TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 325.408 | Formula: C18H23N5O
H donors: 3 H acceptors: 3 LogP: 1.24 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: NCCCCN(Cc1ncccc1O)Cc1nc2c([nH]1)cccc2
InChi: 1S/C18H23N5O/c19-9-3-4-11-23(12-16-17(24)8-5-10-20-16)13-18-21-14-6-1-2-7-15(14)22-18/h1-2,5-8,10,24H,3-4,9,11-13,19H2,(H,21,22)
InChiKey: JJGIMBLFDDBAOR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	btb and poz domain-containing protein	0.0024	0.0014	0.0014
Toxoplasma gondii	serpin (serine proteinase inhibitor) superfamily protein	0.0022	0.0012	0.0231
Trichomonas vaginalis	conserved hypothetical protein	0.133	0.2001	0.3253
Echinococcus granulosus	growth factor receptor bound protein 2	0.0122	0.0163	0.0163
Brugia malayi	Sex muscle abnormal protein 5	0.0122	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0012	0.0012
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0035	0.0031	0.0031
Toxoplasma gondii	subtilisin SUB11	0.0294	0.0425	0.8198
Schistosoma mansoni	serpin	0.0022	0.0012	0.0012
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0294	0.0425	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.0145	0.0198	0.0198
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0002	0.0002
Schistosoma mansoni	septate junction protein	0.0028	0.0021	0.0021
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0294	0.0425	0.0425
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0102	0.0133	0.2329
Plasmodium falciparum	plasmepsin IX	0.0035	0.0031	0.0535
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0338	0.0491	0.0781
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0502	0.0741	0.0929
Toxoplasma gondii	subtilisin SUB8	0.0294	0.0425	0.8198
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0016	0.0002	0.0003
Brugia malayi	serpin	0.0022	0.0012	0.0012
Brugia malayi	serpin	0.0022	0.0012	0.0012
Brugia malayi	aspartic protease BmAsp-2, identical	0.0035	0.0031	0.0031
Schistosoma mansoni	discoidin domain receptor	0.0024	0.0014	0.0014
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0122	0.0163	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0012	0.0012
Toxoplasma gondii	subtilisin SUB10	0.0294	0.0425	0.8198
Giardia lamblia	High cysteine membrane protein Group 2	0.2416	0.3652	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0031	0.0031
Schistosoma mansoni	chromatin regulatory protein sir2	0.005	0.0054	0.0054
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0031	0.0031
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0086	0.0109	0.0109
Brugia malayi	Calcium binding EGF domain containing protein	0.0018	0.0006	0.0006
Brugia malayi	proprotein convertase 2	0.4175	0.6326	0.6326
Echinococcus granulosus	discoidin domain containing receptor 2	0.0024	0.0014	0.0014
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0308	0.0446	0.9091
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0133	0.0133
Echinococcus multilocularis	discoidin domain containing receptor 2	0.0024	0.0014	0.0018
Schistosoma mansoni	serine protease inhibitors serpins	0.0022	0.0012	0.0012
Onchocerca volvulus		0.0044	0.0045	0.0558
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0294	0.0425	0.0533
Echinococcus granulosus	MAM	0.0044	0.0045	0.0045
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0102	0.0133	0.2708
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.005	0.0054	0.0064
Brugia malayi	hypothetical protein	0.0022	0.0012	0.0012
Schistosoma mansoni	hypothetical protein	0.0141	0.0192	0.0192
Onchocerca volvulus		0.0141	0.0192	0.2382
Echinococcus granulosus	plasminogen activator inhibitor 2	0.0022	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0006
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.133	0.2001	0.3253
Toxoplasma gondii	subtilisin SUB2	0.0294	0.0425	0.8198
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0002	0.0002
Schistosoma mansoni	growth factor receptor-bound protein	0.0122	0.0163	0.0163
Schistosoma mansoni	hypothetical protein	0.0024	0.0014	0.0014
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.005	0.0054	0.0868
Brugia malayi	BmSERPIN, truncated	0.0022	0.0012	0.0012
Plasmodium vivax	aspartyl proteinase, putative	0.0035	0.0031	0.0535
Schistosoma mansoni	hypothetical protein	0.0044	0.0045	0.0045
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.005	0.0054	0.0054
Plasmodium vivax	hypothetical protein, conserved	0.0102	0.0133	0.2329
Brugia malayi	Will die slowly protein	0.0141	0.0192	0.0192
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0294	0.0425	0.0425
Schistosoma mansoni	amine oxidase	0.0102	0.0133	0.0133
