Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.0123 | 0.1079 | 0.0734 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0084 | 0.0172 | 0.0172 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0364 | 0.6653 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0215 | 0.3199 | 0.2936 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0364 | 0.6653 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0364 | 0.6653 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0093 | 0.0372 | 0.0372 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0364 | 0.6653 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0215 | 0.3199 | 0.2936 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0364 | 0.6653 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0364 | 0.6653 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0091 | 0.0336 | 0.0336 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0093 | 0.0372 | 0.0372 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0091 | 0.0336 | 0.0336 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0084 | 0.0172 | 0.0172 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0364 | 0.6653 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0364 | 0.6653 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0364 | 0.6653 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.