Detailed information for compound 1506656

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 461.387 | Formula: C22H26Cl2N6O
  • H donors: 2 H acceptors: 3 LogP: 2.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc2[nH]c(nc2cc1Cl)[C@@H]1CCCN1C(=O)CCN1CCC(CC1)c1nc[nH]c1
  • InChi: 1S/C22H26Cl2N6O/c23-15-10-17-18(11-16(15)24)28-22(27-17)20-2-1-6-30(20)21(31)5-9-29-7-3-14(4-8-29)19-12-25-13-26-19/h10-14,20H,1-9H2,(H,25,26)(H,27,28)/t20-/m0/s1
  • InChiKey: XGMRKHKTQXMQEK-FQEVSTJZSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prolylcarboxypeptidase (angiotensinase C) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Serine carboxypeptidase S28 family protein Get druggable targets OG5_130246 All targets in OG5_130246
Echinococcus granulosus Lysosomal Pro X carboxypeptidase Get druggable targets OG5_130246 All targets in OG5_130246
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) Get druggable targets OG5_130246 All targets in OG5_130246
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130246 All targets in OG5_130246
Schistosoma japonicum ko:K01285 lysosomal Pro-X carboxypeptidase [EC3.4.16.2], putative Get druggable targets OG5_130246 All targets in OG5_130246
Schistosoma japonicum IPR008758,Peptidase S28,domain-containing Get druggable targets OG5_130246 All targets in OG5_130246
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130246 All targets in OG5_130246
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase Get druggable targets OG5_130246 All targets in OG5_130246
Schistosoma japonicum IPR008758,Peptidase S28,domain-containing Get druggable targets OG5_130246 All targets in OG5_130246
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130246 All targets in OG5_130246

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi serine carboxypeptidase S28, putative prolylcarboxypeptidase (angiotensinase C) 496 aa 414 aa 24.1 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Uncoordinated protein 44 0.0014 0.004 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0002 0.0004
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0025 0.0155 0.0153
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.004 0.004
Brugia malayi cytochrome P450 0.0011 0.0002 0.0001
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0002 0.0004
Giardia lamblia NADPH oxidoreductase, putative 0.0078 0.0735 0.0589
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.0001 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0002 0.0002
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Brugia malayi Cytochrome P450 family protein 0.0011 0.0002 0.0001
Echinococcus multilocularis tyrosine protein kinase Srms 0.0044 0.0363 0.0363
Echinococcus granulosus death domain containing protein 0.0014 0.004 0.004
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Trypanosoma brucei zeta tubulin 0.0217 0.2255 0.2254
Loa Loa (eye worm) hypothetical protein 0.026 0.2728 0.2728
Giardia lamblia Gamma tubulin 0.0491 0.5253 0.5178
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0053 0.0468 0.0468
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0045 0.0376 0.0374
Schistosoma mansoni alpha tubulin 0.0657 0.7071 0.7071
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Echinococcus granulosus nuclear factor of activated T cells 5 0.0215 0.2239 0.2239
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0155 0.0154
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0376 0.0374
Entamoeba histolytica tubulin gamma chain 0.0491 0.5253 0.5252
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0002 0.0004
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0024 0.0152 0.015
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0215 0.2239 0.2239
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0019 0.0099 0.0097
Echinococcus granulosus alpha tubulin 0.0657 0.7071 0.7071
Onchocerca volvulus 0.0015 0.0046 0.0155
Echinococcus multilocularis tyrosine protein kinase Blk 0.0044 0.0363 0.0363
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0013 0.0012
Schistosoma mansoni tyrosine kinase 0.0015 0.0046 0.0045
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Brugia malayi Serine protease Z688.6 precursor 0.0025 0.0155 0.0154
Brugia malayi Protein kinase domain containing protein 0.0015 0.0046 0.0045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0376 0.0374
Leishmania major protein kinase, putative 0.0031 0.023 0.0229
Schistosoma mansoni hypothetical protein 0.0014 0.004 0.0039
Echinococcus multilocularis growth factor receptor bound protein 2 0.002 0.01 0.01
Echinococcus granulosus tyrosine protein kinase Blk 0.0044 0.0363 0.0363
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0097
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0001 0.0001
Brugia malayi hypothetical protein 0.0031 0.023 0.0229
Brugia malayi Tubulin beta chain 0.0217 0.2255 0.2254
Schistosoma mansoni tyrosine kinase 0.0053 0.0468 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.023 0.0229
Plasmodium vivax delta tubulin, putative 0.0217 0.2255 0.2254
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0024 0.0152 0.0152
Trichomonas vaginalis tubulin, putative 0.0217 0.2255 0.2254
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0376 0.0374
Trichomonas vaginalis tubulin gamma chain, putative 0.0491 0.5253 0.5252
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0002 0.0004
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0045 0.0376 0.0374
Echinococcus granulosus Ankyrin 0.0014 0.0041 0.0041