Plasmodium falciparum	subtilisin-like protease 1	0.0294	0.0425	0.7441
Brugia malayi	Protein kinase domain containing protein	0.0044	0.0045	0.0045
Brugia malayi	aspartic protease BmAsp-1, identical	0.0035	0.0031	0.0031
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0035	0.0031	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0012	0.0012
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0294	0.0425	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0031	0.0031
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.005	0.0054	0.0064
Schistosoma mansoni	serine protease inhibitors serpins	0.0022	0.0012	0.0012
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.005	0.0054	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0198	0.0198
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0102	0.0133	0.0133
Mycobacterium ulcerans	monoamine oxidase	0.0102	0.0133	0.214
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0035	0.0031	0.0589
Toxoplasma gondii	aspartyl protease ASP3	0.0035	0.0031	0.0589
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.005	0.0054	0.0937
Mycobacterium leprae	Possible secreted protease	0.0294	0.0425	1
Loa Loa (eye worm)	hypothetical protein	0.0502	0.0741	0.0741
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0035	0.0031	0.0027
Toxoplasma gondii	subtilisin SUB12	0.0294	0.0425	0.8198
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.005	0.0054	0.0868
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0102	0.0133	0.5
Schistosoma mansoni	tyrosine kinase	0.0616	0.0915	0.0915
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Plasmodium vivax	aspartyl proteinase, putative	0.0035	0.0031	0.0535
Toxoplasma gondii	subtilisin SUB7	0.0294	0.0425	0.8198
Plasmodium vivax	hypothetical protein, conserved	0.005	0.0054	0.0937
Brugia malayi	hypothetical protein	0.0035	0.0031	0.0031
Brugia malayi	hypothetical protein	0.0035	0.0031	0.0031
Onchocerca volvulus		0.0294	0.0425	0.5271
Brugia malayi	serpin	0.0022	0.0012	0.0012
Loa Loa (eye worm)	serpin	0.0022	0.0012	0.0012
Plasmodium falciparum	plasmepsin II	0.0035	0.0031	0.0535
Onchocerca volvulus		0.0024	0.0014	0.0178
Mycobacterium tuberculosis	Possible oxidoreductase	0.0102	0.0133	0.289
Echinococcus granulosus	chromatin regulatory protein sir2	0.0338	0.0491	0.0491
Plasmodium vivax	subtilisin-like serine protease, putative	0.0294	0.0425	0.7441
Giardia lamblia	Furin precursor putative serine protease	0.133	0.2001	0.5464
Loa Loa (eye worm)	transcriptional regulator	0.005	0.0054	0.0054
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0294	0.0425	0.0425
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0031	0.0031
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1624	0.2448	0.3984
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0294	0.0425	0.0533
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Entamoeba histolytica	SWIRM domain protein	0.0042	0.0042	0.0635
Entamoeba histolytica	hypothetical protein	0.0042	0.0042	0.0635
Brugia malayi	serpin	0.0022	0.0012	0.0012
Leishmania major	subtilisin-like serine peptidase	0.0294	0.0425	0.8651
Loa Loa (eye worm)	hypothetical protein	0.255	0.3856	0.3856
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0014	0.0014
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0502	0.0741	0.0741
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.133	0.2001	0.3253
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0338	0.0491	1
Plasmodium falciparum	LCCL domain-containing protein	0.0024	0.0014	0.0251
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0338	0.0491	1
Trichomonas vaginalis	WD repeat domain, putative	0.0141	0.0192	0.0291
Echinococcus multilocularis	Estrogen regulated protein EP45	0.0022	0.0012	0.0015
Entamoeba histolytica	PH domain containing protein kinase, putative	0.007	0.0085	0.1522
Schistosoma mansoni	serine protease inhibitors serpins	0.0022	0.0012	0.0012
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Brugia malayi	transcriptional regulator, Sir2 family protein	0.005	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0045	0.0045
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0338	0.0491	0.0616
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0034	0.003	0.003
Onchocerca volvulus		0.0024	0.0014	0.0178
Leishmania major	UDP-galactopyranose mutase	0.0102	0.0133	0.2708
Schistosoma mansoni	chromatin regulatory protein sir2	0.005	0.0054	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0042	0.0046
Brugia malayi	serpin	0.0022	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0545	0.0806	0.0806
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0045	0.0045
