Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | aldo-keto reductase, putative | 0.0092 | 0.0781 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0318 | 0.4287 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.0427 | 0.0101 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0092 | 0.0781 | 0.0468 |
Loa Loa (eye worm) | oxidoreductase | 0.0318 | 0.4287 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0226 | 0.2858 | 0.2614 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0318 | 0.4287 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0318 | 0.4287 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.0092 | 0.0781 | 0.1142 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0318 | 0.4287 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0318 | 0.4287 | 0.4093 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0686 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0318 | 0.4287 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0092 | 0.0781 | 0.1822 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.0427 | 0.0101 |
Loa Loa (eye worm) | oxidoreductase | 0.0318 | 0.4287 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0318 | 0.4287 | 0.4093 |
Onchocerca volvulus | 0.0318 | 0.4287 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.4287 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0318 | 0.4287 | 0.4093 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0318 | 0.4287 | 0.4093 |
Giardia lamblia | Aldose reductase | 0.0318 | 0.4287 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.0427 | 0.0101 |
Schistosoma mansoni | aldo-keto reductase | 0.0318 | 0.4287 | 0.4093 |
Echinococcus granulosus | aldo keto reductase | 0.0318 | 0.4287 | 0.4093 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0318 | 0.4287 | 0.4093 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0318 | 0.4287 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0318 | 0.4287 | 0.4093 |
Schistosoma mansoni | potassium channel beta | 0.0092 | 0.0781 | 0.0468 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.0427 | 0.0101 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0318 | 0.4287 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 0.0781 | 0.1822 |
Echinococcus multilocularis | aldo keto reductase | 0.0318 | 0.4287 | 0.4093 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0318 | 0.4287 | 0.4093 |
Echinococcus granulosus | hypothetical protein | 0.0318 | 0.4287 | 0.4093 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.0427 | 0.0247 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0318 | 0.4287 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0226 | 0.2858 | 0.5922 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.0427 | 0.0247 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0.0781 | 0.1822 |
Echinococcus multilocularis | aldo keto reductase | 0.0318 | 0.4287 | 0.4093 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0318 | 0.4287 | 0.4093 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0318 | 0.4287 | 1 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0092 | 0.0781 | 0.0468 |
Echinococcus multilocularis | aldehyde reductase | 0.0226 | 0.2858 | 0.2614 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Schistosoma mansoni | pol-related | 0.0318 | 0.4287 | 0.4093 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0092 | 0.0781 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0686 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 0.0781 | 0.1822 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 0.0781 | 0.1822 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0318 | 0.4287 | 0.4093 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0318 | 0.4287 | 0.4093 |
Onchocerca volvulus | 0.0318 | 0.4287 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0318 | 0.4287 | 0.4093 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.0427 | 0.0995 |
Giardia lamblia | Aldose reductase | 0.0318 | 0.4287 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0318 | 0.4287 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0318 | 0.4287 | 0.4093 |
Toxoplasma gondii | aldose reductase, putative | 0.0318 | 0.4287 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0092 | 0.0781 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0318 | 0.4287 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0318 | 0.4287 | 0.4093 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0318 | 0.4287 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0092 | 0.0781 | 0.0468 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0318 | 0.4287 | 0.4093 |
Plasmodium vivax | aldehyde reductase, putative | 0.0092 | 0.0781 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0318 | 0.4287 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0318 | 0.4287 | 1 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0092 | 0.0781 | 0.1142 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.0427 | 0.0101 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0318 | 0.4287 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0318 | 0.4287 | 0.4093 |
Onchocerca volvulus | 0.0318 | 0.4287 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0318 | 0.4287 | 0.4093 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0318 | 0.4287 | 0.4093 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0318 | 0.4287 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0318 | 0.4287 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0318 | 0.4287 | 1 |
Onchocerca volvulus | 0.0318 | 0.4287 | 1 | |
Loa Loa (eye worm) | oxidoreductase | 0.0318 | 0.4287 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0318 | 0.4287 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0318 | 0.4287 | 0.4093 |
Trypanosoma cruzi | aldo-keto reductase | 0.0318 | 0.4287 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0318 | 0.4287 | 0.4093 |
Onchocerca volvulus | 0.0318 | 0.4287 | 1 | |
Onchocerca volvulus | 0.0092 | 0.0781 | 0.1822 | |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.0427 | 0.0101 |
Loa Loa (eye worm) | oxidoreductase | 0.0318 | 0.4287 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Onchocerca volvulus | 0.0318 | 0.4287 | 1 | |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0092 | 0.0781 | 0.1142 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0318 | 0.4287 | 0.4093 |
Entamoeba histolytica | aldose reductase, putative | 0.0318 | 0.4287 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0318 | 0.4287 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.0427 | 0.0995 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0318 | 0.4287 | 0.4093 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0318 | 0.4287 | 0.4093 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0318 | 0.4287 | 0.4093 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0318 | 0.4287 | 0.4093 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0318 | 0.4287 | 0.4093 |
Entamoeba histolytica | aldose reductase, putative | 0.0318 | 0.4287 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0318 | 0.4287 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0318 | 0.4287 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose (functional) | = 10.7 mg kg-1 | Evaluated for in vivo neuroprotective activity in a mouse head injury model expressed as 1 hr post injury grip scores | ChEMBL. | 2319560 |
Dose (functional) | = 10.7 mg kg-1 | Evaluated for in vivo neuroprotective activity in a mouse head injury model expressed as 1 hr post injury grip scores | ChEMBL. | 2319560 |
IC50 (functional) | = 15 uM | Ability to inhibit iron-dependent lipid peroxidation in rat brain homogenate using MDA (malonyldialdehyde) formation assay | ChEMBL. | 2319560 |
Lowest effective dose (functional) | = 0.03 mg kg-1 | Lowest effective dose in a mouse head injury model was reported | ChEMBL. | 2319560 |
Lowest effective dose (functional) | = 0.03 mg kg-1 | Lowest effective dose in a mouse head injury model was reported | ChEMBL. | 2319560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.