Detailed information for compound 1507172

Basic information

Technical information
  • TDR Targets ID: 1507172
  • Name: 4-amino-N'-(3-fluorophenyl)-N'-[2-oxo-2-(oxol an-2-ylmethylamino)-1-thiophen-2-ylethyl]-1,2 -thiazole-3,5-dicarboxamide
  • MW: 503.57 | Formula: C22H22FN5O4S2
  • H donors: 3 H acceptors: 4 LogP: 2.68 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1cccc(c1)N(C(=O)c1snc(c1N)C(=O)N)C(c1cccs1)C(=O)NCC1CCCO1
  • InChi: 1S/C22H22FN5O4S2/c23-12-4-1-5-13(10-12)28(22(31)19-16(24)17(20(25)29)27-34-19)18(15-7-3-9-33-15)21(30)26-11-14-6-2-8-32-14/h1,3-5,7,9-10,14,18H,2,6,8,11,24H2,(H2,25,29)(H,26,30)
  • InChiKey: SNYVAZDXJKRLLQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-amino-N'-(3-fluorophenyl)-N'-[2-oxo-2-(tetrahydrofuran-2-ylmethylamino)-1-(2-thienyl)ethyl]isothiazole-3,5-dicarboxamide
  • 4-amino-N'-(3-fluorophenyl)-N'-[2-oxo-2-(2-tetrahydrofuranylmethylamino)-1-(2-thienyl)ethyl]isothiazole-3,5-dicarboxamide
  • 4-amino-N'-(3-fluorophenyl)-N'-[2-keto-2-(tetrahydrofurfurylamino)-1-(2-thienyl)ethyl]isothiazole-3,5-dicarboxamide
  • 4-amino-N'-(3-fluorophenyl)-N'-[2-oxo-2-(oxolan-2-ylmethylamino)-1-thiophen-2-yl-ethyl]-1,2-thiazole-3,5-dicarboxamide
  • MLS000710365
  • SMR000280132
  • ASN 03438280
  • Oprea1_402371

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0021 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0205 0.3945 0.3853
Plasmodium vivax subtilisin-like serine protease, putative 0.0021 0.0149 0.007
Echinococcus multilocularis glycoprotein Antigen 5 0.0024 0.021 0.0092
Plasmodium vivax subtilisin-like protease 1 0.0021 0.0149 0.007
Onchocerca volvulus 0.0049 0.0727 0.3623
Trypanosoma cruzi subtilisin peptidase 0.0021 0.0149 0.007
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0021 0.0149 0.5
Echinococcus granulosus Mastin 0.0024 0.021 0.0074
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0185 0.006
Plasmodium falciparum subtilisin-like protease 2 0.0021 0.0149 0.007
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0096 0.17 0.2667
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0125 0.2303 0.2303
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0185 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0404 0.0437
Plasmodium falciparum cysteine repeat modular protein 1 0.0069 0.1136 1
Brugia malayi Kringle domain containing protein 0.0069 0.1136 0.1136
Schistosoma mansoni growth factor receptor-bound protein 0.0125 0.2303 0.2186
Echinococcus granulosus epidermal growth factor receptor 0.0117 0.2131 0.2022
Echinococcus granulosus tissue type plasminogen activator 0.0069 0.1136 0.1012
Echinococcus granulosus enteropeptidase 0.0024 0.021 0.0074
Brugia malayi Furin-like cysteine rich region family protein 0.0117 0.2131 0.2131
Leishmania major hypothetical protein, conserved 0.0069 0.1136 1
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0021 0.0149 0.5
Echinococcus multilocularis tissue type plasminogen activator 0.0069 0.1136 0.1261
Giardia lamblia Furin precursor putative serine protease 0.0096 0.17 0.4593
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0404 0.0437
Brugia malayi proprotein convertase 2 0.0312 0.6176 0.6176
Schistosoma mansoni hypothetical protein 0.0205 0.3945 0.3853
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.17 0.2667
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0404 0.0437
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0185 0.0036
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0117 0.214 0.3423
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0024 0.021 0.0062
Loa Loa (eye worm) subtilase 0.0021 0.0149 0.0149
Entamoeba histolytica protein kinase, putative 0.0031 0.0361 0.836
Loa Loa (eye worm) hypothetical protein 0.0111 0.2007 0.2007
Echinococcus multilocularis membrane bound transcription factor site 1 0.0021 0.0149 0.0015
Entamoeba histolytica protein kinase, putative 0.0034 0.0404 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.021 0.0062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0117 0.214 0.3423
Echinococcus granulosus glycoprotein Antigen 5 0.0024 0.021 0.0074
Giardia lamblia High cysteine membrane protein Group 2 0.0185 0.3533 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.021 0.021
Toxoplasma gondii subtilisin SUB2 0.0021 0.0149 0.1316
Schistosoma mansoni hypothetical protein 0.0024 0.021 0.0062
Echinococcus multilocularis epidermal growth factor receptor 0.0117 0.2131 0.252
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0021 0.0149 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.021 0.0062
Schistosoma mansoni hypothetical protein 0.0069 0.1136 0.1001