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Echinococcus granulosus tyrosine protein kinase Src64B 0.0053 0.0468 0.0468
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0376 0.0374
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0031 0.023 0.0229
Echinococcus multilocularis tubulin alpha chain 0.0657 0.7071 0.7071
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus multilocularis Tubulin alpha 1 chain 0.0657 0.7071 0.7071
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0002 0.0001
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Trichomonas vaginalis tubulin epsilon chain, putative 0.0657 0.7071 0.7071
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0002 0.0004
Onchocerca volvulus 0.026 0.2728 0.9458
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0323 0.3414 0.3413
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0025 0.0155 0.0155
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0217 0.2255 0.5
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0031 0.023 0.0229
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0053 0.0468 0.0468
Brugia malayi Tubulin alpha-2 chain 0.0657 0.7071 0.7071
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Onchocerca volvulus 0.0015 0.0046 0.0155
Trypanosoma brucei alpha tubulin 0.0657 0.7071 0.7071
Trypanosoma brucei alpha tubulin 0.0657 0.7071 0.7071
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0025 0.0155 0.0154
Giardia lamblia Alpha-tubulin 0.0657 0.7071 0.7025
Leishmania major alpha tubulin 0.0657 0.7071 0.7071
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0053 0.0468 0.0468
Echinococcus multilocularis Immunoglobulin 0.0012 0.0013 0.0013
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Trypanosoma brucei zeta tubulin, putative 0.0217 0.2255 0.2254
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.023 0.0229
Brugia malayi tubulin alpha-2 chain 0.0657 0.7071 0.7071
Trypanosoma brucei alpha tubulin 0.0657 0.7071 0.7071
Trypanosoma cruzi zeta tubulin, putative 0.0217 0.2255 0.2254
Onchocerca volvulus 0.0274 0.2885 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0002 0.0004
Trypanosoma brucei tubulin gamma chain 0.0491 0.5253 0.5252
Schistosoma mansoni tyrosine kinase 0.0015 0.0047 0.0046
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0046 0.0046
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0045 0.0376 0.0374
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0155 0.0154
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0019 0.0099 0.0097
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0046 0.0046
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0367 0.3902 0.3902
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0383 0.4074 0.4073
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0046 0.0046
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.004 0.004
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0001 0.0001
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0031 0.023 0.0228
Schistosoma mansoni tubulin subunit delta 0.0217 0.2255 0.2254
Trichomonas vaginalis tubulin alpha chain, putative 0.0274 0.2885 0.2884
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0053 0.0468 0.0468
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0376 0.0374
Toxoplasma gondii alpha tubulin TUBA1 0.0657 0.7071 0.7071
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0097
Loa Loa (eye worm) hypothetical protein 0.0112 0.1115 0.1115
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.023 0.0229
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0045 0.0376 0.0376
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Echinococcus granulosus tyrosine protein kinase Lyn 0.0053 0.0468 0.0468
Echinococcus granulosus tubulin alpha 1C chain 0.0657 0.7071 0.7071
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0046 0.0046
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Trichomonas vaginalis tubulin epsilon chain, putative 0.0657 0.7071 0.7071
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0019 0.0099 0.0097
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0012 0.0013 0.0012
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Brugia malayi Tubulin gamma chain 0.0491 0.5253 0.5252
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0001 0.0001
Leishmania major alpha tubulin 0.0657 0.7071 0.7071
Trypanosoma brucei epsilon tubulin 0.0491 0.5253 0.5252
Brugia malayi SRC-1 0.0053 0.0468 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Echinococcus granulosus NCK adaptor protein 0.002 0.01 0.01
Schistosoma mansoni single-minded 0.0121 0.1208 0.1206
Trichomonas vaginalis guanylate cyclase, putative 0.0031 0.023 0.0229
Echinococcus multilocularis neuroglian 0.0015 0.0045 0.0045
Loa Loa (eye worm) TK protein kinase 0.0044 0.0363 0.0363
Echinococcus multilocularis Ankyrin 0.0014 0.0041 0.0041
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Trypanosoma cruzi epsilon tubulin, putative 0.0491 0.5253 0.5252
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0155 0.0154
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0363 0.0363
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0045 0.0376 0.0374
Plasmodium falciparum phosphodiesterase gamma, putative 0.0045 0.0376 0.0374
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0046 0.0046
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0491 0.5253 0.5252
Loa Loa (eye worm) tubulin alpha-3 chain 0.0383 0.4074 0.4074
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0025 0.0155 0.0154
