Detailed information for compound 1505114

Basic information

Technical information
  • TDR Targets ID: 1505114
  • Name: 6-chloro-N-[(3S)-1-(1-methylamino-2,3-dihydro -1H-inden-5-yl)-2-oxopyrrolidin-3-yl]naphthal ene-2-sulfonamide
  • MW: 469.984 | Formula: C24H24ClN3O3S
  • H donors: 2 H acceptors: 3 LogP: 3.81 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC1CCc2c1ccc(c2)N1CC[C@@H](C1=O)NS(=O)(=O)c1ccc2c(c1)ccc(c2)Cl
  • InChi: 1S/C24H24ClN3O3S/c1-26-22-9-4-17-13-19(6-8-21(17)22)28-11-10-23(24(28)29)27-32(30,31)20-7-3-15-12-18(25)5-2-16(15)14-20/h2-3,5-8,12-14,22-23,26-27H,4,9-11H2,1H3/t22?,23-/m0/s1
  • InChiKey: KYECAPPDCLIEEJ-WCSIJFPASA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-N-[(3S)-1-(1-methylaminoindan-5-yl)-2-oxo-pyrrolidin-3-yl]naphthalene-2-sulfonamide
  • 6-chloro-N-[(3S)-1-(1-methylamino-5-indanyl)-2-oxo-3-pyrrolidinyl]-2-naphthalenesulfonamide
  • 6-chloro-N-[(3S)-2-keto-1-(1-methylaminoindan-5-yl)pyrrolidin-3-yl]naphthalene-2-sulfonamide
  • 6-chloro-N-[(3S)-1-(1-methylamino-2,3-dihydro-1H-inden-5-yl)-2-oxo-pyrrolidin-3-yl]naphthalene-2-sulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei beta tubulin 0.0014 0.0069 0.0688
Trypanosoma brucei beta tubulin 0.0014 0.0069 0.0688
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0123 0.0121
Echinococcus multilocularis tubulin alpha chain 0.0014 0.0069 0.0049
Echinococcus granulosus dual specificity 0.0096 0.1006 0.1163
Echinococcus multilocularis Tubulin beta 2C chain 0.0014 0.0069 0.0049
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0174 0.0465
Echinococcus granulosus tubulin alpha 3 chain 0.0014 0.0069 0.0058
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0059 0.0209
Plasmodium vivax importin-beta 2, putative 0.0032 0.0269 0.0323
Echinococcus granulosus tubulin gamma 1 chain 0.0014 0.0069 0.0058
Echinococcus granulosus tubulin alpha 1C chain 0.0014 0.0069 0.0058
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0656 1
Trichomonas vaginalis tubulin beta chain, putative 0.0014 0.0069 0.1591
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0102 0.0083
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0102 0.0082
Trypanosoma brucei alpha tubulin 0.0014 0.0069 0.0688
Loa Loa (eye worm) hypothetical protein 0.0096 0.1001 0.2676
Schistosoma mansoni egf-like domain protein 0.0016 0.0093 0.0072
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0205 0.126
Schistosoma mansoni alpha tubulin 0.0014 0.0069 0.0044
Echinococcus granulosus geminin 0.0185 0.2018 0.2357
Trichomonas vaginalis tubulin beta chain, putative 0.0014 0.0069 0.1591
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.1252 0.8906
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0201 0.023
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0114 0.0094
Brugia malayi Tubulin beta-1 chain 0.0014 0.0069 0.0243
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.1402 0.1781
Trypanosoma brucei tubulin gamma chain 0.0014 0.0069 0.0688
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0102 0.0096
Echinococcus multilocularis tubulin alpha chain 0.0014 0.0069 0.0049
Echinococcus granulosus tubulin alpha chain 0.0014 0.0069 0.0058
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0174 0.0154
Echinococcus granulosus Tubulin alpha 1 chain 0.0014 0.0069 0.0058
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0205 0.0236
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0032 0.074
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0114 0.011
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0174 0.0609
Trichomonas vaginalis tubulin beta chain, putative 0.0014 0.0069 0.1591
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.013 0.0134
Brugia malayi jmjC domain containing protein 0.0017 0.0102 0.0359
Brugia malayi jmjC domain containing protein 0.0017 0.0102 0.0359
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.1006 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0114 0.0111
Toxoplasma gondii thioredoxin reductase 0.0052 0.0498 0.747
Brugia malayi Protein kinase domain containing protein 0.0096 0.1006 0.3529
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.1402 0.1781
Onchocerca volvulus 0.0089 0.0926 0.9809
Echinococcus granulosus cpg binding protein 0.0033 0.0287 0.0315
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0498 0.0532
Echinococcus granulosus tubulin alpha 3 chain 0.0014 0.0069 0.0058
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0102 0.0097
Schistosoma mansoni tubulin subunit alpha 0.0014 0.0069 0.0044