Echinococcus granulosus membrane bound transcription factor site 1 0.0021 0.0149 0.0012
Echinococcus multilocularis 0.0401 0.801 0.995
Echinococcus multilocularis neuroendocrine convertase 2 0.0312 0.6176 0.7632
Onchocerca volvulus 0.0111 0.2007 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.021 0.0062
Brugia malayi hypothetical protein 0.0024 0.021 0.021
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.5964 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.021 0.0062
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0021 0.0143 0.0006
Toxoplasma gondii subtilisin SUB1 0.0021 0.0149 0.1316
Toxoplasma gondii kringle domain-containing protein 0.0069 0.1136 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0024 0.021 0.021
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.8049 1
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0021 0.0149 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.17 0.2667
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0185 0.0432
Brugia malayi Trypsin-like protease protein 5 0.0024 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0024 0.021 0.021
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.021 0.0062
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0096 0.17 0.2667
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.021 0.0062
Echinococcus multilocularis growth factor receptor bound protein 2 0.0125 0.2303 0.2736
Onchocerca volvulus 0.0024 0.021 0.1049
Loa Loa (eye worm) hypothetical protein 0.0024 0.021 0.021
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0117 0.214 0.3423
Brugia malayi Sex muscle abnormal protein 5 0.0125 0.2303 0.2303
Mycobacterium ulcerans hypothetical protein 0.0024 0.021 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.021 0.0062
Toxoplasma gondii subtilisin SUB6 0.0021 0.0149 0.1316
Toxoplasma gondii subtilisin SUB4 0.0021 0.0149 0.1316
Echinococcus multilocularis enteropeptidase 0.0024 0.021 0.0092
Schistosoma mansoni growth factor receptor-bound protein 0.0125 0.2303 0.2186
Loa Loa (eye worm) trypsin family protein 0.0024 0.021 0.021
Toxoplasma gondii subtilisin SUB10 0.0021 0.0149 0.1316
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.1136 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.3746 0.3746
Onchocerca volvulus 0.0024 0.021 0.1049
Brugia malayi Trypsin family protein 0.0024 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0096 0.17 0.1574
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0117 0.214 0.2021
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0117 0.214 0.3423
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0024 0.021 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0404 0.0437
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0021 0.0143 0.0005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0111 0.2007 0.1885
Echinococcus granulosus neuroendocrine convertase 2 0.0312 0.6176 0.6123
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0185 0.164
Plasmodium vivax subtilisin-like protease 2, putative 0.0021 0.0149 0.007
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.021 0.0062
Brugia malayi celfurPC protein 0.0401 0.801 0.801
Echinococcus granulosus expressed conserved protein 0.0043 0.0592 0.0461
Loa Loa (eye worm) AGC/AKT protein kinase 0.0034 0.0404 0.0404
Toxoplasma gondii subtilisin SUB9 0.0021 0.0149 0.1316
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0021 0.0149 0.007
Mycobacterium leprae Possible secreted protease 0.0021 0.0149 0.5
Toxoplasma gondii AGC kinase 0.0031 0.0361 0.3178
Loa Loa (eye worm) proprotein convertase 2 0.0117 0.214 0.214
Echinococcus granulosus dnaJ subfamily B 0.0403 0.8049 0.8022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0117 0.214 0.3423
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.5964 1
Echinococcus granulosus transmembrane protease serine 3 0.0024 0.021 0.0074
Trichomonas vaginalis hypothetical protein 0.0096 0.17 0.2667
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0117 0.214 0.3423
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.17 0.2667
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0096 0.17 0.2667
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0024 0.021 0.0092
Onchocerca volvulus 0.0087 0.1506 0.7504
Loa Loa (eye worm) hypothetical protein 0.0111 0.2007 0.2007
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.17 0.2667
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.021 0.0062
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0302 0.5964 0.5907
Loa Loa (eye worm) TK/EGFR protein kinase 0.0117 0.2131 0.2131
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0404 0.0437
