Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0.306 | 0.2498 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.306 | 0.306 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0032 | 0.306 | 0.2498 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0032 | 0.306 | 0.3166 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0032 | 0.306 | 0.306 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0032 | 0.306 | 0.306 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0032 | 0.306 | 0.2498 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0032 | 0.306 | 0.3166 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.306 | 0.306 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0032 | 0.306 | 0.2498 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.8878 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0032 | 0.306 | 0.3166 |
Brugia malayi | steroid hormone receptor | 0.0032 | 0.306 | 0.3166 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0032 | 0.306 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.306 | 0.3166 |
Brugia malayi | nuclear receptor NHR-88 | 0.0032 | 0.306 | 0.3166 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0032 | 0.306 | 0.3166 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.306 | 0.306 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0032 | 0.306 | 0.306 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0032 | 0.306 | 0.3166 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.306 | 0.306 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.306 | 0.3166 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0032 | 0.306 | 0.2498 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0032 | 0.306 | 0.306 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0032 | 0.306 | 0.3166 |
Onchocerca volvulus | 0.0032 | 0.306 | 0.5 | |
Brugia malayi | nuclear hormone receptor | 0.0032 | 0.306 | 0.3166 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0032 | 0.306 | 0.306 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0032 | 0.306 | 0.2498 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0032 | 0.306 | 0.306 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0032 | 0.306 | 0.306 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.7241 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.306 | 0.306 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.306 | 0.3166 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.306 | 0.3166 |
Brugia malayi | ecdysteroid receptor | 0.0032 | 0.306 | 0.3166 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.306 | 0.3166 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0032 | 0.306 | 0.2498 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0032 | 0.306 | 0.2498 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0032 | 0.306 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0.306 | 0.2498 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0032 | 0.306 | 0.306 |
Schistosoma mansoni | coup transcription factor | 0.0032 | 0.306 | 0.2498 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.306 | 0.306 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.5304 | 0.5392 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.306 | 0.306 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0041 | 0.5304 | 0.3233 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.6119 | 0.8166 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.306 | 0.3166 |
Schistosoma mansoni | nuclear hormone receptor | 0.0032 | 0.306 | 0.2498 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.306 | 0.306 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.7241 | 0.7241 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0032 | 0.306 | 0.2498 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0032 | 0.306 | 0.3166 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0032 | 0.306 | 0.3166 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0041 | 0.5304 | 0.3233 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0032 | 0.306 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0032 | 0.306 | 0.2498 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.306 | 0.3166 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0032 | 0.306 | 0.3166 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 90 % | Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilization at 30 uM relative to glutamate | ChEMBL. | 21315585 |
EC50 (binding) | = 550 nM | Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilization | ChEMBL. | 21315585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.