Trypanosoma cruzi epsilon tubulin, putative 0.0014 0.0069 0.038
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0032 0.0014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0114 0.0835
Plasmodium falciparum alpha tubulin 2 0.0014 0.0069 0.0051
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.013 0.0134
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0032 0.074
Loa Loa (eye worm) BEN-1 protein 0.0014 0.0069 0.0185
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0174 0.1727
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0114 0.0111
Brugia malayi jmjC domain containing protein 0.0064 0.0632 0.2217
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0201 0.2701
Schistosoma mansoni tubulin subunit alpha 0.0014 0.0069 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0086
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0093 0.0327
Echinococcus granulosus expressed conserved protein 0.0101 0.1061 0.1227
Echinococcus granulosus beta tubulin 0.0014 0.0069 0.0058
Trichomonas vaginalis tubulin beta chain, putative 0.0014 0.0069 0.1591
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0091 0.0944 0.1078
Echinococcus multilocularis beta tubulin 0.0014 0.0069 0.0049
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0123 0.0103
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0205 0.0236
Schistosoma mansoni hypothetical protein 0.0447 0.4999 0.5868
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0926 0.3248
Entamoeba histolytica tubulin gamma chain 0.0014 0.0069 0.0336
Echinococcus multilocularis tubulin alpha 3 chain 0.0014 0.0069 0.0049
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0926 0.3248
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0249
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.0926 0.2477
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0654 0.7347 1
Plasmodium vivax JmjC domain containing protein 0.0017 0.0102 0.0096
Schistosoma mansoni tubulin subunit epsilon 0.0014 0.0069 0.0044
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0201 0.1729
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0014 0.0069 0.0594
Plasmodium falciparum importin beta, putative 0.0032 0.0269 0.0323
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.0926 0.2477
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0114 0.0473
Echinococcus multilocularis tubulin subunit beta 0.0014 0.0069 0.0049
Loa Loa (eye worm) hypothetical protein 0.0096 0.1001 0.2676
Trichomonas vaginalis tubulin epsilon chain, putative 0.0014 0.0069 0.1591
Brugia malayi Common central domain of tyrosinase family protein 0.0089 0.0926 0.3248
Loa Loa (eye worm) glutathione reductase 0.0052 0.0498 0.1332
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0835
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.1252 0.1574
Leishmania major hypothetical protein, conserved 0.0017 0.0102 0.0354
Treponema pallidum NADH oxidase 0.0018 0.0114 0.4831
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.013 0.0134
Brugia malayi Fibulin-1 precursor 0.0016 0.0093 0.0327
Trichomonas vaginalis tubulin gamma chain, putative 0.0014 0.0069 0.1591
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0114 0.2609
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0201 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0118 0.0006
Schistosoma mansoni patched 1 0.0046 0.0435 0.0476
Brugia malayi beta-tubulin, identical 0.0014 0.0069 0.0243
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0114 0.0111
Onchocerca volvulus 0.0089 0.0926 0.9809
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0096 0.1006 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0114 0.1129
Onchocerca volvulus 0.0089 0.0926 0.9809
Loa Loa (eye worm) hypothetical protein 0.0259 0.2852 0.7626
Trypanosoma cruzi beta tubulin, putative 0.0014 0.0069 0.038
Echinococcus granulosus alpha tubulin 0.0014 0.0069 0.0058
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0205 0.0718
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0656 0.6259
Loa Loa (eye worm) hypothetical protein 0.0032 0.0269 0.0718
Trypanosoma cruzi alpha tubulin, putative 0.0014 0.0069 0.038
Trypanosoma brucei alpha tubulin 0.0014 0.0069 0.0688
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0656 0.075
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0114 0.0111
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0205 0.1565
Loa Loa (eye worm) tubulin gamma chain 0.0014 0.0069 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1006 0.1151