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Brugia malayi Cell division protein ftsZ 0.0217 0.2255 0.2254
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0053 0.0468 0.0468
Schistosoma mansoni vesicular amine transporter 0.0012 0.0013 0.0012
Echinococcus multilocularis roundabout 2 0.0015 0.0045 0.0045
Brugia malayi hypothetical protein 0.0015 0.0046 0.0045
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0045 0.0376 0.0374
Loa Loa (eye worm) tubulin alpha chain 0.0657 0.7071 0.7071
Loa Loa (eye worm) PDE1B protein 0.0045 0.0376 0.0376
Plasmodium falciparum alpha tubulin 1 0.0657 0.7071 0.7071
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0051 0.0446 0.0446
Giardia lamblia hypothetical protein 0.0045 0.0376 0.0224
Echinococcus granulosus netrin receptor unc 5 0.0014 0.004 0.004
Echinococcus granulosus tubulin alpha chain 0.0657 0.7071 0.7071
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0031 0.023 0.0229
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0002 0.0004
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0045 0.0376 0.0374
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0031 0.023 0.0228
Echinococcus granulosus tubulin alpha chain 0.0657 0.7071 0.7071
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0217 0.2255 0.2254
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus granulosus tyrosine kinase 0.0044 0.0363 0.0363
Echinococcus multilocularis hypothetical protein 0.0657 0.7071 0.7071
Loa Loa (eye worm) hypothetical protein 0.0015 0.0045 0.0045
Echinococcus multilocularis Tubulin alpha 1 chain 0.0657 0.7071 0.7071
Trichomonas vaginalis tubulin beta chain, putative 0.0657 0.7071 0.7071
Entamoeba histolytica tubulin alpha chain, putative 0.0657 0.7071 0.7071
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0097
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0002 0.0002
Echinococcus granulosus single minded 2 0.0089 0.0864 0.0864
Echinococcus multilocularis tubulin alpha chain 0.0657 0.7071 0.7071
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0001 0.0001
Schistosoma mansoni DNA topoisomerase type I 0.0139 0.1409 0.1408
Trypanosoma cruzi alpha tubulin, putative 0.0657 0.7071 0.7071
Schistosoma mansoni tyrosine kinase 0.0103 0.1008 0.1007
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0323 0.3414 0.3414
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.2255 0.2254
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Loa Loa (eye worm) hypothetical protein 0.0025 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0045 0.0376 0.0376
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0025 0.0155 0.0154
Giardia lamblia Hypothetical protein 0.0045 0.0376 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Schistosoma mansoni DNA topoisomerase type I 0.0186 0.192 0.1919
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Trypanosoma brucei tubulin delta chain 0.0217 0.2255 0.2254
Leishmania major zeta tubulin, putative 0.0217 0.2255 0.2254
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0376 0.0374
Loa Loa (eye worm) tubulin alpha 2 0.0441 0.4703 0.4703
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0011 0.0009 0.0009
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0155 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Leishmania major alpha tubulin 0.0657 0.7071 0.7071
Brugia malayi PAS domain containing protein 0.0121 0.1208 0.1206
Brugia malayi Variant SH3 domain containing protein 0.002 0.01 0.0099
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0078 0.0735 0.0734
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0031 0.023 0.0229
Loa Loa (eye worm) TK/INSR protein kinase 0.0051 0.0446 0.0446
Trichomonas vaginalis tubulin, putative 0.0274 0.2885 0.2884
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0112 0.1115 0.1114
Onchocerca volvulus 0.0015 0.0046 0.0155
Schistosoma mansoni tyrosine kinase 0.0053 0.0468 0.0467
Trichomonas vaginalis tubulin beta chain, putative 0.0657 0.7071 0.7071
Echinococcus multilocularis 0.0046 0.0388 0.0388
Schistosoma mansoni tubulin subunit alpha 0.0657 0.7071 0.7071
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0002 0.0004
Brugia malayi Cytochrome P450 family protein 0.0011 0.0002 0.0001
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0015 0.0046 0.0046
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0045 0.0376 0.0376
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus granulosus epidermal growth factor receptor 0.0152 0.1548 0.1548
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0367 0.3902 0.3902
Echinococcus multilocularis 0.0011 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0002 0.0004
Leishmania major hypothetical protein, conserved 0.0045 0.0376 0.0374
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0274 0.2885 0.2884
Trypanosoma brucei alpha tubulin 0.0657 0.7071 0.7071
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0312 0.0312
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0025 0.0155 0.0153
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0002 0.0004
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0046 0.0046
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0045 0.0376 0.0374
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.023 0.0228
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0155 0.0154
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus granulosus tubulin gamma 1 chain 0.0491 0.5253 0.5253
Plasmodium vivax tubulin alpha chain, putative 0.0657 0.7071 0.7071
