Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.0183 | 0.4381 | 1 |
Brugia malayi | Matrixin family protein | 0.0183 | 0.4381 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0168 | 0.3458 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.018 | 0.4183 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0179 | 0.4125 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0179 | 0.4125 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0179 | 0.4125 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0179 | 0.4125 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0179 | 0.4125 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0179 | 0.4125 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0179 | 0.4125 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0179 | 0.4125 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0179 | 0.4125 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0168 | 0.3458 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0168 | 0.3458 | 0.7894 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25.73 uM | Inhibition of mushroom tyrosinase preincubated for 20 mins | ChEMBL. | 21256757 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.