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0294	0.0425	1
Loa Loa (eye worm)	hypothetical protein	0.0502	0.0741	0.0741
Onchocerca volvulus		0.0022	0.0012	0.0148
Onchocerca volvulus		0.0044	0.0045	0.0558
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0031	0.0031
Echinococcus multilocularis	epidermal growth factor receptor	0.0616	0.0915	0.1147
Trichomonas vaginalis	conserved hypothetical protein	0.133	0.2001	0.3253
Trichomonas vaginalis	conserved hypothetical protein	0.0294	0.0425	0.0672
Toxoplasma gondii	subtilisin SUB6	0.0294	0.0425	0.8198
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Brugia malayi	Serpin protein 6	0.0022	0.0012	0.0012
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0338	0.0491	0.0491
Trichomonas vaginalis	conserved hypothetical protein	0.133	0.2001	0.3253
Toxoplasma gondii	aspartyl protease	0.0035	0.0031	0.0589
Onchocerca volvulus		0.0035	0.0031	0.0379
Loa Loa (eye worm)	transcriptional regulator	0.0338	0.0491	0.0491
Trichomonas vaginalis	conserved hypothetical protein	0.133	0.2001	0.3253
Toxoplasma gondii	SWIRM domain-containing protein	0.0042	0.0042	0.0818
Entamoeba histolytica	hypothetical protein, conserved	0.005	0.0054	0.0868
Echinococcus granulosus	Furin 1	0.1624	0.2448	0.2448
Onchocerca volvulus		0.0166	0.023	0.2857
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.005	0.0054	0.0067
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0079	0.0098	0.0123
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0308	0.0446	0.9091
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0031	0.0031
Echinococcus multilocularis	Coagulation factor 5 8 type, C terminal	0.0024	0.0014	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.133	0.2001	0.3253
Plasmodium falciparum	plasmepsin VIII, putative	0.0035	0.0031	0.0535
Loa Loa (eye worm)	serpin protein 6	0.0022	0.0012	0.0012
Schistosoma mansoni	cathepsin D (A01 family)	0.0035	0.0031	0.0031
Toxoplasma gondii	F5/8 type C domain-containing protein	0.0024	0.0014	0.0276
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0102	0.0133	0.214
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0238	0.034	0.034
Schistosoma mansoni	dock	0.0024	0.0014	0.0014
Echinococcus granulosus	discoidin domain containing receptor 2	0.0024	0.0014	0.0014
Loa Loa (eye worm)	TK/ALK protein kinase	0.0044	0.0045	0.0045
Brugia malayi	protein kinase C II.	0.0086	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.133	0.2001	0.3253
Trichomonas vaginalis	conserved hypothetical protein	0.0294	0.0425	0.0672
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0102	0.0133	0.214
Schistosoma mansoni	chromatin regulatory protein sir2	0.0338	0.0491	0.0491
Echinococcus granulosus	protein kinase c epsilon type	0.0086	0.0109	0.0109
Plasmodium falciparum	plasmepsin IV	0.0035	0.0031	0.0535
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1624	0.2448	0.3984
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0294	0.0425	0.0425
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1624	0.2448	0.3984
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0031	0.0031
Schistosoma mansoni	chromatin regulatory protein sir2	0.005	0.0054	0.0054
Schistosoma mansoni	serine protease inhibitors serpins	0.0022	0.0012	0.0012
Echinococcus granulosus	Coagulation factor 5 8 type C terminal	0.0024	0.0014	0.0014
Toxoplasma gondii	aspartyl protease ASP5	0.0355	0.0518	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0003	0.0003
Entamoeba histolytica	SWIRM domain protein	0.0042	0.0042	0.0635
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Plasmodium vivax	plasmepsin V, putative	0.039	0.0571	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0014	0.0014
Plasmodium falciparum	subtilisin-like protease 3	0.0294	0.0425	0.7441
Plasmodium vivax	plasmepsin IV, putative	0.0035	0.0031	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0012	0.0012
Trichomonas vaginalis	hypothetical protein	0.133	0.2001	0.3253
Loa Loa (eye worm)	hypothetical protein	0.005	0.0054	0.0054
Echinococcus granulosus	neuroendocrine convertase 2	0.4175	0.6326	0.6326
Plasmodium vivax	LCCL domain-containing protein	0.0024	0.0014	0.0251
Echinococcus granulosus	serine protease inhibitor	0.0022	0.0012	0.0012
Plasmodium vivax	aspartyl protease, putative	0.0035	0.0031	0.0535
Brugia malayi	neuroendocrine convertase 1 precursor	0.4175	0.6326	0.6326
Loa Loa (eye worm)	transcriptional regulator	0.005	0.0054	0.0054
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0294	0.0425	1
Plasmodium falciparum	LCCL domain-containing protein	0.0024	0.0014	0.0251
Plasmodium vivax	LCCL domain-containing protein	0.0024	0.0014	0.0251
