Detailed information for compound 150572

Basic information

Technical information
  • TDR Targets ID: 150572
  • Name: [(E)-1-(3,4-dichlorophenyl)propylideneamino]u rea
  • MW: 260.12 | Formula: C10H11Cl2N3O
  • H donors: 2 H acceptors: 1 LogP: 2.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC/C(=N\NC(=O)N)/c1ccc(c(c1)Cl)Cl
  • InChi: 1S/C10H11Cl2N3O/c1-2-9(14-15-10(13)16)6-3-4-7(11)8(12)5-6/h3-5H,2H2,1H3,(H3,13,15,16)/b14-9+
  • InChiKey: NLQPPJBKYADNSY-NTEUORMPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(E)-1-(3,4-dichlorophenyl)propylideneamino]urea
  • [1-(3,4-dichlorophenyl)propylideneamino]urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5485 0.5
Onchocerca volvulus Cathepsin L homolog 0.002 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0129 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0129 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0061 0.4099 0.3738
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0129 1 1
Leishmania major cathepsin L-like protease 0.0077 0.5485 1
Plasmodium vivax vivapain-2 0.002 0.0577 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Onchocerca volvulus 0.002 0.0577 0.0577
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0129 1 1
Schistosoma mansoni nuclear receptor 0.0061 0.4099 0.4099
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.4061 0.7098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0577 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0129 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5485 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.5485 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0061 0.4099 0.4099
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0577 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0129 1 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0577 0.0577
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0129 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0129 1 1
Brugia malayi Nuclear hormone receptor E75 0.0061 0.4099 0.4099
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0129 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0129 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Brugia malayi Nuclear hormone receptor-like 1 0.0068 0.4731 0.4731
Loa Loa (eye worm) ctsf protein 0.002 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0129 1 1
Schistosoma mansoni nuclear hormone receptor 0.0061 0.4099 0.4099
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0129 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0577 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0129 1 1
Brugia malayi hypothetical protein 0.0068 0.4731 0.4731
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0129 1 1
Brugia malayi nuclear receptor RXR 0.0068 0.4731 0.4731
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0577 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0129 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.4731 0.4731
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0129 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.4731 0.4731
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0061 0.4099 0.4099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5485 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0129 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5485 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0129 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0129 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0061 0.4099 0.4099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Schistosoma mansoni zinc finger protein 0.0061 0.4099 0.4099
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0129 1 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0577 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0577 1
Brugia malayi nuclear receptor RXR 0.0061 0.4099 0.4099
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Echinococcus multilocularis thyroid hormone receptor alpha 0.0129 1 1
Brugia malayi tailless protein 0.0061 0.4099 0.4099
Echinococcus granulosus Nuclear hormone receptor HR96 0.0061 0.4099 0.4099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5485 0.5
Brugia malayi nuclear hormone receptor family member nhr-6 0.0061 0.4099 0.4099
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0577 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0577 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0129 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0068 0.4731 0.4731
Plasmodium vivax vivapain-2 0.002 0.0577 0.5
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0577 0.0577
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0577 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0577 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0129 1 1
Toxoplasma gondii cathepsin CPL 0.002 0.0577 0.5
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Echinococcus granulosus FTZ F1 alpha 0.0129 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0061 0.4099 0.4099
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Brugia malayi conserved hypotetical protein 0.0061 0.4099 0.4099
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0068 0.4731 0.4731
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.4099 0.3738
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0129 1 1
Brugia malayi steroid hormone receptor 0.0129 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0061 0.4099 0.3738
Brugia malayi Cathepsin L-like precursor 0.002 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0129 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0061 0.4099 0.4099
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0577 1
Brugia malayi ecdysone receptor 0.0061 0.4099 0.4099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5485 0.5
Onchocerca volvulus 0.002 0.0577 0.0577
Onchocerca volvulus 0.002 0.0577 0.0577
Brugia malayi nuclear receptor NHR-88 0.0129 1 1
Leishmania major cathepsin L-like protease 0.0077 0.5485 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0129 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.4731 0.4731
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0129 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0061 0.4099 0.3738
Schistosoma mansoni thyroid hormone receptor 0.0129 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0129 1 1
Schistosoma mansoni coup transcription factor 0.0129 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.4908 0.8824
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0129 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0129 1 1
Onchocerca volvulus 0.0061 0.4099 0.4099
Leishmania major cathepsin L-like protease 0.0077 0.5485 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0577 0.0577
