TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 287.397 | Formula: C18H25NO2
H donors: 0 H acceptors: 1 LogP: 3.22 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)C1CCN(CC1)C(=O)C1CC1(C)C
InChi: 1S/C18H25NO2/c1-18(2)12-16(18)17(20)19-9-7-13(8-10-19)14-5-4-6-15(11-14)21-3/h4-6,11,13,16H,7-10,12H2,1-3H3
InChiKey: WKWIGQJWWPSRKL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0078	0.0369	0.0324
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0258	0.1771	0.1732
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0258	0.1771	0.1733
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0078	0.0369	0.0324
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0078	0.0369	0.0324
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0258	0.1771	0.1771
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0078	0.0369	0.0324
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0258	0.1771	0.1732
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0078	0.0369	0.0324
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0258	0.1771	0.1771
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0037	0.0047	0.0047
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0037	0.0047	0.0001
Loa Loa (eye worm)	TATA binding protein associated factor	0.0037	0.0047	0.0001
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0696	0.5187	0.5165
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0258	0.1771	0.1732
Echinococcus granulosus	proteasome subunit alpha type 6	0.0258	0.1771	0.1733
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0258	0.1771	0.1733
Schistosoma mansoni	coup transcription factor	0.0078	0.0369	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0763	0.072
Echinococcus multilocularis	serotonin receptor	0.0129	0.0763	0.072
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0632	0.4689	0.4664
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0258	0.1771	0.1732
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0258	0.1771	0.1732
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0258	0.1771	0.1732
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0258	0.1771	0.1771
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0258	0.1771	0.1771
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0632	0.4689	0.4664
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0258	0.1771	0.1733
Schistosoma mansoni	phosphatidylinositol-4-phosphate 5-kinase type II	0.016	0.1005	0.0963
Leishmania major	proteasome alpha 7 subunit, putative	0.0258	0.1771	0.1771
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0078	0.0369	0.0324
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0258	0.1771	0.1733
Leishmania major	proteasome beta-1 subunit, putative	0.0258	0.1771	0.1771
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0258	0.1771	0.1732
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0258	0.1771	0.1771
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0258	0.1771	0.1771
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0632	0.4689	0.4689
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0258	0.1771	0.1732
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0078	0.0369	0.0324
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0078	0.0369	0.0324
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0696	0.5187	0.5165
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0369	0.0324
Brugia malayi	proteasome subunit alpha type 6	0.0258	0.1771	0.1733
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0632	0.4689	0.4664
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0258	0.1771	0.1771
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0078	0.0369	0.0324
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0258	0.1771	0.1771
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0258	0.1771	0.1733
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0258	0.1771	0.1732
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0632	0.4689	0.4664
Plasmodium falciparum	proteasome subunit beta type-4	0.0258	0.1771	0.1732
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0078	0.0369	0.0324
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0258	0.1771	0.1732
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0258	0.1771	0.1732
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0258	0.1771	0.1733
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0632	0.4689	0.4664
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0037	0.0047	0.0047
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.1019	0.7715	0.7705
Schistosoma mansoni	RAR-like nuclear receptor	0.0078	0.0369	0.0324
Brugia malayi	proteasome subunit beta type 1	0.1019	0.7715	0.7705
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0078	0.0369	0.0324
Mycobacterium ulcerans	proteasome PrcA	0.0258	0.1771	0.1732
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0258	0.1771	0.1732
Onchocerca volvulus		0.0049	0.0138	0.0531
Trypanosoma cruzi	DNA polymerase eta, putative	0.0044	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0047	0.0001
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0258	0.1771	0.1732
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0258	0.1771	0.1732
Brugia malayi	20S proteasome alpha5 subunit	0.0258	0.1771	0.1733
Toxoplasma gondii	proteasome beta subunit	0.0258	0.1771	0.1771
Echinococcus multilocularis	aminopeptidase N	0.0037	0.0047	0.0001
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0258	0.1771	0.1771