Echinococcus granulosus tubulin alpha 0.0491 0.5253 0.5253
Onchocerca volvulus 0.0025 0.0155 0.0533
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0657 0.7071 0.7071
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0312 0.0312
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0097
Mycobacterium leprae cell division protein FtsZ 0.0217 0.2255 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Trichomonas vaginalis tubulin alpha chain, putative 0.0274 0.2885 0.2884
Loa Loa (eye worm) hypothetical protein 0.0657 0.7071 0.7071
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0045 0.0376 0.0376
Entamoeba histolytica protein kinase, putative 0.0034 0.0254 0.0253
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0031 0.023 0.0228
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0468 0.0468
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0012 0.0013 0.0013
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0013 0.0013
Echinococcus multilocularis tyrosine protein kinase HCK 0.0034 0.0254 0.0254
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.0376 0.0374
Brugia malayi Protein kinase domain containing protein 0.0015 0.0046 0.0045
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0001 0.0001
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.023 0.0228
Echinococcus multilocularis tubulin alpha chain 0.0657 0.7071 0.7071
Leishmania major DNA topoisomerase IB, large subunit 0.0139 0.1409 0.1408
Echinococcus multilocularis Tubulin alpha 1 chain 0.0657 0.7071 0.7071
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0045 0.0376 0.0374
Brugia malayi Tubulin alpha chain 0.0657 0.7071 0.7071
Loa Loa (eye worm) hypothetical protein 0.0367 0.3902 0.3902
Echinococcus multilocularis tyrosine protein kinase shark 0.0015 0.0047 0.0047
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0441 0.4703 0.4702
Schistosoma mansoni tyrosine kinase 0.0024 0.0152 0.015
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0045 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0166 0.1701 0.1701
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0103 0.1008 0.1008
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0045 0.0376 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0155 0.0154
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0031 0.023 0.0228
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0032 0.0241 0.0241
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0045 0.0376 0.0376
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0053 0.0468 0.0468
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0155 0.0154
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Echinococcus granulosus tubulin alpha chain 0.0657 0.7071 0.7071
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0045 0.0376 0.0374
Schistosoma mansoni growth factor receptor-bound protein 0.002 0.01 0.0099
Echinococcus granulosus twitchin 0.0015 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Leishmania major alpha tubulin 0.0657 0.7071 0.7071
Entamoeba histolytica tubulin alpha-1 chain 0.0657 0.7071 0.7071
Echinococcus granulosus active breakpoint cluster region 0.0106 0.1046 0.1046
Echinococcus granulosus tyrosine protein kinase Srms 0.0015 0.0046 0.0046
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Schistosoma mansoni tubulin subunit alpha 0.0657 0.7071 0.7071
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0139 0.1409 0.1408
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0019 0.0099 0.0097
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0001 0.0001
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0045 0.0376 0.0376
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.004 0.0039
Echinococcus granulosus fibroblast growth factor receptor 4 0.0103 0.1008 0.1008
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0002 0.0004
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0217 0.2255 0.2254
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0045 0.0376 0.0376
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0001 0.0001
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0012 0.0013 0.0012
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0024 0.0152 0.0152
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.0001 0.0001
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Schistosoma mansoni tyrosine kinase 0.0079 0.0748 0.0747
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0002 0.0001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Brugia malayi Tubulin beta chain 0.0274 0.2885 0.2884
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0019 0.0099 0.0097
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.0014 0.004 0.0039
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.2255 0.2254
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0046 0.0046
Schistosoma mansoni tyrosine kinase 0.0051 0.0446 0.0445
Echinococcus multilocularis tubulin subunit TubB 0.0657 0.7071 0.7071
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0064 0.0063
Brugia malayi Serine protease Z688.6 precursor 0.0025 0.0155 0.0154
Plasmodium falciparum tubulin epsilon chain, putative 0.0491 0.5253 0.5252
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0083 0.0799 0.0799
Mycobacterium ulcerans putative regulatory protein 0.0089 0.0864 0.3827
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0112 0.1115 0.1115
Plasmodium vivax phosphodiesterase gamma, putative 0.0045 0.0376 0.0374
Toxoplasma gondii alpha-tubulin I, putative 0.0657 0.7071 0.7071