Loa Loa (eye worm) cysteine protease 0.002 0.0577 0.0577
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0129 1 1
Loa Loa (eye worm) DR-78 0.0061 0.4099 0.4099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5485 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.5485 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0577 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.5485 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0129 1 1
Brugia malayi hypothetical protein 0.0061 0.4099 0.4099
Brugia malayi Nuclear hormone receptor-like 1 0.0129 1 1
Onchocerca volvulus 0.002 0.0577 0.0577
Schistosoma mansoni nuclear receptor 0.0061 0.4099 0.4099
Brugia malayi nuclear hormone receptor family member odr-7 0.0061 0.4099 0.4099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0129 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0577 0.0577
Echinococcus multilocularis ecdysone induced protein 78C 0.0129 1 1
Loa Loa (eye worm) hypothetical protein 0.0129 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0577 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Onchocerca volvulus Bile acid receptor homolog 0.0129 1 1
Loa Loa (eye worm) hypothetical protein 0.0129 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Loa Loa (eye worm) nuclear hormone receptor 0.0061 0.4099 0.4099
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0061 0.4099 0.4099
Loa Loa (eye worm) hypothetical protein 0.0129 1 1
Brugia malayi hypothetical protein 0.0068 0.4731 0.4731
Onchocerca volvulus 0.0061 0.4099 0.4099
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0129 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Echinococcus granulosus ecdysone induced protein 78C 0.0129 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Brugia malayi Steroid receptor seven-up type 2 0.0129 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0129 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5485 0.5
Loa Loa (eye worm) nuclear receptor NHR-67 0.0061 0.4099 0.4099
Onchocerca volvulus Cathepsin F homolog 0.002 0.0577 0.0577
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0577 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0129 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0577 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0068 0.4731 0.4731
Loa Loa (eye worm) steroid hormone receptor 0.0129 1 1
Schistosoma mansoni nuclear hormone receptor 0.0061 0.4099 0.4099
Onchocerca volvulus 0.002 0.0577 0.0577
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0129 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0129 1 1
Brugia malayi nuclear receptor NHR-88 0.0061 0.4099 0.4099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5485 0.5
Loa Loa (eye worm) fibroinase 0.002 0.0577 0.0577
Brugia malayi orphan nuclear receptor NR2E1 0.0061 0.4099 0.4099
Onchocerca volvulus 0.002 0.0577 0.0577
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.4731 0.4731
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Schistosoma mansoni nuclear hormone receptor 0.0129 1 1
Brugia malayi nuclear hormone receptor 0.0129 1 1
Brugia malayi nuclear receptor NHR-67 0.0061 0.4099 0.4099
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0577 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0129 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0061 0.4099 0.4099
Brugia malayi Nuclear hormone receptor-like 1 0.0068 0.4731 0.4731
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0129 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0129 1 1
Brugia malayi hypothetical protein 0.0061 0.4099 0.4099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0577 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0061 0.4099 0.4099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0577 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0129 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0061 0.4099 0.4099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5485 0.5
Loa Loa (eye worm) hypothetical protein 0.0061 0.4099 0.4099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0129 1 1
Schistosoma mansoni thyroid hormone receptor 0.0129 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.5485 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0129 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0129 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0129 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.0129 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0061 0.4099 0.3738
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0129 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0061 0.4099 0.4099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0577 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Echinococcus granulosus cathepsin l1 0.002 0.0577 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Onchocerca volvulus 0.002 0.0577 0.0577
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0577 0.0577
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0129 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.4099 0.4099
Brugia malayi Cathepsin L-like precursor 0.002 0.0577 0.0577
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0068 0.4731 0.4731
Brugia malayi Cathepsin L-like precursor 0.002 0.0577 0.0577
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0068 0.4731 0.4408
Brugia malayi nuclear hormone receptor 0.0061 0.4099 0.4099
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0577 0.0577
Echinococcus granulosus thyroid hormone receptor alpha 0.0061 0.4099 0.4099
Loa Loa (eye worm) hypothetical protein 0.002 0.0577 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0129 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0129 1 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0577 0.0577
Brugia malayi Nuclear hormone receptor E75 0.0061 0.4099 0.4099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5485 0.5
Loa Loa (eye worm) hypothetical protein 0.0129 1 1
Onchocerca volvulus 0.0129 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.4731 0.4731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0577 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0061 0.4099 0.3738

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibitory activity against Trypanosoma cruzi cathepsin L-like protease (cruzain) was determined using purified recombinant protein ChEMBL. 12061873
IC50 (binding) > 10 uM Inhibitory activity against Trypanosoma cruzi cathepsin L-like protease (cruzain) was determined using purified recombinant protein ChEMBL. 12061873

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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