
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.2127 0.3328
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Brugia malayi Nuclear hormone receptor E75 0.0074 0.2685 0.3028
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.4251 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Brugia malayi 6-phosphofructokinase 0.0109 0.4251 0.484
Echinococcus granulosus nuclear receptor nhr 48 0.0074 0.2685 0.4201
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0157 0.6392 1
Brugia malayi Nuclear hormone receptor E75 0.0074 0.2685 0.3028
Brugia malayi ecdysteroid receptor 0.0157 0.6392 0.7317
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0074 0.2685 0.2161
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0157 0.6392 0.7317
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0715 0.1118
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.4251 0.4122
Loa Loa (eye worm) hypothetical protein 0.0083 0.3082 0.3539
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0157 0.6392 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0669 0.0768
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0083 0.3082 0.3539
Brugia malayi hypothetical protein 0.0074 0.2685 0.3028
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.2127 0.4732
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0157 0.6392 0.7317
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.2542 0.2862
Schistosoma mansoni coup transcription factor 0.0157 0.6392 1
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0693 0.4153
Echinococcus granulosus transcription factor Dp 1 0.0041 0.1208 0.1891
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.4251 0.6532
Trypanosoma brucei unspecified product 0.0024 0.0451 0.0576
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.1208 0.1891
Entamoeba histolytica deoxycytidyl transferase, putative 0.0035 0.0936 0.1777
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0069 0.0079
Brugia malayi conserved hypotetical protein 0.0074 0.2685 0.3028
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0693 0.4586
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.2542 0.3977
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.2211 0.494
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0693 0.0484
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0035 0.0936 0.1464
Brugia malayi phosphofructokinase 0.0109 0.4251 0.484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0157 0.6392 0.7338
Schistosoma mansoni nuclear hormone receptor 0.0074 0.2685 0.3995
Loa Loa (eye worm) hypothetical protein 0.0035 0.0936 0.1074
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0157 0.6392 1
Brugia malayi nuclear receptor NHR-67 0.0074 0.2685 0.3028
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Toxoplasma gondii exonuclease III APE 0.0019 0.0219 0.0346
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0715 0.0803
Loa Loa (eye worm) hypothetical protein 0.0083 0.3082 0.3539
Loa Loa (eye worm) hypothetical protein 0.0083 0.3082 0.3539
Onchocerca volvulus 0.0074 0.2685 0.2161
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.2211 0.494
Schistosoma mansoni nuclear receptor nhr-48 0.0074 0.2685 0.3995
Loa Loa (eye worm) hypothetical protein 0.0083 0.3082 0.3539
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.2127 0.3091
Echinococcus granulosus FTZ F1 alpha 0.0157 0.6392 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0157 0.6392 0.7338
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0157 0.6392 0.7317
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0768 0.1361
Trypanosoma brucei unspecified product 0.0057 0.1895 0.4155
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.142 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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