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0015 0.0046 0.0045
Trypanosoma cruzi epsilon tubulin, putative 0.0491 0.5253 0.5252
Leishmania major alpha tubulin 0.0657 0.7071 0.7071
Trichomonas vaginalis tubulin beta chain, putative 0.0657 0.7071 0.7071
Trichomonas vaginalis tubulin beta chain, putative 0.0657 0.7071 0.7071
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0053 0.0468 0.0468
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0001 0.0001
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0376 0.0374
Giardia lamblia Epsilon tubulin 0.0217 0.2255 0.2133
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0155 0.0154
Onchocerca volvulus 0.0015 0.0046 0.0155
Echinococcus multilocularis tubulin alpha 3 chain 0.0657 0.7071 0.7071
Trichomonas vaginalis tubulin gamma chain, putative 0.0217 0.2255 0.2254
Schistosoma mansoni tyrosine kinase 0.0083 0.0799 0.0798
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Loa Loa (eye worm) hypothetical protein 0.0383 0.4074 0.4074
Entamoeba histolytica hypothetical protein 0.0019 0.0099 0.0097
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0155 0.0154
Schistosoma mansoni nck2/grb4 0.002 0.01 0.0099
Loa Loa (eye worm) tubulin beta chain 0.0217 0.2255 0.2255
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0323 0.3414 0.3414
Loa Loa (eye worm) hypothetical protein 0.0441 0.4703 0.4703
Trichomonas vaginalis adenylate cyclase, putative 0.0031 0.023 0.0229
Loa Loa (eye worm) hypothetical protein 0.0112 0.1115 0.1115
Leishmania major gamma-tubulin 0.0491 0.5253 0.5252
Loa Loa (eye worm) cytochrome P450 0.0011 0.0002 0.0002
Loa Loa (eye worm) TK protein kinase 0.0106 0.1041 0.1041
Echinococcus multilocularis tubulin delta chain 0.0217 0.2255 0.2255
Brugia malayi alpha-tubulin 0.0657 0.7071 0.7071
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Echinococcus multilocularis epidermal growth factor receptor 0.0152 0.1548 0.1548
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0001 0.0001
Echinococcus granulosus Tubulin alpha 1 chain 0.0657 0.7071 0.7071
Mycobacterium leprae Possible regulatory protein 0.0031 0.023 0.1012
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0155 0.0154
Brugia malayi Protein kinase domain containing protein 0.0015 0.0046 0.0045
Plasmodium falciparum phosphodiesterase delta, putative 0.0045 0.0376 0.0374
Echinococcus multilocularis c src tyrosine kinase 0.0024 0.0152 0.0152
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0045 0.0376 0.0376
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0367 0.3902 0.3806
Schistosoma mansoni netrin receptor unc5 0.0014 0.004 0.0039
Echinococcus multilocularis peroxisome assembly protein 26 0.0657 0.7071 0.7071
Giardia lamblia NADPH oxidoreductase, putative 0.0078 0.0735 0.0589
Trichomonas vaginalis tubulin alpha chain, putative 0.0274 0.2885 0.2884
Echinococcus multilocularis tubulin alpha 0.0491 0.5253 0.5253
Schistosoma mansoni nephrin 0.0015 0.0045 0.0044
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus granulosus tubulin subunit TubB 0.0657 0.7071 0.7071
Mycobacterium ulcerans cell division protein FtsZ 0.0217 0.2255 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0155 0.0154
Schistosoma mansoni alpha tubulin 0.0657 0.7071 0.7071
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0025 0.0155 0.0154
Onchocerca volvulus 0.0015 0.0046 0.0155
Echinococcus granulosus peroxisome assembly protein 26 0.0657 0.7071 0.7071
Loa Loa (eye worm) variant SH3 domain-containing protein 0.002 0.01 0.01
Brugia malayi Variant SH3 domain containing protein 0.0011 0.0009 0.0008
Trichomonas vaginalis tubulin gamma chain, putative 0.0491 0.5253 0.5252
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0045 0.0376 0.0374
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Schistosoma mansoni aryl hydrocarbon receptor 0.035 0.3717 0.3716
Echinococcus multilocularis transfer RNA-Lys 0.0089 0.0864 0.0864
Schistosoma mansoni DNA topoisomerase type I 0.0139 0.1409 0.1408
Echinococcus multilocularis tubulin alpha 1C chain 0.0657 0.7071 0.7071
Echinococcus granulosus Tubulin alpha 1 chain 0.0657 0.7071 0.7071
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0002 0.0004
Onchocerca volvulus 0.009 0.0876 0.3033
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0228 0.2385 0.2385
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0376 0.0374
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0045 0.0376 0.0374
Leishmania major DNA topoisomerase type IB small subunit 0.0047 0.0398 0.0397
Echinococcus granulosus aryl hydrocarbon receptor 0.0261 0.274 0.274
Echinococcus granulosus tubulin alpha 1C chain 0.0657 0.7071 0.7071
Schistosoma mansoni cytochrome P450 0.0011 0.0002 0.0001
Trypanosoma brucei epsilon tubulin 0.0491 0.5253 0.5252
Echinococcus multilocularis DNA topoisomerase 1 0.0186 0.192 0.192
Plasmodium falciparum tubulin delta chain, putative 0.0217 0.2255 0.2254
Brugia malayi bHLH-PAS transcription factor 0.0089 0.0864 0.0863
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0045 0.0376 0.0374
Echinococcus multilocularis tyrosine kinase 0.0015 0.0046 0.0046
Leishmania major alpha tubulin 0.0657 0.7071 0.7071
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0041 0.004
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0367 0.3902 0.3902
Trypanosoma cruzi zeta tubulin, putative 0.0217 0.2255 0.2254
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Echinococcus granulosus growth factor receptor bound protein 2 0.002 0.01 0.01
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0002 0.0004