Toxoplasma gondii	subtilisin SUB5	0.0294	0.0425	0.8198
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.404	0.6122	0.6122
Schistosoma mansoni	serine protease inhibitors serpins	0.0022	0.0012	0.0012
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0338	0.0491	1
Brugia malayi	hypothetical protein	0.0022	0.0012	0.0012
Loa Loa (eye worm)	serpin	0.0022	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0012	0.0012
Echinococcus multilocularis	serine protease inhibitor	0.0022	0.0012	0.0015
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0109	0.0109
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0338	0.0491	0.0781
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.005	0.0054	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0012	0.0012
Schistosoma mansoni	furin-1 (S08 family)	0.2844	0.4303	0.4303
Schistosoma mansoni	hypothetical protein	0.133	0.2001	0.2001
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0003	0.0003
Echinococcus granulosus	epidermal growth factor receptor	0.0616	0.0915	0.0915
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0031	0.0031
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0035	0.0031	0.0031
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Trypanosoma cruzi	subtilisin peptidase	0.0294	0.0425	0.8651
Plasmodium vivax	subtilisin-like protease 1	0.0294	0.0425	0.7441
Trypanosoma brucei	subtilisin peptidase	0.0294	0.0425	0.8486
Schistosoma mansoni	SWI/SNF complex-related	0.0042	0.0042	0.0042
Echinococcus granulosus	discoidin domain receptor	0.0024	0.0014	0.0014
Echinococcus multilocularis	protein kinase c epsilon type	0.0086	0.0109	0.0137
Echinococcus multilocularis	neuroendocrine convertase 2	0.4175	0.6326	0.793
Trichomonas vaginalis	conserved hypothetical protein	0.133	0.2001	0.3253
Echinococcus multilocularis	discoidin domain receptor	0.0024	0.0014	0.0018
Giardia lamblia	Hypothetical protein	0.0338	0.0491	0.1316
Brugia malayi	SWIRM domain containing protein	0.0042	0.0042	0.0042
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0035	0.0031	0.0031
Echinococcus multilocularis	Estrogen regulated protein EP45	0.0022	0.0012	0.0015
Giardia lamblia	hypothetical protein	0.0042	0.0042	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0036	0.0036
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.133	0.2001	0.3253
Echinococcus granulosus	serine protease inhibitor	0.0022	0.0012	0.0012
Onchocerca volvulus		0.0545	0.0806	1
Toxoplasma gondii	histone deacetylase SIR2-like	0.005	0.0054	0.1033
Plasmodium vivax	aspartyl protease, putative	0.0035	0.0031	0.0535
Brugia malayi	serpin (BmSERPIN)	0.0022	0.0012	0.0012
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.005	0.0054	0.0064
Toxoplasma gondii	F5/8 type C domain-containing protein	0.0024	0.0014	0.0276
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0031	0.0031
Plasmodium falciparum	protoporphyrinogen oxidase	0.0102	0.0133	0.2329
Brugia malayi	transcriptional regulator, Sir2 family protein	0.005	0.0054	0.0054
Schistosoma mansoni	serpin	0.0022	0.0012	0.0012
Plasmodium falciparum	plasmepsin VII	0.0035	0.0031	0.0535
Toxoplasma gondii	subtilisin SUB4	0.0294	0.0425	0.8198
Echinococcus granulosus	Protein kinase C brain isozyme	0.0016	0.0002	0.0002
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Schistosoma mansoni	cathepsin D (A01 family)	0.0035	0.0031	0.0031
Echinococcus multilocularis	protein will die slowly	0.0141	0.0192	0.0241
Plasmodium falciparum	plasmepsin III	0.0035	0.0031	0.0535
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0338	0.0491	1
Echinococcus multilocularis	discoidin domain containing receptor 2	0.0024	0.0014	0.0018
Onchocerca volvulus		0.0022	0.0012	0.0148
Plasmodium falciparum	subtilisin-like protease 2	0.0294	0.0425	0.7441
Echinococcus granulosus	membrane bound transcription factor site 1	0.0294	0.0425	0.0425
Trichomonas vaginalis	conserved hypothetical protein	0.0294	0.0425	0.0672
Schistosoma mansoni	memapsin-2 (A01 family)	0.0035	0.0031	0.0031
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1624	0.2448	0.3984
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0045	0.0045
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0616	0.0915	0.0915
Plasmodium vivax	subtilisin-like protease 2, putative	0.0294	0.0425	0.7441
Loa Loa (eye worm)	subtilase	0.0294	0.0425	0.0425
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.1624	0.2448	0.2448
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Schistosoma mansoni	serine protease inhibitors serpins	0.0022	0.0012	0.0012
Schistosoma mansoni	hypothetical protein	0.0044	0.0045	0.0045
