Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.0569 | 0.1279 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0391 | 0.4447 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0089 | 0.0569 | 0.102 |
Leishmania major | carbonic anhydrase-like protein | 0.0391 | 0.4447 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0391 | 0.4447 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0089 | 0.0569 | 0.102 |
Brugia malayi | Serotonin receptor | 0.0479 | 0.5576 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0391 | 0.4447 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0089 | 0.0569 | 0.1279 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0391 | 0.4447 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0089 | 0.0569 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0391 | 0.4447 | 0.7975 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0391 | 0.4447 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0391 | 0.4447 | 0.7975 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0391 | 0.4447 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0391 | 0.4447 | 1 |
Mycobacterium ulcerans | secreted antigen 85-C FbpC | 0.0823 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0089 | 0.0569 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0089 | 0.0569 | 0.102 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0391 | 0.4447 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0089 | 0.0569 | 0.1279 |
Echinococcus granulosus | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0089 | 0.0569 | 0.102 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0089 | 0.0569 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0569 | 0.1279 |
Echinococcus multilocularis | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0569 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0569 | 0.1279 |
Echinococcus granulosus | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0391 | 0.4447 | 0.5 |
Mycobacterium tuberculosis | Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) | 0.0823 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Schistosoma mansoni | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0089 | 0.0569 | 0.102 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 160 uM | Compound was tested for its ability to inhibit the thrombin-induced platelet aggregation in washed human platelets | ChEMBL. | 9873606 |
IC50 (functional) | = 160 uM | Compound was tested for its ability to inhibit the thrombin-induced platelet aggregation in washed human platelets | ChEMBL. | 9873606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.