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0205 0.126
Trypanosoma brucei beta tubulin 0.0014 0.0069 0.0688
Entamoeba histolytica hypothetical protein 0.0039 0.0357 0.2949
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0114 0.1129
Echinococcus granulosus tubulin beta 4A class IVa 0.0014 0.0069 0.0058
Schistosoma mansoni tubulin subunit alpha 0.0014 0.0069 0.0044
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0473
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0102 0.0083
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0435 0.1164
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0032 0.074
Trichomonas vaginalis tubulin, putative 0.0014 0.0069 0.1591
Plasmodium vivax tubulin alpha chain, putative 0.0014 0.0069 0.0051
Schistosoma mansoni hypothetical protein 0.0185 0.2018 0.2346
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0091 0.0944 0.3311
Echinococcus multilocularis snurportin 1 0.0337 0.374 0.3727
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0102 0.0082
Onchocerca volvulus 0.0091 0.0944 1
Brugia malayi Tubulin alpha chain 0.0014 0.0069 0.0243
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0118 0.0006
Trichomonas vaginalis tubulin gamma chain, putative 0.0014 0.0069 0.1591
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0656 0.0637
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0926 0.3248
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0668 0.0751
Brugia malayi Thioredoxin reductase 0.0052 0.0498 0.1746
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0498 0.0564
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0205 0.0236
Echinococcus granulosus beta tubulin 0.0014 0.0069 0.0058
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0435 0.049
Plasmodium vivax tubulin epsilon chain, putative 0.0014 0.0069 0.0051
Echinococcus granulosus tubulin alpha chain 0.0014 0.0069 0.0058
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0205 0.0236
Echinococcus multilocularis neuropeptide s receptor 0.0508 0.5693 0.5685
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0093 0.0249
Entamoeba histolytica protein kinase, putative 0.0096 0.1006 0.8836
Plasmodium falciparum glutathione reductase 0.0052 0.0498 0.0637
Echinococcus multilocularis neuropeptide receptor A26 0.0508 0.5693 0.5685
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0654 0.7347 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0014 0.0069 0.1591
Onchocerca volvulus Arrow homolog 0.0016 0.0093 0.0987
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0656 0.0853
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0032 0.0000055466
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0096 0.1006 0.2691
Trypanosoma brucei alpha tubulin 0.0014 0.0069 0.0688
Entamoeba histolytica tubulin family protein 0.0014 0.0069 0.0336
Entamoeba histolytica fatty acid elongase, putative 0.0085 0.0876 0.7649
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0032 0.074
Entamoeba histolytica fatty acid elongase, putative 0.0085 0.0876 0.7649
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0249
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0174 0.0181
Schistosoma mansoni hypothetical protein 0.0045 0.0416 0.0454
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0201 0.023
Echinococcus multilocularis Tubulin alpha 1 chain 0.0014 0.0069 0.0049
Entamoeba histolytica fatty acid elongase, putative 0.0085 0.0876 0.7649
Schistosoma mansoni hypothetical protein 0.0185 0.2018 0.2346
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0269 0.0249
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0201 0.4608
Brugia malayi Importin beta-1 subunit 0.0032 0.0269 0.0941
Brugia malayi tubulin alpha chain - mouse 0.0014 0.0069 0.0243
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0654 0.7347 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.1154 0.1325
Trichomonas vaginalis tubulin beta chain, putative 0.0014 0.0069 0.1591
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0102 0.0082
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0174 0.1453
Loa Loa (eye worm) hypothetical protein 0.0089 0.0926 0.2477
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0653 0.0733
Schistosoma mansoni tubulin subunit beta 0.0014 0.0069 0.0044
Echinococcus granulosus dnaJ subfamily B 0.0447 0.4999 0.5874
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0654 0.7347 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0205 0.0126
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0205 0.1445