Schistosoma mansoni	phosphatidylinositol-4-phosphate 5-kinase type II	0.016	0.1005	0.0963
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0258	0.1771	0.1771
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0258	0.1771	0.1733
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0258	0.1771	0.1733
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0258	0.1771	0.1771
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0037	0.0047	0.0047
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0258	0.1771	0.1733
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0369	0.0324
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0258	0.1771	0.1732
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0258	0.1771	0.1732
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0258	0.1771	0.1732
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0258	0.1771	0.1733
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.0081	0.0035
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0258	0.1771	0.1733
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0037	0.0047	0.0047
Brugia malayi	TATA binding protein associated factor	0.0037	0.0047	0.0001
Leishmania major	proteasome alpha 2 subunit, putative	0.0258	0.1771	0.1771
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0041	0.0081	0.0035
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0037	0.0047	0.0001
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0258	0.1771	0.1771
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0078	0.0369	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0369	0.0324
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0258	0.1771	0.1732
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0078	0.0369	0.0324
Echinococcus granulosus	dna polymerase eta	0.0044	0.0102	0.0056
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0037	0.0047	0.0001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0078	0.0369	0.0324
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0258	0.1771	0.1771
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0258	0.1771	0.1732
Brugia malayi	Pip kinase protein 2	0.016	0.1005	0.0963
Trypanosoma brucei	DNA polymerase eta, putative	0.0044	0.0102	0.0055
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0078	0.0369	0.0324
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0258	0.1771	0.1732
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0258	0.1771	0.1732
Brugia malayi	nuclear receptor RXR	0.0041	0.0081	0.0035
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0037	0.0047	0.0001
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.1019	0.7715	0.7705
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.004	0.0071	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0081	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0081	0.0035
Onchocerca volvulus	Bile acid receptor homolog	0.0078	0.0369	0.1868
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0258	0.1771	0.1732
Brugia malayi	photoreceptor-specific nuclear receptor	0.0078	0.0369	0.0324
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.1019	0.7715	0.7715
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0258	0.1771	0.1733
Leishmania major	proteasome beta 7 subunit, putative	0.0258	0.1771	0.1771
Leishmania major	proteasome beta 2 subunit, putative	0.0632	0.4689	0.4689
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0258	0.1771	0.1733
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0138	0.0092
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0258	0.1771	0.1732
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0258	0.1771	0.1732
Brugia malayi	nuclear receptor NHR-88	0.0078	0.0369	0.0324
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0258	0.1771	0.1733
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0037	0.0047	0.0001
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0258	0.1771	0.1732
Toxoplasma gondii	aminopeptidase N, putative	0.0037	0.0047	0.0047
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0258	0.1771	0.1732
Echinococcus multilocularis	proteasome subunit beta type 6	0.0258	0.1771	0.1733
Brugia malayi	hypothetical protein	0.0037	0.0047	0.0001
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0696	0.5187	0.5165
Toxoplasma gondii	aminopeptidase N protein	0.0037	0.0047	0.0047
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0258	0.1771	0.1732
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0258	0.1771	0.1732
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0258	0.1771	0.1771
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0258	0.1771	0.1732
Brugia malayi	steroid hormone receptor	0.0078	0.0369	0.0324
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.1019	0.7715	0.7715
Brugia malayi	proteasome subunit alpha type 4	0.0258	0.1771	0.1733
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0258	0.1771	0.1732
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.1019	0.7715	0.7715
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0078	0.0369	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0078	0.0369	0.0324
Brugia malayi	proteasome subunit alpha type 2	0.0258	0.1771	0.1733
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0078	0.0369	0.0324
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0632	0.4689	0.4664
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0041	0.0081	0.0035
Plasmodium vivax	proteasome subunit beta type-1, putative	0.1019	0.7715	0.7705
