TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 269.231 | Formula: C14H8FN3O2
H donors: 1 H acceptors: 3 LogP: 3.35 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc2c(c1)nc(n2c1nc2c(o1)cccc2)O
InChi: 1S/C14H8FN3O2/c15-8-5-6-11-10(7-8)16-13(19)18(11)14-17-9-3-1-2-4-12(9)20-14/h1-7H,(H,16,19)
InChiKey: FOSOKBNWILBLSN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 2	451 aa	393 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0015	0.0209	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Schistosoma mansoni	cellular tumor antigen P53	0.0032	0.0597	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0007	0.0027	0.0025
Giardia lamblia	Kinase, CMGC MAPK	0.0033	0.0619	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0161	0.0164
Schistosoma mansoni	nAChR subunit	0.0015	0.0209	0.0182
Onchocerca volvulus		0.0008	0.0053	0.0459
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0013	0.0161	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0053	0.0053
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0008	0.0052	0.0025
Brugia malayi	Intermediate filament tail domain containing protein	0.0018	0.0267	0.0275
Trichomonas vaginalis	CMGC family protein kinase	0.0033	0.0619	1
Onchocerca volvulus		0.0032	0.0597	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0015	0.0209	0.0215
Schistosoma mansoni	rab6-interacting	0.0013	0.0161	0.0134
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0009	0.0062	0.0061
Onchocerca volvulus		0.0013	0.0161	0.2344
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0209	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Brugia malayi	hypothetical protein	0.0013	0.0161	0.0166
Onchocerca volvulus		0.0018	0.0267	0.421
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0209	0.0215
Brugia malayi	Pepsin A precursor	0.0008	0.0052	0.0054
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.0438	0.9703	0.9703
Brugia malayi	hypothetical protein	0.0007	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0008	0.0052	0.0025
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0019	0.0293	0.03
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0015	0.0209	0.0215
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.0438	0.9703	0.9703
Loa Loa (eye worm)	hypothetical protein	0.0017	0.026	0.0266
Schistosoma mansoni	microtubule-associated protein tau	0.0452	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Schistosoma mansoni	loxhd1	0.0013	0.0161	0.0134
Brugia malayi	MAP kinase sur-1	0.0033	0.0619	0.0638
Brugia malayi	hypothetical protein	0.0007	0.0027	0.0028
Entamoeba histolytica	hypothetical protein	0.0008	0.0053	0.5
Schistosoma mansoni	cpg binding protein	0.002	0.0317	0.0291
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0209	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Brugia malayi	hypothetical protein	0.0007	0.0027	0.0028
Echinococcus granulosus	RUN	0.0013	0.0161	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0007	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0438	0.9703	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Brugia malayi	excitatory GABA receptor EXP-1A	0.0015	0.0209	0.0215
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0209	0.0214
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0209	0.0215
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0015	0.0209	0.0215
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0015	0.0209	0.0215
Schistosoma mansoni	cathepsin D (A01 family)	0.0008	0.0052	0.0025
Brugia malayi	hypothetical protein	0.0007	0.0027	0.0028
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0008	0.0052	0.0025
Echinococcus granulosus	lipoxygenase domain containing protein	0.0013	0.0161	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0008	0.0053	0.0055
Trichomonas vaginalis	CMGC family protein kinase	0.0033	0.0619	1
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0015	0.0209	0.0214
Echinococcus multilocularis	RUN	0.0013	0.0161	0.0159
Brugia malayi	Cation transporter family protein	0.0015	0.0209	0.0215
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0007	0.0027	0.0028
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0015	0.0209	0.0182
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0007	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0209	0.0215
Schistosoma mansoni	neurotransmitter gated ion channel	0.0008	0.0053	0.0026
Schistosoma mansoni	hypothetical protein	0.0013	0.0161	0.0134
Echinococcus granulosus	lipoxygenase domain containing protein	0.0013	0.0161	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Onchocerca volvulus		0.0018	0.0267	0.421
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0018	0.0267	0.0274
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0008	0.0052	0.0052
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0209	0.0215
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0007	0.0027	0.0025
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0077	0.1602	0.1601
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0209	0.0215
Schistosoma mansoni	memapsin-2 (A01 family)	0.0201	0.4374	0.4359
Echinococcus multilocularis	musashi	0.0018	0.0267	0.0265
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0015	0.0209	0.0207
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0009	0.0083	0.0084
Schistosoma mansoni	rab6-interacting	0.0013	0.0161	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0614
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0209	0.0207
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0209	0.0207
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0015	0.0209	0.0215