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Trypanosoma brucei epsilon tubulin 0.0491 0.5253 0.5252
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0376 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0097
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0436 0.4658 0.4658
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0045 0.0376 0.0374
Leishmania major cytochrome p450-like protein 0.0011 0.0002 0.0001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0468 0.0468
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0025 0.0155 0.0154
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0031 0.023 1
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0001 0.0001
Trichomonas vaginalis tubulin beta chain, putative 0.0274 0.2885 0.2884
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0376 0.0374
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Brugia malayi SH2 domain containing protein 0.0015 0.0046 0.0045
Echinococcus granulosus intersectin 2 0.0011 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0155 0.0154
Trypanosoma brucei alpha tubulin, putative 0.0274 0.2885 0.2883
Onchocerca volvulus 0.0015 0.0046 0.0155
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Brugia malayi Furin-like cysteine rich region family protein 0.0152 0.1548 0.1547
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0139 0.1409 0.1408
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Schistosoma mansoni tyrosine kinase 0.0083 0.0799 0.0798
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.004 0.004
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0045 0.0376 0.0374
Loa Loa (eye worm) hypothetical protein 0.0045 0.0376 0.0376
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0032 0.0241 0.0241
Giardia lamblia Delta tubulin 0.0217 0.2255 0.2133
Echinococcus granulosus Tubulin alpha 1 chain 0.0657 0.7071 0.7071
Loa Loa (eye worm) TK/EGFR protein kinase 0.0152 0.1548 0.1548
Trichomonas vaginalis tubulin epsilon chain, putative 0.0217 0.2255 0.2254
Echinococcus granulosus tubulin delta chain 0.0217 0.2255 0.2255
Loa Loa (eye worm) hypothetical protein 0.0045 0.0376 0.0376
Echinococcus multilocularis epidermal growth factor receptor 0.0083 0.0799 0.0799
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.004 0.0039
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Brugia malayi DNA topoisomerase I 0.0186 0.192 0.1919
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0228 0.2385 0.2384
Brugia malayi Tyrosine-protein kinase abl-1 0.0261 0.2735 0.2734
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0002 0.0002
Echinococcus granulosus tyrosine kinase 0.0015 0.0046 0.0046
Brugia malayi protein-tyrosine kinase 0.0044 0.0363 0.0361
Echinococcus granulosus c src tyrosine kinase 0.0024 0.0152 0.0152
Schistosoma mansoni tubulin subunit beta 0.0217 0.2255 0.2254
Brugia malayi Protein kinase domain containing protein 0.0051 0.0446 0.0445
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Loa Loa (eye worm) tubulin gamma chain 0.0491 0.5253 0.5253
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0045 0.0376 0.0376
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Leishmania major alpha tubulin 0.0657 0.7071 0.7071
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0112 0.1115 0.1115
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0015 0.0046 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Leishmania major alpha tubulin 0.0657 0.7071 0.7071
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0217 0.2255 0.2254
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0045 0.0376 0.0374
Brugia malayi Tubulin alpha chain 0.0217 0.2255 0.2254
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0046 0.0046
Leishmania major cytochrome p450-like protein 0.0011 0.0002 0.0001
Trichomonas vaginalis tubulin alpha chain, putative 0.0491 0.5253 0.5252
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.1041 0.104
Echinococcus multilocularis tubulin gamma 1 chain 0.0491 0.5253 0.5253
Echinococcus granulosus tyrosine protein kinase shark 0.0015 0.0047 0.0047
Plasmodium vivax tubulin alpha chain, putative 0.0657 0.7071 0.7071
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Brugia malayi Cytochrome P450 family protein 0.0011 0.0002 0.0001
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Leishmania major alpha tubulin 0.0657 0.7071 0.7071
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Brugia malayi Fibronectin type III domain containing protein 0.0012 0.0013 0.0012
Echinococcus granulosus epidermal growth factor receptor 0.0083 0.0799 0.0799
Loa Loa (eye worm) TK/ABL protein kinase 0.0436 0.4658 0.4658
Brugia malayi hypothetical protein 0.0012 0.0013 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0002 0.0004
Leishmania major protein kinase, putative 0.0031 0.023 0.0229
Echinococcus granulosus tubulin epsilon chain 0.0491 0.5253 0.5253
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0097
Echinococcus granulosus insulin receptor 0.0051 0.0446 0.0446
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.0047 0.0398 0.0396
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Trypanosoma cruzi tubulin gamma chain 0.0491 0.5253 0.5252
Echinococcus multilocularis insulin receptor 0.0051 0.0446 0.0446
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus granulosus tubulin alpha chain 0.0657 0.7071 0.7071
Echinococcus multilocularis tyrosine protein kinase Abl 0.0186 0.1915 0.1915
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0376 0.0374