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0037	0.0047	0.0047
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0258	0.1771	0.1771
Leishmania major	proteasome alpha 7 subunit, putative	0.0258	0.1771	0.1771
Onchocerca volvulus		0.016	0.1005	0.556
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0632	0.4689	0.4664
Trypanosoma brucei	proteasome alpha 7 subunit	0.0258	0.1771	0.1732
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0081	0.0035
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0258	0.1771	0.1771
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0102	0.0056
Echinococcus multilocularis	snurportin 1	0.0302	0.212	0.2083
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0037	0.0047	0.0001
Trypanosoma brucei	proteasome beta 7 subunit	0.0258	0.1771	0.1732
Echinococcus multilocularis	FTZ F1 alpha	0.0078	0.0369	0.0324
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0258	0.1771	0.1732
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0632	0.4689	0.4664
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0078	0.0369	0.0324
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0258	0.1771	0.1732
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0037	0.0047	0.0001
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0258	0.1771	0.1733
Echinococcus granulosus	aminopeptidase N	0.0037	0.0047	0.0001
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0258	0.1771	0.1732
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0258	0.1771	0.1732
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0258	0.1771	0.1732
Schistosoma mansoni	thyroid hormone receptor	0.0078	0.0369	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0078	0.0369	0.0324
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0258	0.1771	0.1733
Toxoplasma gondii	proteasome subunit	0.0258	0.1771	0.1771
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0078	0.0369	0.0324
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0696	0.5187	0.5165
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0078	0.0369	0.0324
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0258	0.1771	0.1732
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0078	0.0369	0.0324
Onchocerca volvulus	Protein ultraspiracle homolog	0.0078	0.0369	0.1868
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0258	0.1771	0.1733
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0078	0.0369	0.0324
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0078	0.0369	0.0324
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0258	0.1771	0.1771
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.1019	0.7715	0.7705
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0258	0.1771	0.1732
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0632	0.4689	0.4664
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0041	0.0081	0.0035
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0258	0.1771	0.1733
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0258	0.1771	0.1771
Trypanosoma cruzi	aminopeptidase, putative	0.0037	0.0047	0.0047
Brugia malayi	Peptidase family M1 containing protein	0.0037	0.0047	0.0001
Brugia malayi	proteasome subunit alpha type 3	0.0258	0.1771	0.1733
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0081	0.0035
Echinococcus multilocularis	proteasome subunit beta type 7	0.0258	0.1771	0.1733
Brugia malayi	Steroid receptor seven-up type 2	0.0078	0.0369	0.0324
Onchocerca volvulus		0.0037	0.0047	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0078	0.0369	0.0324
Leishmania major	proteasome beta 3 subunit, putative	0.0258	0.1771	0.1771
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0037	0.0047	0.0047
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0258	0.1771	0.1732
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.1019	0.7715	0.7715
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0258	0.1771	0.1732
Brugia malayi	ecdysteroid receptor	0.0078	0.0369	0.0324
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0258	0.1771	0.1771
Onchocerca volvulus		0.0078	0.0369	0.1868
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0258	0.1771	0.1732
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0258	0.1771	0.1732
Trypanosoma cruzi	20S proteasome subunit	0.0632	0.4689	0.4689
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0258	0.1771	0.1732
Echinococcus granulosus	ecdysone induced protein 78C	0.0078	0.0369	0.0324
Schistosoma mansoni	nuclear hormone receptor	0.0078	0.0369	0.0324
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0258	0.1771	0.1733
Leishmania major	proteasome beta 2 subunit, putative	0.0258	0.1771	0.1771
Echinococcus multilocularis	phosphatidylinositol 5 phosphate 4 kinase type 2	0.016	0.1005	0.0963
Brugia malayi	Proteasome A-type and B-type family protein	0.0258	0.1771	0.1733
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0258	0.1771	0.1771
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0258	0.1771	0.1733
Echinococcus multilocularis	tumor protein p63	0.0332	0.235	0.2315
Brugia malayi	Proteasome subunit alpha type 1	0.0258	0.1771	0.1733
Echinococcus granulosus	FTZ F1 alpha	0.0078	0.0369	0.0324
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0258	0.1771	0.1732
Echinococcus granulosus	proteasome subunit beta type 7	0.0258	0.1771	0.1733
Schistosoma mansoni	hypothetical protein	0.0302	0.212	0.2083
Leishmania major	proteasome alpha 1 subunit, putative	0.0258	0.1771	0.1771
