Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | No references |
Homo sapiens | retinoid X receptor, gamma | Starlite/ChEMBL | No references |
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | No references |
Homo sapiens | retinoid X receptor, beta | Starlite/ChEMBL | No references |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, gamma | 340 aa | 338 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0027 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0027 | 0.0032 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0027 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0027 | 0.0032 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0027 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.887 | 0.9433 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0027 | 0.0032 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0494 | 0.8512 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0494 | 0.8512 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0027 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0027 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0464 | 0.7915 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0027 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.054 | 0.9403 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0027 | 0.0034 |
Brugia malayi | nuclear hormone receptor | 0.054 | 0.9403 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | nM | Agonist activity for retinoic acid receptor RAR alpha in transcriptional activation assay; NA means not active (EC50>10e4 nM) | ChEMBL. | No reference |
EC50 (functional) | 0 nM | Agonist activity for retinoic acid receptor RAR alpha in transcriptional activation assay; NA means not active (EC50>10e4 nM) | ChEMBL. | No reference |
EC50 (functional) | = 3 nM | Agonist activity for retinoic acid receptor RXR beta in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 3 nM | Agonist activity for retinoic acid receptor RXR beta in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 4 nM | Agonist activity for retinoic acid receptor RXR alpha in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 4 nM | Agonist activity for retinoic acid receptor RXR gamma in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 4 nM | Agonist activity for retinoic acid receptor RXR alpha in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 4 nM | Agonist activity for retinoic acid receptor RXR gamma in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 200 nM | Agonist activity for retinoic acid receptor RAR gamma in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 200 nM | Agonist activity for retinoic acid receptor RAR gamma in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 220 nM | Agonist activity for retinoic acid receptor RAR beta in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 220 nM | Agonist activity for retinoic acid receptor RAR beta in transcriptional activation assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.