Schistosoma mansoni tubulin subunit gamma 0.0014 0.0069 0.0044
Echinococcus multilocularis tubulin alpha chain 0.0014 0.0069 0.0049
Echinococcus granulosus tubulin beta 1 chain 0.0014 0.0069 0.0058
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0632 0.0722
Echinococcus granulosus Tubulin alpha 1 chain 0.0014 0.0069 0.0058
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.1252 0.1574
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0498 0.0637
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.1135 0.3979
Schistosoma mansoni cpg binding protein 0.0033 0.0287 0.0302
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.2852 0.2838
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0498 0.1332
Loa Loa (eye worm) tubulin beta-2A chain 0.0014 0.0069 0.0185
Schistosoma mansoni tyrosinase precursor 0.0089 0.0926 0.1056
Loa Loa (eye worm) tubulin alpha-2 chain 0.0014 0.0069 0.0185
Echinococcus multilocularis tumor protein p63 0.037 0.4114 0.4102
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0632 0.0613
Plasmodium falciparum glutathione reductase 0.0018 0.0114 0.0111
Echinococcus granulosus Tubulin alpha 1 chain 0.0014 0.0069 0.0058
Entamoeba histolytica hypothetical protein 0.0039 0.0357 0.2949
Plasmodium falciparum tubulin epsilon chain, putative 0.0014 0.0069 0.0051
Brugia malayi hypothetical protein 0.0011 0.0032 0.0113
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0653 0.0733
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0102 0.1126
Plasmodium vivax tubulin alpha chain, putative 0.0014 0.0069 0.0051
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0653 0.0746
Entamoeba histolytica fatty acid elongase, putative 0.0085 0.0876 0.7649
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0205 0.1445
Leishmania major importin beta-1 subunit, putative 0.0026 0.0201 0.1402
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0032 0.074
Mycobacterium tuberculosis Probable reductase 0.0118 0.1252 0.1574
Schistosoma mansoni ran 0.0023 0.0174 0.0167
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0086
Loa Loa (eye worm) tubulin beta-1 chain 0.0014 0.0069 0.0185
Loa Loa (eye worm) hypothetical protein 0.0026 0.0205 0.0547
Brugia malayi glutathione reductase 0.0052 0.0498 0.1746
Echinococcus multilocularis tubulin epsilon chain 0.0014 0.0069 0.0049
Echinococcus granulosus Tubulin beta 2C chain 0.0014 0.0069 0.0058
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0835
Schistosoma mansoni alpha tubulin 0.0014 0.0069 0.0044
Plasmodium falciparum alpha tubulin 1 0.0014 0.0069 0.0051
Schistosoma mansoni survival motor neuron protein 0.0053 0.051 0.0564
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0656 0.0737
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.1252 0.1574
Loa Loa (eye worm) hypothetical protein 0.0108 0.1135 0.3034
Brugia malayi ShTK domain containing protein 0.0089 0.0926 0.3248
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0102 0.1126
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0032 0.074
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0249
Echinococcus granulosus nibrin 0.0011 0.0032 0.0014
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0654 0.7347 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0205 0.0547
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0435 0.049
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0357 0.0398
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0114 0.1129
Echinococcus multilocularis dual specificity 0.0096 0.1006 0.0988
Onchocerca volvulus 0.0026 0.0205 0.2168
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.1135 0.1117
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0205 0.1565
Entamoeba histolytica Ran family GTPase 0.0023 0.0174 0.1284
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0654 0.7347 1
Entamoeba histolytica hypothetical protein 0.0039 0.0357 0.2949
Loa Loa (eye worm) hypothetical protein 0.0091 0.0944 0.2525
Echinococcus granulosus peroxisome assembly protein 26 0.0014 0.0069 0.0058
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0114 0.0111
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0102 0.0083
Echinococcus granulosus tubulin alpha chain 0.0014 0.0069 0.0058
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0032 0.0113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0835
Loa Loa (eye worm) tyrosinase 1 0.0089 0.0926 0.2477
Echinococcus multilocularis protein patched 0.0046 0.0435 0.0416
Mycobacterium ulcerans hypothetical protein 0.0026 0.0205 0.0236