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0258	0.1771	0.1771
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0258	0.1771	0.1733
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0258	0.1771	0.1732
Brugia malayi	Peptidase family M1 containing protein	0.0037	0.0047	0.0001
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0258	0.1771	0.1733
Brugia malayi	hypothetical protein	0.032	0.2254	0.2218
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0258	0.1771	0.1732
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.1019	0.7715	0.7705
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0037	0.0047	0.0001
Brugia malayi	Proteasome A-type and B-type family protein	0.0258	0.1771	0.1733
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0078	0.0369	0.1868
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0632	0.4689	0.4689
Schistosoma mansoni	DNA polymerase eta	0.0044	0.0102	0.0056
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0258	0.1771	0.1732
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0258	0.1771	0.1732
Echinococcus granulosus	phosphatidylinositol 5 phosphate 4 kinase type 2	0.016	0.1005	0.0963
Echinococcus granulosus	proteasome subunit beta type 6	0.0258	0.1771	0.1733
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0041	0.0081	0.0035
Brugia malayi	Nuclear hormone receptor-like 1	0.0078	0.0369	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0078	0.0369	0.0324
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0258	0.1771	0.1732
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0369	0.0324
Loa Loa (eye worm)	pip kinase 2	0.016	0.1005	0.0963
Toxoplasma gondii	peptidase, T1 family protein	0.0258	0.1771	0.1771
Schistosoma mansoni	retinoic acid receptor RXR	0.0078	0.0369	0.0324
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0037	0.0047	0.0001
Brugia malayi	Peptidase family M1 containing protein	0.0037	0.0047	0.0001
Loa Loa (eye worm)	steroid hormone receptor	0.0078	0.0369	0.0324
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0258	0.1771	0.1733
Echinococcus granulosus	Proteasome subunit alpha beta	0.0258	0.1771	0.1733
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0302	0.212	0.2083
Brugia malayi	proteasome subunit beta type 3	0.0258	0.1771	0.1733
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0078	0.0369	0.0324
Echinococcus multilocularis	dna polymerase eta	0.0044	0.0102	0.0056
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.0081	0.0035
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0037	0.0047	0.0001
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0258	0.1771	0.1732
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0258	0.1771	0.1771
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0258	0.1771	0.1771
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0258	0.1771	0.1733
Loa Loa (eye worm)	PAS-3 protein	0.0258	0.1771	0.1733
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0258	0.1771	0.1733
Echinococcus multilocularis	serotonin receptor	0.0129	0.0763	0.072
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0037	0.0047	0.0047
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0258	0.1771	0.1733
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0258	0.1771	0.1771
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0632	0.4689	0.4664
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0369	0.0324
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0037	0.0047	0.0001
Brugia malayi	ImpB/MucB/SamB family protein	0.0044	0.0102	0.0056
Brugia malayi	proteasome subunit beta type 2	0.0632	0.4689	0.4664
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0047	0.0001
Schistosoma mansoni	thyroid hormone receptor	0.0078	0.0369	0.0324
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0037	0.0047	0.0001
Echinococcus granulosus	snurportin 1	0.0302	0.212	0.2083
Leishmania major	DNA polymerase eta, putative	0.0044	0.0102	0.0102
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0258	0.1771	0.1771
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0258	0.1771	0.1733
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0258	0.1771	0.1771
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0258	0.1771	0.1732
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0037	0.0047	0.0047
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.1019	0.7715	0.7705
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0632	0.4689	0.4664
Brugia malayi	hypothetical protein	0.0041	0.0081	0.0035
Brugia malayi	proteasome subunit alpha type 1	0.0258	0.1771	0.1733
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.1019	0.7715	0.7705
Leishmania major	proteasome alpha 1 subunit, putative	0.0258	0.1771	0.1771
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0078	0.0369	0.0324
Brugia malayi	Proteasome subunit alpha type 7-1	0.0258	0.1771	0.1733
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0078	0.0369	0.0324
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0258	0.1771	0.1732
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0258	0.1771	0.1733
Trypanosoma brucei	proteasome beta 6 subunit	0.1019	0.7715	0.7705
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0258	0.1771	0.1733
Echinococcus granulosus	proteasome subunit beta t family	0.0258	0.1771	0.1733
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0258	0.1771	0.1771
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0078	0.0369	0.0324
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0258	0.1771	0.1771