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0008	0.0053	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Loa Loa (eye worm)	acetylcholine receptor protein	0.0007	0.0027	0.0026
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0209	0.0182
Echinococcus granulosus	cpg binding protein	0.002	0.0317	0.0315
Echinococcus granulosus	intermediate filament protein	0.0018	0.0267	0.0265
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0033	0.0619	0.0618
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0015	0.0209	0.0207
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0008	0.0052	0.0025
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0008	0.0053	0.0026
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0033	0.0619	0.0636
Brugia malayi	hypothetical protein	0.0007	0.0027	0.0028
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0007	0.0027	0.0028
Echinococcus multilocularis	tumor protein p63	0.0221	0.4831	0.483
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0015	0.0209	0.0207
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0008	0.0052	0.0052
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0013	0.0161	0.0159
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0209	0.0214
Onchocerca volvulus	Putative nachr subunit	0.0015	0.0209	0.3191
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0209	0.0182
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0209	0.0207
Schistosoma mansoni	nAChR subunit	0.0015	0.0209	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0052	0.0052
Brugia malayi	hypothetical protein	0.0008	0.0052	0.0054
Schistosoma mansoni	nAChR subunit	0.0015	0.0209	0.0182
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0209	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0007	0.0027	0.0025
Brugia malayi	CXXC zinc finger family protein	0.0019	0.0293	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0062	0.0062
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0015	0.0209	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0008	0.0052	0.005
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0209	0.0207
Onchocerca volvulus		0.0015	0.0209	0.3191
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0209	0.0215
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0619	0.0594
Schistosoma mansoni	intermediate filament proteins	0.0018	0.0267	0.0241
Schistosoma mansoni	cathepsin D (A01 family)	0.0008	0.0052	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0052	0.0052
Trichomonas vaginalis	CMGC family protein kinase	0.0033	0.0619	1
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0007	0.0027	0.0028
Echinococcus granulosus	nAChR subunit	0.0008	0.0053	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0053	0.0053
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0209	0.0182
Echinococcus multilocularis	mitogen activated protein kinase	0.0033	0.0619	0.0618
Brugia malayi	fructose-1,6-bisphosphatase	0.0438	0.9703	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0209	0.0207
Schistosoma mansoni	nAChR subunit	0.0015	0.0209	0.0182
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0163	0.3528	0.3202
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0008	0.0052	0.0025
Schistosoma mansoni	hypothetical protein	0.0268	0.5875	0.5864
Echinococcus granulosus	lamin	0.0018	0.0267	0.0265
Echinococcus granulosus	mitogen activated protein kinase 3	0.0033	0.0619	0.0618
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0209	0.0207
Onchocerca volvulus		0.0015	0.0209	0.3191
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0209	0.0207
Echinococcus multilocularis	microtubule associated protein 2	0.0452	1	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0015	0.0209	0.0207
Echinococcus granulosus	nAChR subunit	0.0015	0.0209	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Brugia malayi	Doublecortin family protein	0.0013	0.0161	0.0166
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0209	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Schistosoma mansoni	nAChR subunit	0.0015	0.0209	0.0182
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0009	0.0062	0.0061
Echinococcus multilocularis	dnaJ subfamily B	0.0268	0.5875	0.5874
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0015	0.0209	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0015	0.0209	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Echinococcus multilocularis	lamin dm0	0.0018	0.0267	0.0265
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0007	0.0027	0.0025
Toxoplasma gondii	fructose-bisphospatase II	0.0438	0.9703	1
Schistosoma mansoni	nAChR subunit	0.0015	0.0209	0.0182
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0209	0.0207
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0008	0.0052	0.0025
Onchocerca volvulus		0.0019	0.0293	0.4661
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0015	0.0209	0.0214
Schistosoma mansoni	cpg binding protein	0.002	0.0317	0.0291
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0209	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0267	0.0274
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0438	0.9703	1
Brugia malayi	hypothetical protein	0.0008	0.0052	0.0054
Brugia malayi	Cation transporter family protein	0.0015	0.0209	0.0215
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0008	0.0053	0.0026
Loa Loa (eye worm)	aspartyl protease 6	0.0008	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Echinococcus multilocularis	nAChR subunit	0.0008	0.0053	0.0052
Echinococcus granulosus	mitogen activated protein kinase	0.0033	0.0619	0.0618