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0357 0.0338
Schistosoma mansoni hypothetical protein 0.0337 0.374 0.4381
Loa Loa (eye worm) tubulin alpha chain 0.0014 0.0069 0.0185
Schistosoma mansoni cpg binding protein 0.0033 0.0287 0.0302
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0201 0.1402
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0114 0.1129
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0093 0.0249
Echinococcus granulosus phd:f box containing protein 0.0017 0.0102 0.0097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0656 0.0853
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0205 0.0236
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0205 0.1565
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0435 0.0416
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0089 0.0926 0.3248
Brugia malayi hypothetical protein 0.0039 0.0357 0.1253
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0201 1
Trypanosoma cruzi epsilon tubulin, putative 0.0014 0.0069 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0032 0.074
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0114 0.0835
Brugia malayi alpha-tubulin 0.0014 0.0069 0.0243
Echinococcus granulosus tubulin alpha chain 0.0014 0.0069 0.0058
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0249
Echinococcus granulosus tumor protein p63 0.037 0.4114 0.483
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0032 0.0113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0835
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0498 0.0479
Loa Loa (eye worm) hypothetical protein 0.0026 0.0205 0.0547
Onchocerca volvulus 0.0053 0.051 0.54
Loa Loa (eye worm) hypothetical protein 0.0017 0.0102 0.0274
Echinococcus granulosus microtubule associated protein 2 0.0755 0.8497 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0632 0.0613
Trichomonas vaginalis tubulin epsilon chain, putative 0.0014 0.0069 0.1591
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0093 0.0327
Trypanosoma brucei beta tubulin 0.0014 0.0069 0.0688
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0102 0.0083
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0201 0.123
Echinococcus granulosus tubulin epsilon chain 0.0014 0.0069 0.0058
Giardia lamblia Gamma tubulin 0.0014 0.0069 0.2616
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0114 0.0111
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0114 0.1305
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0174 0.1453
Trichomonas vaginalis tubulin gamma chain, putative 0.0014 0.0069 0.1591
Echinococcus granulosus importin subunit beta 1 0.0032 0.0269 0.0293
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0174 0.0194
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0093 0.0072
Trichomonas vaginalis tubulin beta chain, putative 0.0014 0.0069 0.1591
Plasmodium vivax tubulin beta chain, putative 0.0014 0.0069 0.0051
Loa Loa (eye worm) hypothetical protein 0.0057 0.0554 0.1481
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0185
Echinococcus granulosus neuropeptide s receptor 0.0508 0.5693 0.6693
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.1135 0.1315
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0096 0.1006 1
Trypanosoma brucei epsilon tubulin 0.0014 0.0069 0.0688
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.1661 0.1935
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0032 0.00000040868
Entamoeba histolytica fatty acid elongase, putative 0.0085 0.0876 0.7649
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0114 0.0096
Entamoeba histolytica tubulin alpha chain, putative 0.0014 0.0069 0.0336
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0114 0.2609
Brugia malayi jmjC domain containing protein 0.0017 0.0102 0.0359
Trichomonas vaginalis tubulin beta chain, putative 0.0014 0.0069 0.1591
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0835
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0267 0.0714
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0032 0.074
Plasmodium falciparum thioredoxin reductase 0.0052 0.0498 0.0637
Echinococcus granulosus laminin 0.0016 0.0093 0.0086
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0014 0.0069 0.0049
Giardia lamblia Alpha-tubulin 0.0014 0.0069 0.2616
Schistosoma mansoni tyrosinase precursor 0.0089 0.0926 0.1056
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0114 0.5749
Brugia malayi hypothetical protein 0.0011 0.0032 0.0113