Plasmodium falciparum	plasmepsin V	0.039	0.0571	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0502	0.0741	0.0741
Schistosoma mansoni	amine oxidase	0.0102	0.0133	0.0133
Brugia malayi	BmSERPIN	0.0022	0.0012	0.0012
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0035	0.0031	0.0031
Toxoplasma gondii	PA14 domain-containing protein	0.0024	0.0014	0.0276
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0102	0.0133	0.214
Toxoplasma gondii	histone deacetylase SIR2	0.005	0.0054	0.1033
Mycobacterium ulcerans	oxidoreductase	0.0102	0.0133	0.214
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0031	0.0031
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.005	0.0054	0.109
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1624	0.2448	0.3984
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.404	0.6122	1
Schistosoma mansoni	discoidin domain receptor	0.0024	0.0014	0.0014
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0035	0.0031	0.0589
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.005	0.0054	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0012	0.0012
Brugia malayi	serpin	0.0022	0.0012	0.0012
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0338	0.0491	0.0491
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0102	0.0133	0.289
Brugia malayi	hypothetical protein	0.0102	0.0133	0.0133
Onchocerca volvulus	Putative cubilin	0.0018	0.0006	0.0072
Onchocerca volvulus		0.0022	0.0012	0.0148
Brugia malayi	SWIRM domain containing protein	0.0545	0.0806	0.0806
Brugia malayi	celfurPC protein	0.526	0.7977	0.7977
Plasmodium falciparum	plasmepsin X	0.0035	0.0031	0.0535
Giardia lamblia	Sirtuin type 2	0.005	0.0054	0.0114
Echinococcus granulosus	SWI:SNF complex subunit SMARCC2	0.0042	0.0042	0.0042
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0338	0.0491	0.0616
Echinococcus granulosus	Estrogen regulated protein EP45	0.0022	0.0012	0.0012
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0032	0.0026	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.133	0.2001	0.3253
Echinococcus multilocularis	Furin 1	0.1624	0.2448	0.3069
Trichomonas vaginalis	conserved hypothetical protein	0.0294	0.0425	0.0672
Echinococcus multilocularis	serine protease inhibitor	0.0022	0.0012	0.0015
Onchocerca volvulus		0.0022	0.0012	0.0148
Onchocerca volvulus		0.0022	0.0012	0.0148
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.005	0.0054	0.109
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.005	0.0054	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.133	0.2001	0.3253
Loa Loa (eye worm)	aspartyl protease 6	0.0035	0.0031	0.0031
Toxoplasma gondii	aspartyl protease ASP1	0.0035	0.0031	0.0589
Brugia malayi	Pepsin A precursor	0.0035	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0133	0.0133
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0294	0.0425	1
Echinococcus multilocularis		0.0102	0.0133	0.0167
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0102	0.0133	0.0167
Loa Loa (eye worm)	serpin	0.0022	0.0012	0.0012
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0122	0.0163	0.0163
Loa Loa (eye worm)	serpin	0.0022	0.0012	0.0012
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0308	0.0446	0.898
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0294	0.0425	0.0425
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1624	0.2448	0.3984
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.404	0.6122	0.7674
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0102	0.0133	0.2329
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0102	0.0133	0.2329
Loa Loa (eye worm)	proprotein convertase 2	0.1624	0.2448	0.2448
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0014	0.0014
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0338	0.0491	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0122	0.0163	0.0163
Echinococcus granulosus	serine:threonine protein kinase N2	0.007	0.0085	0.0085
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.005	0.0054	0.0067
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0102	0.0133	0.289
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0032	0.0026	0.0026
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.005	0.0054	0.0955
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.005	0.0054	0.0064
Leishmania major	sir2-family protein-like protein	0.005	0.0054	0.109
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0294	0.0425	1
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0294	0.0425	0.0425
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0031	0.0031
Schistosoma mansoni	chromatin regulatory protein sir2	0.0338	0.0491	0.0491
