Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.1402 | 0.1309 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.8295 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.1402 | 0.1309 | 0.1309 |
Onchocerca volvulus | 0.1402 | 0.1309 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.8295 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.8295 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.8295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.8295 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.8295 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.8295 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1402 | 0.1309 | 0.5 |
Schistosoma mansoni | gliotactin | 0.1402 | 0.1309 | 0.1309 |
Onchocerca volvulus | 0.1402 | 0.1309 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.8295 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1402 | 0.1309 | 0.1309 |
Onchocerca volvulus | 0.1402 | 0.1309 | 0.5 | |
Onchocerca volvulus | 0.1402 | 0.1309 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1402 | 0.1309 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.8295 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1402 | 0.1309 | 0.1309 |
Echinococcus multilocularis | acetylcholinesterase | 0.8295 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1402 | 0.1309 | 0.1309 |
Loa Loa (eye worm) | hypothetical protein | 0.8295 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.1402 | 0.1309 | 0.5 |
Onchocerca volvulus | 0.1402 | 0.1309 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.8295 | 1 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.4725 | 0.5499 | 0.5499 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.1402 | 0.1309 | 0.1309 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.1402 | 0.1309 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.1402 | 0.1309 | 0.1309 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.1402 | 0.1309 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21000 nM | The compound was tested for its inhibitory activity against human renal renin at pH 7 | ChEMBL. | No reference |
IC50 (binding) | = 21000 nM | The compound was tested for its inhibitory activity against human renal renin at pH 7 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.