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0078 0.0735 0.0734
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.004
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0045 0.0376 0.0374
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0468 0.0468
Schistosoma mansoni tyrosine kinase 0.0079 0.0748 0.0747
Echinococcus multilocularis tubulin epsilon chain 0.0491 0.5253 0.5253
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0032 0.0241 0.0241
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.004 0.004
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0002 0.0004
Schistosoma mansoni tubulin subunit alpha 0.0217 0.2255 0.2254
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0025 0.0155 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0002 0.0004
Echinococcus granulosus tubulin alpha 3 chain 0.0657 0.7071 0.7071
Giardia lamblia Alpha-tubulin 0.0657 0.7071 0.7025
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0376 0.0374
Echinococcus granulosus tubulin alpha 3 chain 0.0657 0.7071 0.7071
Loa Loa (eye worm) sex muscle abnormal protein 5 0.002 0.01 0.01
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0043 0.0042
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Plasmodium vivax tubulin epsilon chain, putative 0.0491 0.5253 0.5252
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0046 0.0046
Leishmania major epsilon tubulin, putative 0.0491 0.5253 0.5252
Leishmania major cytochrome p450-like protein 0.0011 0.0002 0.0001
Brugia malayi Tubulin alpha-2 chain 0.0657 0.7071 0.7071
Echinococcus multilocularis tubulin alpha 1C chain 0.0657 0.7071 0.7071
Brugia malayi tubulin alpha chain - mouse 0.0657 0.7071 0.7071
Leishmania major hypothetical protein, conserved 0.0045 0.0376 0.0374
Leishmania major alpha tubulin 0.0657 0.7071 0.7071
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0002 0.0004
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0045 0.0376 0.0376
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0002 0.0004
Schistosoma mansoni alpha tubulin 0.0657 0.7071 0.7071
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0045 0.0376 0.0374
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Echinococcus granulosus tyrosine protein kinase HCK 0.0034 0.0254 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.023 0.0229
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0044 0.0363 0.0363
Plasmodium falciparum topoisomerase I 0.0186 0.192 0.1919
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0045 0.0376 0.0376
Echinococcus multilocularis intersectin 2 0.0011 0.0008 0.0008
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0468 0.0468
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0045 0.0376 0.0376
Schistosoma mansoni hypothetical protein 0.0011 0.0002 0.0001
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0103 0.1008 0.1008
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0002 0.0002
Plasmodium falciparum alpha tubulin 2 0.0657 0.7071 0.7071
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0097
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0468 0.0468
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0441 0.4703 0.4703
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0155 0.0154
Loa Loa (eye worm) alpha-tubulin 0.0657 0.7071 0.7071
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0001 0.0001
Loa Loa (eye worm) tubulin alpha chain 0.0657 0.7071 0.7071
Echinococcus multilocularis aryl hydrocarbon receptor 0.0261 0.274 0.274
Schistosoma mansoni growth factor receptor-bound protein 0.002 0.01 0.0099
Plasmodium vivax topoisomerase I, putative 0.0186 0.192 0.1919
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0045 0.0376 0.0374
Trypanosoma brucei beta tubulin 0.0491 0.5253 0.5252
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Loa Loa (eye worm) SRC-1 0.0053 0.0468 0.0468
Brugia malayi Cytochrome P450 family protein 0.0011 0.0002 0.0001
Echinococcus multilocularis active breakpoint cluster region 0.0106 0.1046 0.1046
Brugia malayi Sex muscle abnormal protein 5 0.002 0.01 0.0099
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus granulosus neuroglian 0.0015 0.0045 0.0045
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0367 0.3902 0.3902
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0002 0.0004
Echinococcus granulosus tyrosine protein kinase ABL1 0.0436 0.4658 0.4658
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0045 0.0376 0.0374
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0045 0.0376 0.0374
Schistosoma mansoni tyrosine kinase 0.0051 0.0446 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0097
Trichomonas vaginalis tubulin beta chain, putative 0.0657 0.7071 0.7071
Loa Loa (eye worm) TK protein kinase 0.0034 0.0254 0.0254
Leishmania major delta tubulin, putative 0.0217 0.2255 0.2254
Echinococcus granulosus roundabout 2 0.0015 0.0045 0.0045
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0046 0.0046
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0045 0.0376 0.0376
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0045 0.0376 0.0374
Treponema pallidum cell division protein FtsZ 0.0217 0.2255 0.5
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0323 0.3414 0.3414
Schistosoma mansoni tyrosine kinase 0.0152 0.1548 0.1547
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0078 0.0735 0.0734
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0016 0.0064 0.0064
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.0047 0.0398 0.0396