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.005	0.0054	0.0937
Leishmania major	silent information regulator 2, putative	0.0338	0.0491	1
Trichomonas vaginalis	conserved hypothetical protein	0.0294	0.0425	0.0672
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.131	0.1969	0.1969
Brugia malayi	serpin (BmSERPIN)	0.0022	0.0012	0.0012
Plasmodium vivax	NAD-dependent deacetylase, putative	0.005	0.0054	0.0937
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0294	0.0425	1
Mycobacterium ulcerans	dehydrogenase	0.0102	0.0133	0.214
Echinococcus multilocularis	discoidin domain containing receptor 2	0.0024	0.0014	0.0018
Toxoplasma gondii	histone lysine-specific demethylase	0.0102	0.0133	0.2566
Echinococcus granulosus	protein will die slowly	0.0141	0.0192	0.0192
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.005	0.0054	0.0114
Toxoplasma gondii	subtilisin SUB1	0.0294	0.0425	0.8198
Onchocerca volvulus		0.0035	0.0031	0.0379
Trichomonas vaginalis	conserved hypothetical protein	0.133	0.2001	0.3253
Plasmodium vivax	aspartyl protease, putative	0.0035	0.0031	0.0535
Brugia malayi	hypothetical protein	0.0044	0.0045	0.0045
Echinococcus multilocularis	SWI:SNF complex subunit SMARCC2	0.0042	0.0042	0.0053
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.404	0.6122	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0616	0.0915	0.0915
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Toxoplasma gondii	F5/8 type C domain-containing protein	0.0024	0.0014	0.0276
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.005	0.0054	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0031	0.0031
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0102	0.0133	0.2329
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0042	0.0042
Plasmodium falciparum	plasmepsin I	0.0035	0.0031	0.0535
Loa Loa (eye worm)	sirtuin 4	0.005	0.0054	0.0054
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0102	0.0133	0.2566
Echinococcus multilocularis	nuclear receptor 2C2 associated protein	0.0024	0.0014	0.0018
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.005	0.0054	0.109
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0294	0.0425	1
Plasmodium falciparum	plasmepsin VI	0.0035	0.0031	0.0535
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0102	0.0133	0.0133
Brugia malayi	Subtilase family protein	0.0294	0.0425	0.0425
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.005	0.0054	0.0064
Echinococcus granulosus	Estrogen regulated protein EP45	0.0022	0.0012	0.0012
Brugia malayi	NAD-dependent deacetylase SIRT1	0.005	0.0054	0.0054
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.005	0.0054	0.0054
Echinococcus granulosus	serine protease inhibitor	0.0022	0.0012	0.0012
Toxoplasma gondii	subtilisin SUB9	0.0294	0.0425	0.8198
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0294	0.0425	0.0672
Trichomonas vaginalis	conserved hypothetical protein	0.133	0.2001	0.3253
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0425	0.0425
Echinococcus multilocularis	MAM	0.0044	0.0045	0.0056
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.005	0.0054	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0042	0.0046
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0294	0.0425	1
Giardia lamblia	Transcriptional regulator, Sir2 family	0.005	0.0054	0.0114
Echinococcus granulosus	discoidin domain containing receptor 2	0.0024	0.0014	0.0014
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0599	0.0889	0.0889
Onchocerca volvulus		0.0022	0.0012	0.0148
Schistosoma mansoni	chromatin regulatory protein sir2	0.0338	0.0491	0.0491
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0294	0.0425	0.0425
Toxoplasma gondii	protease inhibitor PI1	0.0022	0.0012	0.0231
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0102	0.0133	0.2708
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0294	0.0425	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0012	0.0012
Plasmodium vivax	hypothetical protein, conserved	0.0102	0.0133	0.2329
Brugia malayi	serpin precursor	0.0022	0.0012	0.0012
Brugia malayi	Angiotensin-converting enzyme family protein	0.0599	0.0889	0.0889
Echinococcus multilocularis		0.526	0.7977	1
Schistosoma mansoni	chromatin regulatory protein sir2	0.005	0.0054	0.0054
Loa Loa (eye worm)	WD40 repeat protein	0.0141	0.0192	0.0192

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (ADMET)	> 149200 nM	Cytotoxicity against human MT4 cells expressing CD4 and CXCR4 assessed as cell viability	ChEMBL.	21295470

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1682873

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1504685