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0024 0.021 0.0092
Trypanosoma cruzi Protein kinase B 0.0023 0.0185 0.0432
Entamoeba histolytica protein kinase, putative 0.0034 0.0404 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.021 0.0062
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0021 0.0149 0.007
Schistosoma mansoni tyrosine kinase 0.0117 0.2131 0.2012
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0021 0.0149 0.5
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0021 0.0149 0.5
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0185 0.164
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.17 0.2667
Plasmodium falciparum subtilisin-like protease 3 0.0021 0.0149 0.007
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.021 0.0062
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0361 0.0361
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0361 0.0361
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0021 0.0149 0.0015
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.021 0.0062
Loa Loa (eye worm) hypothetical protein 0.0024 0.021 0.021
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0069 0.1136 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.1136 0.1136
Echinococcus multilocularis Furin 1 0.0117 0.214 0.2531
Echinococcus granulosus growth factor receptor bound protein 2 0.0125 0.2303 0.2195
Brugia malayi Trypsin family protein 0.0024 0.021 0.021
Toxoplasma gondii subtilisin SUB12 0.0035 0.044 0.3873
Schistosoma mansoni hypothetical protein 0.0403 0.8049 0.802
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.17 0.2667
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.021 0.0062
Echinococcus granulosus Furin 1 0.0117 0.214 0.203
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.17 0.2667
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0302 0.5964 0.7364
Onchocerca volvulus 0.0069 0.1136 0.5659
Loa Loa (eye worm) TK/ROR protein kinase 0.0069 0.1136 0.1136
Brugia malayi Protein kinase domain containing protein 0.0069 0.1136 0.1136
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.17 0.2667
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.021 0.0062
Toxoplasma gondii subtilisin SUB7 0.0021 0.0149 0.1316
Schistosoma mansoni furin-1 (S08 family) 0.0216 0.4186 0.4097
Trypanosoma brucei rac serine-threonine kinase, putative 0.0034 0.0404 1
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0185 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0149 0.0149
Brugia malayi Subtilase family protein 0.0021 0.0149 0.0149
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0111 0.2007 0.1885
Brugia malayi Protein kinase domain containing protein 0.0034 0.0404 0.0404
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0404 0.0437
Brugia malayi neuroendocrine convertase 1 precursor 0.0312 0.6176 0.6176
Echinococcus granulosus serine threonine protein kinase nrc 0.0021 0.0143 0.0005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.021 0.0062
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0404 0.0437
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0024 0.021 0.0074
Echinococcus multilocularis geminin 0.0205 0.3945 0.4812
Brugia malayi Trypsin family protein 0.0111 0.2007 0.2007
Loa Loa (eye worm) hypothetical protein 0.0024 0.021 0.021
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0021 0.0149 0.0012
Echinococcus granulosus geminin 0.0205 0.3945 0.386
Echinococcus multilocularis Mastin 0.0024 0.021 0.0092
Plasmodium falciparum subtilisin-like protease 1 0.0021 0.0149 0.007
Echinococcus multilocularis transmembrane protease serine 3 0.0024 0.021 0.0092
Toxoplasma gondii subtilisin SUB11 0.0021 0.0149 0.1316
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.17 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.17 0.2667
Toxoplasma gondii subtilisin SUB5 0.0021 0.0149 0.1316
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.17 0.2667
Echinococcus multilocularis expressed conserved protein 0.0043 0.0592 0.0574
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0021 0.0149 0.5
Onchocerca volvulus 0.0021 0.0149 0.0745
Toxoplasma gondii subtilisin SUB8 0.0021 0.0149 0.1316
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0021 0.0149 0.007
Onchocerca volvulus 0.0024 0.021 0.1049
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.021 0.0062
Schistosoma mansoni hypothetical protein 0.0024 0.021 0.0062
Onchocerca volvulus 0.0024 0.021 0.1049
Brugia malayi Trypsin family protein 0.0024 0.021 0.021
Onchocerca volvulus 0.0024 0.021 0.1049

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.