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0367 0.3902 0.3902
Leishmania major cAMP-specific phosphodiesterase, putative 0.0045 0.0376 0.0374
Loa Loa (eye worm) DNA topoisomerase I 0.0186 0.192 0.192
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.01
Echinococcus multilocularis NCK adaptor protein 0.002 0.01 0.01
Plasmodium falciparum tubulin gamma chain 0.0491 0.5253 0.5252
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0103 0.1008 0.1008
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.002 0.01 0.0099
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Echinococcus multilocularis Immunoglobulin 0.0012 0.0013 0.0013
Mycobacterium tuberculosis Cell division protein FtsZ 0.0217 0.2255 1
Plasmodium vivax tubulin gamma chain, putative 0.0491 0.5253 0.5252
Trichomonas vaginalis tubulin beta chain, putative 0.0657 0.7071 0.7071
Echinococcus granulosus tubulin alpha chain 0.0657 0.7071 0.7071
Toxoplasma gondii DNA topoisomerase I, putative 0.0186 0.192 0.1919
Loa Loa (eye worm) hypothetical protein 0.0112 0.1115 0.1115
Trichomonas vaginalis guanylate cyclase, putative 0.0031 0.023 0.0229
Schistosoma mansoni tyrosine kinase 0.0024 0.0152 0.015
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0155 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0376 0.0374
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0367 0.3902 0.3902
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0468 0.0468
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0072 0.0246
Brugia malayi Tyrosine-protein kinase abl-1 0.0186 0.1915 0.1914
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0045 0.0376 0.0374
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0045 0.0376 0.0374
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0376 0.0374
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0045 0.0376 0.0374
Echinococcus granulosus DNA topoisomerase 1 0.0186 0.192 0.192
Loa Loa (eye worm) hypothetical protein 0.0031 0.023 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0523 0.0522
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0041
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0053 0.0468 0.0468
Schistosoma mansoni adapter molecule crk 0.002 0.01 0.0099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Schistosoma mansoni tubulin subunit epsilon 0.0491 0.5253 0.5252
Echinococcus multilocularis tubulin alpha chain 0.0657 0.7071 0.7071
Echinococcus granulosus tyrosine protein kinase Src42A 0.0053 0.0468 0.0468
Schistosoma mansoni tubulin subunit alpha 0.0657 0.7071 0.7071
Brugia malayi Variant SH3 domain containing protein 0.002 0.01 0.0099
Loa Loa (eye worm) tubulin alpha-2 chain 0.0657 0.7071 0.7071
Schistosoma mansoni cell adhesion molecule 0.0012 0.0013 0.0012
Echinococcus multilocularis tubulin alpha chain 0.0657 0.7071 0.7071
Loa Loa (eye worm) tubulin alpha 2 0.0166 0.1705 0.1705
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0376 0.0374
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0045 0.0045
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0031 0.023 0.0229
Brugia malayi SH2 domain containing protein 0.0015 0.0046 0.0045
Brugia malayi Serine carboxypeptidase S28 family protein 0.0112 0.1115 0.1114
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0735 0.0734
Loa Loa (eye worm) hypothetical protein 0.0015 0.0046 0.0046
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0051 0.0446 0.0446
Schistosoma mansoni tyrosine kinase 0.0427 0.455 0.4549
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Loa Loa (eye worm) tubulin alpha 2 0.0441 0.4703 0.4703
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0015 0.0046 0.0046
Leishmania major alpha tubulin 0.0657 0.7071 0.7071
Trypanosoma cruzi tubulin delta chain 0.0217 0.2255 0.2254
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0155 0.0154
Echinococcus granulosus Immunoglobulin 0.0012 0.0013 0.0013
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0155 0.0154
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0099 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0155 0.0154
Loa Loa (eye worm) alpha-tubulin 0.0657 0.7071 0.7071
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Schistosoma mansoni tyrosine kinase 0.0079 0.0748 0.0747
Leishmania major alpha tubulin 0.0657 0.7071 0.7071
Brugia malayi Death domain containing protein 0.0014 0.004 0.0039
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0025 0.0155 0.0153
Brugia malayi Protein kinase domain containing protein 0.0015 0.0046 0.0045
Giardia lamblia NADPH oxidoreductase, putative 0.0078 0.0735 0.0589
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Trypanosoma cruzi tubulin delta chain 0.0217 0.2255 0.2254
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0376 0.0374
Loa Loa (eye worm) hypothetical protein 0.023 0.2396 0.2396
Schistosoma mansoni tubulin subunit gamma 0.0491 0.5253 0.5252
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0045 0.0376 0.0374
Echinococcus multilocularis tubulin alpha 3 chain 0.0657 0.7071 0.7071
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0002 0.0004
Trichomonas vaginalis tubulin, putative 0.0274 0.2885 0.2884
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0045 0.0376 0.0374
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0376 0.0374
Echinococcus granulosus defective proboscis extension response 0.0012 0.0013 0.0013

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 129 nM Inhibition of human PrCP ChEMBL. 21315588

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.