Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 50 ug ml-1 | Cytotoxic concentration reducing HEL cell growth by 50%. | ChEMBL. | 12217359 |
CC50 (functional) | > 50 ug ml-1 | Cytotoxic concentration reducing HEL cell growth by 50%. | ChEMBL. | 12217359 |
IC50 (functional) | > 50 ug ml-1 | Antiviral activity was tested against human cytomegalovirus AD-169 which reduces virus plaque formation by 50% | ChEMBL. | 12217359 |
IC50 (functional) | > 50 ug ml-1 | Antiviral activity was tested against human cytomegalovirus Davis which reduces virus plaque formation by 50% | ChEMBL. | 12217359 |
IC50 (functional) | > 50 ug ml-1 | Antiviral activity was tested against TK+ varicella-zoster virus YS which reduces virus plaque formation by 50% | ChEMBL. | 12217359 |
IC50 (functional) | > 50 ug ml-1 | Antiviral activity was tested against TK+ varicella-zoster virus OKA which reduces virus plaque formation by 50% | ChEMBL. | 12217359 |
IC50 (functional) | > 50 ug ml-1 | Antiviral activity was tested against TK- varicella-zoster virus 07/1 which reduces virus plaque formation by 50% | ChEMBL. | 12217359 |
IC50 (functional) | > 50 ug ml-1 | Antiviral activity was tested against TK- varicella-zoster virus YS/R which reduces virus plaque formation by 50% | ChEMBL. | 12217359 |
IC50 (functional) | > 200 ug ml-1 | Antiproliferative activity was tested against murine leukemia cells-L1210/0 | ChEMBL. | 12217359 |
IC50 (functional) | > 200 ug ml-1 | Antiproliferative activity was tested against human T-lymphocyte cells-Molt 4/C8 | ChEMBL. | 12217359 |
IC50 (functional) | > 200 ug ml-1 | Antiproliferative activity was tested against human T-lymphocyte cells-CEM/0 | ChEMBL. | 12217359 |
IC50 (functional) | > 200 ug ml-1 | Antiproliferative activity was tested against murine leukemia cells-L1210/0 | ChEMBL. | 12217359 |
MCC (functional) | > 50 ug ml-1 | Minimum cytotoxic concentration against HEL cell morphology. | ChEMBL. | 12217359 |
MCC (functional) | > 50 ug ml-1 | Minimum cytotoxic concentration against HEL cell morphology. | ChEMBL. | 12217359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.