Echinococcus multilocularis tubulin alpha 1C chain 0.0014 0.0069 0.0049
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0174 0.227
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0032 0.074
Echinococcus multilocularis geminin 0.0185 0.2018 0.2002
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0656 0.0737
Entamoeba histolytica protein kinase, putative 0.0096 0.1006 0.8836
Echinococcus granulosus tubulin subunit TubB 0.0014 0.0069 0.0058
Brugia malayi jmjC domain containing protein 0.0017 0.0102 0.0359
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.013 0.0023
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0102 0.0274
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0835
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0086
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0269 0.2668
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0174 1
Echinococcus multilocularis dnaJ subfamily B 0.0447 0.4999 0.4989
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.1661 0.1644
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.1252 0.1574
Echinococcus multilocularis Tubulin beta 2C chain 0.0014 0.0069 0.0049
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0201 0.023
Onchocerca volvulus 0.0054 0.0525 0.5561
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0205 0.0718
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0249
Leishmania major trypanothione reductase 0.0052 0.0498 0.4576
Giardia lamblia Beta tubulin 0.0014 0.0069 0.2616
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0654 0.7347 1
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0357 0.0384
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0114 0.0111
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.013 0.0134
Echinococcus multilocularis peroxisome assembly protein 26 0.0014 0.0069 0.0049
Schistosoma mansoni ran 0.0023 0.0174 0.0167
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0102 0.0082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0118 0.0006
Echinococcus multilocularis nibrin 0.0011 0.0032 0.0012
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.1135 1
Echinococcus granulosus Tubulin beta 2C chain 0.0014 0.0069 0.0058
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0014 0.0069 0.1591
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0032 0.0000031374
Echinococcus multilocularis tubulin alpha 1C chain 0.0014 0.0069 0.0049
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0653 0.1746
Echinococcus granulosus neuropeptide receptor A26 0.0508 0.5693 0.6693
Echinococcus granulosus Tubulin beta 2C chain 0.0014 0.0069 0.0058
Trichomonas vaginalis tubulin alpha chain, putative 0.0014 0.0069 0.1591
Toxoplasma gondii alpha-tubulin I, putative 0.0014 0.0069 0.0594
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0086
Schistosoma mansoni hypothetical protein 0.0045 0.0416 0.0454
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0498 0.4782
Entamoeba histolytica hypothetical protein 0.0096 0.1006 0.8836
Echinococcus multilocularis hypothetical protein 0.0014 0.0069 0.0049
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0114 0.0111
Echinococcus multilocularis Tubulin beta 2C chain 0.0014 0.0069 0.0049
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0656 0.075
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0102 0.0083
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0032 0.032
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0174 0.0194
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.1252 0.1574
Giardia lamblia Beta tubulin 0.0014 0.0069 0.2616
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0032 0.0012
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0654 0.7347 1
Echinococcus granulosus tubulin subunit beta 0.0014 0.0069 0.0058
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0201 0.4608
Echinococcus granulosus Tubulin beta 2C chain 0.0014 0.0069 0.0058
Brugia malayi RNA, U transporter 1 0.009 0.093 0.3261
Schistosoma mansoni importin beta-1 0.0032 0.0269 0.0279
Echinococcus multilocularis Tubulin alpha 1 chain 0.0014 0.0069 0.0049
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0093 0.0978
Entamoeba histolytica tubulin family protein 0.0014 0.0069 0.0336
Entamoeba histolytica hypothetical protein 0.0026 0.0201 0.1528
Echinococcus multilocularis laminin 0.0016 0.0093 0.0073
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0269 0.2668
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0032 0.074
Echinococcus granulosus snurportin 1 0.0337 0.374 0.4388