Brugia malayi	hypothetical protein	0.0037	0.0047	0.0001
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0258	0.1771	0.1733
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0369	0.0324
Onchocerca volvulus		0.0037	0.0047	0.0004
Toxoplasma gondii	heat shock protein hslv, putative	0.0258	0.1771	0.1771
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0078	0.0369	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0078	0.0369	0.0324
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0037	0.0047	0.0001
Toxoplasma gondii	aminopeptidase n, putative	0.0037	0.0047	0.0047
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0078	0.0369	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0081	0.0035
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0258	0.1771	0.1732
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0258	0.1771	0.1733
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0258	0.1771	0.1771
Brugia malayi	Proteasome A-type and B-type family protein	0.0258	0.1771	0.1733
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0041	0.0081	0.0035
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0037	0.0047	0.0001
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0078	0.0369	0.0324
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0258	0.1771	0.1732
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0258	0.1771	0.1732
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0258	0.1771	0.1732
Giardia lamblia	Proteasome subunit beta type 1	0.1019	0.7715	0.7224
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0763	0.072
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0078	0.0369	0.0324
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0258	0.1771	0.1733
Brugia malayi	nuclear hormone receptor	0.0078	0.0369	0.0324
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0078	0.0369	0.0324
Brugia malayi	RNA, U transporter 1	0.0081	0.0388	0.0343
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0129	0.0763	0.072
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0258	0.1771	0.1733
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0258	0.1771	0.1732
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0258	0.1771	0.1733
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0258	0.1771	0.1771
Echinococcus granulosus	proteasome subunit alpha type 2	0.0258	0.1771	0.1733
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0258	0.1771	0.1733
Trypanosoma cruzi	aminopeptidase, putative	0.0037	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0138	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0369	0.0324
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0258	0.1771	0.1732
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0258	0.1771	0.1771
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0258	0.1771	0.1733
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0078	0.0369	0.0324
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0258	0.1771	0.1733
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0258	0.1771	0.1733
Onchocerca volvulus	Notchless protein homolog	0.0258	0.1771	1
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0258	0.1771	0.1771
Brugia malayi	hypothetical protein	0.0041	0.0081	0.0035
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0078	0.0369	0.0324
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0258	0.1771	0.1771
Echinococcus granulosus	biogenic amine 5HT receptor	0.0129	0.0763	0.072
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0037	0.0047	0.0001
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0037	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.016	0.1005	0.0963
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0258	0.1771	0.1733
Giardia lamblia	Proteasome subunit beta type 2	0.0632	0.4689	0.3546
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0037	0.0047	0.0047
Echinococcus multilocularis	ecdysone induced protein 78C	0.0078	0.0369	0.0324
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0258	0.1771	0.1732
Loa Loa (eye worm)	proteasome subunit beta type 1	0.1019	0.7715	0.7705
Loa Loa (eye worm)	aminopeptidase N	0.0037	0.0047	0.0001
Leishmania major	proteasome alpha 3 subunit, putative	0.0258	0.1771	0.1771
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0258	0.1771	0.1732
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0258	0.1771	0.1771
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0258	0.1771	0.1733
Onchocerca volvulus		0.0037	0.0047	0.0004
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0037	0.0047	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0369	0.0324
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0258	0.1771	0.1732
Echinococcus granulosus	tumor protein p63	0.0332	0.235	0.2315
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0078	0.0369	0.0324
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0258	0.1771	0.1771
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0258	0.1771	0.5
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0258	0.1771	0.1732
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0258	0.1771	0.1733
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0078	0.0369	0.0324
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0258	0.1771	0.1771
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0047	0.0001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1669687

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1506631