Echinococcus multilocularis	cpg binding protein	0.002	0.0317	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Onchocerca volvulus		0.0015	0.0209	0.3191
Schistosoma mansoni	lipoxygenase	0.0054	0.1081	0.1057
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0007	0.0027	0.0026
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0209	0.0207
Schistosoma mansoni	cpg binding protein	0.0019	0.0293	0.0266
Schistosoma mansoni	lamin	0.0018	0.0267	0.0241
Loa Loa (eye worm)	GABA receptor subunit	0.0008	0.0053	0.0053
Schistosoma mansoni	polycystin 1-related	0.0013	0.0161	0.0134
Loa Loa (eye worm)	LGC-31 protein	0.0015	0.0209	0.0214
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0015	0.0209	0.0215
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0007	0.0027	0.0028
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0077	0.1602	0.1601
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0209	0.0214
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.0438	0.9703	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.004	0.0765	0.074
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0053	0.0053
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.0163	0.3528	0.3202
Plasmodium vivax	multidomain scavenger receptor, putative	0.0013	0.0161	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0008	0.0053	0.0055
Toxoplasma gondii	fructose-bisphospatase I	0.0163	0.3528	0.3601
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Echinococcus multilocularis	Polycystic kidney disease protein	0.0013	0.0161	0.0159
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0209	0.0207
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0033	0.0619	0.0588
Brugia malayi	intermediate filament protein	0.0018	0.0267	0.0275
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0015	0.0209	0.0214
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0015	0.0209	0.0207
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0007	0.0027	0.0026
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.0438	0.9703	1
Brugia malayi	aspartic protease BmAsp-1, identical	0.0008	0.0052	0.0054
Echinococcus granulosus	lamin dm0	0.0018	0.0267	0.0265
Echinococcus granulosus	dnaJ subfamily B	0.0268	0.5875	0.5874
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0015	0.0209	0.0215
Onchocerca volvulus		0.0015	0.0209	0.3191
Echinococcus multilocularis	nAChR subunit	0.0015	0.0209	0.0207
Leishmania major		0.0438	0.9703	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0008	0.0053	0.0055
Onchocerca volvulus		0.0013	0.0161	0.2344
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0008	0.0052	0.0054
Loa Loa (eye worm)	intermediate filament protein	0.0018	0.0267	0.0274
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0008	0.0052	0.0025
Plasmodium falciparum	LCCL domain-containing protein	0.0013	0.0161	1
Brugia malayi	cytoplasmic intermediate filament protein	0.0009	0.0083	0.0086
Brugia malayi	hypothetical protein	0.0013	0.0161	0.0166
Schistosoma mansoni	lamin	0.0018	0.0267	0.0241
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0209	0.0207
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0008	0.0052	0.0025
Trichomonas vaginalis	CMGC family protein kinase	0.0033	0.0619	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0053	0.0053
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0008	0.0052	0.0025
Echinococcus multilocularis	glycine receptor subunit beta	0.0015	0.0209	0.0207
Schistosoma mansoni	lipoxygenase	0.0077	0.1602	0.158
Brugia malayi	aspartic protease BmAsp-2, identical	0.0008	0.0052	0.0054
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0015	0.0209	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0053	0.0053
Brugia malayi	Cation transporter family protein	0.0015	0.0209	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0026
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0163	0.3528	0.3601
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0008	0.0052	0.005
Echinococcus multilocularis	lamin	0.0018	0.0267	0.0265
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0015	0.0209	0.0214
Echinococcus granulosus	tumor protein p63	0.0221	0.4831	0.483
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0053	0.0053
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0007	0.0027	0.0025
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0036	0.067	0.064
Onchocerca volvulus		0.0015	0.0209	0.3191
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0015	0.0209	0.0207
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0163	0.3528	0.3202
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.0438	0.9703	0.9703
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0209	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0053	0.0053
Onchocerca volvulus		0.0008	0.0053	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0161	0.0164
Echinococcus granulosus	Polycystic kidney disease protein	0.0013	0.0161	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Schistosoma mansoni	nAChR subunit	0.0015	0.0209	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0015	0.0209	0.0214
Onchocerca volvulus		0.0015	0.0209	0.3191
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0209	0.0214
Onchocerca volvulus		0.0008	0.0052	0.044
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0015	0.0209	0.0207
Loa Loa (eye worm)	doublecortin family protein	0.0013	0.0161	0.0164
Onchocerca volvulus		0.0008	0.0052	0.044

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 32 nM	Binding affinity against GABA-A benzodiazepine receptor	ChEMBL.	11133077
Ki (binding)	= 32 nM	Binding affinity against GABA-A benzodiazepine receptor	ChEMBL.	11133077

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 150657