Toxoplasma gondii beta tubulin 0.0014 0.0069 0.0594
Brugia malayi tubulin alpha-2 chain 0.0014 0.0069 0.0243
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0093 0.0073
Toxoplasma gondii beta-1 tubulin, putative 0.0014 0.0069 0.0594
Schistosoma mansoni microtubule-associated protein tau 0.0755 0.8497 1
Toxoplasma gondii alpha tubulin TUBA1 0.0014 0.0069 0.0594
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0205 0.0718
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0201 0.023
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0201 0.2701
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0019 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0205 0.0236
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0201 0.1994
Loa Loa (eye worm) alpha-tubulin 0.0014 0.0069 0.0185
Brugia malayi hypothetical protein 0.0259 0.2852 1
Onchocerca volvulus 0.0011 0.0032 0.0341
Trichomonas vaginalis tubulin epsilon chain, putative 0.0014 0.0069 0.1591
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0118 0.0006
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0093 0.0978
Schistosoma mansoni tubulin subunit beta 0.0014 0.0069 0.0044
Loa Loa (eye worm) hypothetical protein 0.0089 0.0926 0.2477
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0114 0.1305
Schistosoma mansoni tubulin subunit beta 0.0014 0.0069 0.0044
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0269 0.3789
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0201 0.023
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0587 0.8891
Echinococcus multilocularis microtubule associated protein 2 0.0755 0.8497 0.8494
Trypanosoma brucei epsilon tubulin 0.0014 0.0069 0.0688
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.051 0.1788
Echinococcus multilocularis Tubulin alpha 1 chain 0.0014 0.0069 0.0049
Loa Loa (eye worm) hypothetical protein 0.0017 0.0102 0.0274
Onchocerca volvulus 0.0031 0.0267 0.2828
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0114 0.0398
Echinococcus multilocularis Tubulin beta 2C chain 0.0014 0.0069 0.0049
Echinococcus multilocularis tubulin alpha 0.0014 0.0069 0.0049
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0348
Schistosoma mansoni hypothetical protein 0.0045 0.0416 0.0454
Echinococcus multilocularis tubulin alpha 3 chain 0.0014 0.0069 0.0049
Loa Loa (eye worm) tubulin alpha chain 0.0014 0.0069 0.0185
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0632 0.0709
Toxoplasma gondii beta-tubulin, putative 0.0014 0.0069 0.0594
Giardia lamblia Beta tubulin 0.0014 0.0069 0.2616
Echinococcus granulosus Tubulin beta 2C chain 0.0014 0.0069 0.0058
Plasmodium falciparum thioredoxin reductase 0.0018 0.0114 0.0111
Leishmania major GTP-binding protein, putative 0.0023 0.0174 0.1115
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0102 0.0097
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0102 0.0274
Entamoeba histolytica hypothetical protein 0.0039 0.0357 0.2949
Entamoeba histolytica hypothetical protein 0.0026 0.0201 0.1528
Schistosoma mansoni hypothetical protein 0.0053 0.051 0.0564
Brugia malayi Tubulin alpha-2 chain 0.0014 0.0069 0.0243
Plasmodium vivax tubulin gamma chain, putative 0.0014 0.0069 0.0051
Echinococcus granulosus L aminoadipate semialdehyde 0.0091 0.0944 0.109
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0201 0.4608
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0205 0.1445
Echinococcus multilocularis fibrillin 1 0.0016 0.0093 0.0073
Trypanosoma cruzi tubulin gamma chain 0.0014 0.0069 0.038
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0102 0.0274
Echinococcus multilocularis tubulin gamma 1 chain 0.0014 0.0069 0.0049
Trypanosoma brucei beta tubulin 0.0014 0.0069 0.0688
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0348
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0102 0.0097
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0086
Trichomonas vaginalis ran, putative 0.0023 0.0174 0.3991
Plasmodium falciparum tubulin beta chain 0.0014 0.0069 0.0051
Schistosoma mansoni hypothetical protein 0.0039 0.0357 0.0384
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.1006 0.8836
Brugia malayi CHE-14 protein 0.0046 0.0435 0.1527
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0102 0.1018
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0114 0.0473
Schistosoma mansoni tubulin subunit beta 0.0014 0.0069 0.0044
Echinococcus granulosus tubulin alpha chain 0.0014 0.0069 0.0058
Echinococcus multilocularis beta tubulin 0.0014 0.0069 0.0049
