TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 275.386 | Formula: C17H25NO2
H donors: 0 H acceptors: 1 LogP: 3.2 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)C1CCN(CC1)C(=O)CC(C)C
InChi: 1S/C17H25NO2/c1-13(2)11-17(19)18-9-7-14(8-10-18)15-5-4-6-16(12-15)20-3/h4-6,12-14H,7-11H2,1-3H3
InChiKey: CYRNGCSWFLNGPC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	proteasome beta 2 subunit, putative	0.0231	0.1059	0.1059
Brugia malayi	proteasome subunit alpha type 6	0.0231	0.1059	0.1059
Echinococcus multilocularis	proteasome subunit beta type 6	0.0231	0.1059	0.1059
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0231	0.1059	0.1059
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0565	0.4229	0.4229
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0231	0.1059	0.1059
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0912	0.7518	0.7518
Brugia malayi	Proteasome subunit alpha type 1	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0231	0.1059	0.1059
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0231	0.1059	0.1059
Brugia malayi	proteasome subunit alpha type 4	0.0231	0.1059	0.1059
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0565	0.4229	0.4229
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0565	0.4229	0.4229
Echinococcus granulosus	proteasome subunit alpha type 2	0.0231	0.1059	0.1059
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0231	0.1059	0.1059
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0231	0.1059	0.1059
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0231	0.1059	0.1059
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0231	0.1059	0.1059
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0565	0.4229	0.3546
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0231	0.1059	0.1059
Leishmania major	proteasome alpha 7 subunit, putative	0.0231	0.1059	0.1059
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0231	0.1059	0.1059
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0565	0.4229	0.3546
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0231	0.1059	0.1059
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0912	0.7518	0.7224
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0231	0.1059	0.1059
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0231	0.1059	0.1059
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0231	0.1059	0.1059
Brugia malayi	Proteasome A-type and B-type family protein	0.0231	0.1059	0.1059
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0565	0.4229	0.3546
Leishmania major	proteasome alpha 1 subunit, putative	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0231	0.1059	0.1059
Trypanosoma brucei	proteasome beta 7 subunit	0.0231	0.1059	0.1059
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0912	0.7518	0.7224
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0565	0.4229	0.4229
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0912	0.7518	0.7518
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0231	0.1059	0.1059
Echinococcus granulosus	proteasome subunit beta type 7	0.0231	0.1059	0.1059
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0231	0.1059	0.1059
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0231	0.1059	0.1059
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0231	0.1059	0.1059
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0231	0.1059	0.1059
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0565	0.4229	0.3546
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0231	0.1059	0.1059
Echinococcus multilocularis	proteasome subunit beta type 7	0.0231	0.1059	0.1059
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0231	0.1059	0.1059
Trypanosoma brucei	proteasome beta 6 subunit	0.0912	0.7518	0.7518
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0231	0.1059	0.1059
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0231	0.1059	0.1059
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0231	0.1059	0.1059
Brugia malayi	proteasome subunit beta type 3	0.0231	0.1059	0.1059
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0912	0.7518	0.7518
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0231	0.1059	0.1059
Loa Loa (eye worm)	PAS-3 protein	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0231	0.1059	0.1059
Leishmania major	proteasome alpha 3 subunit, putative	0.0231	0.1059	0.1059
Giardia lamblia	Proteasome subunit beta type 1	0.0912	0.7518	0.7224
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0565	0.4229	0.4229
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0231	0.1059	0.1059
Trypanosoma cruzi	20S proteasome subunit	0.0565	0.4229	0.4229
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0231	0.1059	0.1059
Echinococcus granulosus	proteasome subunit beta type 6	0.0231	0.1059	0.1059
Onchocerca volvulus	Notchless protein homolog	0.0231	0.1059	0.5
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0565	0.4229	0.4229
Brugia malayi	Proteasome subunit alpha type 7-1	0.0231	0.1059	0.1059
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0231	0.1059	0.1059
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0231	0.1059	0.5
Leishmania major	proteasome beta 3 subunit, putative	0.0231	0.1059	0.1059
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0231	0.1059	0.1059
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0912	0.7518	0.7224
Leishmania major	proteasome alpha 7 subunit, putative	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0231	0.1059	0.1059
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0912	0.7518	0.7518
Brugia malayi	proteasome subunit alpha type 3	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0231	0.1059	0.1059
Brugia malayi	proteasome subunit beta type 2	0.0565	0.4229	0.4229
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0231	0.1059	0.1059
Brugia malayi	20S proteasome alpha5 subunit	0.0231	0.1059	0.1059
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0231	0.1059	0.1059
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0231	0.1059	0.1059
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0565	0.4229	0.4229
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0231	0.1059	0.1059
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0231	0.1059	0.1059
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0231	0.1059	0.1059
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0912	0.7518	0.7518
Leishmania major	proteasome alpha 2 subunit, putative	0.0231	0.1059	0.1059
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0231	0.1059	0.1059
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0231	0.1059	0.1059
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0231	0.1059	0.1059
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0231	0.1059	0.1059
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0231	0.1059	0.1059
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0231	0.1059	0.1059
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0231	0.1059	0.1059
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0231	0.1059	0.1059
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0912	0.7518	0.7224
Brugia malayi	proteasome subunit alpha type 1	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0912	0.7518	0.7518
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0231	0.1059	0.1059
Brugia malayi	Proteasome A-type and B-type family protein	0.0231	0.1059	0.1059
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0231	0.1059	0.1059
Brugia malayi	Proteasome A-type and B-type family protein	0.0231	0.1059	0.1059
Trypanosoma brucei	proteasome alpha 7 subunit	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0912	0.7518	0.7518
Brugia malayi	proteasome subunit alpha type 2	0.0231	0.1059	0.1059
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0231	0.1059	0.1059
Leishmania major	proteasome beta-1 subunit, putative	0.0231	0.1059	0.1059
Leishmania major	proteasome alpha 1 subunit, putative	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0231	0.1059	0.1059
Giardia lamblia	Proteasome subunit beta type 2	0.0565	0.4229	0.3546
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0231	0.1059	0.1059
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0231	0.1059	0.1059
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0231	0.1059	0.1059
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0231	0.1059	0.1059
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0912	0.7518	0.7224
Leishmania major	proteasome beta 2 subunit, putative	0.0565	0.4229	0.4229
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0231	0.1059	0.1059
Echinococcus granulosus	proteasome subunit beta t family	0.0231	0.1059	0.1059
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0231	0.1059	0.1059
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0565	0.4229	0.3546
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0231	0.1059	0.1059
Leishmania major	proteasome beta 7 subunit, putative	0.0231	0.1059	0.1059
Echinococcus granulosus	Proteasome subunit alpha beta	0.0231	0.1059	0.1059
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0565	0.4229	0.3546
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0231	0.1059	0.1059
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0231	0.1059	0.1059
Brugia malayi	proteasome subunit beta type 1	0.0912	0.7518	0.7518
Echinococcus granulosus	proteasome subunit alpha type 6	0.0231	0.1059	0.1059

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1669684

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1507318