Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0503 | 0.4007 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0419 | 0.1466 | 0.1466 |
Brugia malayi | nuclear hormone receptor | 0.0419 | 0.1466 | 0.1466 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0616 | 0.7459 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 40 uM | Cytotoxicity activity against human KB cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay | ChEMBL. | 21316977 |
GI50 (functional) | > 40 uM | Cytotoxicity activity against human A549 cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay | ChEMBL. | 21316977 |
GI50 (functional) | > 40 uM | Cytotoxicity activity against human DU145 cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay | ChEMBL. | 21316977 |
Inhibition (functional) | = 0 % | Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of lipopolysaccharide/interferon-gamma induced PGE2 production at 1 uM by EIA | ChEMBL. | 21316977 |
Inhibition (functional) | = 95 % | Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of lipopolysaccharide/interferon-gamma induced PGE2 production at 3 uM after 18 hrs | ChEMBL. | 21316977 |
Inhibition (functional) | = 95 % | Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of lipopolysaccharide/interferon-gamma induced PGE2 production at 10 uM after 18 hrs | ChEMBL. | 21316977 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.