Brugia malayi DKFZp564C0469 protein 0.0011 0.0032 0.0113
Brugia malayi jmjC domain containing protein 0.0065 0.0653 0.2289
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.2852 0.3341
Echinococcus multilocularis L aminoadipate semialdehyde 0.0091 0.0944 0.0926
Loa Loa (eye worm) hypothetical protein 0.0054 0.0525 0.1404
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0348
Loa Loa (eye worm) tubulin beta-4 chain 0.0014 0.0069 0.0185
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0348
Loa Loa (eye worm) tubulin beta chain 0.0014 0.0069 0.0185
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0656 0.0853
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0435 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0205 0.0236
Trypanosoma brucei trypanothione reductase 0.0052 0.0498 0.4949
Echinococcus multilocularis Tubulin beta 2C chain 0.0014 0.0069 0.0049
Entamoeba histolytica tubulin alpha-1 chain 0.0014 0.0069 0.0336
Loa Loa (eye worm) histone methyltransferase 0.001 0.002 0.0054
Echinococcus granulosus tubulin alpha 1C chain 0.0014 0.0069 0.0058
Echinococcus multilocularis tubulin alpha chain 0.0014 0.0069 0.0049
Schistosoma mansoni cpg binding protein 0.0031 0.0267 0.0277
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0059 0.0209
Echinococcus multilocularis cpg binding protein 0.0033 0.0287 0.0268
Loa Loa (eye worm) beta-tubulin 0.0014 0.0069 0.0185
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0201 0.012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0205 0.0126
Echinococcus granulosus Tolloid protein 1 0.0016 0.0093 0.0086
Plasmodium falciparum tubulin gamma chain 0.0014 0.0069 0.0051
Brugia malayi Tubulin alpha-2 chain 0.0014 0.0069 0.0243
Onchocerca volvulus 0.0089 0.0926 0.9809
Trichomonas vaginalis tubulin alpha chain, putative 0.0014 0.0069 0.1591
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0473
Schistosoma mansoni alpha tubulin 0.0014 0.0069 0.0044
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0114 0.0835
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0093 0.0249
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0348
Brugia malayi Tubulin gamma chain 0.0014 0.0069 0.0243
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0114 0.0111
Echinococcus multilocularis tubulin beta 1 chain 0.0014 0.0069 0.0049
Echinococcus multilocularis tubulin subunit TubB 0.0014 0.0069 0.0049
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0525 0.0582
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0102 0.0721
Echinococcus multilocularis expressed conserved protein 0.0101 0.1061 0.1042
Giardia lamblia Alpha-tubulin 0.0014 0.0069 0.2616
Brugia malayi topoisomerase 0.0011 0.0032 0.0113
Loa Loa (eye worm) BEN-1 protein 0.0014 0.0069 0.0185
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0337 0.374 1
Schistosoma mansoni tubulin subunit beta 0.0014 0.0069 0.0044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0102 0.0274
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.1164
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.1006 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0102 0.0721
Plasmodium vivax glutathione reductase, putative 0.0052 0.0498 0.0637
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.1402 0.1781
Trypanosoma brucei alpha tubulin 0.0014 0.0069 0.0688
Brugia malayi CXXC zinc finger family protein 0.0031 0.0267 0.0936
Schistosoma mansoni hypothetical protein 0.0045 0.0416 0.0454
Echinococcus granulosus tubulin alpha 0.0014 0.0069 0.0058
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0086
Trypanosoma brucei epsilon tubulin 0.0014 0.0069 0.0688
Echinococcus multilocularis tubulin alpha chain 0.0014 0.0069 0.0049
Loa Loa (eye worm) alpha-tubulin 0.0014 0.0069 0.0185
Echinococcus multilocularis protein dispatched 1 0.0053 0.051 0.049
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.1402 1
Schistosoma mansoni tubulin subunit beta 0.0014 0.0069 0.0044

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 6.5 uM Anticoagulant activity in human plasma assessed as concentration required to 1.5 prothrombin time ChEMBL. 21349710
FC (ADMET) = 2.5 Inhibition of CYP3A4 using BFC substrate after 25 mins by TDI experiment relative to initial IC50 ChEMBL. 21349710
Ki (binding) = 5 nM Inhibition of factor 10a activity measured using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrate ChEMBL. 21349710

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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